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Behavioral, respiratory and metabolic consequences of impaired cerebrovascular reactivity

Wenzel, Jan and Richter, Marius and Bettoni, Carla and Vogt, Miriam A and Natsagdorj, Rentsenkhand and Huber, Gianna and Brands, Josefine and Assmann, Julian C and Lembrich, Beate and Stölting, Ines and Sedlacik, Jan and Fiehler, Jens and Ludewig, Peter and Wegmann, Michael and MüllerFielitz, Helge and Wlather, Thomas and Schmidt, Kjestine and König, Gabriele M and Kostenis, Evi and Raasch, Walter and deWit, Cor and Gass, Peter and Offermanns, Stefan and Wagner, Carsten A and Schwaninger, Markus (2020) Behavioral, respiratory and metabolic consequences of impaired cerebrovascular reactivity. Proceedings of the National Academy of Sciences of the United States of America PNAS.. ISSN 1091-6490; 0027-8424

Abstract

Carbon dioxide (CO2) and protons (H+) have a strong influence on cerebral perfusion, but the function of this is not clear yet. Here, we found that GPR4, a receptor for H+ in the vasculature, sensed CO2/H+ and that an endothelial Gαq/11-dependent signaling pathway mediated the CO2/H+ effect on cerebrovascular reactivity. While CO2/H+-induced Gαq/11 signaling constricted vessels in the retrotrapezoid nucleus, it had a dilative effect in other brain areas explaining why loss of cerebrovascular reactivity in mice differentially modulated CO2 effects: it reduced respiration but aggravated behavioral and metabolic responses to CO2. Even with normal CO2 concentrations mice with impaired cerebrovascular reactivity were more anxious and showed metabolic changes indicating that cerebrovascular reactivity is essential for normal physiology.

Item Type: Article
Date Deposited: 18 Jan 2020 00:45
Last Modified: 18 Jan 2020 00:45
URI: https://oak.novartis.com/id/eprint/37818

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