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Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [(1)(1)C]ABP688

DeLorenzo, Christine and Sovago, Judit and Behrje, Rhett and Kumar, Dileep / JS and Devanand, Davangere / P and Pelton, Gregory / H and Mathis, Chester / A and Mason, Scott / N and Gomez-Mancilla, Baltazar and Aizenstein, Howard and Mann, John / J and Parsey, Ramin V (2015) Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [(1)(1)C]ABP688. Transl Psychiatry, 5. ISSN 2158-3188 (Electronic); 2158-3188 (Linking)

Abstract

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in the pathophysiology of mood and anxiety disorders and is a potential treatment target in major depressive disorder (MDD). This study compared brain mGluR5 binding in elderly patients suffering from MDD with that in elderly healthy volunteers using positron emission tomography (PET) and [(11)C]ABP688. Twenty elderly (mean age: 63.0 +/- 6.3) subjects with MDD and twenty-two healthy volunteers in the same age range (mean age: 66.4 +/- 7.3) were examined with PET after a single bolus injection of [(11)C]ABP688, with many receiving arterial sampling. PET images were analyzed on a region of interest and a voxel level to compare mGluR5 binding in the brain between the two groups. Differences in [(11)C]ABP688 binding between patients with early- and late-onset depression were also assessed. In contrast to a previously published report in a younger cohort, no significant difference in [(11)C]ABP688 binding was observed between elderly subjects with MDD and healthy volunteers. [(11)C]ABP688 binding was also similar between subgroups with early- or late-onset depression. We believe this is the first study to examine mGluR5 expression in depression in the elderly. Although future work is required, results suggest potential differences in the pathophysiology of elderly depression versus depression earlier in life.

Item Type: Article
Additional Information: Unmapped bibliographic data: LA - eng [Field not mapped to EPrints] ET - 2015/12/10 [Field not mapped to EPrints] ST - Characterization of brain mGluR5 binding in a pilot study of late-life major depressive disorder using positron emission tomography and [(1)(1)C]ABP688 [Field not mapped to EPrints] AU - DeLorenzo, C. [Field not mapped to EPrints] AU - Sovago, J. [Field not mapped to EPrints] AU - Gardus, J. [Field not mapped to EPrints] AU - Xu, J. [Field not mapped to EPrints] AU - Yang, J. [Field not mapped to EPrints] AU - Behrje, R. [Field not mapped to EPrints] AU - Kumar, J. S. [Field not mapped to EPrints] AU - Devanand, D. P. [Field not mapped to EPrints] AU - Pelton, G. H. [Field not mapped to EPrints] AU - Mathis, C. A. [Field not mapped to EPrints] AU - Mason, N. S. [Field not mapped to EPrints] AU - Gomez-Mancilla, B. [Field not mapped to EPrints] AU - Aizenstein, H. [Field not mapped to EPrints] AU - Mann, J. J. [Field not mapped to EPrints] AU - Parsey, R. V. [Field not mapped to EPrints] AD - Department of Psychiatry, Columbia University, New York, NY, USA. [Field not mapped to EPrints] DP - NLM [Field not mapped to EPrints] AN - 26645628 [Field not mapped to EPrints]
Keywords: Aged
Date Deposited: 01 Mar 2017 00:45
Last Modified: 01 Mar 2017 00:45
URI: https://oak.novartis.com/id/eprint/8998

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