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Recent Progress in Radical Decarboxylative Functionalizations Enabled by Transition-Metal (Ni, Cu, Fe, Co or Cr) Catalysis

Liu, Yahu and Chen, Hui and Liao, Xuebin (2020) Recent Progress in Radical Decarboxylative Functionalizations Enabled by Transition-Metal (Ni, Cu, Fe, Co or Cr) Catalysis. Synthesis (Germany), 53 (1). pp. 1-29. ISSN 1437210X

Abstract

Aliphatic carboxylic acids are abundant in natural and synthetic sources and are widely used as connection points in many chemical transformations. Radical decarboxylative functionalization promoted by transition-metal catalysis has achieved great success, enabling carboxylic acids to be easily transformed into a wide variety of products. Herein, we highlight the recent advances made on transition-metal (Ni, Cu, Fe, Co or Cr) catalyzed C-X (X = C, N, H, O, B, or Si) bond formation as well as syntheses of ketones, amino acids, alcohols, ethers and difluoromethyl derivatives via radical decarboxylation of carboxylic acids or their derivatives, including, among others, redox-active esters (RAEs), anhydrides, and diacyl peroxides. 1 Introduction 2 Ni-Catalyzed Decarboxylative Functionalizations 3 Cu-Catalyzed Decarboxylative Functionalizations 4 Fe-Catalyzed Decarboxylative Functionalizations 5 Co- and Cr-Catalyzed Decarboxylative Functionalizations 6 Conclusions.

Item Type: Article
Keywords: C-X bond formation carboxylic acids catalysis decarboxylative functionalization radicals redox-active esters (RAEs) transition metals
Date Deposited: 22 Dec 2020 00:45
Last Modified: 22 Dec 2020 00:45
URI: https://oak.novartis.com/id/eprint/42496

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