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Huang, Ching-Ting, Chang, Ming-Cheng, Chen, Yu-Li, Chen, Tsung-Ching, Chen, Chi-An and Cheng, Wen-Fang (2015) Insulin-like Growth Factors Inhibit Dendritic Cell-Mediated Anti-tumor Immunity through Regulation of ERK1/2 Phosphorylation and P38 Dephosphorylation. Cancer Letters.

Hurth, Konstanze, Jacquier, Sebastien, Lehmann, Hansjoerg and Wilcken, Rainer (2015) Regioselective nitration of 3-fluoro-2-substituted benzoic acids. Tetrahedron Letters.

Huynh, Hung, Hao, Huaixiang, Chan, Stephen L. , Chen, David, Ong, Richard, Soo, Khee Chee, Pochanard, Panisa, Yang, David, Ruddy, David, Liu, Manway, Derti, Adnan, Balak, Marissa, Palmer, Michael, Wang, Yan, Lee, Benjamin, Sellami, Dalila, Zhu, Andrew, Schlegel, Robert and Huang, Alan (2015) Loss of Tuberous Sclerosis Complex 2 (TSC2) Confers Sensitivity to mTOR Inhibitor Everolimus in Hepatocellular Carcinoma. Mol Cancer Ther..

Imbach-Weese, Patricia, Gerspacher, Marc, Caravatti, Giorgio, Furet, Pascal, Zoller, Thomas, Fritsch, Christine, Haasen, Dorothea, Trappe, Joerg, Guthy, Daniel Alexander, Arz, Dorothee and Wirth, Jasmin (2015) Identification and optimisation of a 4',5-bisthiazole series of selective phosphatidylinositol-3 kinase alpha inhibitors. Bioorganic and Medicinal Chemistry Letters, 25. pp. 3569-3574.

Jackson, David R., Tu, Stephanie S., Nguyen, MyChi, Barajas, Jesus F., Krug, Daniel, Pistorius, Dominik, Müller, Rolf and Tsai, Shiou-Chuan (2015) Structural Insights Into Anthranilate Priming During Type II Polyketide Biosynthesis. Biochemistry, 11 (1). pp. 95-103. ISSN 1554-89291554-8937

Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas, Ofner, Silvio, Pelle, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Christelle, Hemmig, Rene, Green, Jonathan and Rondeau, Jean-Michel (2015) A General Strategy for Targeting Drugs to Bone. Angewandte Chemie Int Edition, 54 (48). pp. 14575-14579. ISSN 14337851

Jain, Rama, Mathur, Michelle, Jiong, Lan, Abran, Costales, Gordana, Atallah, Ramurthy, Savithri, Subramanian, Sharadha, Lina, Setti, Feucht, Paul, Warne, Robert, Laura, Doyle, Steven, Basham, Anne, Jefferson, Lindvall, Mika, Brent, Appleton and Shafer, Cynthia (2015) Development of Potent RSK Inhibitors as Biological Probes. Journal of Medicinal Chemistry, 58 (17). pp. 6766-6783. ISSN 0022-26231520-4804

James, Alexander David, Blumenstein, Lars, Glaenzel, Ulrike, Jin, Yi, Demailly, Arnold, Jakab, Annamaria, Hansen, Regine, Hazell, Katharine Mary, Mehta, Anuradha, Trandafir, Lucia, Coughlin, Christina and Swart, Pieter Jacob (2015) Absorption, distribution, metabolism, and excretion of [14C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemotherapy and Pharmacology, 76. pp. 751-760.

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Jian, Zhigang, Ray, Tapan, Wu, Amy, Jones, Lawrence and Forseth, Ry (2015) Proton Exchange Reactions in Isotope Chemistry (II) Synthesis of Stable Isotope Labeled LCQ908. Journal of Labelled Compounds and Radiopharmaceuticals.

Jiang, Xiaomo, Kheifets, Olga, Zamponi, Raffaella, Yang, Yi and Cong, Feng (2015) Dishevelled promotes wnt receptor degradation through recruitment of znrf3/rnf43 e3ubiquitin ligases. Molecular Cell, 58 (3). pp. 522-533. ISSN 1097-4164

Jing, Weiqing, Gershan, Jill A, Weber, James, Tlomak, Dominique, McOlash, Laura, Sabatos-Peyton, Catherine and Johnson, Bryon D (2015) Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma. Journal for ImmunoTherapy of Cancer, 3 (1). ISSN 2051-1426

Jones, Christopher (2015) The N-terminal Helical Region of the Hepatitis C Virus p7 Protein is Critical for Infectious Virus Production. PLoS Pathogens, 11 (11). e1005297. ISSN 1553-7374

Jones, Hannah, Chen, Yuan, Gibson, Christopher, Heimbach, Tycho, Parrott, Neil, Peters, Sheila, Snoeys, Jan, Upreti, Vijay, Zheng, Ming and Hall , Stephen (2015) Physiologically Based Pharmacokinetic Modelling in Drug Discovery and Development: A Pharmaceutical Industry Perspective. Clinical Pharmacology and Therapeutics.

Junt, Tobias and Barchet, Winfried (2015) Translating nucleic acid sensing pathways into therapies. Nature Reviews Immunology, 15 (9). pp. 529-544.

Kaniskan, H. Umit , Szewczyk, Magdalena , Yu, Zhengtian, Eram, Mohammad S. , Luo, Xiao, Yang, Xiaobao, Schmidt, Keith , Dai, Miao, He, Feng, Zang, Irene, Li, Fengling, Smil, David, Dong, Aiping, Landon, Melissa, Lin-Jones, Jennifer, Huang, Xi-Ping, Roth, Bryan, Schapira, Matthieu, Atadja, Peter, Barsyte-Lovejoy, Dalia , Arrowsmith, Cherry H., Brown, Peter, Zhao, Kehao, Jin, Jian and Vedadi, Masoud (2015) A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angewandte Chemie (International ed. in English), 54 (17). pp. 5166-5170. ISSN 1521-3773

Karkare, Shantanu, Bergdoll, Marc, Leighton-Davies, Juliet, Filipuzzi, Ireos, Fioretto, Celine, Hoepfner, Dominic, Hofmann, Andreas, Imbert, Pierre-Eloi, Jeker, Rolf, Knochenmuss, Richard, Krastel, Philipp, Margerit, Anais, Memmert, Klaus, Miault, Charlotte, Movva, Rao, Naegeli, Hans Ulrich, Oberer, Lukas, Rahier, Alain, Reinker, Stefan, Riedl, Ralph, Roggo, Silvio, Sexton, Jessica, Schuierer, Sven, Wagner, Beatrix, Zhang, Juan, Helliwell, Stephen and Parker, Christian (2015) FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p. Nature Communications, 6. p. 8613. ISSN 2041-1723

Karpov, Alexei, Bellamacina, Cornelia, Bellance, Marie-Helene, Breitenstein, Werner, Denay, Regis, Fernandez, Cesar, Galuba, Inga, Gutmann, Sascha, Jahnke, Wolfgang, Klopp, Julia, Guerro-Lagasse, Stephanie, Lindvall, Mika, Ma, Sylvia, Moebitz, Henrik, Rummel, Gabriele, Trappe, Joerg, Jacob, Sandra and Marzinzik, Andreas (2015) Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Medicinal Chemistry Letters, 6 (7). pp. 776-781. ISSN 1948-58751948-5875

Karpov, Alexei and Grotzfeld, Robert (2015) OAK-approved research summary for the postdoc website. OAK-approved research summary for the postdoc website .

Kasteleijn-Nolst Trenité, D, Brandt, C, Mayer, T, Rosenow, F, Schmidt, B, Steinhoff, BJ, Gardin, Anne, Imbert, Georges, Johns, Donald, Sagkriotis, Alexandros and Kucher, Klaus (2015) Dose-dependent suppression of human photoparoxysmal response with the competitive AMPA/kainate receptor antagonist BGG492. Epilepsia, 56 (6). pp. 924-932. ISSN 1528-1167

Kaufmann, Markus, Schuffenhauer, Ansgar, Fruh, Isabelle, Klein, Jessica, Thiemeyer, Anke, Rigo, Pierre, Gomez-Mancilla, Baltazar, Heidinger-Millot, Valerie, Bouwmeester, Antonius, Schopfer, Ulrich, Mueller, Matthias, Fodor, Barna and Cobos-Correa, Amanda (2015) High Throughput Screening using iPSC-derived neuronal progenitors to identify compounds counteracting epigenetic gene silencing in Fragile X Syndrome. Journal of Biomolecular Screening, 20 (9). pp. 1101-1111. ISSN 1087-05711552-454X

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Kelley, Brian, Brown, Scott P, Warren, Gregory L and Muchmore, Steven W (2015) POSIT: Flexible Shape-Guided Docking For Pose Prediction. Journal of Chemical Information and Modeling.

Kim, Munkyung, Piaia, Alessandro, Shenoy, Neeta, Kagan, David, Gapp, Berangere, Kueng, Benjamin, Weber, Delphine, Dietrich, Bill and Ksiazek, Iwona (2015) Progression of Alport Kidney Disease in Col4a3 knock out mice is independent of sex or macrophage depletion by clodronate treatment. PLoS ONE, 10 (11). ISSN 1932-6203

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Kizuka, Yasushiko, Kitazume, Shinobu, Fujinawa, Reiko, Saito, Takashi, Iwata, Nobuhisa, Saido, Takaomi C, Nakano, Miyako, Yamaguchi, Yoshiki, Hashimoto, Yasuhiro, Staufenbiel, Matthias, Hatsuda, Hisoshi, Endo, Tamao and Taniguchi, Naoyuki (2015) Loss of bisected glycan decreases Abeta generation by relocating BACE1 to the lysosomal degradation pathway. Biochemical Journal, 473 (1). pp. 21-30. ISSN 0264-60211470-8728

Klein, Theo, Fung, Shane-Yu, Renner, Florian, Blank, Michael, Dufour, Antoine, Kang , Sohyeong, Bolger-Munro, Madison, Scurll, Joshua, Priatel, John, Schweigler, Patrick, Melkko, Samu, Gold, Michael, Viner, Rosa, Regnier, Catherine, Turvey, Stuart and Overall, Christopher (2015) The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. Nature Communications, 6. p. 8777. ISSN 2041-1723

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Klocks, Cathelijne, Berger, Claudia, Cortez, Pierre, Yann, Dean, Heinrich, Julia, Jensen Bjerring, Lisbeth, Koppenburg, Vera, Kostense, Stefan, Kramer, Daniel, Spindeldreher, Sebastian and Kirby, Hishani (2015) A fit-for-purpose strategy for the risk-based immunogenicity testing of biotherapeutics - a European industry perspective. Journal of Immunological Methods.

Klumpp, Martin (2015) Non-Stoichiometric Inhibition in Integrated Lead Finding – A Literature Review. Expert Opinion on Drug Discovery, 11 (2). pp. 149-162. ISSN 1746-04411746-045X

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Krumova, Petranka, Reyniers, Lauran, Meyer, Marc, Stauffer, Daniela, Gerrits, Bertran, Hoving, Sjouke, Kaupmann, Klemens, Voshol, Johannes, Fabbrio, Dario, Bauer, Andreas, Rovelli, Giorgio, Taymans, Jean-Marc, Bouwmeester, Antonius and Baekelandt, Veerle (2015) Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate. FASEB Journal, 29 (7). pp. 2980-2992. ISSN 1530-6860

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Langenickel, Thomas Heiko, Tsubouchi, Chiaki , Ayalasomayajula, Surya, Pal, Parasar, Valentin, Marie-Anne, Hinder, Markus, Gevorkyan, Hakop, Jhee, Stanford and Rajman, Iris (2015) The Effect of LCZ696 on Amyloid-β Concentrations in Cerebrospinal Fluid in Healthy Subjects. British Journal of Clinical Pharamcology.

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Lantermann, Alexandra, Mccutcheon, Kaitlin and Sharma, Sreenath (2015) The role of epigenetics in drug resistance in cancer. Epigenetic Diagnosis & Therapy, 1 (2). pp. 106-119. ISSN 2214-0840

Lazic, Stanley (2015) Analytical strategies for the marble burying test: avoiding impossible predictions and invalid p-values. BMC Research Notes.

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Leisegang, Matthias, Engels, Boris, Schreiber, Karin, Yew, Poh Yin, Kiyotani, Kazuma , Idel, Christian, Arina, Ainhoa , Duraiswamy, Jaikumar, Uckert, Wolfgang , Nakamura, Yusuke and Schreiber, Hans (2015) Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation. Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancer-specific point mutation.

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Leroy, Cedric, Qiong, Shen, Strande, Vaik, Lezan, Emmanuelle, Bentires-Alj, Mohamed, Voshol, Johannes, Bonenfant, Debora and Gaither, Larry (2015) CUB-domain-containing protein 1 overexpression in solid cancers promotes cancer cell growth by activating Src family kinases. Oncogene, 34 (44). pp. 5593-5598. ISSN 1476-5594

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Li, Fang, Li, Xiaoyan, Ruddy, David, Tam, Angela, Rakiec, Daniel, Battalagine, Linda, Schlegel, Robert, Monahan, John and Huang, Alan (2015) FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors. Cancer Discovery.

Li, Li, Vashisht, Kapil, Boisclair, Julie, Li, Wenkui, Lin, Tsu-Han, Schmid, Herbert, Kluwe, William, Schoenfeld, Heidi and Hoffmann, Peter (2015) LCI699, a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats. Toxicology and Applied Pharmacology, 286 (3). pp. 224-233. ISSN 0041008X

Li, Nanxin, Molteni, Valentina, Liu, Bo, Tuntland, Tove, Loren, Jon, Gordon, William, Brodeur, Garrett, Iyer, Radhika and Croucher, Jamie (2015) TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts. Cancer Chemotherapy and Pharmacology, 75 (1). pp. 131-141. ISSN 1432-0843

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Lim, Siew Pheng, Noble, Christian Guy and Shi, Pei-Yong (2015) The dengue virus NS5 protein as a target for drug discovery. Anti-viral Research Journal.

Lim, Siew Pheng, Soh, Sherryl, Shi, Pei-Yong, Zhao, Yongqian, Chung, Ka Yan, Swaminathan , Kunchithapadam , Vasudevan , Subhash G , Lescar, Julien and Luo, Dahai (2015) Molecular basis for specific viral RNA recognition and 2’-O ribose methylation by the dengue virus NS5 protein. Proceedings of the National Academy of Sciences.

Lim, Siew Pheng, Wan, Kah Fei, Abas, Siti Nurdiana, Seh, Cheah Chen, Dong, Hongping, Lim, Chin Chin, Chao, Alexander, Lee, Chang Bok, Shi, Pei-Yong, Beer, David, Niyomrattanakit , Pornwaratt , Chung , Ka Yan , Lescar, Julien and Nilar, Shahul (2015) STABILIZATION OF DENGUE VIRUS POLYMERASE IN DE NOVO INITIATION ASSAY PROVIDES ADVANTAGES FOR COMPOUND SCREENING. Anti-viral Research Journal.

Litovchick, Alexander, Dumelin, Christoph, Habeshian, Sevan, Gikunju, Diana, Guié, Marie-Aude, Centrella, Paolo, Zhang, Ying, Sigel, Eric, Cuozzo, John, Keefe, Anthony and Clark, Matthew (2015) Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library. Scientific Reports , 5. ISSN 2045-2322

Liu, L, Tang, M, Walsh, MJ, Brimacombe, KR, Pragani, R, Tanega, C, Rohde, JM, Baker, HL, Fernandez, E, Blackman, B, Bougie, JM, Leister, WH, Auld, DS, Shen, M, Lai, K and Boxer, MB (2015) Structure activity relationships of human galactokinase inhibitors. Bioorganic and Medicinal Chemistry Letters. pp. 721-727.

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London, Anne, Japutra, Chietara, Planck, Kyle, Lihon, Michael and Nguyen, Andrew (2015) A novel method to determine residual detergent in biological samples post endotoxin reduction treatment and evaluation of strategies for subsequent detergent removal. International Immunopharmacology.

Lovsin Barle, Ester, Weideman, Patricia, Bercu, Joel, Dolan, Dave, Faria, Ellen, Flueckiger, Andreas, Gould, Janet, Luo, Wendy, Molnar, Lance, Morinello, Eric, Naumann, Bruce, Olson, Mike, Pfister, Thomas, Sandhu, Reena, Sargent, Edward, Seaman, Chris, Sehner, Claudia, Shipp, Brian, Stanard, Brad, Streeter, Anthony, Sussnam, Robert, Walsh, Andy, Willis, Alison and Maier, Andy (2015) A Harmonization Effort for Deriving Health-Based Exposure Limits in the Pharmaceutical Industry: Report of a Workshop. A Harmonization Effort for Deriving Health-Based Exposure Limits in the Pharmaceutical Industry: Report of a Workshop.

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Lukacs, Viktor, Mathur, Jayanti, Bayrak-Toydemir, Pinar, Rong, Mao, Longo, Nicola, Day, Ronald, Procter, Melinda, Cahalan, Stuart, Kim, Helen J, Bandell, Michael, Stevenson, David A, Patapoutian, Ardem and Krock, Bryan L (2015) Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia. Nature communications, 6. p. 8329. ISSN 2041-1723

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