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Items where Year is 2015

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Number of items: 411.

Ménard, Joël, Watson, Catherine, Rigel, Dean, Jeng, Arco Y., Liang, Guiqing, Rebello, Sam, Zhang, Yiming, Dole, William, Fu, Fumin, Beil, Michael, Liu, Jing, Chen, Wei, Hu, Chii-Whei, Leung-Chu, Jennifer and LaSala, Daniel (2015) Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects. Journal of Translational Medicine.


Altmann, Eva, Grosche, Philipp, Sirockin, Finton, Mac Sweeney, Aengus, Ramage, Paul, Erbel, Paulus, Melkko, Samu, Bernardi, Anna, Hughes, Nicola, Ellis, David and Jarrousse Coscoy, Nadine (2015) Structure-based design and optimization of potent inhibitors of the adenoviral protease. Structure-based design and optimization of potent inhibitors of the adenoviral protease, 25 (3). pp. 438-443. ISSN 0960-894X

Alzahrani, Mohammad M., Makhdom , Asim M., Rauch, Frank, Lauzier, Dominique, Kotsiopriftis, Maria and Hamdy, Reggie C. (2015) Assessment of the Effect of Systemic Delivery of Sclerostin Antibodies on WNT Signaling in Distraction Osteogenesis Using Immunohistochemistry. Journal of orthopaedic research.

Ammann, P, Zacchetti, G, Gasser, Juerg Andreas, Lavet, C and Rizzoli, R (2015) Protein malnutrition attenuates bone anabolic response to PTH in female rats. Endocrinology.

Annan, Kofi, Ekuadzi, Edmund, Asare, Cindy, Sarpong, Kwane, Pistorius, Dominik, Oberer, Lukas, Gyan, Ben A. and Ofori, Michael (2015) Antiplasmodial Constituents from the Stem Bark of Polyalthia longifolia var Pendula. Phytochemistry Letters, 11. pp. 28-31.

April, Myriam, Daniels, Thomas, Forster, Cornelia, Jain, Monish, Kanter, Aaron, Li, Jingzhou, Streeper, Ryan, Wang, Bing, Brewer, Jason, Gilmore, Thomas, Kwak, Youngshin, Serrano-Wu, Michael, Szklennik, Paul, Thompson, James and McQuire , Les (2015) Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors. Bioorganic and medicinal chemistry letters, 26 (4). pp. 1245-1248. ISSN 0960894X

Arduin, Elodie, Arora, Seguinde, Bamert, Paulo Roky, Kuiper, Torsten, Popp, Simone, Geisse, Sabine, Grau, Roger, Calzascia, Thomas, Zenke, Gerhard and Kovarik, Jiri (2015) Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a. Molecular Immunology, 63 (2). pp. 456-463.

Arias, HR, Feuerbach, Dominik and Ortells, Marcelo (2015) Functional and Structural Interaction of (-)-Lobeline with human α4β2 and α4β4 Nicotinic Acetylcholine Receptor Subtypes. Int. J. Biochem. Cell Bio.

Arias, HR, Targowska-Duda, KM, Feuerbach, Dominik and Jozwiak, K (2015) The antidepressant-like activity of nicotine, but not 3-furan-2-yl-N-p-tolyl-acrylamide, is regulated by the nicotinic receptor β4 subunit. Neuroscience letter.

Arias, Hugo R, Targowska-Duda, Katarzyna M, Feuerbach, Dominik and Jozwiak, Krzysztof (2015) Coronaridine congeners inhibit human α3β4 Nicotinic Acetylcholine Receptors by interacting with luminal and non-luminal sites. Biochemistry.

Arista, Luca, Renier , van der Westhuyzena, Susan, Winks, Colin, Wilson, Grant, Boyle, Richard, Gessner, Candice, Soares de Melo, Dale, Taylor, Carmen, de Kock, Mathew, Njoroge, Christel, Brunschwig, Nina, Lawrence, Frik, Sirgel, Paul, van Helden, Ronnett, Seldon, Atica, Moose, Digby, Warner, Ujjini , Manjunatha, Paul, Smith, Leslie, Street and Kelly, Chibale (2015) Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A new anti-mycobacterial class that targets mycobacterial energy metabolism. Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A new anti-mycobacterial class that targets mycobacterial energy metabolism, 58 (23). pp. 9371-9381. ISSN 0022-26231520-4804

Ashok, Y, Nanekar, R and Jaakola, V-P (2015) Defining thermostability of membrane proteins by western blotting. Protein engineering, design & selection : PEDS, 28 (12). pp. 539-542. ISSN 1741-0134

Asmus, Lutz R., Grimshaw, John, Richle, Philipp, Eicher, Barbara, Urech, David M., Gurny, Robert and Moeller, Michael (2015) Injectable Formulations for an Intravitreal Sustained-Release Application of a Novel Single-Chain VEGF Antibody Fragment. European Journal of Pharmaceutics and Biopharmaceutics, 95 (Part B). pp. 250-260. ISSN 0939-6411

Auld, Douglas and Jimenez, Marta (2015) Examining Ligand-based Stabilization of Proteins in Cells with MEK1 Kinase Inhibitors. Assay and Drug Development Technologies, 13 (5). pp. 266-276. ISSN 1540-658X1557-8127

Auld, Douglas, Wassermann, Anne and Camargo, Miguel (2015) Composition and applications of focus libraries to phenotypic assays. Frontiers in Pharmacology, 5. ISSN 1663-9812

Awan, Zuhier, Denis, Maxime, Awan, Amani, Gram, Hermann, Seidah, Nabil and Genest, Jaques (2015) Inhibition of Interleukin-1β by a Monoclonal Antibody Therapy Reduces Vascular Calcification in Ldlr-/- Mice. Angiology.

Ayalasomayajula, Surya, Meyers, Charles, Koo, Phil, Salunke, Atish Azad, Majumdar, Tapan, Rebello, Sam, Sunkara, Gangadhar and Chen, Jin (2015) Assessment of Pharmacokinetic Drug-Drug Interaction between Pradigastat and Acetaminophen in Healthy Subjects. European Jouranl of Clinical Pharmacology.

Ayalasomayajula, Surya, Meyers, Charles, Yu, Jing, Kagan, Mark, Matott, Ralph, Pal, Parasar, Majumdar, Tapan, Crissey, Anne, Rebello, Sam, Sunkara, Gangadhar and Chen, Jin (2015) Evaluation of food effect on the oral bioavailability of pradigastat, a diacylglycerol acyltransferase 1 inhibitor. Biopharmaceutics & Drug Disposition .


Bagdanoff, Jeffrey, Jain, Rama, Han, Wooseok, Ding, Yu, Poon, Daniel, Lee, Patrick and Lindvall, Mika (2015) Highly ligand efficient tetrahydro-pyrazolopyridines as inhibitors of ERK2 kinase. Bioorganic and Medicinal Chemistry Letters.

Bagdanoff, Jeffrey, Jain, Rama, Han, Wooseok, Zhu, Shejin, Madera, Ann Marie, Lee, Patrick and Poon, Daniel (2015) Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase. Bioorganic and Medicinal Chemistry Letters, 25 (18). pp. 3788-3792. ISSN 14643405

Bagdanoff, Jeffrey, Xu, Yongjin, Dollinger, Gavin and Martin, Eric (2015) Effect of Chirality on Common in Vitro Experiments: An Enantiomeric Pair Analysis. Journal of Medicinal Chemistry, 58 (15). pp. 5781-5788. ISSN 1520-4804

Bagdanoff, Jeffrey, Xu, Yongjin, Martin, Eric and Dollinger, Gavin (2015) The Effect of Chirality on Common In Vitro Experiments: An Enantiomeric Pair Analysis. Jounal of Medicinal Chemistry.

Balakrishnan, Karthikeyan, Upadhaya, Ajeet Rijal, Steinmetz, Julia, Abramowski, Dorothee, Faendrich, Marcus, Kumar, Satish, Yamaguchi, Haruyasu, Walter, Jochen, Staufenbiel, Matthias and Thal, Dietmar R (2015) Impact of amyloid beta aggregate maturation on antibody treatment in APP23 mice. Acta Neuropathol Comm., 3 (1). p. 41.

Bandell, Michael, Cahalan, Stuart, Lukacs, Victor, Ranade, Sanjeev, Chien, Shu and Patapoutian, Ardem (2015) Piezo1 links mechanical forces to red blood cell volume. eLife, 4 (MAY). ISSN 2050-084X

Bandell, Michael, Xu, Jie, Mathur, Jayanti, Huynh, Truc, Matzen, Jason, Lao, Jianmin, Tully, David, Petrassi, Hank, Schumacher, Andrew, montal, Mauricio, syeda, Ruhma, Dubin, Adrienne, Coste, Bertrand and Patapoutian, Ardem (2015) Chemical activation of the mechanotransduction channel Piezo1. eLife, 4 (MAY). ISSN 2050084X

Banigan, James R, Gayen, Anindita, Cho, Min-Kyu and Traaseth, Nathaniel J (2015) A structured loop modulates coupling between the substrate-binding and dimerization domains in the multidrug resistance transporter EmrE. Journal of Biological Chemistry, 290 (2). pp. 805-814. ISSN 0021-92581083-351X

Barsanti, Paul, Aversa, Robert, Jin, Jeff, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, George, Xiao, Linda and Yue, Qin (2015) Structure based drug design of novel potent and selective tetrahydropyrazolo[1,5-a]pyrazines as ATR inhibitors. ACS Medicinal Chemistry Letters, 6 (1). pp. 37-41. ISSN 1948-58751948-5875

Barsanti, Paul A., Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert, Dillon, Michael, Elling, Robert, Hu, Cheng, Jin, Jeff, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathus, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda and Yue, Qin (2015) Structure-based Drug Design of Novel, Potent and Selective Azabenzimidazoles (ABI) as ATR Inhibitors. ACS Medicinal Chemistry Letters, 6 (1). pp. 42-46. ISSN 1948-58751948-5875

Bednarczyk, Dallas and Boiselle, Carri (2015) Transport of coproporphyrins I and III by organic anion transporting polypeptides (OATP) 1B1 and 1B3. Xenobiotica, 46 (5). pp. 457-466. ISSN 1366-5928

Behnke, Dirk, Cotesta, Simona, Hintermann, Samuel, Fendt, Markus, Gee, Christine, Jacobson, Laura, Laue, Grit, Meyer, Arndt, Wagner, Beatrix, Badiger, Sangamesh, Chaudhari, Vinod, Chebrolu, Murali, Pandit, Chetan, Hoyer, Daniel and Betschart, Claudia (2015) Discovery of 1H-pyrazolo[3,4-b]pyridines as potent dual orexin receptor antagonists (DORAs). Bioorganic and Medicinal Chemistry Letters, 25 (23). pp. 5555-5560. ISSN 0960-894X

Benjamin, Amanda, Gallacher, David J, Gintant, Gary, Greiter-Wilke, Andrea, Guillon, Jean-Michel, Kasia, Cheiko, Leishman, Derek, Levesque, Paul, Louttit, James, Prelle, Katja, Ratcliffe, Sian, Sannajust, Frederick, Ledieu, David, Vargas, Hugo and Valentin, Jean-Pierre (2015) Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies. Journal of Pharmacological and Toxicological Methods.

Bhansali, Suraj, Mullane, Kathleen, Ting, Lillian, Leeds, Jennifer, Dabovic, Kristina, Praestgaard, Jens and Pertel, Peter (2015) Pharmacokinetics of LFF571 and vancomycin in patients with moderate Clostridium difficile infections. Antimicrobial Agents and Chemotherapy, 59 (3). pp. 1441-1445. ISSN 1098-6596

Bhattacharjee, Maumita , Coburn, Jeannine , Centola, Matteo, Murab, Sumit , Barbero, Andrea , Kaplan, David L., Martin, Ivan and Ghosh, Sourabh (2015) Tissue engineering strategies to study cartilage development, degeneration and regeneration. Advanced Drug Delivery Reviews, 84. pp. 107-122. ISSN 0169409X

Biswal, Shibadas, Polus, Florine, Pal, Parasar, Veldandi, Uday Kiran and Legangneux, Eric (2015) Pharmacokinetic and pharmacodynamic interaction of siponimod (BAF312) and propranolol in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics, 53 (10). pp. 855-865. ISSN 0946-1965

Biswal, Shibadas, Polus, Florine, Pal, Parasar, Veldandi, Uday Kiran and Legangneux, Eric (2015) Pharmacokinetic and pharmacodynamic interaction of siponimod (BAF312) and propranolol in healthy subjects. International Journal of Clinical Pharmacology and Therapeutics, 53 (10). pp. 855-865. ISSN 0946-1965

Bizet, Albane, Becker-Heck, Anita, Ryan, Rebecca, Weber, Kristina, Filhol, Emilie, Krug, Pauline, Halbritter, Jan, Linghu, Bolan, Oakeley, Edward James, Bole-Feysot, Christine, Nitschke, Patrick, Serluca-Aegerter, Fabrizio, Schmidt, Swetlana, Lasbennes-Eckerlen, Marie-Christine, Damask, Amy, Yang, Fan, Bouwmeester, Antonius, Valette, Huguette, Pinson, Lucile, Cassuto, Elisabeth, Dubot, Philippe, Soliman, Neveen, Sahel, Jose, Salomon, Remi, Antignac, Corinne, Gubler, Marie-Claire, Chibout, Salah-Dine, Szustakowski, Joseph, Hildebrandt, Friedhelm, Lorentzen, Esben, Sailer, Andreas, Benmerah, Alexandre, Saint-Mezard, Pierre and Saunier, Sophie (2015) Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization. Nat Comm. pp. 1-14. ISSN 2041-1723 (Electronic); 2041-1723 (Linking)

Blakeley, Daniel, Sykes, David, Aston, Philip and Charlton, Steven (2015) Simulating the influence of plasma protein on measured receptor affinity in biochemical assays reveals the utility of Schild analysis for estimating compound affinity for plasma proteins. British Journal of Pharmacology, 172 (21). pp. 5037-5049. ISSN 1476-5381

Blanz, Joachim, Delemonte, Thierry, Pearson, David, Luneau, Alexandre, Ritzau, Michael, Gertsch, Werner, Ramstein, Philippe, Dayer, Jerome, Desrayaud, Sandrine, Braun, Elisabeth and Aichholz, Reiner (2015) Micropreparative isolation and NMR structure elucidation of metabolites of a drug candidate from rat bile and urine. Journal of Chromatography B: Biomedical Sciences and Applications, 989. pp. 1-10.

Blatter, Markus, Dunin-Horkawicz, Stanislaw, Grishina, Inna , Maris, Christophe , Thore, Stephane , Maier, Timm , Bindereif, Albrecht and Allain, Frédéric H.-T. (2015) The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein. Journal of Molecular Biology.

Bojkovic, Jade, Richie, Daryl, Six, David, Rath, Christopher, Sawyer, William and Dean, Charles (2015) Characterization of an Acinetobacter baumannii lptD Deletion Strain; Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis. Journal of Bacteriology, 198 (4). pp. 731-741. ISSN 1098-5530

Bojkovic, Jade, Richie, Daryl, Six, David, Rath, Christopher, Sawyer, William, Hu, Daniel and Dean, Charles (2015) Characterization of an A. baumannii lptD Deletion Strain; Permeability Defects and Response to Inhibition of Lipopolysaccharide and Fatty Acid Biosynthesis. Journal of Bacteriology, 198 (4). pp. 731-741.

Bold, Guido, Schnell, Christian, Mcsheehy, Paul M.J., Brueggen, Josef, Mestan, Juergen, Manley, Paul W., Drueckes, Peter, Burglin, Marion, Duerler, Ursula, Loretan, Jacqueline, Reuter, Robert, Wartmann, Markus, Theuer, Andreas, Bauer-Probst, Beatrice, Martiny-Baron, Georg, Allegrini, Peter Roland, Furet, Pascal, Wood, Jeanette, Littlewood-Evans, Amanda and Goepfert, Arnaud (2015) A novel potent oral series of VEGFR2 inhibitors abrogate tumor growth by inhibiting angiogenesis. Journal of medicinal chemistry, 59 (1). pp. 132-146. ISSN 0022-26231520-4804

Boone, Jonathan, Cooper, Sara, Johnston, Bobby, Arend, Rebecca, Gilchrest, Austin, Oelschlager, Denise, Grizzle, William, McGwin, Gerald, Gangrade, Abhishek, Straughn, J. Michael and Buchsbaum, Donald (2015) Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974. Laboratory Investigation.

Bornancin, Frederic, Renner, Florian, Touil, Ratiba, Kolb, Yeter, Touil, Ismahane, Rush, James, Smith, Paul, Bigaud, Marc, Zamurovic Ribrioux, Natasa, Junker Walker, Ursula, Burkhart, Christoph, Dawson King, Janet, Regnier, Catherine, Niwa, Satoru, Katopodis, Andreas, Nuesslein-Hildesheim, Barbara, Weckbecker, Gisbert, Zenke, Gerhard, Kinzel, Bernd, Traggiai, Elisabetta, Brenner, Dirk, Brüstle, Anne, St Paul, Michael, McCoy, Kathy D., Rolink, Antonius, Mak, Tak W, Ohashi, Pamela S, Patel, Dhavalkumar and Calzascia, Thomas (2015) Deficiency in MALT1 paracaspase activity promotes multi-organ inflammation. Journal of Immunology, 194 (8). pp. 3723-3734. ISSN 1550-6606

Bouslimani, Amina , Porto, Carla , Rath, Christopher, Wang, Mingxun , Yurong , Guo , Gonzalez, Antonio , Berg-Lyon, Donna , Ackermann, Gail , Christensen , Gitte Julie Moeller , Teruaki , Nakatsuji , Zhang , Lingjuan , Borkowski , Andrew , Meehan , Michael , Dorrestein , Kathleen , Gallo , Richard , Bandeira, Nuno , Knight , Rob , Alexandrov , Theodore and Dorrestein , Pieter (2015) 3D molecular cartography of the human skin surface. PNAS.

Bradley, Michelle, Brown, Zarin, Charlton, Steven, Cromie, Karen, Dombrecht, Bruno, De Taeye, Severine, Van den Heede, Kim, Van Heeke, Gino, Kent, Toby, Laeremans, Toon, Manini, Jodie, Roobrouck, Annelies, Steffensen, Soren, Vlerick, David and Willis, Jennifer (2015) Potent and efficacious inhibition of CXCR2 signaling by biparatopic nanobodies combining two distinct modes of action. Molecular Pharmacology, 87 (2). pp. 251-262. ISSN 1521-0111

Briard, Emmanuelle, Rudolph, Bettina, Desrayaud, Sandrine, Krauser, Joel and Auberson, Yves (2015) MS565, a SPECT tracer for evaluating the brain penetration of BAF312 (siponimod). ChemMedChem, 10 (6). pp. 1008-1018. ISSN 18607179

Bringer, Pauline, Jensen, Michael Rugaard and Gembarska, Agnieszka (2015) Identification of piggyBac transposon insertions in malignant tumors. Master degree Bio-engineering applied to health, University of Toulouse III.

Brogdon, Jennifer, Loew, Andreas, Thekkat, Pramod, Idamakanti, Neeraja, Engels, Boris, Singh, Reshma, Ezell, Tucker, Zhou, Li, Ramones, Melissa, Li, Na, Maus, Marcela, Johnson, Laura, Scholler, John, June, Carl, Okada, Hideho, Plesa, Gabriela, Patel, Prachi, McGettigan, Shannon, Nace, Arben, Ohkuri, Takayuki, Kosaka, Akemi, Chen, Taylor, Fraietta, Joseph, Kloss, Christopher, Boesteanu, Alina, Cogdill, Alexandria and Seykora, John (2015) Validation of a humanized anti-EGFR variant III chimeric antigen receptor for a Phase I trial of CART-EGFRvIII in glioblastoma. Science Translational Medicine.

Burger, Matthew, Nishiguchi, Gisele, Han, Wooseok, Lan, Jiong, Simmons, Bob, Atallah, Gordana, Ding, Yu, Tamez Jr., Victoriano, zhang, yanchen, mathur, michelle, muller, kristine, Bellamacina, Cornelia, Lindvall, Mika, Zang, Richard, Huh, Kay, Feucht, Paul, Zavorotinskaya, Tatiana, Dai, Yumin, Basham, Steve, Chan, Julie, Ginn, Elaine, Aycinena, Alex, Holash, Jocelyn, Castillo, Joseph, Langowski, John, Wang, Yingyun, Chen, Min, Lambert, Amy, Fritsch, Christine, Kauffmann, Audrey, Pfister-Wagner, Estelle, Vanasse, K. Gary and Garcia, Pablo (2015) Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. Journal of Medicinal Chemistry.

Busby, Scott (2015) MALDI High-Throughput Screening beyond 100,000 Samples per Day in Drug Discovery. Bruker Poster Note PN-05.

Busche, Marc Aurel, Adelsberger, Helmuth, Kekus, Maja, Förstl, Hans, Nelken, Israel and Konnerth, Arthur (2015) Breakdown of slow-wave oscilliations in mouse modles of Alzheimer's disease. Nature Neuroscience.

Busche, Marc Aurel, Grienberger, Christine, Keskin, Aylin Derya, Song, Beomjong, Neumann, Ulf, Staufenbiel, Matthias, Förstl, Hans and Konnerth, Arthur (2015) Decreased amyloid-β but increased neuronal hyperactivity by immunotherapy in Alzheimer´s models. Nature Neuroscience.

Bushee, Jennifer, Dunne, Christine and Argikar, Upendra (2015) An in vitro approach to investigate ocular metabolism: Part II - Betaxolol. Xenobiotica.

Butler, Rebecca, Smith, Nichola and Hunt, Thomas (2015) ENaC Inhibitors for the Treatment of Cystic Fibrosis. Pharmaceutical Patent Analysis.


Camargo, Miguel, Zhang, X D, Loerch, Patrick, Caceres, RM, Marine, SD, UVa, P, Ferrer, M, Majercak, J, Ray, WJ, Yi-An, C, Shearman, MS and Mizuguchi, Kenji (2015) PATHWAY-BASED ANALYSIS OF GENOME-WIDE SIRNA SCREENS REVEALS THE REGULATORY LANDSCAPE OF APP PROCESSING. PLOS ONE, 10 (2). ISSN 1932-6203

Camenisch, Gian P., Poller, Birk, Kunze, Annett and Huwyler, Jörg (2015) Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins. Drug Metabolism and Personalized Therapy, 30 (3). pp. 175-188. ISSN 23638915

Camenisch, Gian P., Riede, Julia, Kunze, Annett, Huwyler, Jörg, Poller, Birk and Umehara, Ken-Ichi (2015) The extended clearance model and its use for the interpretation of hepatobiliary elimination data. ADMET&DMPK.

Canapari, CA, Barrowman, N, Hoey, L, Walker, SW, Townsend, E, Tseng, BS and Katz, SL (2015) Truncal Fat Distribution Correlates With Decreased Vital Capacity in Duchenne Muscular Dystrophy. Pediatric Pulmonology. pp. 63-70.

Carballido, Jose, Regairaz Kalenga Kapiamba, Camille, Raad, Layla and Rauld, Celine (2015) IL17A/CCR6 expression in human T cells. Lab meeting at D-BSSE, Basel.

Carson, Cheryl, Raman, Pichai, Tullai, Jennifer, Xu, Lei, Henault, Martin, Thomas, Emily, Yeola, Sarita, Lao, Jianmin, McPate, Mark, Verkuyl, J Martin, Marsh, George, Sarber, Jason, Amaral, Adam, Bailey, Scott, Lubicka, Danuta, Pham, Helen, Miranda, Nicolette, Ding, Jian, Tang, Hai-Ming, Ju, Haisong, Tranter, Pamela, Ji, Nan, Krastel, Philipp, Jain, Rishi K, Schumacher, Andrew M, Loureiro, Joseph J, George, Elizabeth, Berellini, Giuliano, Ross, Nathan T, Bushell, Simon M, Erdemli, Gül and Solomon, Jonathan M (2015) Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation. PloS one, 10 (6). e0127498. ISSN 1932-6203

Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Wang, LiAnn, Ren, Xiao-Qin, Soifer, Harris, Koch, Troels, Hansen, Bo Rode, Armstrong, Brian, Wang, Zhigang, Bauer, Paul, Rossi, John and Stein, CA (2015) A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells. Science Advances, 43 (19). pp. 9350-9361. ISSN 1362-4962

Chalmin, Fanny, Rochemont, Viviane, Lippens, Carla, Clottu, A, Sailer, Andreas, Merkler, Doron, Hugues, Stephanie and Pot, Caroline (2015) Oxysterols regulate CD4+ T cell trafficking during experimental autoimmune encephalomyelitis. Journal of Autoimmunity, 56. pp. 45-55.

Chandramouli, Sumana, Ciferri, Claudio, Gerrein, Rachel, Nikitin, Pavel, Calo', Stefano, Balabanis, Kara, Settembre, Ethan, Monroe, James, Hebner, Christy and Carfi, Andrea (2015) Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody. Nature Communications, 6. ISSN 2041-1723

Chappuis, Quentin, Bornet, Aurelien, Milani, Jonas, Vichoud, Basile, Gossert, Alvar, Bodenhausen, Geoffrey and Jannin, Sami (2015) The Preparation of Hyperpolarized Water and its Use to Enhance "waterLOGSY" Drug Screening. J Phys Chem Lett, 6 (9). pp. 1674-1678. ISSN 1948-7185

Chatterji, Udayan, Garcia-Rivera, Jose A., Baugh, James, Gawlik, Katarzyna, Wong, Kelly, Zhong, Weidong, Brass, Cliff, Naoumov, Nikolai and Gallay, Philippe A. (2015) The combination of alisporivir plus an NS5A inhibitor provides additive to synergistic anti-hepatitis C virus activity without detectable cross-resistance,. Antimicrobial Agents and Chemotherapy.

Chen, Jin, Bhansali, Suraj, Neelakantham, Srikanth Raju, Trusley, Craig, Majumdar, Tapan, Rebello, Sam, Sunkara, Gangadhar and Meyers, Charles (2015) Effect of Pradigastat, a Diacylglycerol Acyltransferase 1 Inhibitor, on the Pharmacokinetics of a Combination Oral Contraceptive in Healthy Female Subjects. International journal of clinical pharmacology and therapeutics, 53 (4). pp. 317-324. ISSN 0946-1965

Chen, Jin, Bhansali, Suraj, Neelakantham, Srikanth Raju, Trusley, Craig, Majumdar, Tapan, Rebello, Sam, Sunkara, Gangadhar and Meyers, Charles (2015) Effect of pradigastat, a diacylglycerol acyltransferase 1 inhibitor, on the pharmacokinetics of a combination oral contraceptive in healthy female subjects. International Journal of Clinical Pharmacology and Therapeutics, 53 (4). pp. 317-324. ISSN 0946-1965

Chen, Qiuyan, Vishnivetskiy, Sergey A., Zhuang, Tiandi, Cho, Min-Kyu, Thaker, Tarjani M., Sanders, Charles R., Gurevich, Vsevolod V. and Iverson, T. M. (2015) The Rhodopsin-Arrestin-1 Interaction in Bicelles. Methods in molecular biology, 1271. pp. 77-95. ISSN 1940-6029; 1064-3745

Chen, Yen Liang, Shi, Pei-Yong and Yokokawa, Fumiaki (2015) Nucleoside inhibitors of dengue virus. Antiviral Research, 122. pp. 12-19. ISSN 01663542

Chitnis, Shripad, Kulmatycki, Kenneth, Han, Yi, Sunkara, Gangadhar, Yamaguchi, Masayuki, Nozaki, Sachiko and Zhao, Rong (2015) Population pharmacokinetic modeling and noncompartmental analysis demonstrated bioequivalence between metformin component of metformin/vildagliptin fixed-dose combination products and metformin immediate-release tablet sourced from various countries. Clinical Pharmacology in Drug Developement, 5 (1). pp. 40-51.

Choi, Vivian, Bigelow, Chad, Mcgee, Terri, Gujar, Akshata, Li, Hui, Hanks, Shawn, Vrouvlianis, Joanna, Maker, Michael, Leehy, Barrett, Zhang, Yiqin, Aranda, Jorge, Bounoutas, George, Demirs, John, Yang, Junzheng, Richard, Ornberg, Wang, Yu, Martin, Wendy, Stout, Kelly, Argentieri, Gregory, Grosenstein, Paul, Diaz, Danielle, Turner, Oliver, Jaffee, Bruce, Police, Seshidhar and Dryja, Ted (2015) AAV-mediated RLBP1 gene therapy improves the rate of dark adaption in Rlbp1 knockout mice. AAV-mediated RLBP1 gene therapy improves the rate of dark adaption in Rlbp1 knockout mice.

Christ, Andreas Dominik and Soldermann, Nicolas (2015) An open-label, non-randomized, within-patient dose-finding study followed by a randomized, double-blind placebo controlled study with extension to assess the safety and efficacy of CDZ173 in patients with APDS/PASLI (Activated phosphoinositide 3-kinase delta syndrome/ p110δ-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency). Part of a CRADA with NIH, thus NIH will be allowed to make the abstract publicly available.

Ciferri, Claudio, Chandramouli, Sumana, Danilo, Donnaruma, Nikitin, Pavel, Michael A., Cianfrocco, Gerrein, Rachel, Feire, Adam, Barnett, Susan, Lilja, Anders, Rappuoli, Rino, Nathalie , Norais, Settembre, Ethan and Carfi, Andrea (2015) Structural and biochemical studies of HCMV gH/gL/gO and pentamer reveal mutually exclusive cell entry complexes. Proceedings of the National Academy of Sciences of the United States of America, 112 (6). pp. 1767-1772. ISSN 1091-6490

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Danahay, Henry, Pessotti, Angelica, Coote, Julie, Montgomery, Brooke, Xia, Donghui, Wilson, Aaron, Yang, Haidi, Wang, Zhao, Bevan, Luke, Thomas, Chris, Petit, Stephanie, London, Anne, Lemotte, Peter, Doelemeyer, Arno, Velez-Reyes, German, Bernasconi, Paula, Fryer, Christy, Edwards, Matthew, Capodieci, Paola, Chen, Amy, Hild, Marc and Jaffe, Aron (2015) Notch2 is required for inflammatory cytokine-driven goblet cell metaplasia in the lung. Cell Reports.

Das, Suman, Morvan, Frederic, Jourde, Benjamin, Meier, Viktor, Brebbia, Pascale, Toussaint, Gauthier, Glass, David and Fornaro, Mara (2015) ATP Citrate Lyase Improves Mitochondrial Function in Skeletal Muscle. Cell Metabolism (6). pp. 868-876.

Davies, Alastair H., Reipas, Kristen, Hu, Kaiji and Dunn, Sandra E. (2015) YB-1 enhances ABCG2 expression in breast cancer to elicit chemoresistance that can be circumvented using RSK inhibitors. Oncotarget, 6 (24). pp. 20570-20577. ISSN 1949-2553

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DeLorenzo, Christine, Sovago, Judit, Behrje, Rhett, Kumar, Dileep / JS, Devanand, Davangere / P, Pelton, Gregory / H, Mathis, Chester / A, Mason, Scott / N, Gomez-Mancilla, Baltazar, Aizenstein, Howard, Mann, John / J and Parsey, Ramin V (2015) Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [(1)(1)C]ABP688. Transl Psychiatry, 5. ISSN 2158-3188 (Electronic); 2158-3188 (Linking)

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Delise, Anthony, Scialli, Anthony, Bailey, Graham, Beyer, Bruce, Bruck Bogh, Ingrid, Breslin, William, Chen, Connie, Moffat, Graeme, Hui, Julia, Stewart, Jane and Thompson, Kary (2015) Potential seminal transport of pharmaceuticals to the conceptus. Reproductive Toxicology, 58. pp. 213-221.

Demirkan, Ayşe, Henneman, Peter, Verhoeven, Aswin, Dharuri, Harish, Amin, Najaf, van Klinken, Jan Bert, Karssen, Lennart C, de Vries, Boukje, Meissner, Axel, Göraler, Sibel, van den Maagdenberg, Arn M J M, Deelder, André M, C 't Hoen, Peter A, van Duijn, Cornelia M and van Dijk, Ko Willems (2015) Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses. PLoS genetics, 11 (1). e1004835. ISSN 1553-7404

Deng, Xiaoyan, Myrand-Lapierre, Marie-Eve, Matthews, Kerryn, Santoso, Aline Teresa, Du, Yiling, Ryan, Katherine S and Ma, Hongshen (2015) REDUCED DEFORMABILITY OF PARASITIZED RED BLOOD CELLS AS A BIOMARKER FOR ANTIMALARIAL DRUG EFFICACY. Malaria Journal.

Dudal, Sherri, Subramanian, Kulandayan, Flandre, Thierry, Law, Wai Siang , Lowe, Phil, Skerjanec, Andrej, Genin, Jean-Christophe, Duval, Martine, Piequet, Aline, Cordier, Andre, Jarai, Gabor, Van Heeke, Gino, Taplin, Sarah, Krantz, Carsten, Jones, Stewart, Bennan, Frank, Warren, Andrew Paul, Sims, Jennifer and Lloyd, Peter (2015) Integrated Pharmacokinetic, Pharmacodynamic and Immunogenicity profiling of QBP359 and its target, CCL21. mAbs.

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Egli, Nicole, Zajonz, Alexandra, Burger, Matthew and Schweighoffer, Tamas (2015) Human CD180 transmits proinflammatory signals via the Pim 1L kinase. PLoS ONE (e01427).

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Elkabets, Moshe , Scaltriti, Maurizio , Baselga, José , Sheng, Qing, Huang, Alan, Das, Rita, Wang, Hui-Qin, Liu, Manway, Liang, Jinsheng, Chen, Yan and Tam, Angela (2015) AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas. Cancer Cell, 27 (4). pp. 533-546. ISSN 15356108

Erdemli, Gul, Fermini, Bernard, Hancox, Jules C. , Abi-Gerges, Najah, Bridgland-Taylor, Mark, Chaudray, Khuram, Colatsky, Thomas, Correll, Krystle, Crumb, William, Damiano, Bruce, Gintant, Gary, Imredy, John, Koerner, John, Kramer, James, Leishman, Derek, Levesque, Paul , Li, Zhihua, Lindqvist, Andrew, Obejero-Paz, Carlos, Sawada, Kowei, Strauss, David, Vandenberg, Jamie and Vargas, Hugo (2015) Next generation cardiac safety testing through the Comprehensive in vitro Proarrhythmia Assay (CiPA) paradigm. Journal of Biomolecular Screening, 21 (1). pp. 1-11. ISSN 1087-05711552-454X

Erpenbeck, Veit (2015) Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. European Respiratory Journal.

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Evans, Chris, Arnold, Mark, Bryan, Peter, Duggan4, Jeffrey , James5, Chris , Li, Wenkui, Lowes, Steve, Matassa, Luca , Olah, Timothy , Timmerman, Philip , Wang, Xiaomin, Wickremsinhe, Enaksha, Williams, John , Woolf, Eric and Zane, Patricia (2015) Implementing Dried Blood Spot Sampling for Clinical Pharmacokinetic Determinations; Considerations from the IQ Consortium Microsampling Working Group. AAPS Journal.


Fabbro, Doriano, Jacob, Sandra and Moebitz, Henrik (2015) The 10 things you should know about protein kinases and inhibitors. British Journal of Pharmacology, 172 (11). pp. 2675-2700. ISSN 00071188

Farmer, Pierre, Valsesia, Armand, Chatelain, Pierre and Clayton, Peter (2015) GH deficiency status combined with GH receptor polymorphism affects response to GH in children. European Journal of Endocrinology, 173 (6). pp. 777-789. ISSN 1479-683X

Fitamant, Julien, Kottakis, Filippos, Benhamouche, Samira, Tian, Helen, Chuvin, Nicolas , Parachoniak, Christine A., Nagle, Julia M. , Perera, Rushika M. , Deshpande, Vikram , Zhu, Andrew X. , Lai, Albert, Bosun, Min, Hoshida, Yujin, McClatchey, Andrea I, Avruch, Joseph, Sia, Daniela, Camprecisos, Genís, Llovet, Josep M. , Morrissey, David, Raj, Lakshmi and Bardeesy, Nabeel (2015) YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Cell Reports, 10 (10). pp. 1692-1707. ISSN 2211-1247

Fouche, Marianne, Roth, Hans-Joerg, Masse, Florence, Furrer, David, Garcia Martin, Aimar and Ertl, Peter (2015) Hydroxymethyl salicylaldehyde-promoted ligation: a new functionalization for chemoselective ligations. Angewandte Chemie, Int. Ed., 17 (20). pp. 4936-4939. ISSN 1523-70601523-7052

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Francotte, Eric, DESFONTAINE, Vincent, GUILLARME, Davy and Novakova, Lucie (2015) Supercritical fluid chromatography in pharmaceutical analysis. Journal of Pharmaceutical and Biomedical Analysis, 113. pp. 56-71. ISSN 07317085

Frederiksen, Mathias and Edwards et al., Aled (2015) The promise and peril of chemical probes. Nature Chemical Biology.


Gabrielsson, Johan, Hjorth, Stephan, Vogg, Barbara, Harlfinger, Stephanie, Gutierrez, Pablo, Peletier, Lambertus, Pehrson, Rikard and Davidsson, Pia (2015) Modeling and Design of Challenge Tests: Inflammatory and Metabolic Biomarkers. Modeling and Design of Challenge Tests: Inflammatory and Metabolic Biomarkers .

Gaidatzis, Dimos, Lerch, Anita, Hahne, Florian and Stadler, Michael (2015) QuasR: Quantification and annotation of short reads in R. QuasR: Quantification and annotation of short reads in R.

Gaither, Larry and Bill, Anke (2015) Variomics screen identifies the re-entrant loop of the calcium-activated chloride channel ANO1 that facilitates channel activation. Journal of Biological Chemistry, 290 (2). pp. 889-903. ISSN 0021-9258; 1083-351X

Gaither, Larry, Bill, Anke, Gutierrez, Abraham, Kulkarni, Sucheta, Kemp, Carolyn, Bonenfant, Debora, Voshol, Johannes and Duvvuri, Umamaheswar (2015) ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer. Oncotarget, 6 (11). pp. 9173-9188. ISSN 19492553

Gao, Zhenhai, Fong, Susan, Arias, Carolina, Lin, Julie, Lu, Huasong, Xue, Yuhua, Faure, Michel, Mercier, Alexandre, Weisburd, Ben, Yu, Karen, Ji, Xiaodan, luo, kunxin, Zhou, Qiang and Sutton, James (2015) Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism. eLife, 4 (JUNE20). ISSN 2050-084X

Gargis, Amy S., Kalman, Lisa, Bick, David P., Silva, Cristina da, Dimmock, David P., Funke, Birgit H., Gowrisankar, Sivakumar, Hegde, Madhuri R., Kulkarni, Shashikant, Mason, Christopher E., Nagarajan, Rakesh, Voelkerding, Karl V., Worthey, Elizabeth A., Aziz, Nazneen, Barnes, John, Bennett, Sarah F., Bisht, Himani, Church, Deanna M., Dimitrova, Zoya, Gargis, Shaw R., Hafez, Nabil, Hambuch, Tina, Hyland, Fiona C.L., Luna, Ruth Ann, Manion, Megan, MacCannell, Duncan, Mann, Tobias, McDaniel, Timothy K., Ganova-Raeva, Lilia M., Rehm, Heidi L., Reid, Jeffrey, Campo Rendon, David S., Resnick, Richard B., Ridge, Perry G., Salit, Marc L., Skums, Pavel, Ajay, Subramanian Shankar, Wong, Lee-Jun C., Zehnbauer, Barbara A., Zook, Justin M. and Lubin, Ira M. (2015) Optimization of Next-Generation Sequencing Informatics Pipelines for Clinical Laboratory Practice. Nature Biotechnology, 33 (7). pp. 689-693.

Gaul, Christoph, Radimerski, Thomas, Vangrevelinghe, Eric, Baffert, Fabienne, Hofmann, Francesco, Murakami, Masato, Sterker, Dario, Doelemeyer, Arno, Romanet, Vincent, Andraos-Rey, Rita, Ebel, Nicolas, Mandon, Emeline, Zender, Michael, Weinstock, David M., Letai, Anthony, Sallan, Stephen E., Silverman, Lewis, Eck, Michael J., Rodig, Scott J., Wu, Shuo-Chieh, Li, Loretta S., Kopp, Nadja, Montero, Joan, Chapuy, Bjoern, Christie, Amanda L., Liu, Huiyun, Christodoulou, Alexandra, van Bodegom, Diederik, Tivey, Trevor, Lane, Andrew A., Ryan, Jeremy A., Yoda, Akinori, DeAngelo, Daniel, Stone, Richard M., Steensma, David, Wadleigh, Martha and Harris, Marian (2015) Type II JAK2 inhibition in B-cell acute lymphoblastic leukemia. Cancer Cell, 28 (1). pp. 29-41.

Geier, Martina, Bachler, Thorsten, Hanlon, Steven P., Eggimann, Fabian, Kittelmann, Matthias, Weber, Hansjörg, Luetz, Stephan, Wirz, Beat and Winkler, Margit (2015) Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis. Journal Microbial Cell Factories, 14 (82).

Gerspacher, Marc, Fairhurst, Robin, Mah, Robert, Roehn-Carnemolla, Esther, Furet, Pascal, Fritsch, Christine and Guthy, Daniel Alexander (2015) Discovery of a Novel Tricyclic 4H-Thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino Scaffold and its Application in a PI3K Inhibitor with High PI3K Isoform Selectivity and Potent Cellular Activity. Bioorg. Med. Chem. Letters, 25 (17). pp. 3582-3584. ISSN 0960-894X

Gerspacher, Marc, Imbach-Weese, Patricia, Mah, Robert, Caravatti, Giorgio, Furet, Pascal, Fritsch, Christine, Schnell, Christian, Blanz, Joachim, Blasco, Francesca, Desrayaud, Sandrine, Guthy, Daniel Alexander, Knapp, Mark, Arz, Dorothee, Wirth, Jasmin, Roehn-Carnemolla, Esther and Luu, Van Huy (2015) Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic and Medicinal Chemistry Letters, 25. pp. 3575-3581. ISSN 0960-894X

Gessier, Francois, Kallen, Joerg, Jacoby, Edgar, Chene, Patrick, Valat, Therese-Marie, Ruetz, Stephan, Jeay, Sebastien, Holzer, Philipp, Masuya, Keiichi and Furet, Pascal (2015) Discovery of dihydroisoquinolinone derivatives as novel inhibitors of the p53-MDM2 interaction with a distinct binding mode. Bioorganic & Medicinal Chemistry Letters, 25 (17). pp. 3621-3625. ISSN 0960894X

Ghode, Pramila Baban, Sivaraman , Jayaraman, Chacko , Jobichen and Bifani, Juan Pablo (2015) Crystallization of uracil phosphoribosyltransferase (MtUPRT) from Mycobacterium tuberculosis. Biochemical and biophysical research communications : BBRC, 467 (3). pp. 577-582. ISSN 0006291X

Glowienke, Susanne (2015) Establishing best practise in the application of expert review of mutagenicity under ICH M7. Regulatory Toxicology and Pharmacology.

Goldberg, Hilary, Harari, Sergio, Cottin, Vincent, Rosas, Ivan, Peters, Elizabeth, Biswal, Shibadas, Cheng, Yi, Khindri, Sanjeev, Kovarik, John M., Ma, Shenglin, McCormack, Francis and Henske, Elizabeth (2015) Everolimus for the treatment of lymphangioleiomyomatosis: A phase II study. European Respiratory Journal, 46 (3). pp. 783-794. ISSN 1399-3003

Gonzalez-Sandoval, Adriana, D. Towbin, Benjamin, Gaidatzis, Dimos, Geng, Liqing, Wang, Li, Yang, Teddy, Zhao, Kehao and Gasser, Susan (2015) Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos. Cell.

Green, Alexa/S, Maciel, Thiago/T, Hospital, Marie-Anne, Yin, Chae, Townsend, Elizabeth/C, Pilorge, Sylvain, Jacquel, Arnaud, Lambert, Mireille, Paubelle, Etienne, Zylbersztejn, Florence, Decroocq, Justine, Kosmider, Olivier, Auberger, Patrick, Hermine, Olivier, Weinstock, David/M, Lacombe, Catherine, Mayeux , P, Vanasse, K. Gary, Leung, Anscar Y, Moura, IC, Bouscary, Didier and Tamburini, Jerome (2015) Pim kinases modulate resistance to tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia. Science Advances, 1 (8). e1500221. ISSN 2375-2548

Grosskreutz, Cynthia, Brigell, Mitchell, Letko, Eric, Yeh, Stephen, Foster, C. Stephen and Pleyer, Uwe (2015) Efficacy and Safety of Intravenous Secukinumab in Noninfectious Uveitis Requiring Steroid-Sparing Immunosuppressive Therapy. Ophthalmology, 122 (5). pp. 939-948. ISSN 1549-4713

Grosskreutz, Cynthia, Hockey, Hans-Ulrich, Serra, Denise and Dryja, Ted (2015) Dry eye signs and symptoms persist during systemic neutralization of IL-1β by canakinumab or IL-17A by secukinumab. Cornea, 34 (12). pp. 1551-1556.

Grunewald, Jan, Klock, Heath, Cellitti, Susan, Bursulaya, Badry, Mcmullan, Daniel, Jones, David, Chiu, Hsien-Po, Patterson, Paula, Zhou, Huanfang, Vance, Julie, Nigoghossian, Edward, Tong, Hung, Daniel, Dylan, Mallet, William, Ou, Weijia, Uno, Tetsuo, Brock, Ansgar, Lesley, Scott and Geierstanger, Bernhard (2015) Efficient preparation of site-specific antibody-drug conjugates using phosphopantetheinyl transferases. Bioconjugate Chemistry, 26 (12). pp. 2554-2562. ISSN 1520-4812

Gueret, Stephanie and Wagner, Beatrix (2015) A Cyclic Carbo-Isosteric Penta-Depsipeptide: cyclo(Phe1–D-Ala2–Gly3–Phe4–APO5). Acta Crystallographica Section E, E71. pp. 113-116.

Guthertz, Nicolas, Klopp, Julia, Winterhalter, Aurelie, Fernandez, Cesar and Gossert, Alvar (2015) Auto-inducing media for uniform isotope labeling of proteins with 15N, 13C and 2H. Journal of Biomolecular NMR, 62 (2). pp. 169-177.

Guthy, Daniel Alexander and Voshol, Johannes (2015) Antibody-based arrays in disease proteomics. Antibody Technology Journal.

Gutmann, Sascha, Hinniger, Alexandra, Fendrich, Gabriele, Drueckes, Peter, Antz, Sylvie, Mattes, Henri, Moebitz, Henrik, Ofner, Silvio, Schmiedeberg, Niko, Stojanovic, Aleksandar, Rieffel, Sebastien, Strauss, Andre, Troxler, Thomas J., Sparrer, Helmut and Glatthar, Ralf (2015) The Crystal structure of the cancer osaka thyroid kinase reveals an unexpected kinase domain fold. The Journal of Biological Chemistry, 290 (24). ISSN 0021-92581083-351X

Göke, Friederike, Franzen, Alina, Hinz, Trista, Yoon, Petros, Marek4, Lindsay , Sharma, Rakesh, Bode, Maike , Maessenhausen, Anne, Lankat-Buttgereit, Brigitte, Göke, Antonia, Golletz, Carsten, Kirsten, Robert , Boehm, Diana , Vogel, Wenzel, Kleczko, Emily, Eagles-Soukup, Justin, Hirsch, Fred , Bremen, Tobias , Bootz, Friedrich, Schroeck, Andreas, Tan, Aik-Choon, Jimeno, Antonio , Heasley, Lynn and Perner, Sven (2015) FGFR1 expression levels predict BGJ398 Sensitivity of FGFR1-dependent head and neck Squamous cell cancers. Clinical Cancer Research, 21 (19). pp. 4356-4364. ISSN 15573265

Göke, Friederike, Franzen, Alina, Sharma, Rakesh, Bode, Maike, von Maessenhausen, Anne, Heasley, Lynn E and Perner, Sven (2015) FGFR1 expression, not gene amplification, predicts FGFR inhibitor sensitivity in head and neck squamous cell cancer cells. Clinical cancer research, 21 (19). pp. 4356-4364. ISSN 26015511


Harwood, Iain and Rooney, Lisa (2015) Towards Novel 1,2,4,5-Tetrazine Mediated Peptide Macrocyclisations. PhD Thesis to be submitted to University of Edinburgh.

Haver, Hana, Chua, Adeline, Ghode, Pramila Baban, Lakshminarayana, Suresh Bangalore, Singhal, Amit, Mathema, Barun, Wintjens, Rene and Bifani, Juan Pablo (2015) Mutations in the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in PA-824 spontaneous mutants in Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy, 59 (9). pp. 5316-5323. ISSN 0000-0000

Haynes, Katelin R. , Thomas, Gethin P. , Brown, Matthew A. , Kneissel, Michaela and Glant, Tibor T. (2015) Treatment of a mouse model of ankylosing spondylitis with exogenous sclerostin has no effect on disease progression. BMC Musculoskeletal Disorders, 16 (1). ISSN 1471-2474

He, Jing, Hamann, Lawrence, Davies, Huw and Beckwith, Rohan (2015) Late-stage C-H functionalization of complex alkaloids & drug molecules via intermolecular rhodium-carbenoid insertion. Nature Communications.

Hechinger, Anne-Kathrin, Smith, Benjamin, Flynn, Ryan, Hanke, Kathrin, McDonald-Hyman, Cameron, Taylor, Patricia A, Pfeifer, Dietmar, Hackanson, Björn, Leonhardt, Franziska, Prinz, Gabriele, Dierbach, Heide, Schmmitt-Gräff, Annette, Kovarik, Jiri, Blazar, Bruce and Zeiser, Robert (2015) Therapeutic activity of multiple common g-chain cytokine inhibition in acute and chronic GVHD. Blood, 125 (3). pp. 570-580.

Heining, Peter and Ruysschaert, Tristan (2015) THE USE OF MINIPIG IN DRUG DISCOVERY AND DEVELOPMENT; Pros and cons of minipig selection and strategies to use as a preferred non-rodent species. Journal of Toxicologic Pathology, 44 (3). pp. 467-473. ISSN 0192-62331533-1601

Helliwell, Stephen, Abraham, Yann, Movva, Rao, Filipuzzi, Ireos, Stahl, Michael, Rispal, Delphine, Eltschinger, Vaga, Bodenmiller, Bernd, Aebersold, Ruedi, Loewith, Robbie and Vaga, Stefania (2015) Sphingolipids mediate the signals for all the essential functions of Target Of Rapamycin Complex 2. Journal of Biological Chemistry, tba (o.

Hirano, Masaru, Meyers, Charles, Golla, Ganga Raju, Pal, Parasar, Pinot, Pascale, Lin, Tsu-Han, Majumdar, Tapan, Rebello, Sam, Sunkara, Gangadhar and Chen, Jin (2015) Effect of Hepatic Impairment on the Pharmacokinetics of Pradigastat, a Diacylglycerol Acyltransferase-1 (DGAT1) Inhibitor. Clinical Pharmacokinetics, 54 (7). pp. 761-770. ISSN 0312-5963

Hoepfner, Dominic, Krastel, Philipp, Schirle, Markus, Schmitt, Esther and Roggo, Silvio (2015) Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties. Angewandte Chemie Int Edition, 54 (35). pp. 10149-10154. ISSN 14337851

Hoffmann, Peter (2015) The Evaluation of Drug-induced Changes in Cardiac Inotropy in Dogs: results from a HESI-sponsored consortium. J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:70-90. doi: 10.1016/j.vascn.2015.02.002. Epub 2015 Apr 3.

Holenstein, Fabian, Christer, Eriksson, Ioanna, Erlandsson, Nils , Norrman, Jill, Simon, Ake , Danielsson, Milicov, Adriana, Schindler, Patrick and Schlaeppi, Jean-Marc (2015) Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies. Journal of Chromatography A, 1418. pp. 103-109. ISSN 18733778

Holenstein, Fabian, Christer, Eriksson, Ioanna, Erlandsson, Nils , Norrman, Jill, Simon, Ake , Danielsson, Milicov, Adriana, Schindler, Patrick and Schlaeppi, Jean-Marc (2015) Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies. Journal of Chromatography A, 1418. pp. 103-109. ISSN 18733778

Holopainen, Tanja, Räsänen, Markus, Anisimov, Andrey, Tuomainen, Tomi, Wei, Zheng, Tvogorov, Denis, Hulmi, Juha, Andersson, Leif, Cenni, Bruno, Tavi, Pasi, Mervaala, Eero, Kivelä, Riikka and Alitalo, Kari (2015) Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Proceedings of the National Academy of Sciences of the United States of America.

Holzer, Philipp, Masuya, Keiichi, Furet, Pascal, Kallen, Joerg, Valat, Therese-Marie, Ferretti, Stephane Raymond, Berghausen, Joerg, Bouisset-Leonard, Michele, Buschmann, Nicole, Pissot Soldermann, Carole, Rynn, Caroline, Ruetz, Stephan, Stutz, Stefan, Chene, Patrick, Jeay, Sebastien and Gessier, Francois (2015) Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors. Journal of Medicinal Chemistry, 58 (16). pp. 6348-6358.

Hopkins, Neil (2015) test. test, 16. p. 409. ISSN 1745-6215

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Hortobagyi, Gabriel , Chen, David, Piccart, Martine , Rugo, Hope , Burris , Howard , Pritchard, Kathleen, Campone, Mario , Noguchi, Shinzaburo , Perez, Alejandra , Deleu, Ines, Shtivelband, Mikhail , Masuda, Norikazu , Dakhil, Shaker , Anderson, Ian , Robinson, Douglas, He, Wei, Garg, Abhishek, Mcdonald Iii, Earl, Derti, Adnan, Bitter, Hans, Huang, Alan, Taran, Tetiana, Bachelot, Thomas , Lebrun, Fabienne , Lebwohl, David and Baselga, Jose (2015) Correlative Analysis of Genetic Alterations and Everolimus Benefit in Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer: Results From BOLERO-2. Journal of Clinical Oncology, 34 (5). pp. 419-426. ISSN 0732-183X1527-7755

Hosseinzadeh, Zohreh, Singh, Yogesh, Yan, Jing, Shimshek, Derya, Van Der Putten, P. Herman, Wagner, Carsten and Lang, Florian (2015) Leucine-rich repeat kinase 2-sensitive Na+/K+ ATPase activity in dendritic cells. FASEB, 29 (5). pp. 1701-1710. ISSN 1530-6860

Hsiao, Hsiu-Ling, Langenickel, Thomas Heiko, Greeley, Michael, Roberts, John, Zhou, Wei, Pal, Parasar, Rebello, Sam, Rajman, Iris and Sunkara, Gangadhar (2015) Pharmacokinetic drug-drug interaction assessment between LCZ696, an angiotensin receptor neprilysin inhibitor, and hydrochlorothiazide, amlodipine, or carvedilol. Clinical Pharmacology in Drug Development, 4 (6). pp. 407-417. ISSN 2160-7648

Hu, Qi-Ying and Usera, Aimee (2015) Sugar-Protein Connectivity Impacts on the Immunogenicity of Site-Selective Salmonella O-Antigen Glycoconjugate Vaccines. Angewandte Chemie (International ed. in English), 54 (45). pp. 13198-13203. ISSN 1521-3773

Hu, Tiancen, Yeh, Jennifer, Pinello, Luca, Jacob, Jaison, Yuan, Guo-Cheng, Harrison, Stephen, Frank, David and Chopra, Rajiv (2015) The N-terminal domain of STAT3 plays a critical role in STAT3-dependent transcriptional activity. Molecular and Cellular Biology, 35 (19). pp. 3284-3300. ISSN 1098-5549

Huang, Ching-Ting, Chang, Ming-Cheng, Chen, Yu-Li, Chen, Tsung-Ching, Chen, Chi-An and Cheng, Wen-Fang (2015) Insulin-like Growth Factors Inhibit Dendritic Cell-Mediated Anti-tumor Immunity through Regulation of ERK1/2 Phosphorylation and P38 Dephosphorylation. Cancer Letters.

Hurth, Konstanze, Jacquier, Sebastien, Lehmann, Hansjoerg and Wilcken, Rainer (2015) Regioselective nitration of 3-fluoro-2-substituted benzoic acids. Tetrahedron Letters.

Huynh, Hung, Hao, Huaixiang, Chan, Stephen L. , Chen, David, Ong, Richard, Soo, Khee Chee, Pochanard, Panisa, Yang, David, Ruddy, David, Liu, Manway, Derti, Adnan, Balak, Marissa, Palmer, Michael, Wang, Yan, Lee, Benjamin, Sellami, Dalila, Zhu, Andrew, Schlegel, Robert and Huang, Alan (2015) Loss of Tuberous Sclerosis Complex 2 (TSC2) Confers Sensitivity to mTOR Inhibitor Everolimus in Hepatocellular Carcinoma. Mol Cancer Ther..


Imbach-Weese, Patricia, Gerspacher, Marc, Caravatti, Giorgio, Furet, Pascal, Zoller, Thomas, Fritsch, Christine, Haasen, Dorothea, Trappe, Joerg, Guthy, Daniel Alexander, Arz, Dorothee and Wirth, Jasmin (2015) Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic and Medicinal Chemistry Letters, 25. pp. 3569-3574.


Jackson, David R., Tu, Stephanie S., Nguyen, MyChi, Barajas, Jesus F., Krug, Daniel, Pistorius, Dominik, Müller, Rolf and Tsai, Shiou-Chuan (2015) Structural Insights Into Anthranilate Priming During Type II Polyketide Biosynthesis. Biochemistry, 11 (1). pp. 95-103. ISSN 1554-89291554-8937

Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas, Ofner, Silvio, Pelle, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Christelle, Hemmig, Rene, Green, Jonathan and Rondeau, Jean-Michel (2015) A General Strategy for Targeting Drugs to Bone. Angewandte Chemie Int Edition, 54 (48). pp. 14575-14579. ISSN 14337851

Jain, Rama, Mathur, Michelle, Jiong, Lan, Abran, Costales, Gordana, Atallah, Ramurthy, Savithri, Subramanian, Sharadha, Lina, Setti, Feucht, Paul, Warne, Robert, Laura, Doyle, Steven, Basham, Anne, Jefferson, Lindvall, Mika, Brent, Appleton and Shafer, Cynthia (2015) Development of Potent RSK Inhibitors as Biological Probes. Journal of Medicinal Chemistry, 58 (17). pp. 6766-6783. ISSN 0022-26231520-4804

James, Alexander David, Blumenstein, Lars, Glaenzel, Ulrike, Jin, Yi, Demailly, Arnold, Jakab, Annamaria, Hansen, Regine, Hazell, Katharine Mary, Mehta, Anuradha, Trandafir, Lucia, Coughlin, Christina and Swart, Pieter Jacob (2015) Absorption, distribution, metabolism, and excretion of [14C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemotherapy and Pharmacology, 76. pp. 751-760.

Jeay, Sebastien, Gaulis, Swann, Ferretti, Stephane Raymond, Bitter, Hans, Ito, Moriko, Valat, Therese-Marie, Murakami, Masato, Ruetz, Stephan, Guthy, Daniel Alexander, Rynn, Caroline, Jensen, Michael Rugaard, Wiesmann, Marion, Kallen, Joerg, Furet, Pascal, Gessier, Francois, Holzer, Philipp, Masuya, Keiichi, Wuerthner, Jens, Halilovic, Ensar, Hofmann, Francesco, Sellers, William and Graus Porta, Diana (2015) A distinct p53 target gene set predicts for response to the selective p53–HDM2 inhibitor NVP-CGM097. eLife, 4. ISSN 2050-084X

Jian, Zhigang, Ray, Tapan, Wu, Amy, Jones, Lawrence and Forseth, Ry (2015) Proton Exchange Reactions in Isotope Chemistry (II) Synthesis of Stable Isotope Labeled LCQ908. Journal of Labelled Compounds and Radiopharmaceuticals.

Jiang, Xiaomo, Kheifets, Olga, Zamponi, Raffaella, Yang, Yi and Cong, Feng (2015) Dishevelled promotes wnt receptor degradation through recruitment of znrf3/rnf43 e3ubiquitin ligases. Molecular Cell, 58 (3). pp. 522-533. ISSN 1097-4164

Jing, Weiqing, Gershan, Jill A, Weber, James, Tlomak, Dominique, McOlash, Laura, Sabatos-Peyton, Catherine and Johnson, Bryon D (2015) Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma. Journal for ImmunoTherapy of Cancer, 3 (1). ISSN 2051-1426

Jones, Christopher (2015) The N-terminal Helical Region of the Hepatitis C Virus p7 Protein is Critical for Infectious Virus Production. PLoS Pathogens, 11 (11). e1005297. ISSN 1553-7374

Jones, Hannah, Chen, Yuan, Gibson, Christopher, Heimbach, Tycho, Parrott, Neil, Peters, Sheila, Snoeys, Jan, Upreti, Vijay, Zheng, Ming and Hall , Stephen (2015) Physiologically Based Pharmacokinetic Modelling in Drug Discovery and Development: A Pharmaceutical Industry Perspective. Clinical Pharmacology and Therapeutics.

Junt, Tobias and Barchet, Winfried (2015) Translating nucleic acid sensing pathways into therapies. Nature Reviews Immunology, 15 (9). pp. 529-544.


Kaniskan, H. Umit , Szewczyk, Magdalena , Yu, Zhengtian, Eram, Mohammad S. , Luo, Xiao, Yang, Xiaobao, Schmidt, Keith , Dai, Miao, He, Feng, Zang, Irene, Li, Fengling, Smil, David, Dong, Aiping, Landon, Melissa, Lin-Jones, Jennifer, Huang, Xi-Ping, Roth, Bryan, Schapira, Matthieu, Atadja, Peter, Barsyte-Lovejoy, Dalia , Arrowsmith, Cherry H., Brown, Peter, Zhao, Kehao, Jin, Jian and Vedadi, Masoud (2015) A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English), 54 (17). pp. 5166-5170. ISSN 1521-3773

Karkare, Shantanu, Bergdoll, Marc, Leighton-Davies, Juliet, Filipuzzi, Ireos, Fioretto, Celine, Hoepfner, Dominic, Hofmann, Andreas, Imbert, Pierre-Eloi, Jeker, Rolf, Knochenmuss, Richard, Krastel, Philipp, Margerit, Anais, Memmert, Klaus, Miault, Charlotte, Movva, Rao, Naegeli, Hans Ulrich, Oberer, Lukas, Rahier, Alain, Reinker, Stefan, Riedl, Ralph, Roggo, Silvio, Sexton, Jessica, Schuierer, Sven, Wagner, Beatrix, Zhang, Juan, Helliwell, Stephen and Parker, Christian (2015) FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p. Nature Communications, 6. p. 8613. ISSN 2041-1723

Karpov, Alexei, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Denay, Regis, Fernandez, Cesar, Galuba, Inga, Gutmann, Sascha, Jahnke, Wolfgang, Klopp, Julia, Guerro-Lagasse, Stephanie, Lindvall, Mika, Ma, Sylvia, Moebitz, Henrik, Rummel, Gabriele, Trappe, Joerg, Jacob, Sandra and Marzinzik, Andreas (2015) Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Medicinal Chemistry Letters, 6 (7). pp. 776-781. ISSN 1948-58751948-5875

Karpov, Alexei and Grotzfeld, Robert (2015) OAK-approved research summary for the postdoc website. OAK-approved research summary for the postdoc website .

Kasteleijn-Nolst Trenité, D, Brandt, C, Mayer, T, Rosenow, F, Schmidt, B, Steinhoff, BJ, Gardin, Anne, Imbert, Georges, Johns, Donald, Sagkriotis, Alexandros and Kucher, Klaus (2015) Dose-dependent suppression of human photoparoxysmal response with the competitive AMPA/kainate receptor antagonist BGG492. Epilepsia, 56 (6). pp. 924-932. ISSN 1528-1167

Kaufmann, Markus, Schuffenhauer, Ansgar, Fruh, Isabelle, Klein, Jessica, Thiemeyer, Anke, Rigo, Pierre, Gomez-Mancilla, Baltazar, Heidinger-Millot, Valerie, Bouwmeester, Antonius, Schopfer, Ulrich, Mueller, Matthias, Fodor, Barna and Cobos-Correa, Amanda (2015) High Throughput Screening using iPSC-derived neuronal progenitors to identify compounds counteracting epigenetic gene silencing in Fragile X Syndrome. Journal of Biomolecular Screening, 20 (9). pp. 1101-1111. ISSN 1087-05711552-454X

Kaufmann, Markus, Schuffenhauer, Ansgar, Fruh, Isabelle, Klein, Jessica, Thiemeyer, Anke, Rigo, Pierre, Gomez-Mancilla, Baltazar, Heidinger-Millot, Valerie, Schopfer, Ulrich, Mueller, Matthias, Fodor, Barna and Cobos-Correa, Amanda (2015) High Throughput Screening using iPSC-derived neuronal progenitors to identify compounds counteracting epigenetic gene silencing in Fragile X Syndrome. Journal of Biomolecular Screening, 20 (9). pp. 1101-1111. ISSN 1087-05711552-454X

Kelley, Brian, Brown, Scott P, Warren, Gregory L and Muchmore, Steven W (2015) POSIT: Flexible Shape-Guided Docking For Pose Prediction. Journal of Chemical Information and Modeling.

Kim, Munkyung, Piaia, Alessandro, Shenoy, Neeta, Kagan, David, Gapp, Berangere, Kueng, Benjamin, Weber, Delphine, Dietrich, Bill and Ksiazek, Iwona (2015) Progression of Alport Kidney Disease in Col4a3 knock out mice is independent of sex or macrophage depletion by clodronate treatment. PLoS ONE, 10 (11). ISSN 1932-6203

Kinzel, Bernd and Mueller, Matthias (2015) Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. Nature Medicine, 21 (7). pp. 777-785. ISSN 1078-8956

Kirillov, Varvara, Siler, Jonathan, Ramadass, Mahalakshmi, Ge, Lingying, Jarai, Gabor and Trujillo, Glenda (2015) Sustained activation of toll-like receptor 9 induces an invasive phenotype in lung fibroblasts: Possible implications in idiopathic pulmonary fibrosis. American Journal of Pathology, 185 (4). pp. 943-957. ISSN 1525-2191

Kizuka, Yasushiko, Kitazume, Shinobu, Fujinawa, Reiko, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi C, Nakano, Miyako, Yamaguchi, Yoshiki, Hashimoto, Yasuhiro, Staufenbiel, Matthias, Hatsuda, Hisoshi, Endo, Tamao and Taniguchi, Naoyuki (2015) Loss of bisected glycan decreases Abeta generation by relocating BACE1 to the lysosomal degradation pathway. Biochemical Journal, 473 (1). pp. 21-30. ISSN 0264-60211470-8728

Klein, Theo, Fung, Shane-Yu, Renner, Florian, Blank, Michael, Dufour, Antoine, Kang , Sohyeong, Bolger-Munro, Madison, Scurll, Joshua, Priatel, John, Schweigler, Patrick, Melkko, Samu, Gold, Michael, Viner, Rosa, Regnier, Catherine, Turvey, Stuart and Overall, Christopher (2015) The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. Nature Communications, 6. p. 8777. ISSN 2041-1723

Kleppe, Maria, Kwak, Minusk, Koppikar, Priya, Riester, Markus, Keller, Matthew, Bastian, Lennart, Hricik, Todd, Bhagwat, Neha, Abdel-Wahab, Omar, Marubayashi, Sachie, Chen, Jonathan, Romanet, Vincent, Fridman, Jordan, Bromberg, Jacqueline, Murakami, Masato, Radimerski, Thomas, Michor, Franziska, Fan, Rong and Levine, Ross (2015) JAK-STAT Pathway Activation in Malignant and Non-Malignant Cells Contributes to MPN Pathogenesis and Therapeutic Response. Cancer discovery, 5 (3). pp. 316-331. ISSN 2159-8290; 2159-8274

Klocks, Cathelijne, Berger, Claudia, Cortez, Pierre, Yann, Dean, Heinrich, Julia, Jensen Bjerring, Lisbeth, Koppenburg, Vera, Kostense, Stefan, Kramer, Daniel, Spindeldreher, Sebastian and Kirby, Hishani (2015) A fit-for-purpose strategy for the risk-based immunogenicity testing of biotherapeutics - a European industry perspective. Journal of Immunological Methods.

Klumpp, Martin (2015) Non-Stoichiometric Inhibition in Integrated Lead Finding – A Literature Review. Expert Opinion on Drug Discovery, 11 (2). pp. 149-162. ISSN 1746-04411746-045X

Kota, Jagannath, Ayalavajjala, Phaninatha Sarma and Sivasubramanian, Rama (2015) Development of orally administered fixed dose combination (FDC) products: Pharmacokinetic & biopharmaceutical considerations. International journal of pharmaceutical sciences and research., 6 (8). pp. 3161-3173. ISSN 0975-8232

Kramer, Christian, Ertl, Peter and Liedl, Klaus R (2015) UNIQUE MACROCYCLES IN THE TAIWAN TCM DATABASE. Planta Medica.

Krumova, Petranka, Reyniers, Lauran, Meyer, Marc, Stauffer, Daniela, Gerrits, Bertran, Hoving, Sjouke, Kaupmann, Klemens, Voshol, Johannes, Fabbrio, Dario, Bauer, Andreas, Rovelli, Giorgio, Taymans, Jean-Marc, Bouwmeester, Antonius and Baekelandt, Veerle (2015) Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate. FASEB Journal, 29 (7). pp. 2980-2992. ISSN 1530-6860

Kuhen, Kelli, Hamed, Kamal, makanga, Michael and Djimde, Abdoulaye (2015) The emerging threat of artemisinin resistance in malaria: Focus on artemether-lumefantrine. Expert Review of Anti-Infective Therapy, 13 (8). pp. 1031-1045. ISSN 1744-8336

Kulmatycki, Kenneth, Meyers, Charles, Salunke, Atish Azad, Hanna, Imad, Movva, Aishwarya, Majumdar, Tapan, Natrillo, Adrienne, Vapurcuyan, Arpine, Rebello, Sam, Sunkara, Gangadhar and Chen, Jin (2015) Evaluation of a potential transporter-mediated drug interaction between rosuvastatin and pradigastat, a novel DGAT-1 inhibitor. International Journal of Clinical Pharmacology and Therapeutics, 53 (5). pp. 345-355. ISSN 0946-1965

Kunze, Annett, Poller, Birk, Huwyler, Jörg and Camenisch, Gian P. (2015) Application of the Extended Clearance Concept Classification System (ECCCS) to predict the victim drug-drug interaction potential of statins. Drug Metabolism and Personalized Therapy, 30 (3). pp. 175-178. ISSN 2363-8907


Langenickel, Thomas Heiko, Tsubouchi, Chiaki , Ayalasomayajula, Surya, Pal, Parasar, Valentin, Marie-Anne, Hinder, Markus, Gevorkyan, Hakop, Jhee, Stanford and Rajman, Iris (2015) The Effect of LCZ696 on Amyloid-β Concentrations in Cerebrospinal Fluid in Healthy Subjects. British Journal of Clinical Pharamcology.

Lanshoeft, Christian, Heudi, Olivier, Raccuglia, Marc, Leuthold, Luc Alexis, Picard, Franck and Kretz, Olivier (2015) Ultra-fast quantitative mass spectrometry based method for ceritinib analysis in human plasma and its application for clinical use. Bioanalysis. pp. 425-435.

Lantermann, Alexandra, Mccutcheon, Kaitlin and Sharma, Sreenath (2015) The role of epigenetics in drug resistance in cancer. Epigenetic Diagnosis & Therapy, 1 (2). pp. 106-119. ISSN 2214-0840

Lazic, Stanley (2015) Analytical strategies for the marble burying test: avoiding impossible predictions and invalid p-values. BMC Research Notes.

Lee, Hyunwoo, Haller, Corinne, Doll, Thierry, Fruh, Isabelle, Gubser Keller, Caroline, Richards, Shola, Ibig-Rehm, Yvonne, Patoor, Maude, Goette, Marjo, Bouchez, Laure and Mueller, Matthias (2015) Identification of Small Molecules Which Induce Skeletal Muscle Differentiation in Embryonic Stem Cells via Activation of the Wnt and Inhibition of Smad2/3 and Sonic Hedgehog Pathways. Stem Cells, 34 (2). pp. 299-310. ISSN 10665099

Leisegang, Matthias, Engels, Boris, Schreiber, Karin, Yew, Poh Yin, Kiyotani, Kazuma , Idel, Christian, Arina, Ainhoa , Duraiswamy, Jaikumar, Uckert, Wolfgang , Nakamura, Yusuke and Schreiber, Hans (2015) Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation. Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation.

Leong, Franz Joel Wen, Li, Ruobing, Jain, Jay Prakash, Lefevre, Gilbert, Magnusson, Baldur, Diagana, Thierry Tidiane and Pertel, Peter (2015) A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel antimalarial spiroindolone KAE609 (cipargamin), to assess the safety, tolerability and pharmacokinetics in healthy adult volunteers. Antimicrobial Agents and Chemotherapy.

Leroy, Cedric, Qiong, Shen, Strande, Vaik, Lezan, Emmanuelle, Bentires-Alj, Mohamed, Voshol, Johannes, Bonenfant, Debora and Gaither, Larry (2015) CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases. Oncogene, 34 (44). pp. 5593-5598. ISSN 1476-5594

Lesley, Scott, Knuth, Mark, Grant, Joanna, Farr, Carol Lynn, Xu, Qingping, Mengin-Lecreulx, Dominique, Patin, Delphine, Chiu, Hsiu-Ju, Jaroszewski, Lukasz, Godzik, Adam, Elsliger, Marc-Andre, Deacon, Ashley and Wilson, Ian (2015) Insights into substrate specificity of NlpC/P60 cell wall hydrolases containing bacterial SH3 domains. mBio, 6 (5). ISSN 2150-7511

Leuthold, Luc Alexis, Heudi, Olivier, Déglon, Julien, Raccuglia, Marc, Augsburger, Marc, Picard, Franck, Kretz, Olivier and Thomas, Aurélien (2015) A new microfluidic-based sampling procedure for overcoming the hematocrit problem associated with dried blood spot analysis. Clinical Chemistry, 87 (4). pp. 2068-2071. ISSN 0003-27001520-6882

Li, Fang, Li, Xiaoyan, Ruddy, David, Tam, Angela, Rakiec, Daniel, Battalagine, Linda, Schlegel, Robert, Monahan, John and Huang, Alan (2015) FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors. Cancer Discovery.

Li, Li, Vashisht, Kapil, Boisclair, Julie, Li, Wenkui, Lin, Tsu-Han, Schmid, Herbert, Kluwe, William, Schoenfeld, Heidi and Hoffmann, Peter (2015) LCI699, a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats. Toxicology and Applied Pharmacology, 286 (3). pp. 224-233. ISSN 0041008X

Li, Nanxin, Molteni, Valentina, Liu, Bo, Tuntland, Tove, Loren, Jon, Gordon, William, Brodeur, Garrett, Iyer, Radhika and Croucher, Jamie (2015) TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. Cancer Chemotherapy and Pharmacology, 75 (1). pp. 131-141. ISSN 1432-0843

Li, Wenkui, Doherty, John, Favara, Sarah, Breen, Chris, Flarakos, Jimmy and Tse, Francis (2015) Evaluation of plasma microsampling for dried plasma spots (DPS) in quantitative LC-MS/MS bioanalysis using ritonavir as a model compound. Journal of Chromatography B.

Li , Jing , Csibi , Alfred , Yang , Sun, Hoffman, Gregory, Li , Chenggang , Zhang , Erik , Yu , Jane J and Blenis , John (2015) Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 112 (1). E21-E29. ISSN 1091-6490

Lim, Siew Pheng, Noble, Christian Guy and Shi, Pei-Yong (2015) The dengue virus NS5 protein as a target for drug discovery. Anti-viral Research Journal.

Lim, Siew Pheng, Soh, Sherryl, Shi, Pei-Yong, Zhao, Yongqian, Chung, Ka Yan, Swaminathan , Kunchithapadam , Vasudevan , Subhash G , Lescar, Julien and Luo, Dahai (2015) Molecular basis for specific viral RNA recognition and 2’-O ribose methylation by the dengue virus NS5 protein. Proceedings of the National Academy of Sciences.

Lim, Siew Pheng, Wan, Kah Fei, Abas, Siti Nurdiana, Seh, Cheah Chen, Dong, Hongping, Lim, Chin Chin, Chao, Alexander, Lee, Chang Bok, Shi, Pei-Yong, Beer, David, Niyomrattanakit , Pornwaratt , Chung , Ka Yan , Lescar, Julien and Nilar, Shahul (2015) STABILIZATION OF DENGUE VIRUS POLYMERASE IN DE NOVO INITIATION ASSAY PROVIDES ADVANTAGES FOR COMPOUND SCREENING. Anti-viral Research Journal.

Litovchick, Alexander, Dumelin, Christoph, Habeshian, Sevan, Gikunju, Diana, Guié, Marie-Aude, Centrella, Paolo, Zhang, Ying, Sigel, Eric, Cuozzo, John, Keefe, Anthony and Clark, Matthew (2015) Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library. Scientific Reports , 5. ISSN 2045-2322

Liu, L, Tang, M, Walsh, MJ, Brimacombe, KR, Pragani, R, Tanega, C, Rohde, JM, Baker, HL, Fernandez, E, Blackman, B, Bougie, JM, Leister, WH, Auld, DS, Shen, M, Lai, K and Boxer, MB (2015) Structure activity relationships of human galactokinase inhibitors. Bioorganic and Medicinal Chemistry Letters. pp. 721-727.

Lizos, Dimitrios, Prescher, Horst, Koch, Guido, Schuhmann, Tim, Bussenault, Alex, Ertl, Peter, Glick, Meir, Dix, Ina and Zimmermann, Kaspar (2015) Construction of a 3D-shaped, natural product like fragment library by defragmentation and diversification of natural products. Angewandte Chemie International Edition.

London, Anne, Japutra, Chietara, Planck, Kyle, Lihon, Michael and Nguyen, Andrew (2015) A novel method to determine residual detergent in biological samples post endotoxin reduction treatment and evaluation of strategies for subsequent detergent removal. International Immunopharmacology.

Lovsin Barle, Ester, Weideman, Patricia, Bercu, Joel, Dolan, Dave, Faria, Ellen, Flueckiger, Andreas, Gould, Janet, Luo, Wendy, Molnar, Lance, Morinello, Eric, Naumann, Bruce, Olson, Mike, Pfister, Thomas, Sandhu, Reena, Sargent, Edward, Seaman, Chris, Sehner, Claudia, Shipp, Brian, Stanard, Brad, Streeter, Anthony, Sussnam, Robert, Walsh, Andy, Willis, Alison and Maier, Andy (2015) A Harmonization Effort for Deriving Health-Based Exposure Limits in the Pharmaceutical Industry: Report of a Workshop. A Harmonization Effort for Deriving Health-Based Exposure Limits in the Pharmaceutical Industry: Report of a Workshop.

Ludwig, Marie-Gabrielle, Seuwen, Klaus and Suply, Thomas (2015) The proton-activated receptor GPR4 contributes to central respiratory chemosensitivity. Science.

Lukacs, Viktor, Mathur, Jayanti, Bayrak-Toydemir, Pinar, Rong, Mao, Longo, Nicola, Day, Ronald, Procter, Melinda, Cahalan, Stuart, Kim, Helen J, Bandell, Michael, Stevenson, David A, Patapoutian, Ardem and Krock, Bryan L (2015) Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia. Nature communications, 6. p. 8329. ISSN 2041-1723

lou, changgang, Singh, Alok, Adams, Christopher, Ksander, Gary, Beil, Michael, Leung-Chu, Jennifer, Fu, Fumin, Gan, Lu, Hu, Chii-Whei, Jeng, Arco, Lasala, Daniel, Liang, Guiqing, Rigel, Dean, Russell, Kerry, Vest, John and Watson, Catherine (2015) Discovery of LFF269, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects. Journal of Medicinal Chemistry, 58 (23). pp. 9382-9394. ISSN 0022-26231520-4804


Maciejewski, Mateusz, Lounkine, Eugen, Whitebread, Steven, Shoichet, Brian, Urban, Laszlo and Chen, Shanni (2015) The Powers and Perils of Post-Marketing Data Analysis: Quantification and Mitigation of Biases in FAERS. Science Translational Medicine.

Maciejewski, Mateusz, Wassermann, Anne, Glick, Meir and Lounkine, Eugen (2015) Experimental Design Strategy: Weak Reinforcement Leads to Increased Hit Rates and Enhanced Chemical Diversity. Journal of Chemical Information and Modelling, 55 (5). pp. 956-962. ISSN 1549-95961549-960X

Maia, Luis F, Kaeser, Stephan A, Reichwald, Julia, Lambert, Marius, Obermüller, Ulrike, Odenthal, Jörg, Martus, Peter, Staufenbiel, Matthias and Jucker, Mathias (2015) Increase in CSF Abeta during the very early phase of cerebral Abeta deposition in mouse models. EMBO Mol Med.

Malan-Müller, Stefanie, Fairbairn, Lorren, Dashti, Mahjoubeh Jalali Sefid, Oakeley, Edward James, Altorfer, Marc, Kidd, Martin, Seedat, Soraya, Gamieldien, Junaid and Hemmings, Sîan Megan Joanna (2015) Molecular mechanisms of D-cycloserine in facilitating fear extinction: Insights from RNAseq. Int J of Neuropsychopharmacology.

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Manjunatha, Ujjini Havaldar and Smith, Paul William (2015) Perspective: Challenges and Opportunities with phenotypic screens in TB drug discovery. Bioorganic & Medicinal Chemistry Special Issue.

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Mannick, Joan, Del Giudice, Giuseppe, Lattanzi, Maria, Valiante, Nick, Praestgaard, Jens, Huang, Baisong, Lonetto, Michael, Maecker, Holden, Kovarik, John M., Carsen, Simon, Glass, David and Klickstein, Lloyd (2015) Effects of mTOR Inhibition on Immunosenescence in the Elderly. Science Translational Medicine.

Mansour, Salah, Tocheva, Anna, Sanderson , Joseph, Goulston, Lyndsey, Platten, Helen, Serhal, Lina, Parsons, Camille, Edwards, Mark, Woelk, Christopher, Elkington, Paul, Elliott, Tim, Cooper, Cyrus, Edwards, Christopher and Gadola, Stephan (2015) Invariant NKT cells in early Rheumatoid Arthritis. Structural and functional changes of the iNKT clonal repertoire in early Rheumatoid Arthritis.

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Muellershausen, Florian and Vitaliti Garami, Alessandra (2015) Pilot study to assess the activation status of the complement system in blood from patients with anti-neutrophil cytoplasmic antibody (ANCA-) associated vasculitis. NHS Health Research Authority website.

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Nozaki, Sachiko, Chitnis, Shripad, Kulmatycki, Kenneth, Salunke, Atish Azad, He, Yan-Ling, Zhou, Wei and Suzuki, Hikoe (2015) Bioequivalence and Food Effect Assessment for Vildagliptin/Metformin Fixed-dose Combination Tablets Relative to Free Combination of Vildagliptin and Metformin in Japanese Healthy Subjects. International Journal of Clinical Pharmacology and Therapeutics.

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Orain, David, Hintermann, Samuel, Pudelko, Maciej, Carballa, Diego and Jedrzejczak, Anna (2015) Synthesis of orthogonally protected 2,6‐diazaspiro[3.5]nonane and 2,6-diazaspiro[3.4]octane analogs as versatile building blocks in medicinal chemistry. Synlett.

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Papadopoulos, Kyriakos, Isaacs, Randi, Bilic, Sanela, Kentsch, Kerstin, Huet, Heather, Hofmann, Matthias, Rasco, Drew, Kundamal, Nicole, Tang, Zhongwen, Cooksey, Jennifer and Mahipal, Amit (2015) Unexpected Hepatotoxicity in a Phase I Study of TAS266, a Novel Tetravalent Agonistic Monoclonal Nanobody® Targeting the DR5 Receptor. Cancer Chemotherapy and Pharmacology.

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Pond, Leslie (2015) Awards and Recognition page for

Poon, Daniel, Williams, Teresa, Subramanian, Sharadha, Verhagen, Joelle, McBride, Christopher M., Costales, Abran, Sung, Leonard, Antonios-McCrea, William, McKenna, Maureen, Louie, Alicia K., Ramurthy, Savithri, Levine, Barry, Shafer, Cynthia, Machajewski, Timothy, Renhowe, Paul A., Appleton, Brent A., Amiri, Payman, Chou, James, Stuart, Darrin and Aardalen, Kimberly (2015) Discovery of RAF 265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma. ACS Medicinal Chemistry Letters.

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Wallace, Owen, Arrowsmith, John, Leach, Andrew, Leeson, Paul, Mandrell, Sam, Owen, Robert, Pairaudeau, Garry, Pennie, William, Pickett, Stephen, Wang, Jibo, Waring, Michael and Weir, Alex (2015) A comprehensive analysis of development attrition in drug candidates from four major pharmaceutical companies. Nature Reviews Drug Discovery.

Wang, Qingyin, Dong, Hongping, Zou, Bin, Karuna, Ratnaningrum, Wan, Kah Fei, Zou, Jing, Susila, Agatha, Yip, Jin Teen, Xu, Haoying, Ding, Mei, Chan, Wai Ling, Gu, Feng, Seah, Peck Gee, Liu, Wei, Lakshminarayana, Suresh Bangalore, Kang , Congbao, Julien, Lescar, Blasco, Francesca, Smith, Paul William and Shi, Pei-Yong (2015) Discovery of dengue virus NS4B inhibitors. Journal of Virology, 89 (16). pp. 8233-8244. ISSN 1098-5514

Warth, Rainer, Salathé, Michelle, Magnin, Annette, Berardi, Simona, Imbert, Georges, Stadelmann, Marie-Monique and Perren, Aurel (2015) Erneuerte Vorlagen für Biobanken-Reglement, Information und Einwilligung: Ausarbeitung von schweizweiten Vorlagen für Biobanken-Reglement, Information und Einwilligung. Schweizerische Ärztezeitung | Bulletin des médecins suisses | Bollettino dei medici svizzeri, 96 (23). pp. 821-823. ISSN 0036-7486

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Wassermann, Anne, Lounkine, Eugen, Le Goff, Gaelle, King, Frederick, Hoepfner, Dominic, Peltier, John, Grippo, Melissa, Prindle, Vivian, Tao, Jianshi, Schuffenhauer, Ansgar, Wallace, Iain, Chen, Shanni, Krastel, Philipp, Cobos-Correa, Amanda, Parker, Christian, Davies, John and Glick, Meir (2015) Dark chemical matter – could “inactive” compounds be good starting points for lead discovery? Nature Chemical Biology, 11 (12). pp. 958-966. ISSN 1552-44501552-4469

Weisberg, Ellen, Halilovic, Ensar, Cooke, Vesselina, Nonami, Atsushi, Ren, Tao, Sanda, Takaomi, Simkin, Irene, Yuan, Jing, Antonakos, Brandon, Barys, Louise, Ito, Moriko, Cowens, Kristen, Nelson, Erik, Sattler, Martin, Jeay, Sebastien, Wuerthner, Jens, McDonough, Sean, Wiesmann, Marion and Griffin, James (2015) Inhibition of wild-type p53-expressing AML by novel small molecule HDM2 inhibitor, CGM097. Mol Cancer Ther, 14 (10). pp. 2249-2259. ISSN 1538-8514

Weisberg, Ellen, Halilovic, Ensar, Cooke, Vesselina, Nonami, Atsushi, Ren, Tao, Sanda, Takaomi, Simkin, Irene, Yuan, Jing, Antonakos, Brandon, Barys, Louise, Ito, Moriko, Cowens, Kristen, Nelson, Erik, Sattler, Martin, Jeay, Sebastien, Wuerthner, Jens U., McDonough, Sean M., Wiesmann, Marion and Griffin, James D. (2015) Inhibition of wild-type p53-expressing AML by the novel small molecule HDM2 inhibitor CGM097. Molecular Cancer Therapeutics, 14 (10). pp. 2249-2259. ISSN 1538-8514

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Welzenbach, Karl, Mancuso, Riccardo, Krähenbühl, Stephan and Weitz-Schmidt, Gabriele (2015) A novel multi-parameter whole blood assay to dissect the pharmacologic effects of different modes of LFA-1 receptor occupancy. British Journal of Pharmacology.

Wendling, Thierry, Dumitras, Swati, Woessner, Ralph, Pigeolet, Etienne, Ogungbenro, Kayode and Aarons, Leon (2015) Application of a Bayesian population approach to physiological modelling of mavoglurant pharmacokinetics. Journal of Pharmacokinetics and Pharmacodynamics.

Werfel, Thomas, Heratizadeh, Annice, Niebuhr, Margarete, Kapp, Alexander, Karch, Annika, Erpenbeck, Veit, Loesche, Christian, Jung, Thomas, Krug, Norbert, Badorrek, Philipp and Hohlfeld, Jens M (2015) Exacerbation of atopic dermatitis upon grass pollen exposure in an environmental challenge chamber. J Allergy Clin Immunol.

Wilson, Stephen C., Baryza, Jeremy, Reynolds, Aimee, Bowman, Keith, Keegan, Mark E., Standley, Stephany, Gardner, Noah, Parmar, Parul, Agir, Vahide, Yadav, Sunita, Zunic, Adnan, Vargeese, Chandra, Lee, Cameron and Rajan, Srinivasan (2015) Real Time Measurement of PEG Shedding from Lipid Nanoparticles in Serum via NMR Spectroscopy. Molecular Pharmaceutics.

Winkler, Gian Christian, Perino, Christopher, Araya, Selene Hilda, Bechter, Rudolf, Kuster, Martin and Lovsin Barle, Ester (2015) Workshop Report Classification of Dermal Sensitizers in Pharmaceutical Manufacturing. Regulatory Toxicology and Pharmacology, 72 (-). pp. 501-505. ISSN 0273-2300

Wlodarska, Marta, Kostic, Aleksandar / D and Xavier, Ramnik / J (2015) An integrative view of microbiome-host interactions in inflammatory bowel diseases. Cell Host and Microbe, 17 (5). pp. 577-591. ISSN 19346069

Wolf, Romain (2015) Extracting Ligands from Receptors by Reversed Targeted Molecular Dynamics. Journal of Chemical Information and Modeling.

wagner, John, brunstein, claudio, Boitano, Anthony, DeFor, Todd, McKenna, David, Sumstad, Darin, Blazar, Bruce, Tolar, Jakub, Le, Chap, Jones, Julie, Cooke, Michael and Bleul, Conrad (2015) Safety and Efficacy of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Cells after Myeloablative Conditioning. Cell Stem Cell.


Xie, Xuping, Zou, Jing, Dong, Hongping and Shi, Pei-Yong (2015) Determinants of dengue virus NS4A protein oligomerization. Journal of Virology, 89 (12). pp. 6171-6183. ISSN 0022-538X

Xie, Xuping, Zou, Jing, Yuan, Zhiming and Shi, Pei-Yong (2015) Two distinct sets of NS2A molecules are responsible for dengue virus RNA synthesis and virion assembly. Journal of Virology, 89 (2). pp. 1298-1313. ISSN 1098-5514

Xu, Xiang, Choi, Sung Hee, Hu, Tiancen, Aster, Jon, Chopra, Rajiv, Fryer, Christy and Blacklow, Stephen (2015) Insights into autoregulation of Notch 3 from Structural and Functional Studies of its negative Regulatory Region. tbd.


Yan, Jing, Almilaji, Ahmad, Schmid, Evi, Shimshek, Derya, Van Der Putten, P. Herman, Wagner, Carsten, Shumilina, Ekaterina and Lang, Florian (2015) LRRK2 sensitive Na+/Ca2+ exchanger activity in dendritic cells. The Federation of American Societies for Experimental Biology Journal.

Yan, Kelly, Merritt, Hanne, Crawford, Kenneth, Pardee, Gwynn, Cheng, Jan Marie, Widger, Stephania, Hekmat-Nejad, Mohammad, Zaror, Isabel and Sim, Janet (2015) Expression, Purification and Characterization of Inactive and Active Forms of ERK2 from Insect Expression System. Protein Expression and Purification.

Yeo, Kim Long, Chen, Yen Liang, Xu, Haoying, Dong, Hongping, Wang, Qingyin, Yokokawa, Fumiaki and Shi, Pei-Yong (2015) Synergistic suppression of dengue virus replication using a combination of nucleoside analogs and nucleoside synthesis inhibitors. Antimicrobial Agents and Chemotherapy, 59 (4). pp. 2086-2093.

Ying, GuoQing, Zhu, FangFang, Yi, Yu, Chen, JianShu, Mei, JianFeng, Zhang, YanLu and Chen, ShuQing (2015) Selecting DNA aptamers for endotoxin separation. Biotechnology letters, 37 (8). pp. 1601-1605. ISSN 1573-6776

Yu, Hongbin, Balani, Suresh, Chen, Weichao, Cui, Donghui, He, Ling, Humphreys, H. Griffith, Mao, Jialin, Lai, George, Lee, Anthony, Lim, Heng-Keang, MacLauchlin, Christopher, Prakash, Chandra, Surapeneni, Sekhar, Tse, Susanna, Upthagrove, Alana, Walsky, Robert, Wen, Bo and Zheng, Zhaopie (2015) Contribution of Metabolites to P450 Inhibition-Based Drug-Drug Interactions: Scholarship from the IQ DMLG Metabolite Group. Drug Metabolism and Disposition.


Zaiss, Mario M., Rapin, Alexis, Lebon, Luc, Dubey, Lalit Kumar, Mosconi, Ilaria, Sarter, Kerstin, Piersigilli, Alessandra, Menin, Laure, Walker, Alan W., Rougemont, Jacques, Oonagh, Paerewick, Geldhof, Peter, McCoy, Kathleen D., Macpherson, Andrew, Croese, John, Giacomin, Paul R., Loukas, Alex, Junt, Tobias, Marsland, Benjamin and Harris, Nicola L. (2015) Intestinal helminths modulate allergic inflammation by altering microbial metabolism. Immunity.

Zhang, M, Eismin, R, Kenttamaa, H, Xiong, H, Wu, Y, Burdette, D and Urbanek, R (2015) Identification of 2-aminothiazolobenzazepine metabolites in human, rat, dog, and monkey microsomes by ion-molecule reactions in linear quadrupole ion trap mass spectrometry. Drug Metabolism and Disposition. pp. 358-366.

Zhang, Tao, Heimbach, Tycho, Zhang, Jin, Lin, Wen and He, Handan (2015) Prospective Predictions of Human Pharmacokinetics for Eighteen Compounds. Journal of Pharmaceutical Sciences, 104 (9). pp. 2795-2806. ISSN 1520-6017

Zhang, Tao, Heimbach, Tycho, Zhang, Jin, Lin, Wen and He, Handan (2015) Prospective Predictions of Human Pharmacokinetics for Eighteen Compounds. Journal of Pharmaceutical Sciences, 104 (9). pp. 2795-2806. ISSN 1520-6017

Zhao, Yuan, Li, Jue, Gu, Hui, Wei, DongQing, Fu, Wei and Yu, Zhengtian (2015) Conformational Preferences of π-π Stacking Between Ligand and Protein, Analysis Derived from Crystal Structure Data Geometric Preference of π-π Interaction. Interdisciplinary sciences, computational life sciences, 7 (3). pp. 211-220. ISSN 1867-1462

Zhao, Yuan, Li, Jue, Gu, Hui, Wei, Dongqing, Xu, Yao-chang and Fu, Wei (2015) Conformational Preferences of π-π stacking between ligand and protein, Analysis derived from Crystal Structure Data. Interdisciplinary Sciences: Computational Life Sciences, 7. pp. 211-220.

Zou, Bin, Seh Yong, Leong, Ding, Mei and Smith, Paul William (2015) A mild and efficient synthesis of spiroquinolinones via an unexpected rearrangement. Tetrahedron Letters, 56 (44). pp. 6016-6018. ISSN 1873-3581

Zou, Jing, Xie, Xuping, Wang, Qingyin, Dong, Hongping, Lee, Michelle Yueqi, Kang, Congbao, Yuan, Zhiming and Shi, Pei-Yong (2015) Characterization of Dengue virus NS4A and NS4B protein interaction. Journal of Virology, 89 (7). pp. 3455-3470. ISSN 1098-5514

This list was generated on Sat Feb 24 11:51:48 2024 UTC.


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