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Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode

Martin, Benjamin and Haber, Julien and Venturoni, Francesco and Sedelmeier, Joerg Mathias and Schenkel, Berthold and Kleinbeck-Riniker, Florian and Kamptmann, Sonja and Pellegatti, Laurent and Bouisseau, Anais and Fernandez-Rodriguez, Patricia and Susanne, Flavien and Hoehn, Pascale and Lanz, Marian and Robertson, Jeremy and Willis, Michael (2017) Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode. Green chemistry, 19. pp. 1439-1448.

Abstract

Hydrogen peroxide embodies an ideal oxidant in terms of atom-economy, availability and green metrics. However, its use has been limited because of risks associated with disproportionation and the exothermic potential of oxidizing reaction mixtures. This study aims to showcase the versatility of hydrogen peroxide in a range of oxidations, while ensuring that such processes operate practically and with a defined and minimized risk. To offset the hazards of using peroxides, continuous-flow equipment was utilized to limit the volume of unquenched peroxides and to maintain process control. A methodological approach was established relying on kinetic and calorimetric understanding. Finally, scalability was highlighted in an organocatalysed heterocyclic N-oxidation using a cascade of stirred tank reactors with nitrogen flushing.

Item Type: Article
Keywords: oxidation; peracetic acid; peroxyacetimidic acid; continuous-flow; sulfoxidation; epoxidation; oxidative amidation; N-oxidation; CSTR
Date Deposited: 21 Mar 2017 00:45
Last Modified: 21 Mar 2017 00:45
URI: https://oak.novartis.com/id/eprint/31273

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