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A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia

Suply, Thomas and Hannedouche, Sebastien and Carte, Nathalie and Li, Jianping and Grosshans, Bianka and Schaefer, Michael and Raad, Layla and Beck, Valerie and Vidal, Solange and Beluch, Noemie and Barbieri, Samuel and Wirsching, Johann and Lageyre, Nadine and Lannoy, Vincent and Detheux, Michel and Bitsch, Francis and Falchetto, Rocco Angelo and Bouwmeester, Antonius and Porter, Jeffrey and Baumgarten, Birgit and Mansfield, Keith and Carballido, Jose and Seuwen, Klaus and Bassilana, Frederic (2017) A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. Science Signaling, 10 (496). ISSN 19379145

Abstract

GPR15 is an orphan G protein-coupled receptor (GPCR) that is found in lymphocytes. It functions as a co-receptor of simian immunodeficiency virus and HIV-2 and plays a role in the trafficking of T cells to the lamina propria in the colon and to the skin. We describe the purification from porcine colonic tissue extracts of an agonistic ligand for GPR15 and its functional characterization. In humans, this ligand, which we named GPR15L, is encoded by the gene C10ORF99 and has some features similar to the CC family of chemokines. GPR15L was found in some human and mouse epithelia exposed to the environment, such as the colon and skin. In humans, GPR15L was also abundant in the cervix. In skin, GPR15L was readily detected after immunologic challenge and in human disease, for example, in psoriatic lesions. Allotransplantation of skin from Gpr15l-deficient mice onto wild-type mice resulted in substantial graft protection, suggesting nonredundant roles for GPR15 and GPR15L in the generation of effector T cell responses. Together, these data identify a receptor-ligand pair that is required for immune homeostasis at epithelia and whose modulation may represent an alternative approach to treating conditions affecting the skin such as psoriasis.

Item Type: Article
Date Deposited: 05 Dec 2017 00:45
Last Modified: 25 Jan 2019 00:45
URI: https://oak.novartis.com/id/eprint/30283

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