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Modifying peptides to enhance permeability

Vorherr, Thomas (2015) Modifying peptides to enhance permeability. Future Medicinal Chemistry, 7 (8). pp. 1009-1021. ISSN 1756-8919


Recently, peptides have been validated to address intracellular targets and/or to be orally bioavailable. This review describes some of these scaffolds, offers insight in new cyclization methodologies thought to be beneficial to enhance permeability and highlights modification on peptides thought to improve oral bioavailability. In this context, side chains and back-bone derivatization beneficial to encourage cellular uptake are presented. In addition, new methodologies supporting the assessment of permeability are discussed.

Item Type: Article
Keywords: peptides, permeability
Date Deposited: 08 Mar 2016 00:45
Last Modified: 08 Mar 2016 00:45


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