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Modulating Target Engagement of Small Molecules Via Drug Delivery – Approaches and Applications in Drug Discovery and Development

Sanchez-Felix, Manuel and Tomic, Ivana and Duvnjak Romic, Marieta and Yang, Wenzhan and Bhattachar, Shobha and Landis, Margaret and Patel, Dipal and Reid, Darren and Phenil , Patel (2020) Modulating Target Engagement of Small Molecules Via Drug Delivery – Approaches and Applications in Drug Discovery and Development. Drug discovery today. ISSN 13596446

Abstract

Drug delivery technologies for modified drug release have been in existence for a long time, but their utilization has been largely limited to extending market exclusivity and improving patient adherence to therapy. Recently, they are gaining renewed importance as pharmaceutical industry is steadily shifting to a more integrated discovery-development approach. In discovery, modulating target engagement via drug delivery technologies can enable crucial pharmacology studies for building a strong foundation and well-defined criteria for molecular design. In development, earlier implementation of delivery technologies can enhance the value of drug products through reduced dosing frequency, improved tolerability and/or safety profile, thereby leading to better adherence and therapeutic effectiveness.

Item Type: Article
Keywords: drug discovery and development, molecular design, extended release, oral, parenteral, patient compliance
Date Deposited: 14 Jan 2021 00:45
Last Modified: 14 Jan 2021 00:45
URI: https://oak.novartis.com/id/eprint/43287

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