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EBI2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis

Clottu, A and Mathias, A and Sailer, Andreas and Schluep, M and Seebach, J and Du Pasquier, R and Pot, Caroline (2017) EBI2 expression and function: robust in memory lymphocytes and increased by natalizumab in multiple sclerosis. Cell Reports, 18 (1). pp. 213-224.

Abstract

The interaction between oxysterols and the G-protein coupled receptor Epstein-Barr virus induced gene 2 (EBI2) fine tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS). We previously showed that memory CD4+ T lymphocytes migrate specifically in response to 7α,25-dihydroxycholesterol (7α,25-OHC) via EBI2 in the MS murine model experimental autoimmune encephalomyelitis. However, EBI2 expression profile in human lymphocytes both in healthy and MS donors is unknown. Here, we characterize EBI2 biology in human lymphocytes. We observed that EBI2 is functionally expressed on memory CD4+ T cells and is enhanced under natalizumab treatment, a drug fighting MS by targeting immune cell trafficking. These data suggest a significant role for EBI2 in human CD4+ T cell migration, notably in patients with MS. A better knowledge of EBI2 involvement in autoimmunity may therefore lead to an improved understanding of the physiopathology of MS.

Item Type: Article
Keywords: Oxysterol; EBI2; GPR183, natalizumab
Date Deposited: 24 Jan 2017 00:45
Last Modified: 24 Jan 2017 00:45
URI: https://oak.novartis.com/id/eprint/30176

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