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Immunological Hallmarks of Stromal Cells in the Tumour Microenvironment

Turley, Shannon, Cremasco, Viviana and Astarita, Jillian (2015) Immunological Hallmarks of Stromal Cells in the Tumour Microenvironment. Nature Review Immunology.


The dynamic mutualism between tumours and stromal cells is a cornerstone principle in oncology. Stromal cells promote the initiation, progression, metastasis and chemo-resistance of solid tumours. Far less understood is the relationship between stroma and tumour-infiltrating leukocytes; however, emerging evidence suggests that the stromal compartment can shape anti-tumour immunity and responsiveness to immunotherapy. Thus, there is growing interest in elucidating the immunomodulatory roles of stroma within the tumour microenvironment. In this review, we discuss the evidence that stromal determinants interact with leukocytes and influence anti-tumour immunity, with emphasis on immunological attributes that may foster their pro-tumorigenic function.

Item Type: Article
Keywords: stroma, tumor, immunology
Date Deposited: 20 Oct 2015 23:45
Last Modified: 20 Oct 2015 23:45


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