Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches

Moebitz, Henrik and Jahnke, Wolfgang and Jacob, Sandra (2017) Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches. Current topics in medicinal chemistry, 17. pp. 59-70. ISSN 1873-4294

Abstract

The need for novel approaches for targeting well-known protein families in drug discovery has been discussed for several years. There is a huge amount of literature on the inhibition of kinases with small molecules targeting the ATP site, and as a result of this extensive research, there are a large number of kinase inhibitors in the clinic. However, even though the idea of targeting other sites on kinases is not new, relatively little has been reported. In this review we give an overview of structurally characterized allosteric kinase inhibitors, outline the benefits of these with the use of case studies and then discuss the challenges that need to be overcome and the opportunities for doing this.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - Eng [Field not mapped to EPrints] ET - 2016/07/28 [Field not mapped to EPrints] ST - Expanding the Opportunities for Modulating Kinase Targets with Allosteric Approaches [Field not mapped to EPrints] AU - Mobitz, H. [Field not mapped to EPrints] AU - Jahnke, W. [Field not mapped to EPrints] AU - Cowan-Jacob, S. W. [Field not mapped to EPrints] AD - Novartis institute of Biomedical Research, Novartis Campus. Sandra.jacob@novartis.com. [Field not mapped to EPrints] DP - NLM [Field not mapped to EPrints] AN - 27448652 [Field not mapped to EPrints]
Date Deposited: 03 Jan 2017 00:45
Last Modified: 03 Jan 2017 00:45
URI: https://oak.novartis.com/id/eprint/27575

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.