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Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors

Smith, Aaron and Ni, ZJ and Poon, Daniel and Huang, Zilin and Chen, Zheng and Zhang, Qiong and Tandeske, Laura and Merritt, Hanne and Shoemaker, Kevin and Chang, John and Kaufman, Sue and Huh, Kay and Murray, Jeremy and Appleton, Brent A. and Jacob, Sandra and Scheufler, Clemens and Kanazawa, Takanori and Jansen, Hanneke and Stuart, Darrin and Shafer, Cynthia (2017) Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors. Bioorganic and Medicinal Chemistry Letters. ISSN 14643405


A series of imidazo[1,2-a]pyridin-6-yl-benzamide analogs was designed as inhibitors of B-RAFV600E. Medicinal chemistry techniques were employed to explore the SAR for this series and improve selectivity versus P38 and VEGFR2.

Item Type: Article
Keywords: Kinase MAPK RAF
Date Deposited: 29 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:45


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