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Clinically established biodegradable long acting injectables: An industry perspective

Isalomboto Nkanga, Christian , Fisch, Andreas, Rad-Malekshahi, Mazda , Duvnjak Romic, Marieta, Kittel, Birgit, Ullrich, Thomas, Wang, Jing, Werner Maçedo Krause, Rui, Adler, Sabine, Lammers, Twan, Hennink, Wim and Ramazani, Farshad (2020) Clinically established biodegradable long acting injectables: An industry perspective. Advanced drug delivery reviews, 167. pp. 19-46. ISSN 33202261


Long acting injectable formulations have been developed to sustain the action of drugs in the body over desired periods of time. These delivery platforms have been utilized for both systemic and local drug delivery applications. This review gives an overview of long acting injectable systems that are currently in clinical use. These products are categorised in three different groups: biodegradable polymeric systems, including microparticles and implants; micro and nanocrystal suspensions and oil-based formulations. Furthermore, the applications of these drug delivery platforms for the management of various chronic diseases are summarized. Finally, this review addresses industrial challenges regarding the development of long acting injectable formulations.

Item Type: Article
Keywords: Long acting injectables, extended release, PLGA microparticles, oil-based formaulations, in situ forming gels, implants
Date Deposited: 04 Dec 2020 00:45
Last Modified: 04 Dec 2020 00:45