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In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines

Brocklehurst, Cara and Rothe-Poellet, Stephanie and Koch, Guido and La Vecchia, Luigi (2017) In Situ Preparation and Consumption of O-Mesitylsulfonylhydroxylamine (MSH) in Continuous Flow for the Amination of Pyridines. Synlett. ISSN 14372096

Abstract

The paper demonstrates a safe method in which highly unstable O-mesitylsulfonylhydroxylamine (MSH) can be prepared and consumed in continuous flow. MSH was prepared in situ and used for the flow amination of a range of pyridines, which were subsequently transformed into useful pyrazolopyridine building blocks.

Item Type: Article
Keywords: flow O-mesitylsulfonylhydroxylamine pyrazolopyridines pyridine safety
Date Deposited: 07 Jul 2017 00:45
Last Modified: 25 Jan 2019 00:45
URI: https://oak.novartis.com/id/eprint/31794

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