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Spontaneous background and procedure-related microscopic findings and common artefacts in ocular tissues of laboratory animals in ocular studies

Sorden, Steven and Larsen, Thomas and McPherson, Leslie and Turner, Oliver and Carroll, Erica and Sharma, Alok (2020) Spontaneous background and procedure-related microscopic findings and common artefacts in ocular tissues of laboratory animals in ocular studies. Toxicologic pathology (Articl).

Abstract

Identification of test article-related microscopic findings in ocular toxicology studies requires a working knowledge of the common background and procedure-related findings and artefacts encountered in such studies. The objective of this manuscript is to provide a mini-atlas of the artefacts and the procedure-related and spontaneous background findings commonly observed in ocular tissues from animals in toxicology studies of ocular drug candidates. Artefacts in the eye are most often related to collection and fixation procedures, and include swelling and vacuolation of lens fibers and separation of the neuroretina from the retinal pigment epithelium (RPE). Common in-life procedure-related findings include intravitreal injection needle tracks in the sclera and ciliary body pars plana and foci of RPE hypertrophy and/or hyperpigmentation at subretinal injection sites. Common background findings include corneal mineralization, uveal mononuclear cell infiltrates, and peripheral displacement of photoreceptor nuclei in the retina. A few uncommon spontaneous background findings that may be confused with test article-related findings, such as bilateral optic atrophy in macaques, are also included.

Item Type: Article
Keywords: artefacts, eye, histopathology, incidental findings, retina, tissue fixation, toxicology
Date Deposited: 19 Dec 2020 00:45
Last Modified: 19 Dec 2020 00:45
URI: https://oak.novartis.com/id/eprint/43108

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