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Characterizing drug-target interactions in complex tissues

Schirle, Markus (2020) Characterizing drug-target interactions in complex tissues. Trends in pharmacological sciences. ISSN 1873-3735


Recently, Perrin et al. reported that the coupling of the cellular shift assay with an unbiased proteomics read-out (Thermal Proteome Profiling, TPP) can be applied to complex tissue samples from model organisms and patients. This study demonstrates that TPP enables organ-specific target engagement and identification studies even in patient-derived material.

Item Type: Article
Date Deposited: 14 Apr 2020 00:45
Last Modified: 14 Apr 2020 00:45


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