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Semiparametric estimation of the cure fraction in population‐based cancer survival analysis

Gu, Ennan and Zhang, Jiajia and Lu, Wenbin and Wang, Lianming and Felizzi, Federico (2020) Semiparametric estimation of the cure fraction in population‐based cancer survival analysis. Statistics in Medicine, 39 (26). pp. 3787-3805. ISSN 0277-6715

Abstract

With rapid development in medical research, the treatment of diseases including cancer has progressed dramatically and those survivors may die from causes other than the one under study, especially among elderly patients. Motivated by the Surveillance, Epidemiology, and End Results (SEER) female breast cancer study, background mortality is incorporated into the mixture cure proportional hazards (MCPH) model to improve the cure fraction estimation in population‐based cancer studies. Here, that patients are “cured” is defined as when the mortality rate of the individuals in diseased group returns to the same level as that expected in the general population, where the population level mortality is presented by the mortality table of the United States. The semiparametric estimation method based on the EM algorithm for the MCPH model with background mortality (MCPH+BM) is further developed and validated via comprehensive simulation studies. Real data analysis shows that the proposed semiparametric MCPH+BM model may provide more accurate estimation in population‐level cancer study.

Item Type: Article
Date Deposited: 12 Dec 2020 00:45
Last Modified: 12 Dec 2020 00:45
URI: https://oak.novartis.com/id/eprint/44024

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