Discovery of a Novel Tricyclic 4H-Thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino Scaffold and its Application in a PI3K Inhibitor with High PI3K Isoform Selectivity and Potent Cellular Activity
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Gerspacher, Marc, Fairhurst, Robin, Mah, Robert, Roehn-Carnemolla, Esther, Furet, Pascal, Fritsch, Christine and Guthy, Daniel Alexander (2015) Discovery of a Novel Tricyclic 4H-Thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino Scaffold and its Application in a PI3K Inhibitor with High PI3K Isoform Selectivity and Potent Cellular Activity. Bioorg. Med. Chem. Letters, 25 (17). pp. 3582-3584. ISSN 0960-894X
Official URL: http://dx.doi.org/10.1016/j.bmcl.2015.06.077
Abstract
A novel, previously undescribed 4H-thiazolo[5',4':4,5]pyrano[2,3-c]pyridine tricyclic scaffold has been discovered. The application of this novel chemotype leading to a potent and selective prototype PI3K inhibitor is described.
| Item Type: | Article |
|---|---|
| Keywords: | Oncology, Phosphatidylinositol-3-kinase (PI3K), selective PI3K Inhibitor, 4H-Thiazolo[5',4':4,5]pyrano[2,3-c]pyridine-2-amino derivative |
| Date Deposited: | 12 Oct 2016 00:45 |
| Last Modified: | 12 Oct 2016 00:45 |
| URI: | https://oak.novartis.com/id/eprint/25268 |