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Items where Year is 2020

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Number of items: 319.

Acharya, Nandini, Sabatos-Peyton, Catherine and Anderson, Ana (2020) Tim-3 finds its place in the cancer immunotherapy landscape. Journal for ImmunoTherapy of Cancer, 8 (1). ISSN 20511426

Adler, Rick, Clark, Elizabeth, Cline, Mark, Connor, Michael, Crabbs, Torrie, Fossey, Stacey, Malarkey, David, Tornquiest, Susan and Vernau, William (2020) Mission Accomplished: The ACVP/STP Coalition for Veterinary Pathology Fellows Completes Its Objectives, but Its Legacy and Spirit Live On. Toxicologic pathology. pp. 1-7.

Akinjiyan, Favour, Fazal, Aleem, Hild, Marc, Beckwith, Rohan, Paulk, Josh and Carbonneau, Seth (2020) A novel luminescence-based high-throughput approach for cellular resolution of protein ubiquitination using tandem ubiquitin binding entities (TUBEs). SLAS DISCOVERY: Advancing the Science of Drug Discovery, 25 (4). pp. 350-360. ISSN 2472-55522472-5560

Algarín, Esperanza, Díaz-Tejedor, Andrea, Mogollón, Pedro, Hernández-García, Susana, Corchete, Luis A, San-Segundo, Laura, Martín-Sánchez, Montserrat, González-Méndez, Lorena, Schoumacher, Marie, Banquet, Sébastien, Kraus-Berthier, Laurence, Kloos, Ioana, Halilovic, Ensar, Maacke, Heiko, Gutiérrez, Norma C, Mateos, María-Victoria, Paíno, Teresa, Garayoa, Mercedes and Ocio, Enrique M (2020) PRECLINICAL EVALUATION OF THE SIMULTANEOUS INHIBITION OF MCL-1 AND BCL-2 WITH THE COMBINATION OF S63845 AND VENETOCLAX IN MULTIPLE MYELOMA. Haematologica : the hematology journal, 105. ISSN 1592-8721

Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi and Zhu, Xuefeng (2020) Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorganic and Medicinal Chemistry Letters, 30 (17). p. 127366. ISSN 14643405

Ambrozic, Rok, Arzensek, Dejan and Podgornik, Ales (2020) Designing scalable ultrafiltration/diafiltration process of monoclonal antibodies via mathematical modeling by coupling mass balances and Poisson–Boltzmann equation. Biotechnology and Bioengineering. ISSN 0006-35921097-0290

Angst, Daniela, Gessier, Francois, Janser, Philipp, Pulz, Robert, Vulpetti, Anna, Waelchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson King, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gutmann, Sascha, Scheufler, Clemens, Hinniger, Alexandra, Zimmerlin, Alfred Gilbert, Funhoff, Enrico and Cenni, Bruno (2020) Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Arat, Seda, Ietswaart, Robert, Chen, Amanda, Farahmand, Saman, Kim, Bunjum, Armstrong, Duncan, Urban, Laszlo, DuMouchel, William, Jeffrey, Sutherland and Fekete, Alexander (2020) Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology. EBioMedicine., 57. pp. 1028-1037. ISSN eBioMedicine

Arbues, Ainhoa, Brees, Dominique, Chibout, Salah-Dine, Fox, Todd, Kammueller, Michael and Portevin , Damien (2020) TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis. PLoS pathogens, 16 (2). e1008312. ISSN 1553-7374

Arbues, Ainhoa, Kammueller, Michael and Portevin, Damien (2020) Generating three-dimensional human granulomas in vitro to study Mycobacterium tuberculosis-host interaction. BIO-PROTOCOL, 10 (22). ISSN 2331-8325

Arora, Rishi, Liew, Chong Wai, Soh, Tingjin Sherryl , Otoo, Dorcas , Seh, Cheah Chen, Yue, Qing, Nilar, Shahul Hameed, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian Guy, Chen, Yen-Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas, Benson, Timothy and Lim, Siew Pheng (2020) Two RNA tunnel inhibitors bind in highly conserved sites in Dengue virus NS5 polymerase: structural and functional studies. Journal of virology.

Auberson, Yves (2020) EFMC, medicinal chemistry and chemical biology in Europe. ChemMedChem : chemistry enabling drug discovery, 15.

Auld, Douglas (2020) Microplate Selection and Recommended Practices in High-throughput Screening and Quantitative Biology. Jun 2020.

Auld, Douglas, Busby, Scott, Smith, Thomas, Renaud, Nicole, Carbonneau, Seth, Numao, Shin, Concannon, John and Dumelin, Christoph (2020) Advancements in assay technologies and strategies to enable drug discovery. ACS Chemical Biology. ISSN 1554-89291554-8937

Auld, Douglas, Casalena, Dominick and Wright, Kirk (2020) Multimodal small-molecule screening for human prion protein binders. Journal of Biological Chemistry, 295 (39). ISSN 0021-92581083-351X

Auld, Douglas, Jenkins, Jeremy and Concannon, John (2020) Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38. bioRxiv.

Baenziger, Markus, Langlois, Audrey, Gschwend, Bjoern, Wickendick, Regina, Baierl, Marcel, Kovacic, Nikola, Haller, Michael, Schuerch, Friedrich, Shen, Xiaodong, Fu, Peng, Lianhe , Coauthor, Eswaran, Sumesh and Devanathan, Krishnaswamy (2020) Synthesis Development of the selective estrogen receptor degrader (SERD) LSZ102. Organic Process Research & Development, 24 (8). pp. 1405-1419. ISSN 1083-61601520-586X

Balakrishnan, Anand, Hekmat-Nejad, Mohammad, Price, Edmund, Cantwell, John, Wartchow, Charles, Shaul, Jacob, Luu, Catherine, Spraggon, Glen, DiDonato, Michael and Vo, Michael (2020) Biochemical characterization of respiratory syncytial virus RNA dependent RNA polymerase complex. ACS infectious diseases, 6 (10). pp. 2800-2811. ISSN 2373-8227

Ballerini, Andrea, Chua, Corrine, Rhudy, Jessica, Susnjar, Antonia, Trani, Nicola, Jain, Priya, Laue, Grit, Lubicka, Danuta, Shirazi-Fard, Yasaman, Ferrari, Mauro, Stodieck, Louis, Cadena, Samuel and Grattoni, Alessandro (2020) Muscle Atrophy: Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of Formoterol. Advanced Therapeutics, 3 (7). ISSN 23663987

Baran, Szczepan, Das Gupta, Ayan, Mathur, Ashwini, Rowlands, David, Walker, Dana, Lim, Maria, Schaevitz, Laura and Shanmukhappa, Kumar (2020) Continuous, Automated Breathing Rate and Body Motion Monitoring of Rats With Paraquat-Induced Progressive Lung Injury. Frontiers in Physiology, 11. ISSN 1664042X

Barkley, Deborah, Hatsis, Panagiotis, Glick, Jim, Li, Wenkui and Flarakos, Jimmy (2020) Dixon's Q-test and Student's t-test to assess analog internal standard response in nonregulated LC-MS/MS bioanalysis. Bioanalysis, 12 (21). pp. 1535-1543. ISSN 17576199

Bačnik, Katarina, Kutnjak, Denis, Jerič Kokelj, Barbara, Tuta, Nika, Lončar, Tan, Vogelsang, Matjaz and Ravnikar, Maja (2020) Metagenomic characterization of parental and production CHO cell lines for detection of adventitious viruses. Biologicals. ISSN 10958320

Beckmann, Nicolau (2020) Editorial for “Echo Time-Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics”. Journal of Magnetic Resonance Imaging, 52 (6). pp. 1655-1656. ISSN 15222586

Beckmann, Nicolau (2020) Editorial on “Validation of Automated Perfusion-Weighted Phase-Resolved Functional Lung (PREFUL)-MRI in Patients With Pulmonary Diseases”. Journal of magnetic resonance imaging, 52 (1). pp. 115-116.

Beckmann, Nicolau (2020) Non-Invasive Preclinical Lung Imaging: A Pharmaceutical Perspective. Bruker White Paper.

Bednarczyk, Dallas and Sanghvi, Menaka (2020) Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1's hypothesized function? Xenobiotica.

Bergboer, Judith GM, Kelder, Martijn JE , van Min, Max, Tuta, Nika, Crček, Mitja and Vogelsang, Matjaz (2020) Targeted Locus Amplification and NGS combined with qPCR-based breakpoint analysis for the assurance of monoclonality in recombinant cell lines. as white paper on Cergentis webpage.

Bhatt, Shruti, Pioso, Marissa, Olesinski, Elyse, Yilma, Binyam, Leutz, Buon, Adamia, Sophia, Zhu, Holly, Yanan, Kuang, Mogili, Abhishek, Ryan, Jeremy, Wang, Youzhen, Morris, Erick, Halilovic, Ensar, Paweletz, Cloud P., Weinstock, David M., Garcia, Jacqueline S. and Letai, Anthony (2020) Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Cancer Cell, 38 (6). 872-890.e6. ISSN 18783686

Blanco, Maria-Jesus (2020) New Chemical Modalities and Strategic Thinking in Early Drug Discovery. ACS medicinal chemistry letters, 11 (3). pp. 228-231. ISSN 1948-5875

Blank, Jutta, Hintermann, Samuel, Schneider, Nadine, Schuffenhauer, Ansgar and Shultz, Michael (2020) Outline for a Perspective Article on Novartis’ approach to compound screening for hit and lead finding and the design of compounds sets for diversity driven screening. Journal of medicinal chemistry for publisher only.

Blümel, Oliver, Buecheler, Jakob, Rodrigues, Miguel, Garaldes, Vitor, Hoelzl, Georg, Bechtold-Peters, Karoline and Friess, Wolfgang (2020) Cryoconcentration and 3D Temperature Profiles during Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device. Pharmaceutical Research, Formul. ISSN 0724-8741

Bogdanffy, Matthew S, Lesniak, Jacob, Mangipudy, Raja, Stanley, Ann Marie, Colman, Karyn and Blanset, Diann (2020) Tg.rasH2 mouse model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey and Recommendations. International Journal of Toxicology. ISSN 1091-58181092-874X

Bogdanffy, Matthew S, Lesniak, Jacob, Mangipudy, Raja, Stanley, Ann Marie, Colman, Karyn, Blanset, Diann, Sistare, Frank D, Garcia-Tapia, David and Monticello, Thomas (2020) Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices. International journal of toxicology. ISSN 1092874X

Boike, Lydia, Cioffi, Alexander, Majewski, Felix C., Co, Jennifer, Henning, Nathaniel J., Jones, Michael, Liu, Gang, McKenna, Jeffrey, Tallarico, John, Schirle, Markus and Nomura, Daniel K. (2020) Discovery of a Covalent Ligand Targeting an Intrinsically Disordered Cysteine Within MYC. Cell chemical biology. ISSN 2451-9448

Bolon, Brad, Caverly Rae, Jessica, Colman, Karyn, Francke, Sabine, Jensen, Karl, Keane, Kevin, McInnes, Elizabeth F., Nakano-Ito, Kyoko, Perry, Rick, Polack, Evelyne, Reagan, Karen S., Romeike, Annette, Young, Jamie K. and Galbreath, Elizabeth (2020) Toxicologic Pathology Forum Opinion Piece: Current Use of Non-blinded vs. Blinded Histopathologic Evaluation in Animal Toxicity Studies. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Bova, Kaitlin (2020) Mitigating Medication Errors in Clinical Research. Clinical Trial Supply Handbook - Summer Edition .

Braun, Marie-Gabrielle , Díaz-Rodríguez , Alba, Louis, Diorazio, Kenneth, Fraunhoffer , John, Hayler, Matthew, Hickey , Jonathan , Latham, Lovelle, Lucie, Mark, McLaws , Andrew, Parsons, Paul, Richardson , Alan, Steven, Jack, Terrett , Timothy, White and Jingjun, Yin (2020) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development. ISSN 1083-61601520-586X

Brovč, Ema Valentina, Mravljak, Janez, Pajk, Stane and Sink, Roman (2020) Degradation of polysorbates 20 and 80 catalysed by histidine chloride buffer. European journal of pharmaceutics and biopharmaceutics, 154. pp. 236-245. ISSN 09396411

Brovč, Ema Valentina, Mravljak, Janez, Pajk, Stane and Sink, Roman (2020) Rational design to biologics development: The polysorbates point of view. International Journal of Pharmaceutics, 581. ISSN 18733476

Bruin, Gerardus, Hockey, Hans-Ulrich, Patekar, Manmath, Charef, Pascal, Woessner, Ralph, Boutouyrie-Dumont, Bruno, Fu, Rong, Philip, La Stella and Bardur, Sigurgeirsson (2020) Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different 2 mL delivery systems in healthy volunteers and in psoriasis patients. British journal of clinical pharmacology. pp. 1-14.

Bucher, Christoph, Linden, Anthony and Heimgartner, Heinz (2020) Synthesis and Solid State Conformation of Tetrapeptide Amides Containing two Aib and two (Me)Phe Residues – Use of Enantiomerically Pure 2-Benzyl-2-methyl-2H-azirin-3-amines as (Me)Phe-Synthons. Chemistry & Biodiversity. ISSN 1612-18721612-1880

Cabanski, Maciej, Teri, Oldaker, Jennifer , Stewart, Nithianandan, Selliah, Steve, Eck, Cherie, Green, Virginia, Litwin and Vitaliti Garami, Alessandra (2020) Flow cytometric method transfer: Recommendations for best practice. Cytometry Part B: Clinical Cytometry, 100 (1). pp. 52-62. ISSN 1552-49491552-4957

Cadena, Samuel (2020) Contrasting atrophy in space and on Earth. Genes in Space: Research Brief.

Caduff, Nicole, McHugh, Donal, Murer, Anita, Rämer, Patrick, Raykova, Ana, Landtwing, Vanessa, Rieble, Lisa, Keller, Christian, Prummer, Michael, Hoffmann, Laurent, Lam, Janice, Chiang, Alan, Raulf, Friedrich, Azzi, Tarik, Berger, Christoph, Rubic-Schneider, Tina, Traggiai, Elisabetta, Lünemann, Jan, Kammueller, Michael and Münz, Christian (2020) Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice. PLoS pathogens, 16 (4). pp. 1-25. ISSN 15537374

Cain, Meredith, Vemula, Janardhana Rao, Zollinger, Markus, Umehara, Ken-Ichi , Elbast, Walid and Erpenbeck, Veit (2020) A study of the effect of cyclosporine on fevipiprant pharmacokinetics and its absolute bioavailability using an intravenous microdose approach. Drug Metabolism and Disposition, 48 (10). pp. 917-924. ISSN 1521009X

Camilleri, Michael, Linker Nord, Sara, Burton, Duane , Oduyebo, Ibironke , Zhang, Yiming, Chen, Jin, Im, Koeun, Bhad, Prafulla, Badman, Michael, Sanders, David and Walters, Julian (2020) A Randomized Controlled Trial of a Farnesoid X Receptor Agonist, Tropifexor, in Patients with Primary Bile Acid Diarrhea. Alimentary pharmacology & therapeutics, 52 (5). pp. 808-820. ISSN 02692813

Canham, Steve, Jenkins, Jeremy and Auld, Douglas (2020) Systematic Chemogenetic Library Assembly. BioRxiv.

Capaldi, Daniel, Akhtar, Nadim, Atherton, Tom, Benstead, David, Charaf, Ayman, De Vijlder, Thomas, Heatherington, Carl, Hoernschemeyer, Joerg, Jiang, Hong, Rieder, Ulrike, Ring, Francis, Peter, Robert, Stolee, Jessica and Wechselberger, Rainer (2020) Strategies for Identity Testing of Therapeutic Oligonucleotide Drug Substances and Drug Products. Nucleic Acid Therapeutics (00). ISSN 2159-33372159-3345

Capdevila, Jaume, Wirth, Lori J, Ernst, Thomas, Ponce Aix, Santiago, Lin, Chia-Chi, Ramlau, Rodryg, Butler, Marcus O, Delord, Jean-Pierre, Fuhrer, Dagmar, Hutter-Kronke, Marie-Luise, Forde, Patrick M, Wrona, Anna, Santoro, Armando, Sadow, Peter M, Szpakowski, Sebastian, Wu, Hongqian, Bostel, Geraldine, Faris, Jason, Cameron, Scott, Varga, Andreea, Taylor, Matthew and Arkoski, Peter (2020) PD-1 Blockade in Anaplastic Thyroid Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. pp. 1-9. ISSN 15277755

Carballido, Jose, Regairaz Kalenga Kapiamba, Camille, Rauld, Celine, Raad, Layla, Picard, Damien and Kammueller, Michael (2020) The emerging jamboree of transformative therapies for autoimmune diseases. Frontiers in Immunology.

Carey, Kimberly , Paulus, Geraldine , Wang, Lingfei , Balce, Dale , Bergman, Phil , Ferder, Ianina , Kong, Lingjia , Renaud, Nicole, Singh, Shantanu , Karhohs, Kyle, Carpenter, Anne, Kost-Alimova, Maria , Nyfeler, Beat, Lassen, Kara , Virgin, Herbert and Xavier, Ramnik (2020) TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. Cell Reports, 33 (6). ISSN 22111247

Chacón Simon, Selena, Wang, Feng, Thomas, Lance R, Phan, Jason, Zhao, Bin, Olejniczak, Edward T, Macdonald, Jonathan D, Shaw, J Grace, Schlund, Caden, Payne, William, Creighton, Joy, Stauffer, Shaun R, Waterson, Alex G, Tansey, William P and Fesik, Stephen W (2020) Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. Journal of medicinal chemistry, 63 (8). pp. 4315-4333. ISSN 1520-4804

Chawla, Shikha, Berkelar, Majoska, Dasen, Boris, Halleux, Christine, Kramer, Ina, Guth-Gundel, Sabine, Ghosh, Sourab, Martin, Ivan, Barbero, Andrea and Occhetta, Paola (2020) Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model. Journal of cell science, 133 (23). ISSN 14779137

Chen, Gregory, Grauzinyte, Migle, van der Vaart, Aad and Boll, Bjoern (2020) Applying Pattern Recognition as a Robust Approach for Silicone Oil Droplet Identification in Flow-Microscopy Images of Protein Formulations. Journal of pharmaceutical sciences. ISSN 00223549

Chen, Hui, Sun, Shuhao, Liu, Yahu and Liao, Xuebin (2020) Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C-CN Bond Cleavage and Cyano Transfer. ACS Catalysis, 10. pp. 1397-1405. ISSN 2155-54352155-5435

Chianelli, Donatella, Rucker, Paul, Tully, David, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy , Chu, Alan, Schmeits, James, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Richmond, Wendy, Sancho Martinez, Ignacio, Badman, Michael, Molteni, Valentina, Jason, Roland, Jane, Wu, David, Huang, Bo, Liu, Andrew, Phimister, Martin, Seidel, Sean, Joseph, Bryan, Laffitte, Prashad, Mahavir, Schlama, Thierry and Liu, Yugang (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. Journal of medicinal chemistry, 63 (8). pp. 3868-3880. ISSN 9b01621

Chianelli, Donatella, Rucker, Paul, Tully, David, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy , Chu, Alan, Schmeits, James, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Richmond, Wendy, Sancho Martinez, Ignacio, Badman, Michael, Molteni, Valentina, Jason, Roland, Jane, Wu, David, Huang, Bo, Liu, Andrew, Phimister, Martin, Seidel, Sean, Joseph and Bryan, Laffitte (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH). Journal of medicinal chemistry, 63 (8). pp. 3868-3880. ISSN 9b01621

Clarke, Adrian and ehkirch, anthony (2020) The Current Status and Future of Two- and Multidimensional Liquid Chromatography in Pharmaceutical R&D and QC. LC-GC Europe : Solutions for Separation Scientists., 33 (3). pp. 136-150. ISSN 1471-6571

Cowan, Cameron, Renner, Magdalena, De Gennaro, Martina, Gross-Scherf, Brigitte, Goldblum, David, Hou, Yanyan, Munz, Martin, Rodrigues, Tiago M., Krol, Jacek, Szikra, Tamas, Cuttat-Theurillat, Rachel, Waldt, Annick, Papasaikas, Panagiotis, Diggelmann, Roland, Patino-Alvarez, Claudia P., Galliker, Patricia, Spirig, Stefan, Pavlinic, Dinko, Gerber-Hollbach, Nadine, Schuierer, Sven, Srdanovic, Aldin, Balogh, Marton, Panero, Riccardo, Kusnyerik, Akos, Szabo, Arnold, Stadler, Michael, Orgül, Selim, Picelli, Simone, Hasler, Pascal W., Hierlemann, Andreas, Scholl, Hendrik P. N., Roma, Guglielmo, Nigsch, Florian and Roska, Botond (2020) Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map. Cell, 182 (6). p. 1623. ISSN 00928674

Czyz, Stefan, Wewers, Martin, Finke, Jan, Kwade, Arno, Van Eerdenbrugh, Bernard, Juhnke, Michael and Bunjes, Heike (2020) Spray 1 drying of API nanosuspensions: Importance of particle size, matrix former content and drying temperature for successful formulation and process development. European journal of pharmaceutics and biopharmaceutics, 152 (July). pp. 63-71. ISSN 1873-3441; 0939-6411

DaSilva, Jamie K., Breidenbach, Laura, Deats, Tracy, Li, Dingzhou, Treinen, Kimberly, Dinklo, Theo, Kervyn, Sophie, Teuns, Greet, Traebert, Martin and Hempel, Katja (2020) Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative. Journal of Pharmacological and Toxicological Methods, 103. ISSN 1873488X

Dalvit, Claudio, Veronesi, Marina and Vulpetti, Anna (2020) Fluorine NMR functional screening: from purified enzymes to human intact living cells. Journal of Biomolecular NMR. ISSN 15735001

Delord, Jean-Pierre , Argilés, Guillem, Fayette, Jerôme , Wirth, Lori, Kasper, Stefan , Siena, Salvatore , Mesia, Ricard , Berardi, Rossana, Cervantes, Andrés , Dekervel, Jeroen, Zhao, Sylvia, Sun, Yongjian , Hao, Lu, Tiedt, Ralph, Vicente Gabarda, Sergio, Myers, Andrea and Siu, Lillian L (2020) A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment. Investigational New Drugs. ISSN 15730646

Di Marco, Giulia, Vallese, Francesca, Jourde, Benjamin, Bergsdorf, Christian, Sturlese, Mattia, De Mario , Agnese, Techer-Etienne, Valerie, Haasen, Dorothea, Oberhauser, Berndt, Schleeger, Simone, Minetti, Giulia, Moro, Stefano, Rizzuto, Rosario, De Stefani, Diego, Fornaro, Mara and Mammucari, Cristina (2020) A high throughput screening identifies MICU1 targeting compounds. Cell Reports, 30. pp. 1-11.

Diagana, Thierry, Gupta, Devendra, Voorberg-van der Wel, Annemarie, Zeeman, Anne-Marie , Nieuwenhuis, Ivonne G, van der Werff, Nicole M. , Klooster, Els J, Klop, Onny, Vermaat, Lars C, Kocken, Clemens and Dembele, Laurent (2020) A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation. Communications biology, 3 (1). ISSN 23993642

Diekhoff, Torsten , Fischer, Thomas, Schefer, Quirino , Dörner, Thomas, Posch, Maximilian Georg, Laurent, Didier, Li, Yue, Wagner, Frank and Oliver, Stephen (2020) Ianalumab (VAY736) in primary Sjögren’s syndrome: assessing disease activity using multi-modal ultrasound. Clinical and Experimental Rheumatology.

Dittrich, Birger, Chan, Stephen, Wiggin, Seth, Stevens, Joanna S. and Pidcock, Elna (2020) Fast energy minimization of the CCDC drug subset structures by molecule-in-cluster computations allows independent structure validation and model completion. CrystEngComm. ISSN 1466-8033

Dittrich, Birger, Sever, Christoph A. and Luebben, Jens (2020) Disappearing disorder. CrystEngComm. ISSN 1466-8033

Do Valle Duraes, Fernanda, Lafont, Armelle, Darribat, Katy, Cuttat-Theurillat, Rachel, Waldt, Annick, Naumann, Ulrike, Wieczorek, Grazyna, Gaulis, Swann, Pfister, Sabina, Beibel, Martin, Li, Jianping, Roma, Guglielmo and Warncke, Max (2020) Immune cell landscaping reveals a protective role for Tregs during kidney injury and fibrosis. "Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis, 5 (3).

Do Valle Duraes, Fernanda, Lafont, Armelle, Darribat, Katy, Martin, Kea, Cuttat-Theurillat, Rachel, Waldt, Annick, Naumann, Ulrike, Wieczorek, Grazyna, Gaulis, Swann, Pfister, Sabina, Beibel, Martin, Li, Jianping, Roma, Guglielmo, Warncke, Max and Mertz, Kirsten (2020) Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis. JCI insight, 5 (3). ISSN 23793708

Dolman, Andrew, Yu, Helen and Gusev, Arkady (2020) Data driven CRO benchmarking for biomarker analysis. Bioanalysis, 12 (16). pp. 1117-1127. ISSN 1757-6180

Doo, David W, Meza-Perez, Selene, Londoño, Angelina I, Goldsberry, Whitney N, Katre, Ashwini A. , Boone, Jonathan D, Moore, Dylana J. , Hudson, Cindy T, Betella, Ilaria, McCaw, Tyler R, Gangrade, Abhishek, Bao, Riyue, Luke, Jason J, Yang, Eddy S, Birrer, Michael J. , Starenki, Dmytro, Cooper, Sara J, Buchsbaum, Donald J, Norian, Lyse A, Randall, Troy D and Arend, Rebecca C (2020) Inhibition of the Wnt/β-catenin pathway enhances anti-tumor immunity in ovarian cancer. Therapeutic Advances in Medical Oncology, 12. pp. 1-16. ISSN 1758-835920913798

Dummer, Reinhard, Brase, Jan Christoph, Garrett, James, Campbell, Katie, Gasal, Eduard, Squires, Matthew, Gusenleitner, Daniel, Santinami, Mario, Atkinson, Victoria, Mandala, Mario, Chiarion-Sileni, Vanna, Flaherty, Keith, Larkin, James, Robert, Caroline, Kefford, Richard, Kirkwood, John, Hauschild, Axel, Schadendorf, Dirk and Long, Georgina (2020) Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV600-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial. The Lancet Oncology, 21 (3). pp. 358-372.

Dummer, Reinhard, Lebbé, Celeste, Atkinson, Victoria, Mandalà, Mario, Nathan, Paul, Arance, Ana, Richtig, Erika, Yamazaki, Naoya, Robert, Caroline, Schadendorf, Dirk, Tawbi, Hussein A., Ascierto, Paolo A., Ribas, Antoni, Flaherty, Keith, Pakhle, Neha, Campbell, Katie, Gusenleitner, Daniel, Masood, Aisha, Brase, Jan Christoph, Gasal, Eduard and Long, Georgina V. (2020) Spartalizumab in Combination With Dabrafenib And Trametinib in Advanced BRAF V600–Mutant Melanoma: Efficacy, Safety, and Biomarker Findings in Parts 1 and 2 of COMBI-i. Nature medicine, 26 (9).

Dumouchel, Jennifer, Argikar, Upendra, Adams, Christopher, Prasanna, Ganesh, Ehara, Takeru, Kim, Sunkyu, Breen, Chris and Mogi, Muneto (2020) Understanding metabolism related differences in ocular efficacy of MGV354. Xenobiotica. pp. 1-10. ISSN 13665928

Ecoeur, Florence, Weiss, Jessica and Guntermann, Christine (2020) Lack of evidence for expression and function of IL-39 in human immune cells. PLoS ONE, 2020 D (2020 D). pp. 1-16. ISSN 1932-6203

El-Hashimy, Mona, Letellier, Franck, Sengupta, Tirtha, Lorenzo, Sebastien, Blumenstein, Lars, Thomas, Marbury and Richard, Preston (2020) Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection. AAPS Journal, 22 (6). ISSN 15507416

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Huppertz, Christine, Wieczorek, Grazyna, Littlewood-Evans, Amanda, Oliver, Stephen, Jaeger, Benedikt, Engelhard, Peggy, Bauernfeind, Franz-Georg, Welte, Tobias, Hornung, Veit and Prasse, Antje (2020) The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation. The European respiratory journal. ISSN 13993003

Isalomboto Nkanga, Christian , Fisch, Andreas, Rad-Malekshahi, Mazda , Duvnjak Romic, Marieta, Kittel, Birgit, Ullrich, Thomas, Wang, Jing, Werner Maçedo Krause, Rui, Adler, Sabine, Lammers, Twan, Hennink, Wim and Ramazani, Farshad (2020) Clinically established biodegradable long acting injectables: An industry perspective. Advanced drug delivery reviews, 167. pp. 19-46. ISSN 33202261

Isobe, Yosuke, Okumura, Mikiko, McGregor, Lynn, Brittain, Scott, Jones, Michael, Liang, Xiaoyou, White, Ross, Forrester, William, McKenna, Jeffrey, Tallarico, John, Schirle, Markus, Maimone, Thomas and Nomura, Daniel (2020) Manumycin polyketides act as molecular glues between UBR7 and P53. Nature chemical biology. ISSN 1552-4469; 1552-4450

Jahnke, Wolfgang, Erlanson, Daniel A, de Esch, Iwan JP, Johnson, Christopher N, Mortenson, Paul N, Ochi, Yuji and Urushima, Tatsuya (2020) Fragment-to-Lead Medicinal Chemistry Publications in 2019. Journal of Medicinal Chemistry, 63 (24). pp. 15494-15507. ISSN 15204804

James, Alexander David, Schiller, Hilmar, Marvalin, Cyrille, Jin, Yi, Borell, Hubert, Roffel, Ad , Glaenzel, Ulrike, Ji, Yan and Camenisch, Gian P. (2020) An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo and human ADME data. Pharmacology Research & Perspectives, 8 (3). ISSN 2052-17072052-1707

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Johnson, Erik C. B., Ho, Kaitlyn, Das, Melanie, Sanchez , Pascal, Djukic, Biljana, Yu, Xinxing, Lopez, Isabel, Gill, Michael, Paz, Jeanne, Palop, Jorge and Mucke, Lennart (2020) Behavioral and neural network abnormalities of human APP transgenic mice resemble those of App knockin mice but are not prevented by early inhibition of BACE1. Molecular neurodegeneration, 15 (1).

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Jones, Graham, Chirino Chace, Bernardita and Wright, Justin (2020) Cultural diversity drives innovation: empowering teams for success. International Journal of Innovation Science, 12 (3). pp. 323-343. ISSN 1757-2223

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Wenzel, Jan, Richter, Marius, Bettoni, Carla, Vogt, Miriam A, Natsagdorj, Rentsenkhand, Huber, Gianna, Brands, Josefine, Assmann, Julian C, Lembrich, Beate, Stölting, Ines, Sedlacik, Jan, Fiehler, Jens, Ludewig, Peter, Wegmann, Michael, MüllerFielitz, Helge, Wlather, Thomas, Schmidt, Kjestine, König, Gabriele M, Kostenis, Evi, Raasch, Walter, deWit, Cor, Gass, Peter, Offermanns, Stefan, Wagner, Carsten A and Schwaninger, Markus (2020) Behavioral, respiratory and metabolic consequences of impaired cerebrovascular reactivity. Proceedings of the National Academy of Sciences of the United States of America PNAS.. ISSN 1091-6490; 0027-8424

Wewers, Martin, Czyz, Stefan, Finke, Jan, John, Edgar, Van Eerdenbrugh, Bernard, Juhnke, Michael, Bunjes, Heike and Kwade, Arno (2020) Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules Produced in a Fluidized Bed Process. Pharmaceutics, 12 (n/a). p. 363. ISSN 1999-4923

Widler, Leo, Amadeu, Nader, Augner, Sven, Janiak, Christoph and Hägele, Gerhard (2020) Symmetric Geminal Bisphosphinic Acids RR´C[P(CH3)(O)OH]2 - NMR and Analytical Studies. Phosphorus, Sulfur, and Silicon and the Related Elements. ISSN 1042-65071563-5325

Wilcken, Rainer, Rodde, Stephane and Udvarhelyi, Aniko (2020) ReSCoSS: A Flexible Quantum Chemistry Workflow Identifying Relevant Solution Conformers of Drug-like Molecules. Journal of computer-aided molecular design.

Wong, Connie, Baum, Jason, Beste, Michael, Bharani Dharan, Bharani, Wang, Amanda, Wang, Xiaoshan, Silvestro, Angela, Prescott, Margaret, Krajkovich, Lynne, Dugan, Margaret, Ridker, Paul, Martin, Ann Marie, Svensson, Eric and Xu, Siyan (2020) Inhibition of IL-1β by canakinumab may be effective against diverse molecular subtypes of lung cancer: An exploratory analysis of the CANTOS trial. Cancer research, 80. pp. 5597-5605. ISSN 1538-7445

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Wu, Bin, Zhang, Sisi, Hong, Tao, Zhou, Yizong, Wang, Hui, Shi, Min, Yang, Hongwei, Tian, Xiangguang, Guo, Jing, Bian, Jianwei, Roache, James, Delgado, Pete, Mo, Ruowei, Fridrich, Cary, Gao, Feng and Wang, Joseph (2020) Development of a Practical Synthesis of an FXI (Factor XI) Inhibitor. Organic process research & development, 24 (11). pp. 2780-2788.

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Wuersch, Kuno, Parrula, Cecilia, Dincer, Zuhal, de Vera Mudry, Maria Cristina, Geoly, Frank and Mysore, Jagannatha (2020) Toxicologic Pathology Forum: Opinion on Obligatory Microscopic Examination of Intermediate-Dose Groups in Toxicity Studies With Biotherapeutics in Cynomolgus Monkeys. Toxicologic Pathology, 48 (8). pp. 939-943. ISSN 15331601

Xing, Jimmy, Loureiro, Joe, Patel, Michael, Mikhailov, Dmitri and Gusev, Arkady (2020) Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis. Bioanalysis, 12. pp. 919-935. ISSN 1757-6199

Xue, J, Domingo-Almenara, X, Fuijas, C, Palermo, A, Rinschen, M, Benton, H P, Isbell, John and Siuzdak, G (2020) Enhanced electrospray in-source fragmentation for higher sensitivity data independent acquisition and autonomous METLIN molecular identification. Analytical Chemistry, 92 (8). pp. 6051-6059. ISSN 0003-27001520-6882

Yang, Haisheng, Büttner, Alexander, Albiol, Laia, Julien, Catherine, Thiele, Tobias, Figge, Christine, Kramer, Ina, Kneissel, Michaela, Duda, Georg N., Checa, Sara and Willie, Bettina M. (2020) Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice. Scientific reports, 10 (1). pp. 22299-22316.

Yang, J, Balog, B, Deng , K, Hanzlicek, B, Rietsch, A, Kuang, M, Hatakeyama, Shinji, Trifilieff, Estelle, Zhu, H and Damaser, MS (2020) Therapeutic potential of muscle growth promoters in a stress urinary incontinence model. American Journal of Physiology-Renal Physiology, 319 (3). F436-F446. ISSN 1931-857X1522-1466

Yi, John , Russo, Melissa, Raja, Shruti, Massey, Janice, Juel, Vern, Shin, Jay, Hobson-Webb, Lisa, Gable, Karissa and Guptill, Jeffrey (2020) Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis. Experimental Neurology, 325 (March ). pp. 1-8. ISSN 0014-4886

Yokokawa, Fumiaki (2020) Recent progress on phenotype-based discovery of dengue inhibitors. RSC Medicinal Chemistry.

Zaidman, Nathan A, Tomilin , Viktor, Damarla, Mahendra, Tidmore, Josephine, Capen , Diane, Brown, Dennis, Pochynyuk, Oleh and Pluznick, Jennifer L (2020) Adhesion-GPCR Gpr116 (ADGRF5) is a Regulator of Urine Acidification and Surface Expression of the Vacuolar-type H+-ATPase in Renal α-Intercalated Cells. Proceedings of the National Academy of Sciences of the United States of America PNAS..

Zhu, Liang, Glick, Jim and Flarakos, Jimmy (2020) Bioanalytical Challenges in Support of Complex Modalities of Antibody-Based Therapeutics. AAPS Journal, 22 (6). pp. 130-135. ISSN 15507416

chaudhury, anwesha, Zhu, Xu, Chu, Lulu, Goliaei, Ardeshir, Kearns, Jeff and Stein, Andrew (2020) Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic-Pharmacodynamic Modeling Approaches. Journal of Clinical Pharmacology, 60 (S1). S147-S159. ISSN 15524604

fassl, anne, lachowicz, iga, butter, deborah, Brain, Christopher, Sheng, Qing, Loo, Alice, michowski, wojciech, otto, tobias, abu-remaileh, monther, stepien, piotr, bergholtz, johann, jovanovic, bojana, nowak, karolina, erikson, maria, zhao, jean, sabatini, david, jeselson, rinath, brown, myles, polyak, kornelia and sicinski, piotr (2020) Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Science advances, 6 (25). ISSN 2375-2548

fassl, anne, lachowicz, iga, butter, deborah, Brain, Christopher, Sheng, Qing, Loo, Alice, michowski, wojciech, otto, tobias, abu-remaileh, monther, stepien, piotr, bergholtz, johann, jovanovic, bojana, nowak, karolina, erikson, maria, zhao, jean, sabatini, david, jeselson, rinath, brown, myles, polyak, kornelia and sicinski, piotr (2020) Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Science advances, 6 (25). ISSN 2375-2548

van Groen, Bianca D., Pilla Reddy, Venkatesh, Badee, Justine Marine, Olivares-Morales, Andrés, Johnson, Trevor N., Nicolaï, Johan, Annaert, Pieter, Smith, Anna, de Wildt, Saskia N., Knibbe, Catherijne A. J. and de Zwart, Loeckie (2020) Pediatric pharmacokinetics and dose predictions: a report of a satellite meeting to the 10th Juvenile Toxicity Symposium. Clinical and translational science. ISSN 1752-8062

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