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Suppressors of superoxide production from mitochondrial complex III

Orr, Adam, Brand, Martin, Vargas, Leonardo, Turk, Carolina, Baaten, Janine, Matzen, Jason, Dardov, Victoria, Attle, Stephen, Li, Jing, Meeusen, Shelly, Ainscow, Edward, Goncalves, Renata, Perevoshchikova, Irina and Petrassi, Hank (2015) Suppressors of superoxide production from mitochondrial complex III. Nature Chemical Biology, 11 (11). pp. 834-836. ISSN 1552-4469


Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen species, which are both cellular signals and damaging oxidants. Superoxide production by respiratory complex III is implicated in diverse signaling events and pathologies, but its role remains controversial. Using high-throughput screening, we identified compounds that selectively eliminate superoxide production by complex III without altering oxidative phosphorylation; they modulate retrograde signaling including cellular responses to hypoxic and oxidative stress.

Item Type: Article
Date Deposited: 25 Nov 2017 00:45
Last Modified: 25 Jan 2019 00:45


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