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It's in Our Blood: A Glimpse of Personalized Medicine

Lamb, John R, Jennings, Lori, Gudmundsdottir, Valborg, Gudnason, Vilmundur and Emilsson, Valur (2020) It's in Our Blood: A Glimpse of Personalized Medicine. Trends in Molecular Medicine. ISSN 1471499X


Recent advances in protein profiling technology has facilitated simultaneous measurement of thousands of proteins in large population studies, exposing the depth and complexity of the plasma and serum proteomes. This revealed that proteins in circulation were organized into regulatory modules under genetic control and closely associated with current and future common diseases. Unlike networks in solid tissues, serum protein networks comprise members synthesized across different tissues of the body. Genetic analysis reveals that this cross-tissue regulation of the serum proteome participates in systemic homeostasis and mirrors the global disease state of individuals. Here, we discuss how application of this information in routine clinical evaluations may transform the future practice of medicine.

Item Type: Article
Keywords: biological networks blood proteome holistic disease state personalized medicine
Date Deposited: 15 Dec 2020 00:45
Last Modified: 15 Dec 2020 00:45


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