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Tissue engineering strategies to study cartilage development, degeneration and regeneration

Bhattacharjee, Maumita and Coburn, Jeannine and Centola, Matteo and Murab, Sumit and Barbero, Andrea and Kaplan, David L. and Martin, Ivan and Ghosh, Sourabh (2015) Tissue engineering strategies to study cartilage development, degeneration and regeneration. Advanced Drug Delivery Reviews, 84. pp. 107-122. ISSN 0169409X

Abstract

Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in vitro cartilage generation. We then review how a tissue engineering approach has been and could be further exploited to investigate different aspects of cartilage development and degeneration. The
generated knowledge is expected to inform new cartilage regeneration strategies, beyond a classical tissue engineering paradigm.

Item Type: Article
Date Deposited: 26 Apr 2016 23:45
Last Modified: 26 Apr 2016 23:45
URI: https://oak.novartis.com/id/eprint/23970

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