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Antiplasmodial Constituents from the Stem Bark of Polyalthia longifolia var Pendula

Annan, Kofi and Ekuadzi, Edmund and Asare, Cindy and Sarpong, Kwane and Pistorius, Dominik and Oberer, Lukas and Gyan, Ben A. and Ofori, Michael (2015) Antiplasmodial Constituents from the Stem Bark of Polyalthia longifolia var Pendula. Phytochemistry Letters, 11. pp. 28-31.

Abstract

Two new clerodane diterpene alkaloids, named cleroda-3-ene pyrrole-15,16-dione and cleroda-3-ene, pyrrolidine-15,16-dione , and two new clerodane diterpenes, named cleroda-3,13(14)E-diene-15,16-diamide and cleroda-3-ene-15,16-diamide, along with two known compounds, were isolated from the stem bark of Polyalthia longifolia. The isolated compounds demonstrated antiplasmodial effects with IC50’s ranging 1.5-68.9 µg/mL.
Polyalthia longifolia (Benth.) Hook.f var. pendula (Annonaceae) is an evergreen tree distributed in tropical regions. Personal interviews with herbalists in the Ashanti region of Ghana revealed that it is used for the treatment of malaria. Previous phytochemical investigations have resulted in the isolation of azafluorene and aporphine alkaloids and clerodane diterpenes with reported biological acitivities such as cytotoxic activity, antimicrobial acitivity, and antileishmanial effects.
In our search for antiplasmodial compounds from Ghanaian medicinal plants, we have investigated the constituents of P. longifolia. Seperation of the CHCl3 extract by preperative LC with MS-triggered fraction collection resulted in two new clerodane diterpenes, two new clerodane diterpene alkaloids and two known compounds. We report herein, the structure elucidation and antiplasmodial effects of the isolated compounds.

Item Type: Article
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/22547

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