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Regioselective nitration of 3-fluoro-2-substituted benzoic acids

Hurth, Konstanze and Jacquier, Sebastien and Lehmann, Hansjoerg and Wilcken, Rainer (2015) Regioselective nitration of 3-fluoro-2-substituted benzoic acids. Tetrahedron Letters.

Abstract

The preparation of a series of 3-fluoro-2-substituted-6-nitro benzoic acids is described. The partially excellent regioselectivities observed in the nitration step can be rationalized in most cases using Fukui indices of local nucleophilicity.

Item Type: Article
Keywords: Regioselective nitration Anthranilic acids Fukui indices Local nucleophilicity
Date Deposited: 13 Oct 2015 13:12
Last Modified: 13 Oct 2015 13:12
URI: https://oak.novartis.com/id/eprint/24102

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