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Number of items: 229.

A

Acharya, Nandini and Sabatos-Peyton, Catherine and Anderson, Ana (2020) Tim-3 finds its place in the cancer immunotherapy landscape. Journal for ImmunoTherapy of Cancer, 8 (1). ISSN 20511426

Adler, Rick and Clark, Elizabeth and Cline, Mark and Connor, Michael and Crabbs, Torrie and Fossey, Stacey and Malarkey, David and Tornquiest, Susan and Vernau, William (2020) Mission Accomplished: The ACVP/STP Coalition for Veterinary Pathology Fellows Completes Its Objectives, but Its Legacy and Spirit Live On. Toxicologic pathology. pp. 1-7.

Akinjiyan, Favour and Fazal, Aleem and Hild, Marc and Beckwith, Rohan and Paulk, Josh and Carbonneau, Seth (2020) A novel luminescence-based high-throughput approach for cellular resolution of protein ubiquitination using tandem ubiquitin binding entities (TUBEs). SLAS DISCOVERY: Advancing the Science of Drug Discovery, 25 (4). pp. 350-360. ISSN 2472-55522472-5560

Algarín, Esperanza and Díaz-Tejedor, Andrea and Mogollón, Pedro and Hernández-García, Susana and Corchete, Luis A and San-Segundo, Laura and Martín-Sánchez, Montserrat and González-Méndez, Lorena and Schoumacher, Marie and Banquet, Sébastien and Kraus-Berthier, Laurence and Kloos, Ioana and Halilovic, Ensar and Maacke, Heiko and Gutiérrez, Norma C and Mateos, María-Victoria and Paíno, Teresa and Garayoa, Mercedes and Ocio, Enrique M (2020) PRECLINICAL EVALUATION OF THE SIMULTANEOUS INHIBITION OF MCL-1 AND BCL-2 WITH THE COMBINATION OF S63845 AND VENETOCLAX IN MULTIPLE MYELOMA. Haematologica : the hematology journal, 105. ISSN 1592-8721

Angst, Daniela and Gessier, Francois and Janser, Philipp and Pulz, Robert and Vulpetti, Anna and Waelchli, Rudolf and Beerli, Christian and Littlewood-Evans, Amanda and Dawson King, Janet and Nuesslein-Hildesheim, Barbara and Wieczorek, Grazyna and Gutmann, Sascha and Scheufler, Clemens and Hinniger, Alexandra and Zimmerlin, Alfred Gilbert and Funhoff, Enrico and Cenni, Bruno (2020) Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Arat, Seda and Ietswaart, Robert and Chen, Amanda and Farahmand, Saman and Kim, Bunjum and Armstrong, Duncan and Urban, Laszlo and DuMouchel, William and Jeffrey, Sutherland and Fekete, Alexander (2020) Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology. EBioMedicine., 57. pp. 1028-1037. ISSN eBioMedicine

Arbues, Ainhoa and Brees, Dominique and Chibout, Salah-Dine and Fox, Todd and Kammueller, Michael and Portevin , Damien (2020) TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis. PLoS pathogens, 16 (2). e1008312. ISSN 1553-7374

Arora, Rishi and Liew, Chong Wai and Soh, Tingjin Sherryl and Otoo, Dorcas and Seh, Cheah Chen and Yue, Qing and Nilar, Shahul Hameed and Wang, Gang and Yokokawa, Fumiaki and Noble, Christian Guy and Chen, Yen-Liang and Shi, Pei-Yong and Lescar, Julien and Smith, Thomas and Benson, Timothy and Lim, Siew Pheng (2020) Two RNA tunnel inhibitors bind in highly conserved sites in Dengue virus NS5 polymerase: structural and functional studies. Journal of virology.

Auberson, Yves (2020) EFMC, medicinal chemistry and chemical biology in Europe. ChemMedChem : chemistry enabling drug discovery, 15.

Auld, Douglas (2020) Microplate Selection and Recommended Practices in High-throughput Screening and Quantitative Biology. Jun 2020.

Auld, Douglas and Busby, Scott and Smith, Thomas and Renaud, Nicole and Carbonneau, Seth and Numao, Shin and Concannon, John and Dumelin, Christoph (2020) Advancements in assay technologies and strategies to enable drug discovery. ACS Chemical Biology. ISSN 1554-89291554-8937

Auld, Douglas and Casalena, Dominick and Wright, Kirk (2020) Multimodal small-molecule screening for human prion protein binders. Journal of Biological Chemistry, 295 (39). ISSN 0021-92581083-351X

Auld, Douglas and Jenkins, Jeremy and Concannon, John (2020) Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38. bioRxiv.

B

Baenziger, Markus and Langlois, Audrey and Gschwend, Bjoern and Wickendick, Regina and Baierl, Marcel and Kovacic, Nikola and Haller, Michael and Schuerch, Friedrich and Shen, Xiaodong and Fu, Peng and Lianhe , Coauthor and Eswaran, Sumesh and Devanathan, Krishnaswamy (2020) Synthesis Development of the selective estrogen receptor degrader (SERD) LSZ102. Organic Process Research & Development, 24 (8). pp. 1405-1419. ISSN 1083-61601520-586X

Balakrishnan, Anand and Hekmat-Nejad, Mohammad and Price, Edmund and Cantwell, John and Wartchow, Charles and Shaul, Jacob and Luu, Catherine and Spraggon, Glen and DiDonato, Michael and Vo, Michael (2020) Biochemical characterization of respiratory syncytial virus RNA dependent RNA polymerase complex. ACS infectious diseases, 6 (10). pp. 2800-2811. ISSN 2373-8227

Ballerini, Andrea and Chua, Corrine and Rhudy, Jessica and Susnjar, Antonia and Trani, Nicola and Jain, Priya and Laue, Grit and Lubicka, Danuta and Shirazi-Fard, Yasaman and Ferrari, Mauro and Stodieck, Louis and Cadena, Samuel and Grattoni, Alessandro (2020) Muscle Atrophy: Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of Formoterol. Advanced Therapeutics, 3 (7). ISSN 23663987

Beckmann, Nicolau (2020) Editorial on “Validation of Automated Perfusion-Weighted Phase-Resolved Functional Lung (PREFUL)-MRI in Patients With Pulmonary Diseases”. Journal of magnetic resonance imaging, 52 (1). pp. 115-116.

Beckmann, Nicolau (2020) Non-Invasive Preclinical Lung Imaging: A Pharmaceutical Perspective. Bruker White Paper.

Bednarczyk, Dallas and Sanghvi, Menaka (2020) Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1's hypothesized function? Xenobiotica.

Bergboer, Judith GM and Kelder, Martijn JE and van Min, Max and Tuta, Nika and Crček, Mitja and Vogelsang, Matjaz (2020) Targeted Locus Amplification and NGS combined with qPCR-based breakpoint analysis for the assurance of monoclonality in recombinant cell lines. as white paper on Cergentis webpage.

Blanco, Maria-Jesus (2020) New Chemical Modalities and Strategic Thinking in Early Drug Discovery. ACS medicinal chemistry letters, 11 (3). pp. 228-231. ISSN 1948-5875

Blank, Jutta and Hintermann, Samuel and Schneider, Nadine and Schuffenhauer, Ansgar and Shultz, Michael (2020) Outline for a Perspective Article on Novartis’ approach to compound screening for hit and lead finding and the design of compounds sets for diversity driven screening. Journal of medicinal chemistry for publisher only.

Blümel, Oliver and Buecheler, Jakob and Rodrigues, Miguel and Garaldes, Vitor and Hoelzl, Georg and Bechtold-Peters, Karoline and Friess, Wolfgang (2020) Cryoconcentration and 3D Temperature Profiles during Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device. Pharmaceutical Research, Formul. ISSN 0724-8741

Bogdanffy, Matthew S and Lesniak, Jacob and Mangipudy, Raja and Stanley, Ann Marie and Colman, Karyn and Blanset, Diann (2020) Tg.rasH2 mouse model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey and Recommendations. International Journal of Toxicology. ISSN 1091-58181092-874X

Bogdanffy, Matthew S and Lesniak, Jacob and Mangipudy, Raja and Stanley, Ann Marie and Colman, Karyn and Blanset, Diann and Sistare, Frank D and Garcia-Tapia, David and Monticello, Thomas (2020) Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices. International journal of toxicology. ISSN 1092874X

Boike, Lydia and Cioffi, Alexander and Majewski, Felix C. and Co, Jennifer and Henning, Nathaniel J. and Jones, Michael and Liu, Gang and McKenna, Jeffrey and Tallarico, John and Schirle, Markus and Nomura, Daniel K. (2020) Discovery of a Covalent Ligand Targeting an Intrinsically Disordered Cysteine Within MYC. Cell chemical biology. ISSN 2451-9448

Bolon, Brad and Caverly Rae, Jessica and Colman, Karyn and Francke, Sabine and Jensen, Karl and Keane, Kevin and McInnes, Elizabeth F. and Nakano-Ito, Kyoko and Perry, Rick and Polack, Evelyne and Reagan, Karen S. and Romeike, Annette and Young, Jamie K. and Galbreath, Elizabeth (2020) Toxicologic Pathology Forum Opinion Piece: Current Use of Non-blinded vs. Blinded Histopathologic Evaluation in Animal Toxicity Studies. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Bova, Kaitlin (2020) Mitigating Medication Errors in Clinical Research. Clinical Trial Supply Handbook - Summer Edition .

Braun, Marie-Gabrielle and Díaz-Rodríguez , Alba and Louis, Diorazio and Kenneth, Fraunhoffer and John, Hayler and Matthew, Hickey and Jonathan , Latham and Lovelle, Lucie and Mark, McLaws and Andrew, Parsons and Paul, Richardson and Alan, Steven and Jack, Terrett and Timothy, White and Jingjun, Yin (2020) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development. ISSN 1083-61601520-586X

Brovč, Ema Valentina and Mravljak, Janez and Pajk, Stane and Sink, Roman (2020) Degradation of polysorbates 20 and 80 catalysed by histidine chloride buffer. European journal of pharmaceutics and biopharmaceutics, 154. pp. 236-245. ISSN 09396411

Brovč, Ema Valentina and Mravljak, Janez and Pajk, Stane and Sink, Roman (2020) Rational design to biologics development: The polysorbates point of view. International Journal of Pharmaceutics, 581. ISSN 18733476

Bruin, Gerardus and Hockey, Hans-Ulrich and Patekar, Manmath and Charef, Pascal and Woessner, Ralph and Boutouyrie-Dumont, Bruno and Fu, Rong and Philip, La Stella and Bardur, Sigurgeirsson (2020) Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different 2 mL delivery systems in healthy volunteers and in psoriasis patients. British journal of clinical pharmacology. pp. 1-14.

Bucher, Christoph and Linden, Anthony and Heimgartner, Heinz (2020) Synthesis and Solid State Conformation of Tetrapeptide Amides Containing two Aib and two (Me)Phe Residues – Use of Enantiomerically Pure 2-Benzyl-2-methyl-2H-azirin-3-amines as (Me)Phe-Synthons. Chemistry & Biodiversity. ISSN 1612-18721612-1880

C

Cadena, Samuel (2020) Contrasting atrophy in space and on Earth. Genes in Space: Research Brief.

Caduff, Nicole and McHugh, Donal and Murer, Anita and Rämer, Patrick and Raykova, Ana and Landtwing, Vanessa and Rieble, Lisa and Keller, Christian and Prummer, Michael and Hoffmann, Laurent and Lam, Janice and Chiang, Alan and Raulf, Friedrich and Azzi, Tarik and Berger, Christoph and Rubic-Schneider, Tina and Traggiai, Elisabetta and Lünemann, Jan and Kammueller, Michael and Münz, Christian (2020) Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice. PLoS pathogens, 16 (4). pp. 1-25. ISSN 15537374

Camilleri, Michael and Linker Nord, Sara and Burton, Duane and Oduyebo, Ibironke and Zhang, Yiming and Chen, Jin and Im, Koeun and Bhad, Prafulla and Badman, Michael and Sanders, David and Walters, Julian (2020) A Randomized Controlled Trial of a Farnesoid X Receptor Agonist, Tropifexor, in Patients with Primary Bile Acid Diarrhea. Alimentary pharmacology & therapeutics, 52 (5). pp. 808-820. ISSN 02692813

Canham, Steve and Jenkins, Jeremy and Auld, Douglas (2020) Systematic Chemogenetic Library Assembly. BioRxiv.

Capaldi, Daniel and Akhtar, Nadim and Atherton, Tom and Benstead, David and Charaf, Ayman and De Vijlder, Thomas and Heatherington, Carl and Hoernschemeyer, Joerg and Jiang, Hong and Rieder, Ulrike and Ring, Francis and Peter, Robert and Stolee, Jessica and Wechselberger, Rainer (2020) Strategies for Identity Testing of Therapeutic Oligonucleotide Drug Substances and Drug Products. Nucleic Acid Therapeutics (00). ISSN 2159-33372159-3345

Capdevila, Jaume and Wirth, Lori J and Ernst, Thomas and Ponce Aix, Santiago and Lin, Chia-Chi and Ramlau, Rodryg and Butler, Marcus O and Delord, Jean-Pierre and Fuhrer, Dagmar and Hutter-Kronke, Marie-Luise and Forde, Patrick M and Wrona, Anna and Santoro, Armando and Sadow, Peter M and Szpakowski, Sebastian and Wu, Hongqian and Bostel, Geraldine and Faris, Jason and Cameron, Scott and Varga, Andreea and Taylor, Matthew and Arkoski, Peter (2020) PD-1 Blockade in Anaplastic Thyroid Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. pp. 1-9. ISSN 15277755

Carballido, Jose and Regairaz Kalenga Kapiamba, Camille and Rauld, Celine and Raad, Layla and Picard, Damien and Kammueller, Michael (2020) The emerging jamboree of transformative therapies for autoimmune diseases. Frontiers in Immunology.

Chacón Simon, Selena and Wang, Feng and Thomas, Lance R and Phan, Jason and Zhao, Bin and Olejniczak, Edward T and Macdonald, Jonathan D and Shaw, J Grace and Schlund, Caden and Payne, William and Creighton, Joy and Stauffer, Shaun R and Waterson, Alex G and Tansey, William P and Fesik, Stephen W (2020) Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. Journal of medicinal chemistry, 63 (8). pp. 4315-4333. ISSN 1520-4804

Chen, Gregory and Grauzinyte, Migle and van der Vaart, Aad and Boll, Bjoern (2020) Applying Pattern Recognition as a Robust Approach for Silicone Oil Droplet Identification in Flow-Microscopy Images of Protein Formulations. Journal of pharmaceutical sciences. ISSN 00223549

Chen, Hui and Sun, Shuhao and Liu, Yahu and Liao, Xuebin (2020) Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C-CN Bond Cleavage and Cyano Transfer. ACS Catalysis, 10. pp. 1397-1405. ISSN 2155-54352155-5435

Chianelli, Donatella and Rucker, Paul and Tully, David and Nelson, John and Liu, Xiaodong and Bursulaya, Badry and Hernandez, Eloy and Chu, Alan and Schmeits, James and Hill, Robert and Bao, Dingjiu and Zoll, Jocelyn and Kim, Young and Groessl, Todd and McNamara, Peter and Richmond, Wendy and Sancho Martinez, Ignacio and Badman, Michael and Molteni, Valentina and Jason, Roland and Jane, Wu and David, Huang and Bo, Liu and Andrew, Phimister and Martin, Seidel and Sean, Joseph and Bryan, Laffitte (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH). Journal of medicinal chemistry, 63 (8). pp. 3868-3880. ISSN 9b01621

Chianelli, Donatella and Rucker, Paul and Tully, David and Nelson, John and Liu, Xiaodong and Bursulaya, Badry and Hernandez, Eloy and Chu, Alan and Schmeits, James and Hill, Robert and Bao, Dingjiu and Zoll, Jocelyn and Kim, Young and Groessl, Todd and McNamara, Peter and Richmond, Wendy and Sancho Martinez, Ignacio and Badman, Michael and Molteni, Valentina and Jason, Roland and Jane, Wu and David, Huang and Bo, Liu and Andrew, Phimister and Martin, Seidel and Sean, Joseph and Bryan, Laffitte and Prashad, Mahavir and Schlama, Thierry and Liu, Yugang (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. Journal of medicinal chemistry, 63 (8). pp. 3868-3880. ISSN 9b01621

Clarke, Adrian and ehkirch, anthony (2020) The Current Status and Future of Two- and Multidimensional Liquid Chromatography in Pharmaceutical R&D and QC. LC-GC Europe : Solutions for Separation Scientists., 33 (3). pp. 136-150. ISSN 1471-6571

Cowan, Cameron and Renner, Magdalena and De Gennaro, Martina and Gross-Scherf, Brigitte and Goldblum, David and Hou, Yanyan and Munz, Martin and Rodrigues, Tiago M. and Krol, Jacek and Szikra, Tamas and Cuttat-Theurillat, Rachel and Waldt, Annick and Papasaikas, Panagiotis and Diggelmann, Roland and Patino-Alvarez, Claudia P. and Galliker, Patricia and Spirig, Stefan and Pavlinic, Dinko and Gerber-Hollbach, Nadine and Schuierer, Sven and Srdanovic, Aldin and Balogh, Marton and Panero, Riccardo and Kusnyerik, Akos and Szabo, Arnold and Stadler, Michael and Orgül, Selim and Picelli, Simone and Hasler, Pascal W. and Hierlemann, Andreas and Scholl, Hendrik P. N. and Roma, Guglielmo and Nigsch, Florian and Roska, Botond (2020) Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map. Cell, 182 (6). p. 1623. ISSN 00928674

Czyz, Stefan and Wewers, Martin and Finke, Jan and Kwade, Arno and Van Eerdenbrugh, Bernard and Juhnke, Michael and Bunjes, Heike (2020) Spray 1 drying of API nanosuspensions: Importance of particle size, matrix former content and drying temperature for successful formulation and process development. European journal of pharmaceutics and biopharmaceutics, 152 (July). pp. 63-71. ISSN 1873-3441; 0939-6411

D

DaSilva, Jamie K. and Breidenbach, Laura and Deats, Tracy and Li, Dingzhou and Treinen, Kimberly and Dinklo, Theo and Kervyn, Sophie and Teuns, Greet and Traebert, Martin and Hempel, Katja (2020) Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative. Journal of Pharmacological and Toxicological Methods, 103. ISSN 1873488X

Dalvit, Claudio and Veronesi, Marina and Vulpetti, Anna (2020) Fluorine NMR functional screening: from purified enzymes to human intact living cells. Journal of Biomolecular NMR. ISSN 15735001

Delord, Jean-Pierre and Argilés, Guillem and Fayette, Jerôme and Wirth, Lori and Kasper, Stefan and Siena, Salvatore and Mesia, Ricard and Berardi, Rossana and Cervantes, Andrés and Dekervel, Jeroen and Zhao, Sylvia and Sun, Yongjian and Hao, Lu and Tiedt, Ralph and Vicente Gabarda, Sergio and Myers, Andrea and Siu, Lillian L (2020) A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment. Investigational New Drugs. ISSN 15730646

Di Marco, Giulia and Vallese, Francesca and Jourde, Benjamin and Bergsdorf, Christian and Sturlese, Mattia and De Mario , Agnese and Techer-Etienne, Valerie and Haasen, Dorothea and Oberhauser, Berndt and Schleeger, Simone and Minetti, Giulia and Moro, Stefano and Rizzuto, Rosario and De Stefani, Diego and Fornaro, Mara and Mammucari, Cristina (2020) A high throughput screening identifies MICU1 targeting compounds. Cell Reports, 30. pp. 1-11.

Diagana, Thierry and Gupta, Devendra and Voorberg-van der Wel, Annemarie and Zeeman, Anne-Marie and Nieuwenhuis, Ivonne G and van der Werff, Nicole M. and Klooster, Els J and Klop, Onny and Vermaat, Lars C and Kocken, Clemens and Dembele, Laurent (2020) A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation. Communications biology, 3 (1). ISSN 23993642

Dittrich, Birger and Chan, Stephen and Wiggin, Seth and Stevens, Joanna S. and Pidcock, Elna (2020) Fast energy minimization of the CCDC drug subset structures by molecule-in-cluster computations allows independent structure validation and model completion. CrystEngComm. ISSN 1466-8033

Dittrich, Birger and Sever, Christoph A. and Luebben, Jens (2020) Disappearing disorder. CrystEngComm. ISSN 1466-8033

Do Valle Duraes, Fernanda and Lafont, Armelle and Darribat, Katy and Cuttat-Theurillat, Rachel and Waldt, Annick and Naumann, Ulrike and Wieczorek, Grazyna and Gaulis, Swann and Pfister, Sabina and Beibel, Martin and Li, Jianping and Roma, Guglielmo and Warncke, Max (2020) Immune cell landscaping reveals a protective role for Tregs during kidney injury and fibrosis. "Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis, 5 (3).

Do Valle Duraes, Fernanda and Lafont, Armelle and Darribat, Katy and Martin, Kea and Cuttat-Theurillat, Rachel and Waldt, Annick and Naumann, Ulrike and Wieczorek, Grazyna and Gaulis, Swann and Pfister, Sabina and Beibel, Martin and Li, Jianping and Roma, Guglielmo and Warncke, Max and Mertz, Kirsten (2020) Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis. JCI insight, 5 (3). ISSN 23793708

Dolman, Andrew and Yu, Helen and Gusev, Arkady (2020) Data driven CRO benchmarking for biomarker analysis. Bioanalysis, 12 (16). pp. 1117-1127. ISSN 1757-6180

Doo, David W and Meza-Perez, Selene and Londoño, Angelina I and Goldsberry, Whitney N and Katre, Ashwini A. and Boone, Jonathan D and Moore, Dylana J. and Hudson, Cindy T and Betella, Ilaria and McCaw, Tyler R and Gangrade, Abhishek and Bao, Riyue and Luke, Jason J and Yang, Eddy S and Birrer, Michael J. and Starenki, Dmytro and Cooper, Sara J and Buchsbaum, Donald J and Norian, Lyse A and Randall, Troy D and Arend, Rebecca C (2020) Inhibition of the Wnt/β-catenin pathway enhances anti-tumor immunity in ovarian cancer. Therapeutic Advances in Medical Oncology, 12. pp. 1-16. ISSN 1758-835920913798

Dummer, Reinhard and Brase, Jan Christoph and Garrett, James and Campbell, Katie and Gasal, Eduard and Squires, Matthew and Gusenleitner, Daniel and Santinami, Mario and Atkinson, Victoria and Mandala, Mario and Chiarion-Sileni, Vanna and Flaherty, Keith and Larkin, James and Robert, Caroline and Kefford, Richard and Kirkwood, John and Hauschild, Axel and Schadendorf, Dirk and Long, Georgina (2020) Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV600-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial. The Lancet Oncology, 21 (3). pp. 358-372.

Dummer, Reinhard and Lebbé, Celeste and Atkinson, Victoria and Mandalà, Mario and Nathan, Paul and Arance, Ana and Richtig, Erika and Yamazaki, Naoya and Robert, Caroline and Schadendorf, Dirk and Tawbi, Hussein A. and Ascierto, Paolo A. and Ribas, Antoni and Flaherty, Keith and Pakhle, Neha and Campbell, Katie and Gusenleitner, Daniel and Masood, Aisha and Brase, Jan Christoph and Gasal, Eduard and Long, Georgina V. (2020) Spartalizumab in Combination With Dabrafenib And Trametinib in Advanced BRAF V600–Mutant Melanoma: Efficacy, Safety, and Biomarker Findings in Parts 1 and 2 of COMBI-i. Nature medicine, 26 (9).

Dumouchel, Jennifer and Argikar, Upendra and Adams, Christopher and Prasanna, Ganesh and Ehara, Takeru and Kim, Sunkyu and Breen, Chris and Mogi, Muneto (2020) Understanding metabolism related differences in ocular efficacy of MGV354. Xenobiotica. pp. 1-10. ISSN 13665928

E

Emilsson, V and Gudmundsson, EF and Aspelund, T and Jonsson , BG and Gudjonsson, A and Lenore, JL and Jennings, Lori and Gudmundsdottir, V and Gudnason, V (2020) Antihypertensive drug treatment and serum ACE2 levels. https://medrxiv.org/cgi/content/short/2020.05.21.20108738v1.

Emilsson, Valur and Gudmundsson, Elias F and Aspelund, Thor and Jonsson G, Brynjolfur and Gudjonsson, Alexander and Laurner, Lenore J and Lamb, John and Gudmundsdottir, Valborg and Jennings, Lori and Gudnason, Vilmundur (2020) ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19 Subtitle: ACE2 serum levels are increased in metabolic disease. https://medrxiv.org/cgi/content/short/2020.06.04.20122044v1.

Erdemli, Gul (2020) RADAR-AD Interview Series. RADAR-AD Project Website.

Ertl, Peter (2020) Craig plot 2.0 - An interactive navigation in the substituent bioisosteric space. Journal of Cheminformatics, 12 (2020). ISSN 1758-2946

Ertl, Peter (2020) Identification of bioisosteric analogs by deep neural network. Journal of Chemical Information and Modeling, 60 (7). pp. 3369-3375. ISSN 1549-95961549-960X

Ertl, Peter and Altmann, Eva and McKenna, Jeffrey (2020) The Most Common Functional Groups in Bioactive Molecules and How Their Popularity Has Evolved over Time. Journal of medicinal chemistry, 63 (15). 8408-8418.

F

Fanous, Marina and Gold, Sarah and Hirsch, Stefan and Ogorka, Joerg and Imanidis, Georgios (2020) Development of Immediate Release (IR) 3D-printed oral dosage forms with focus on industrial relevance. Development of Immediate Release (IR) 3D-printed oral dosage forms with focus on industrial relevance, 105558. ISSN 0928-0987

Fanous, Marina and Gold, Sarah and Muller, Silvain and Hirsch, Stefan and Ogorka, Joerg and Imanidis, Georgios (2020) Simplification of FDM 3D-Printing paradigm: feasibility of 1-step Direct Powder Printing for Immediate Release dosage forms production. International journal of pharmaceutics. ISSN 1873-3476; 0378-5173

Fernandez Vallone, Valeria and Leprovots, Morgane and Gerbier, Romain and Ribatallada-Soriano, Didac and Lefort, Anne and Libert, Frederick and Vassart, Gilbert and Garcia, Marie-Isabelle (2020) LGR5 controls extracellular matrix production by stem cells in the developing intestine. EMBO Reports. ISSN 14693178

Fisher, Benjamin A and Szanto, Antonia and Ng, Wan-Fai and Bombardieri, Michele and Posch, Maximilian and Papas, Athena S and Farag , Arwa S and Daikeler, Tomas and Bannert, Bettina and Kyburz, Diego and Kivitz, Alan J and Carsons, Steven E and Isenberg, David and Barone, Francesca and Bowman, Simon J and Espie, Pascal and Floch, David and Dupuy, Cyrielle and Farber, Petra and Ren, Xiaohui and Wright, Andrew and Hockey, Hans-Ulrich and Rotte, Michael and Milojevic, Julie and Avrameas, Alexandre and Valentin, Marie-Anne and Rush, James and Gergely, Peter (2020) Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren’s syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study. The Lancet Rheumatology, 2 (3). pp. 142-152. ISSN 2665-9913

Flandre, Thierry and Hey, Adam and Spence, Fiona (2020) Nonclinical safety assessment of an inhaled formulation of serelaxin, a recombinant human protein, in rats and cynomolgus monkeys (Macaca fascicularis). Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Flannery, Erika (2020) MAM 2020: Growing Strong on the 20th Anniversary. Trends in Parasitology, 36 (6). pp. 487-494. ISSN 14715007

Folkerts, Jelle and Redegeld, Frank and Folkerts, Gert and Blokhuis, Bart and van den Berg, Mariska P.M. and Marjolein J.W., de Bruijn and Wilfred F.J., van Ijcken and Junt, Tobias and Tam, See-ying and Galli, Stephen J. and Hendriks, Rudi W. and Stadhouders, Ralph and Maurer, Marcus (2020) Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling. Allergy: European Journal of Allergy and Clinical Immunology. ISSN 13989995

Fu, Yue and Estoppey, David and Roggo, Silvio and Pistorius, Dominik and Fuchs, Florian and Studer, Christian and Ibrahim, Ashraf S and Aust, Thomas and Grandjean, Frederic and Mihalic, Manuel and Memmert, Klaus and Prindle, Vivian and Richard, Etienne and Riedl, Ralph and Schuierer, Sven and Weber, Eric and Hunziker, Juerg and Petersen, Frank and Tao, Jianshi and Hoepfner, Dominic (2020) Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol. Nature Communications, 11 (1). ISSN 20411723

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Wagner, Julia A and Wong, Pamela and Schappe, Timothy and Berrien-Elliott, Melissa M and Cubitt, Celia and Jaeger, Natalia and Lee, Madeline and Keppel, Cassie R and Marin, Nancy D and Foltz, Jennifer A and Marsala, Lynne and Neal, Carly C and Sullivan, Ryan and Schneider, Stephanie E and Keppel, Molly P and Saucier, Nermina and Cooper, Megan A and Fehniger, Todd A (2020) Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity. Cell reports, 31 (9). p. 107720. ISSN 2211-1247

Wang, Shirley and Kulldorff, Martin and Poor, Stephen and Rice, Dennis and Banks, Angela and Li, Ning and Lii, Joyce and Gagne, Joshua J (2020) Screening medications for association with progression to wet age-related macular degeneration (AMD). Ophthalmology. ISSN 01616420

Wang, Xiaoliang and Perozzo, Remo and Amirshahrokhi, Keyvan and Kuchen, Stefan and Yousefi, Shida and Simon, Hans-Uwe and Loetscher, Pius and Gessier, Francois (2020) RIPK3-MLKL – Mediated neutrophil death requires concurrent activation of fibroblast activation protein alpha (FAP-α). The Journal of Immunology. ISSN 0022-17671550-6606

Ward, Lesley A and Lee, Dennis SW and Sharma, Anshu and Wang, Angela and Naouar, Ikbel and Ma, Xianjie I and Pikor, Natalia and Nuesslein-Hildesheim, Barbara and Ramaglia, Valeria and Gommerman, Jennifer L (2020) A murine model of meningeal inflammation and subpial demyelination identifies an anti-MOG independent mechanism of cortical injury that is inhibited by Siponimod therapy. JCI insight.

Wartchow, Charles and Kane, Joshua and Shaul, Jacob and Frank, Andreas and Knapp, Mark and Bussiere, Dirksen and Ornelas, Elizabeth and Hyrina, Anastasia (2020) eLive revised manuscript: A POLYOMAVIRUS PEPTIDE BINDS TO THE CAPSID VP1 PORE AND HAS POTENT ANTIVIRAL ACTIVITY AGAINST BK AND JC POLYOMAVIRUSES. ELife., 9. ISSN 2050-084X

Wenzel, Jan and Richter, Marius and Bettoni, Carla and Vogt, Miriam A and Natsagdorj, Rentsenkhand and Huber, Gianna and Brands, Josefine and Assmann, Julian C and Lembrich, Beate and Stölting, Ines and Sedlacik, Jan and Fiehler, Jens and Ludewig, Peter and Wegmann, Michael and MüllerFielitz, Helge and Wlather, Thomas and Schmidt, Kjestine and König, Gabriele M and Kostenis, Evi and Raasch, Walter and deWit, Cor and Gass, Peter and Offermanns, Stefan and Wagner, Carsten A and Schwaninger, Markus (2020) Behavioral, respiratory and metabolic consequences of impaired cerebrovascular reactivity. Proceedings of the National Academy of Sciences of the United States of America PNAS.. ISSN 1091-6490; 0027-8424

Wewers, Martin and Czyz, Stefan and Finke, Jan and John, Edgar and Van Eerdenbrugh, Bernard and Juhnke, Michael and Bunjes, Heike and Kwade, Arno (2020) Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules Produced in a Fluidized Bed Process. Pharmaceutics, 12 (n/a). p. 363. ISSN 1999-4923

Widler, Leo and Amadeu, Nader and Augner, Sven and Janiak, Christoph and Hägele, Gerhard (2020) Symmetric Geminal Bisphosphinic Acids RR´C[P(CH3)(O)OH]2 - NMR and Analytical Studies. Phosphorus, Sulfur, and Silicon and the Related Elements. ISSN 1042-65071563-5325

Wilcken, Rainer and Rodde, Stephane and Udvarhelyi, Aniko (2020) ReSCoSS: A Flexible Quantum Chemistry Workflow Identifying Relevant Solution Conformers of Drug-like Molecules. Journal of computer-aided molecular design.

Woollam, Grahame and Das, Partha P. and Mugnaioli, Enrico and Andrusenko, Iryna and Galanis, Athanassios S. and Jacco, Van De Streek (ext.) and Nicolopoulos, Stavros and Gemmi, Mauro and Wagner, Beatrix (2020) Structural Analysis of Metastable Pharmaceutical Loratadine Form II, by 3D Electron Diffraction and DFT+D Energy Minimisation. CrystEngComm. ISSN 1466-8033

Wu, Quanbing and Li, Lei and Li, Bin and Chen, Like and Wu, Bin and Wang, Xianwen and Guo, Tina (2020) Process Development for the Synthesis of a -monobactam antibiotic - LYS228. Organic Process Research & Development, 24 (3). pp. 363-370. ISSN 1083-61601520-586X

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Xing, Jimmy and Loureiro, Joe and Patel, Michael and Mikhailov, Dmitri and Gusev, Arkady (2020) Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis. Bioanalysis, 12. pp. 919-935. ISSN 1757-6199

Xue, J and Domingo-Almenara, X and Fuijas, C and Palermo, A and Rinschen, M and Benton, H P and Isbell, John and Siuzdak, G (2020) Enhanced electrospray in-source fragmentation for higher sensitivity data independent acquisition and autonomous METLIN molecular identification. Analytical Chemistry, 92 (8). pp. 6051-6059. ISSN 0003-27001520-6882

Y

Yi, John and Russo, Melissa and Raja, Shruti and Massey, Janice and Juel, Vern and Shin, Jay and Hobson-Webb, Lisa and Gable, Karissa and Guptill, Jeffrey (2020) Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis. Experimental Neurology, 325 (March ). pp. 1-8. ISSN 0014-4886

Z

Zaidman, Nathan A and Tomilin , Viktor and Damarla, Mahendra and Tidmore, Josephine and Capen , Diane and Brown, Dennis and Pochynyuk, Oleh and Pluznick, Jennifer L (2020) Adhesion-GPCR Gpr116 (ADGRF5) is a Regulator of Urine Acidification and Surface Expression of the Vacuolar-type H+-ATPase in Renal α-Intercalated Cells. Proceedings of the National Academy of Sciences of the United States of America PNAS..

Zhu, Liang and Glick, Jim and Flarakos, Jimmy (2020) Bioanalytical Challenges in Support of Complex Modalities of Antibody-Based Therapeutics. AAPS Journal, 22 (6). pp. 130-135. ISSN 15507416

This list was generated on Mon Nov 30 21:06:55 2020 UTC.

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