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Antibacterial Activity of Enrofloxacin and Ciprofloxacin Derivatives of beta-Octaarginine

Purkayastha, Nirupam and Capone, Stefania and Beck, Albert / K and Seebach, Dieter and Leeds, Jennifer and Thompson, Katherine and Moser, Heinz (2015) Antibacterial Activity of Enrofloxacin and Ciprofloxacin Derivatives of beta-Octaarginine. Chemistry & Biodiversity, 12 (2). pp. 179-193.

Abstract

beta3-Octaarginine chains were attached to the functional groups NH and CO2H of the antibacterial fluoroquinolones ciprofloxacin (–> 1) and enrofloxacin (–> 2), respectively, in order to find out whether there is increased activity by attachment of the poly-cationic, cell-penetrating peptide (CPP) moiety. For comparison, simple amides (3 - 5) of the two antimicrobial compounds and beta3-octaarginine amide (betaR8) were included in the antibacterial susceptibility tests to clarify the impact of chemical modification on the microbiological activity of either scaffold

Item Type: Article
Keywords: antibiotics, oligo-arginines, fluoroquinolones, conjugates
Date Deposited: 16 Mar 2017 00:45
Last Modified: 16 Mar 2017 00:45
URI: https://oak.novartis.com/id/eprint/24339

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