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Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis

Xing, Jimmy and Loureiro, Joe and Patel, Michael and Mikhailov, Dmitri and Gusev, Arkady (2020) Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis. Bioanalysis, 12. pp. 919-935. ISSN 1757-6199

Abstract

Aim: Evaluation of a novel microsampling device for its use in clinical sample collection and biomarker analysis. Methodology: Matching samples were collected from 16 healthy donors (ten females, six males; age 42 ± 20) via K2EDTA touch activated phlebotomy (TAP) device and phlebotomy. The protein profile differences between sampling groups was evaluated using aptamer-based proteomic assay SomaScan and selected ELISA. Conclusion: Somascan signal concordance between phlebotomy- and TAP-generated samples was studied and comparability of protein abundances between these blood sample collection methods was demonstrated. Statistically significant correlation in selected ELISA assays also confirmed the TAP device applicability to the quantitative analysis of protein biomarkers in clinical trials.

Item Type: Article
Keywords: COVID-19; DBS; SomaScan; TAP; VAMS; biomarkers; microsampling; patient-centric sampling; proteomics; sampling device
Date Deposited: 17 Sep 2020 00:45
Last Modified: 17 Sep 2020 00:45
URI: https://oak.novartis.com/id/eprint/42111

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