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Articular cartilage and joint development from embryogenesis to adulthood.

Decker, Rebekah (2017) Articular cartilage and joint development from embryogenesis to adulthood. Seminars in cell & developmental biology, 62. pp. 50-56. ISSN 1096-3634


Within each synovial joint, the articular cartilage is uniquely adapted to bear dynamic compressive loads and shear forces throughout the joint's range of motion. Injury and age-related degeneration of the articular cartilage often lead to significant pain and disability, as the intrinsic repair capability of the tissue is extremely limited. Current surgical and biological treatment options have been unable to restore cartilage de novo. Before successful clinical cartilage restoration strategies can be developed, a better understanding of how the cartilage forms during normal development is essential. This review focuses on recent progress made towards addressing key questions about articular cartilage morphogenesis, including the origin of synovial joint progenitor cells, postnatal development and growth of the tissue. These advances have provided novel insight into fundamental questions about the developmental biology of articular cartilage, as well as potential cell sources that may participate in joint response to injury.

Item Type: Article
Date Deposited: 17 Jan 2019 00:45
Last Modified: 17 Jan 2019 00:45


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