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Decreased amyloid-β but increased neuronal hyperactivity by immunotherapy in Alzheimer´s models

Busche, Marc Aurel and Grienberger, Christine and Keskin, Aylin Derya and Song, Beomjong and Neumann, Ulf and Staufenbiel, Matthias and Förstl, Hans and Konnerth, Arthur (2015) Decreased amyloid-β but increased neuronal hyperactivity by immunotherapy in Alzheimer´s models. Nature Neuroscience.

Abstract

Among the most promising approaches to treat Alzheimer´s disease (AD) is
immunotherapy with amyloid-β (Aβ)-targeting antibodies. Here, by using in vivo twophoton
imaging in mouse models, we demonstrate that two different anti-Aβ antibodies
used for treatment are ineffective in repairing neuronal dysfunction and can cause an
increase in cortical hyperactivity. This unexpected finding provides a possible cellular
explanation for the lack of cognitive improvement by immunotherapy in human studies.

Item Type: Article
Keywords: Alzheimer's disease, immunotherapy, antibody, neuronal activity
Date Deposited: 06 Jan 2016 00:45
Last Modified: 06 Jan 2016 00:45
URI: https://oak.novartis.com/id/eprint/27477

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