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The role of epigenetics in drug resistance in cancer

Lantermann, Alexandra and Mccutcheon, Kaitlin and Sharma, Sreenath (2015) The role of epigenetics in drug resistance in cancer. Epigenetic Diagnosis & Therapy, 1 (2). pp. 106-119. ISSN 2214-0840

Abstract

Resistance of malignant cells to chemotherapy and molecularly targeted therapy is a major roadblock in our effort to cure cancer. A variety of underlying mechanisms have been described, some of which are shared between resistance to chemotherapy and resistance to molecularly targeted therapy. Although the influence of genetic mutations in the development of drug resistance is beyond question, many examples now support the involvement of epigenetic changes in contributing to drug resistance. Several clinical trials are under way to explore the effectiveness of epigenetics-targeting drugs to reverse or overcome resistance to cancer therapies. In addition to these strategies, we suggest a complementary approach that could utilize epigenetics-targeting drugs to prevent drug resistance.

Item Type: Article
Date Deposited: 28 Nov 2017 00:45
Last Modified: 28 Nov 2017 00:45
URI: https://oak.novartis.com/id/eprint/24151

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