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Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions

Mortzfeld, Frederik and Polenk, Jutta and Guelat, Bertrand and Venturoni, Francesco and Schenkel, Berthold and Filipponi, Paolo (2020) Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions. Organic Process Research & Development. ISSN 1083-61601520-586X

Abstract

A new method for the calorimetric characterization of high-energetic, fast reactions in flow mode has been developed. The use of an engineered flow reactor in combination with a process modelling software allowed the deconvolution of the reaction enthalpy from space-resolved temperature profiles. The new procedure was verified in a comparison with a conventional batch calorimeter and subsequently implemented for the thermal characterization of an organolithium flow process. The information collected for this reaction successfully supported a scale-up to the pilot plant. Overall, the new approach resulted to be superior when compared with established procedures, enabling the generation of precise calorimetric data in an accurate scale-down flow device.

Item Type: Article
Date Deposited: 29 Jul 2020 00:45
Last Modified: 29 Jul 2020 00:45
URI: https://oak.novartis.com/id/eprint/42351

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