Lovelle, Lucie (2017) Highly Regioselective Organocatalytic SNAr Amination of 2,4-Dichloropyrimidine and Related Heteroaryl Chlorides. European journal of organic chemistry. pp. 3222-3228. ISSN 1099-0690; 1434-193X

Abstract

A highly efficient and regioselective method for the SNAr amination of 2,4-dichloropyrimidine with oxazolidin-2-one and related weakly nucleophilic amines is disclosed using sodium sulfinate and tetrabutylammonium bromide as catalysts. The presented strategy facilitates the synthesis of various aminopyrimidines in a regio- and chemoselective manner. Furthermore, this approach was successfully applied to the amination of various activated N-heteroaromatic substrates.

Item Type:	Article
Date Deposited:	27 Jun 2017 00:45
Last Modified:	27 Jun 2017 00:45
URI:	https://oak.novartis.com/id/eprint/32016