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Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors

Smith, Aaron, Ni, ZJ, Poon, Daniel, Huang, Zilin, Chen, Zheng, Zhang, Qiong, Tandeske, Laura, Merritt, Hanne, Shoemaker, Kevin, Chang, John, Kaufman, Sue, Huh, Kay, Murray, Jeremy, Appleton, Brent A., Jacob, Sandra, Scheufler, Clemens, Kanazawa, Takanori, Jansen, Hanneke, Stuart, Darrin and Shafer, Cynthia (2017) Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405


A series of imidazo[1,2-a]pyridin-6-yl-benzamide analogs was designed as inhibitors of B-RAFV600E. Medicinal chemistry techniques were employed to explore the SAR for this series and improve selectivity versus P38 and VEGFR2.

Item Type: Article
Keywords: Kinase MAPK RAF
Date Deposited: 29 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:45


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