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Segmented Flow Platform for On-​Demand Medicinal Chemistry and Compound Synthesis in Oscillating Droplets

Marzinzik, Andreas and Koch, Guido and Spanka, Carsten and Lehmann, Hansjoerg and Hwang, Ye-Jin and Coley, Connor and Abolhasani, Milad and Jensen, Klavs (2017) Segmented Flow Platform for On-​Demand Medicinal Chemistry and Compound Synthesis in Oscillating Droplets. Chem. Commun.. ISSN 1359-73451364-548X

Abstract

We report an automated flow chemistry platform that can efficiently screen a wide range of reactions, including single/multi-phase and single/multi-step, with a reaction volume of just 14 L. In addition to 36 N-X bond forming reactions, we demonstrate the breadth of compatible chemistries with two multi-phase Suzuki-Miyaura cross-coupling reactions and a two-step synthesis of the drug product diclofenac. Products are characterized and isolated online by preparative HPLC/MS/ELSD and can be collected in a vial- or plate-based format.

Item Type: Article
Date Deposited: 20 Jun 2017 00:45
Last Modified: 20 Jun 2017 00:45
URI: https://oak.novartis.com/id/eprint/32011

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