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The emerging threat of artemisinin resistance in malaria: Focus on artemether-lumefantrine

Kuhen, Kelli and Hamed, Kamal and makanga, Michael and Djimde, Abdoulaye (2015) The emerging threat of artemisinin resistance in malaria: Focus on artemether-lumefantrine. Expert Review of Anti-Infective Therapy, 13 (8). pp. 1031-1045. ISSN 1744-8336

Abstract

The development of artemisinin resistance in the Greater Mekong Subregion poses a significant threat to malaria elimination. Artemisinin-based combination therapies including artemether-lumefantrine (AL) are recommended by WHO as first-line treatment for uncomplicated Plasmodium falciparum malaria. This article provides a comprehensive review of the existing and latest data as a basis for interpretation of observed variability in parasite sensitivity to AL over the last 5 years. Clinical efficacy and preclinical data from a range of endemic countries are summarized, including potential molecular markers of resistance. Overall, AL remains effective in the treatment of uncomplicated P. Falciparum malaria in most regions. Establishing validated molecular markers for resistance and strict efficacy monitoring will reinforce timely updates of treatment policies.

Item Type: Article
Keywords: artemether-lumefantrine artemisinin resistance clinical efficacy molecular markers systematic review
Date Deposited: 28 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:45
URI: https://oak.novartis.com/id/eprint/25444

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