Carballido, Jose, Regairaz Kalenga Kapiamba, Camille, Rauld, Celine, Raad, Layla, Picard, Damien and Kammueller, Michael (2020) The emerging jamboree of transformative therapies for autoimmune diseases. Frontiers in Immunology.

Abstract

Standard treatments for autoimmune and autoinflammatory disorders rely mainly on
immunosuppression. These are predominantly symptomatic remedies that do not
affect the root cause of the disease and are associated with multiple side effects.
Immunotherapies are being developed during the last decades as more specific and
safer alternatives to small molecules with broad immunosuppressive activity, but they still
do not distinguish between disease-causing and protective cell targets and thus, they
still have considerable risks of increasing susceptibility to infections and/or malignancy.
Antigen-specific approaches inducing immune tolerance represent an emerging trend
carrying the potential to be curative without inducing broad immunosuppression. These
therapies are based on antigenic epitopes derived from the same proteins that are
targeted by the autoreactive T and B cells, and which are administered to patients
together with precise instructions to induce regulatory responses capable to restore
homeostasis. They are not personalized medicines, and they do not need to be. They are
precision therapies exquisitely targeting the disease-causing cells that drive pathology
in defined patient populations. Immune tolerance approaches are truly transformative
options for people suffering from autoimmune diseases.

Item Type:	Article
Keywords:	Autoimmunity, biologics, immune checkpoints, immune tolerance, immunotherapy, nanomedicine, precision medicine, safety
Date Deposited:	28 Apr 2020 00:45
Last Modified:	28 Apr 2020 00:45
URI:	https://oak.novartis.com/id/eprint/41784