Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Construction of a 3D-shaped, natural product like fragment library by defragmentation and diversification of natural products

Lizos, Dimitrios and Prescher, Horst and Koch, Guido and Schuhmann, Tim and Bussenault, Alex and Ertl, Peter and Glick, Meir and Dix, Ina and Zimmermann, Kaspar (2015) Construction of a 3D-shaped, natural product like fragment library by defragmentation and diversification of natural products. Angewandte Chemie International Edition.

Abstract

A fragment library consisting of 3D-shaped, natural product-like fragments was assembled. Library construction was mainly performed by natural product degradation and natural product diversification reactions and was complemented by the identification of available 3D-shape and natural product like fragments from the available commercial sources. During the course of these studies, a novel rearrangement was discovered for Massarigenin C. The obtained fragment library has an excellent 3D-shape and natural product likeness, covering an underexplored and underrepresented chemical space in fragment based drug discovery (FBDD).

Item Type: Article
Keywords: Fragment Based Drug Discovery; Natural products; Fragment Library; Natural product likeness; Rearrangement
Date Deposited: 26 May 2016 23:45
Last Modified: 26 May 2016 23:45
URI: https://oak.novartis.com/id/eprint/23821

Search

Email Alerts

Register with OAK to receive email alerts for saved searches.