Acharya, Nandini, Sabatos-Peyton, Catherine and Anderson, Ana (2020) Tim-3 finds its place in the cancer immunotherapy landscape. Journal for ImmunoTherapy of Cancer, 8 (1). ISSN 20511426

Adler, Rick, Clark, Elizabeth, Cline, Mark, Connor, Michael, Crabbs, Torrie, Fossey, Stacey, Malarkey, David, Tornquiest, Susan and Vernau, William (2020) Mission Accomplished: The ACVP/STP Coalition for Veterinary Pathology Fellows Completes Its Objectives, but Its Legacy and Spirit Live On. Toxicologic pathology. pp. 1-7.

Akinjiyan, Favour, Fazal, Aleem, Hild, Marc, Beckwith, Rohan, Paulk, Josh and Carbonneau, Seth (2020) A novel luminescence-based high-throughput approach for cellular resolution of protein ubiquitination using tandem ubiquitin binding entities (TUBEs). SLAS DISCOVERY: Advancing the Science of Drug Discovery, 25 (4). pp. 350-360. ISSN 2472-55522472-5560

Algarín, Esperanza, Díaz-Tejedor, Andrea, Mogollón, Pedro, Hernández-García, Susana, Corchete, Luis A, San-Segundo, Laura, Martín-Sánchez, Montserrat, González-Méndez, Lorena, Schoumacher, Marie, Banquet, Sébastien, Kraus-Berthier, Laurence, Kloos, Ioana, Halilovic, Ensar, Maacke, Heiko, Gutiérrez, Norma C, Mateos, María-Victoria, Paíno, Teresa, Garayoa, Mercedes and Ocio, Enrique M (2020) PRECLINICAL EVALUATION OF THE SIMULTANEOUS INHIBITION OF MCL-1 AND BCL-2 WITH THE COMBINATION OF S63845 AND VENETOCLAX IN MULTIPLE MYELOMA. Haematologica : the hematology journal, 105. ISSN 1592-8721

Alper, Phillip, Deane, Jonathan, Betschart, Claudia, Buffet, David, Collignon Zipfel, Geraldine, Gordon, William, Hampton, Janice, Hawtin, Stuart, Ibanez, Maureen, Jiang, Tao, Junt, Tobias, Knoepfel, Thomas, Liu, Bo, Maginnis, Jillian, Mckeever, Una, Michellys, Pierre, Mutnick, Daniel, Nayak, Bishnu, Niwa, Satoru, Richmond, Wendy, Rush, James, Syka, Peter, Zhang, Yi and Zhu, Xuefeng (2020) Discovery of potent, orally bioavailable in vivo efficacious antagonists of the TLR7/8 pathway. Bioorganic and Medicinal Chemistry Letters, 30 (17). p. 127366. ISSN 14643405

Ambrozic, Rok, Arzensek, Dejan and Podgornik, Ales (2020) Designing scalable ultrafiltration/diafiltration process of monoclonal antibodies via mathematical modeling by coupling mass balances and Poisson–Boltzmann equation. Biotechnology and Bioengineering. ISSN 0006-35921097-0290

Angst, Daniela, Gessier, Francois, Janser, Philipp, Pulz, Robert, Vulpetti, Anna, Waelchli, Rudolf, Beerli, Christian, Littlewood-Evans, Amanda, Dawson King, Janet, Nuesslein-Hildesheim, Barbara, Wieczorek, Grazyna, Gutmann, Sascha, Scheufler, Clemens, Hinniger, Alexandra, Zimmerlin, Alfred Gilbert, Funhoff, Enrico and Cenni, Bruno (2020) Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Arat, Seda, Ietswaart, Robert, Chen, Amanda, Farahmand, Saman, Kim, Bunjum, Armstrong, Duncan, Urban, Laszlo, DuMouchel, William, Jeffrey, Sutherland and Fekete, Alexander (2020) Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology. EBioMedicine., 57. pp. 1028-1037. ISSN eBioMedicine

Arbues, Ainhoa, Brees, Dominique, Chibout, Salah-Dine, Fox, Todd, Kammueller, Michael and Portevin , Damien (2020) TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis. PLoS pathogens, 16 (2). e1008312. ISSN 1553-7374

Arbues, Ainhoa, Kammueller, Michael and Portevin, Damien (2020) Generating three-dimensional human granulomas in vitro to study Mycobacterium tuberculosis-host interaction. BIO-PROTOCOL, 10 (22). ISSN 2331-8325

Arora, Rishi, Liew, Chong Wai, Soh, Tingjin Sherryl , Otoo, Dorcas , Seh, Cheah Chen, Yue, Qing, Nilar, Shahul Hameed, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian Guy, Chen, Yen-Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas, Benson, Timothy and Lim, Siew Pheng (2020) Two RNA tunnel inhibitors bind in highly conserved sites in Dengue virus NS5 polymerase: structural and functional studies. Journal of virology.

Auberson, Yves (2020) EFMC, medicinal chemistry and chemical biology in Europe. ChemMedChem : chemistry enabling drug discovery, 15.

Auld, Douglas (2020) Microplate Selection and Recommended Practices in High-throughput Screening and Quantitative Biology. Jun 2020.

Auld, Douglas, Busby, Scott, Smith, Thomas, Renaud, Nicole, Carbonneau, Seth, Numao, Shin, Concannon, John and Dumelin, Christoph (2020) Advancements in assay technologies and strategies to enable drug discovery. ACS Chemical Biology. ISSN 1554-89291554-8937

Auld, Douglas, Casalena, Dominick and Wright, Kirk (2020) Multimodal small-molecule screening for human prion protein binders. Journal of Biological Chemistry, 295 (39). ISSN 0021-92581083-351X

Auld, Douglas, Jenkins, Jeremy and Concannon, John (2020) Cell size homeostasis is maintained by a circuitry involving a CDK4-determined target size that programs the cell size-dependent activation of p38. bioRxiv.

Baenziger, Markus, Langlois, Audrey, Gschwend, Bjoern, Wickendick, Regina, Baierl, Marcel, Kovacic, Nikola, Haller, Michael, Schuerch, Friedrich, Shen, Xiaodong, Fu, Peng, Lianhe, Coauthor, Eswaran, Sumesh and Devanathan, Krishnaswamy (2020) Synthesis Development of the selective estrogen receptor degrader (SERD) LSZ102. Organic Process Research & Development, 24 (8). pp. 1405-1419. ISSN 1083-61601520-586X

Balakrishnan, Anand, Hekmat-Nejad, Mohammad, Price, Edmund, Cantwell, John, Wartchow, Charles, Shaul, Jacob, Luu, Catherine, Spraggon, Glen, DiDonato, Michael and Vo, Michael (2020) Biochemical characterization of respiratory syncytial virus RNA dependent RNA polymerase complex. ACS infectious diseases, 6 (10). pp. 2800-2811. ISSN 2373-8227

Ballerini, Andrea, Chua, Corrine, Rhudy, Jessica, Susnjar, Antonia, Trani, Nicola, Jain, Priya, Laue, Grit, Lubicka, Danuta, Shirazi-Fard, Yasaman, Ferrari, Mauro, Stodieck, Louis, Cadena, Samuel and Grattoni, Alessandro (2020) Muscle Atrophy: Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of Formoterol. Advanced Therapeutics, 3 (7). ISSN 23663987

Baran, Szczepan, Das Gupta, Ayan, Mathur, Ashwini, Rowlands, David, Walker, Dana, Lim, Maria, Schaevitz, Laura and Shanmukhappa, Kumar (2020) Continuous, Automated Breathing Rate and Body Motion Monitoring of Rats With Paraquat-Induced Progressive Lung Injury. Frontiers in Physiology, 11. ISSN 1664042X

Barkley, Deborah, Hatsis, Panagiotis, Glick, Jim, Li, Wenkui and Flarakos, Jimmy (2020) Dixon's Q-test and Student's t-test to assess analog internal standard response in nonregulated LC-MS/MS bioanalysis. Bioanalysis, 12 (21). pp. 1535-1543. ISSN 17576199

Bačnik, Katarina, Kutnjak, Denis, Jerič Kokelj, Barbara, Tuta, Nika, Lončar, Tan, Vogelsang, Matjaz and Ravnikar, Maja (2020) Metagenomic characterization of parental and production CHO cell lines for detection of adventitious viruses. Biologicals. ISSN 10958320

Beckmann, Nicolau (2020) Editorial for “Echo Time-Dependence of Observed Lung T1 in Patients With Cystic Fibrosis and Correlation With Clinical Metrics”. Journal of Magnetic Resonance Imaging, 52 (6). pp. 1655-1656. ISSN 15222586

Beckmann, Nicolau (2020) Editorial on “Validation of Automated Perfusion-Weighted Phase-Resolved Functional Lung (PREFUL)-MRI in Patients With Pulmonary Diseases”. Journal of magnetic resonance imaging, 52 (1). pp. 115-116.

Beckmann, Nicolau (2020) Non-Invasive Preclinical Lung Imaging: A Pharmaceutical Perspective. Bruker White Paper.

Bednarczyk, Dallas and Sanghvi, Menaka (2020) Organic anion transporting polypeptide 2B1 (OATP2B1), an expanded substrate profile, does it align with OATP2B1's hypothesized function? Xenobiotica.

Bergboer, Judith GM, Kelder, Martijn JE , van Min, Max, Tuta, Nika, Crček, Mitja and Vogelsang, Matjaz (2020) Targeted Locus Amplification and NGS combined with qPCR-based breakpoint analysis for the assurance of monoclonality in recombinant cell lines. as white paper on Cergentis webpage.

Bhatt, Shruti, Pioso, Marissa, Olesinski, Elyse, Yilma, Binyam, Leutz, Buon, Adamia, Sophia, Zhu, Holly, Yanan, Kuang, Mogili, Abhishek, Ryan, Jeremy, Wang, Youzhen, Morris, Erick, Halilovic, Ensar, Paweletz, Cloud P., Weinstock, David M., Garcia, Jacqueline S. and Letai, Anthony (2020) Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia. Cancer Cell, 38 (6). 872-890.e6. ISSN 18783686

Blanco, Maria-Jesus (2020) New Chemical Modalities and Strategic Thinking in Early Drug Discovery. ACS medicinal chemistry letters, 11 (3). pp. 228-231. ISSN 1948-5875

Blank, Jutta, Hintermann, Samuel, Schneider, Nadine, Schuffenhauer, Ansgar and Shultz, Michael (2020) Outline for a Perspective Article on Novartis’ approach to compound screening for hit and lead finding and the design of compounds sets for diversity driven screening. Journal of medicinal chemistry for publisher only.

Blümel, Oliver, Buecheler, Jakob, Rodrigues, Miguel, Garaldes, Vitor, Hoelzl, Georg, Bechtold-Peters, Karoline and Friess, Wolfgang (2020) Cryoconcentration and 3D Temperature Profiles during Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device. Pharmaceutical Research, Formul. ISSN 0724-8741

Bogdanffy, Matthew S, Lesniak, Jacob, Mangipudy, Raja, Stanley, Ann Marie, Colman, Karyn and Blanset, Diann (2020) Tg.rasH2 mouse model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey and Recommendations. International Journal of Toxicology. ISSN 1091-58181092-874X

Bogdanffy, Matthew S, Lesniak, Jacob, Mangipudy, Raja, Stanley, Ann Marie, Colman, Karyn, Blanset, Diann, Sistare, Frank D, Garcia-Tapia, David and Monticello, Thomas (2020) Tg.rasH2 Mouse Model for Assessing Carcinogenic Potential of Pharmaceuticals: Industry Survey of Current Practices. International journal of toxicology. ISSN 1092874X

Boike, Lydia, Cioffi, Alexander, Majewski, Felix C., Co, Jennifer, Henning, Nathaniel J., Jones, Michael, Liu, Gang, McKenna, Jeffrey, Tallarico, John, Schirle, Markus and Nomura, Daniel K. (2020) Discovery of a Covalent Ligand Targeting an Intrinsically Disordered Cysteine Within MYC. Cell chemical biology. ISSN 2451-9448

Bolon, Brad, Caverly Rae, Jessica, Colman, Karyn, Francke, Sabine, Jensen, Karl, Keane, Kevin, McInnes, Elizabeth F., Nakano-Ito, Kyoko, Perry, Rick, Polack, Evelyne, Reagan, Karen S., Romeike, Annette, Young, Jamie K. and Galbreath, Elizabeth (2020) Toxicologic Pathology Forum Opinion Piece: Current Use of Non-blinded vs. Blinded Histopathologic Evaluation in Animal Toxicity Studies. Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Bova, Kaitlin (2020) Mitigating Medication Errors in Clinical Research. Clinical Trial Supply Handbook - Summer Edition .

Braun, Marie-Gabrielle , Díaz-Rodríguez , Alba, Louis, Diorazio, Kenneth, Fraunhoffer , John, Hayler, Matthew, Hickey , Jonathan , Latham, Lovelle, Lucie, Mark, McLaws , Andrew, Parsons, Paul, Richardson , Alan, Steven, Jack, Terrett , Timothy, White and Jingjun, Yin (2020) Green Chemistry Articles of Interest to the Pharmaceutical Industry. Organic Process Research & Development. ISSN 1083-61601520-586X

Brovč, Ema Valentina, Mravljak, Janez, Pajk, Stane and Sink, Roman (2020) Degradation of polysorbates 20 and 80 catalysed by histidine chloride buffer. European journal of pharmaceutics and biopharmaceutics, 154. pp. 236-245. ISSN 09396411

Brovč, Ema Valentina, Mravljak, Janez, Pajk, Stane and Sink, Roman (2020) Rational design to biologics development: The polysorbates point of view. International Journal of Pharmaceutics, 581. ISSN 18733476

Bruin, Gerardus, Hockey, Hans-Ulrich, Patekar, Manmath, Charef, Pascal, Woessner, Ralph, Boutouyrie-Dumont, Bruno, Fu, Rong, Philip, La Stella and Bardur, Sigurgeirsson (2020) Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different 2 mL delivery systems in healthy volunteers and in psoriasis patients. British journal of clinical pharmacology. pp. 1-14.

Bucher, Christoph, Linden, Anthony and Heimgartner, Heinz (2020) Synthesis and Solid State Conformation of Tetrapeptide Amides Containing two Aib and two (Me)Phe Residues – Use of Enantiomerically Pure 2-Benzyl-2-methyl-2H-azirin-3-amines as (Me)Phe-Synthons. Chemistry & Biodiversity. ISSN 1612-18721612-1880

Cabanski, Maciej, Teri, Oldaker, Jennifer , Stewart, Nithianandan, Selliah, Steve, Eck, Cherie, Green, Virginia, Litwin and Vitaliti Garami, Alessandra (2020) Flow cytometric method transfer: Recommendations for best practice. Cytometry Part B: Clinical Cytometry, 100 (1). pp. 52-62. ISSN 1552-49491552-4957

Cadena, Samuel (2020) Contrasting atrophy in space and on Earth. Genes in Space: Research Brief.

Caduff, Nicole, McHugh, Donal, Murer, Anita, Rämer, Patrick, Raykova, Ana, Landtwing, Vanessa, Rieble, Lisa, Keller, Christian, Prummer, Michael, Hoffmann, Laurent, Lam, Janice, Chiang, Alan, Raulf, Friedrich, Azzi, Tarik, Berger, Christoph, Rubic-Schneider, Tina, Traggiai, Elisabetta, Lünemann, Jan, Kammueller, Michael and Münz, Christian (2020) Immunosuppressive FK506 treatment leads to more frequent EBV-associated lymphoproliferative disease in humanized mice. PLoS pathogens, 16 (4). pp. 1-25. ISSN 15537374

Cain, Meredith, Vemula, Janardhana Rao, Zollinger, Markus, Umehara, Ken-Ichi , Elbast, Walid and Erpenbeck, Veit (2020) A study of the effect of cyclosporine on fevipiprant pharmacokinetics and its absolute bioavailability using an intravenous microdose approach. Drug Metabolism and Disposition, 48 (10). pp. 917-924. ISSN 1521009X

Camilleri, Michael, Linker Nord, Sara, Burton, Duane , Oduyebo, Ibironke , Zhang, Yiming, Chen, Jin, Im, Koeun, Bhad, Prafulla, Badman, Michael, Sanders, David and Walters, Julian (2020) A Randomized Controlled Trial of a Farnesoid X Receptor Agonist, Tropifexor, in Patients with Primary Bile Acid Diarrhea. Alimentary pharmacology & therapeutics, 52 (5). pp. 808-820. ISSN 02692813

Canham, Steve, Jenkins, Jeremy and Auld, Douglas (2020) Systematic Chemogenetic Library Assembly. BioRxiv.

Capaldi, Daniel, Akhtar, Nadim, Atherton, Tom, Benstead, David, Charaf, Ayman, De Vijlder, Thomas, Heatherington, Carl, Hoernschemeyer, Joerg, Jiang, Hong, Rieder, Ulrike, Ring, Francis, Peter, Robert, Stolee, Jessica and Wechselberger, Rainer (2020) Strategies for Identity Testing of Therapeutic Oligonucleotide Drug Substances and Drug Products. Nucleic Acid Therapeutics (00). ISSN 2159-33372159-3345

Capdevila, Jaume, Wirth, Lori J, Ernst, Thomas, Ponce Aix, Santiago, Lin, Chia-Chi, Ramlau, Rodryg, Butler, Marcus O, Delord, Jean-Pierre, Fuhrer, Dagmar, Hutter-Kronke, Marie-Luise, Forde, Patrick M, Wrona, Anna, Santoro, Armando, Sadow, Peter M, Szpakowski, Sebastian, Wu, Hongqian, Bostel, Geraldine, Faris, Jason, Cameron, Scott, Varga, Andreea, Taylor, Matthew and Arkoski, Peter (2020) PD-1 Blockade in Anaplastic Thyroid Carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. pp. 1-9. ISSN 15277755

Carballido, Jose, Regairaz Kalenga Kapiamba, Camille, Rauld, Celine, Raad, Layla, Picard, Damien and Kammueller, Michael (2020) The emerging jamboree of transformative therapies for autoimmune diseases. Frontiers in Immunology.

Carey, Kimberly , Paulus, Geraldine , Wang, Lingfei , Balce, Dale , Bergman, Phil , Ferder, Ianina , Kong, Lingjia , Renaud, Nicole, Singh, Shantanu , Karhohs, Kyle, Carpenter, Anne, Kost-Alimova, Maria , Nyfeler, Beat, Lassen, Kara , Virgin, Herbert and Xavier, Ramnik (2020) TFEB Transcriptional Responses Reveal Negative Feedback by BHLHE40 and BHLHE41. Cell Reports, 33 (6). ISSN 22111247

Chacón Simon, Selena, Wang, Feng, Thomas, Lance R, Phan, Jason, Zhao, Bin, Olejniczak, Edward T, Macdonald, Jonathan D, Shaw, J Grace, Schlund, Caden, Payne, William, Creighton, Joy, Stauffer, Shaun R, Waterson, Alex G, Tansey, William P and Fesik, Stephen W (2020) Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. Journal of medicinal chemistry, 63 (8). pp. 4315-4333. ISSN 1520-4804

Chawla, Shikha, Berkelar, Majoska, Dasen, Boris, Halleux, Christine, Kramer, Ina, Guth-Gundel, Sabine, Ghosh, Sourab, Martin, Ivan, Barbero, Andrea and Occhetta, Paola (2020) Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model. Journal of cell science, 133 (23). ISSN 14779137

Chen, Gregory, Grauzinyte, Migle, van der Vaart, Aad and Boll, Bjoern (2020) Applying Pattern Recognition as a Robust Approach for Silicone Oil Droplet Identification in Flow-Microscopy Images of Protein Formulations. Journal of pharmaceutical sciences. ISSN 00223549

Chen, Hui, Sun, Shuhao, Liu, Yahu and Liao, Xuebin (2020) Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C-CN Bond Cleavage and Cyano Transfer. ACS Catalysis, 10. pp. 1397-1405. ISSN 2155-54352155-5435

Chianelli, Donatella, Rucker, Paul, Tully, David, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy , Chu, Alan, Schmeits, James, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Richmond, Wendy, Sancho Martinez, Ignacio, Badman, Michael, Molteni, Valentina, Jason, Roland, Jane, Wu, David, Huang, Bo, Liu, Andrew, Phimister, Martin, Seidel, Sean, Joseph, Bryan, Laffitte, Prashad, Mahavir, Schlama, Thierry and Liu, Yugang (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. Journal of medicinal chemistry, 63 (8). pp. 3868-3880. ISSN 9b01621

Chianelli, Donatella, Rucker, Paul, Tully, David, Nelson, John, Liu, Xiaodong, Bursulaya, Badry, Hernandez, Eloy , Chu, Alan, Schmeits, James, Hill, Robert, Bao, Dingjiu, Zoll, Jocelyn, Kim, Young, Groessl, Todd, McNamara, Peter, Richmond, Wendy, Sancho Martinez, Ignacio, Badman, Michael, Molteni, Valentina, Jason, Roland, Jane, Wu, David, Huang, Bo, Liu, Andrew, Phimister, Martin, Seidel, Sean, Joseph and Bryan, Laffitte (2020) Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis (NASH). Journal of medicinal chemistry, 63 (8). pp. 3868-3880. ISSN 9b01621

Clarke, Adrian and ehkirch, anthony (2020) The Current Status and Future of Two- and Multidimensional Liquid Chromatography in Pharmaceutical R&D and QC. LC-GC Europe : Solutions for Separation Scientists., 33 (3). pp. 136-150. ISSN 1471-6571

Cowan, Cameron, Renner, Magdalena, De Gennaro, Martina, Gross-Scherf, Brigitte, Goldblum, David, Hou, Yanyan, Munz, Martin, Rodrigues, Tiago M., Krol, Jacek, Szikra, Tamas, Cuttat-Theurillat, Rachel, Waldt, Annick, Papasaikas, Panagiotis, Diggelmann, Roland, Patino-Alvarez, Claudia P., Galliker, Patricia, Spirig, Stefan, Pavlinic, Dinko, Gerber-Hollbach, Nadine, Schuierer, Sven, Srdanovic, Aldin, Balogh, Marton, Panero, Riccardo, Kusnyerik, Akos, Szabo, Arnold, Stadler, Michael, Orgül, Selim, Picelli, Simone, Hasler, Pascal W., Hierlemann, Andreas, Scholl, Hendrik P. N., Roma, Guglielmo, Nigsch, Florian and Roska, Botond (2020) Cell types of the human retina and its organoids at single-cell resolution: developmental convergence, transcriptomic identity, and disease map. Cell, 182 (6). p. 1623. ISSN 00928674

Czyz, Stefan, Wewers, Martin, Finke, Jan, Kwade, Arno, Van Eerdenbrugh, Bernard, Juhnke, Michael and Bunjes, Heike (2020) Spray 1 drying of API nanosuspensions: Importance of particle size, matrix former content and drying temperature for successful formulation and process development. European journal of pharmaceutics and biopharmaceutics, 152 (July). pp. 63-71. ISSN 1873-3441; 0939-6411

DaSilva, Jamie K., Breidenbach, Laura, Deats, Tracy, Li, Dingzhou, Treinen, Kimberly, Dinklo, Theo, Kervyn, Sophie, Teuns, Greet, Traebert, Martin and Hempel, Katja (2020) Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative. Journal of Pharmacological and Toxicological Methods, 103. ISSN 1873488X

Dalvit, Claudio, Veronesi, Marina and Vulpetti, Anna (2020) Fluorine NMR functional screening: from purified enzymes to human intact living cells. Journal of Biomolecular NMR. ISSN 15735001

Delord, Jean-Pierre , Argilés, Guillem, Fayette, Jerôme , Wirth, Lori, Kasper, Stefan , Siena, Salvatore , Mesia, Ricard , Berardi, Rossana, Cervantes, Andrés , Dekervel, Jeroen, Zhao, Sylvia, Sun, Yongjian , Hao, Lu, Tiedt, Ralph, Vicente Gabarda, Sergio, Myers, Andrea and Siu, Lillian L (2020) A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment. Investigational New Drugs. ISSN 15730646

Di Marco, Giulia, Vallese, Francesca, Jourde, Benjamin, Bergsdorf, Christian, Sturlese, Mattia, De Mario , Agnese, Techer-Etienne, Valerie, Haasen, Dorothea, Oberhauser, Berndt, Schleeger, Simone, Minetti, Giulia, Moro, Stefano, Rizzuto, Rosario, De Stefani, Diego, Fornaro, Mara and Mammucari, Cristina (2020) A high throughput screening identifies MICU1 targeting compounds. Cell Reports, 30. pp. 1-11.

Diagana, Thierry, Gupta, Devendra, Voorberg-van der Wel, Annemarie, Zeeman, Anne-Marie , Nieuwenhuis, Ivonne G, van der Werff, Nicole M. , Klooster, Els J, Klop, Onny, Vermaat, Lars C, Kocken, Clemens and Dembele, Laurent (2020) A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivation. Communications biology, 3 (1). ISSN 23993642

Diekhoff, Torsten , Fischer, Thomas, Schefer, Quirino , Dörner, Thomas, Posch, Maximilian Georg, Laurent, Didier, Li, Yue, Wagner, Frank and Oliver, Stephen (2020) Ianalumab (VAY736) in primary Sjögren’s syndrome: assessing disease activity using multi-modal ultrasound. Clinical and Experimental Rheumatology.

Dittrich, Birger, Chan, Stephen, Wiggin, Seth, Stevens, Joanna S. and Pidcock, Elna (2020) Fast energy minimization of the CCDC drug subset structures by molecule-in-cluster computations allows independent structure validation and model completion. CrystEngComm. ISSN 1466-8033

Dittrich, Birger, Sever, Christoph A. and Luebben, Jens (2020) Disappearing disorder. CrystEngComm. ISSN 1466-8033

Do Valle Duraes, Fernanda, Lafont, Armelle, Darribat, Katy, Cuttat-Theurillat, Rachel, Waldt, Annick, Naumann, Ulrike, Wieczorek, Grazyna, Gaulis, Swann, Pfister, Sabina, Beibel, Martin, Li, Jianping, Roma, Guglielmo and Warncke, Max (2020) Immune cell landscaping reveals a protective role for Tregs during kidney injury and fibrosis. "Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis, 5 (3).

Do Valle Duraes, Fernanda, Lafont, Armelle, Darribat, Katy, Martin, Kea, Cuttat-Theurillat, Rachel, Waldt, Annick, Naumann, Ulrike, Wieczorek, Grazyna, Gaulis, Swann, Pfister, Sabina, Beibel, Martin, Li, Jianping, Roma, Guglielmo, Warncke, Max and Mertz, Kirsten (2020) Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis. JCI insight, 5 (3). ISSN 23793708

Dolman, Andrew, Yu, Helen and Gusev, Arkady (2020) Data driven CRO benchmarking for biomarker analysis. Bioanalysis, 12 (16). pp. 1117-1127. ISSN 1757-6180

Doo, David W, Meza-Perez, Selene, Londoño, Angelina I, Goldsberry, Whitney N, Katre, Ashwini A. , Boone, Jonathan D, Moore, Dylana J. , Hudson, Cindy T, Betella, Ilaria, McCaw, Tyler R, Gangrade, Abhishek, Bao, Riyue, Luke, Jason J, Yang, Eddy S, Birrer, Michael J. , Starenki, Dmytro, Cooper, Sara J, Buchsbaum, Donald J, Norian, Lyse A, Randall, Troy D and Arend, Rebecca C (2020) Inhibition of the Wnt/β-catenin pathway enhances anti-tumor immunity in ovarian cancer. Therapeutic Advances in Medical Oncology, 12. pp. 1-16. ISSN 1758-835920913798

Dummer, Reinhard, Brase, Jan Christoph, Garrett, James, Campbell, Katie, Gasal, Eduard, Squires, Matthew, Gusenleitner, Daniel, Santinami, Mario, Atkinson, Victoria, Mandala, Mario, Chiarion-Sileni, Vanna, Flaherty, Keith, Larkin, James, Robert, Caroline, Kefford, Richard, Kirkwood, John, Hauschild, Axel, Schadendorf, Dirk and Long, Georgina (2020) Adjuvant dabrafenib plus trametinib versus placebo in patients with resected, BRAFV600-mutant, stage III melanoma (COMBI-AD): exploratory biomarker analyses from a randomised, phase 3 trial. The Lancet Oncology, 21 (3). pp. 358-372.

Dummer, Reinhard, Lebbé, Celeste, Atkinson, Victoria, Mandalà, Mario, Nathan, Paul, Arance, Ana, Richtig, Erika, Yamazaki, Naoya, Robert, Caroline, Schadendorf, Dirk, Tawbi, Hussein A., Ascierto, Paolo A., Ribas, Antoni, Flaherty, Keith, Pakhle, Neha, Campbell, Katie, Gusenleitner, Daniel, Masood, Aisha, Brase, Jan Christoph, Gasal, Eduard and Long, Georgina V. (2020) Spartalizumab in Combination With Dabrafenib And Trametinib in Advanced BRAF V600–Mutant Melanoma: Efficacy, Safety, and Biomarker Findings in Parts 1 and 2 of COMBI-i. Nature medicine, 26 (9).

Dumouchel, Jennifer, Argikar, Upendra, Adams, Christopher, Prasanna, Ganesh, Ehara, Takeru, Kim, Sunkyu, Breen, Chris and Mogi, Muneto (2020) Understanding metabolism related differences in ocular efficacy of MGV354. Xenobiotica. pp. 1-10. ISSN 13665928

Ecoeur, Florence, Weiss, Jessica and Guntermann, Christine (2020) Lack of evidence for expression and function of IL-39 in human immune cells. PLoS ONE, 2020 D (2020 D). pp. 1-16. ISSN 1932-6203

El-Hashimy, Mona, Letellier, Franck, Sengupta, Tirtha, Lorenzo, Sebastien, Blumenstein, Lars, Thomas, Marbury and Richard, Preston (2020) Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection. AAPS Journal, 22 (6). ISSN 15507416

Eleanna, Makris, Lucy, Hu, Jones, Graham and Wright, Justin (2020) Moving the Dial on Heart Failure Patient Adherence Rates. Patient preference and adherence, 14. pp. 2407-2418. ISSN 1177-889X

Emilsson, V, Gudmundsson, EF, Aspelund, T, Jonsson , BG, Gudjonsson, A, Lenore, JL, Jennings, Lori, Gudmundsdottir, V and Gudnason, V (2020) Antihypertensive drug treatment and serum ACE2 levels. https://medrxiv.org/cgi/content/short/2020.05.21.20108738v1.

Emilsson, Valur, Gudmundsson, Elias F, Aspelund, Thor, Jonsson G, Brynjolfur, Gudjonsson, Alexander, Laurner, Lenore J, Lamb, John, Gudmundsdottir, Valborg, Jennings, Lori and Gudnason, Vilmundur (2020) ACE2 levels are altered in comorbidities linked to severe outcome in COVID-19 Subtitle: ACE2 serum levels are increased in metabolic disease. https://medrxiv.org/cgi/content/short/2020.06.04.20122044v1.

Erdemli, Gul (2020) RADAR-AD Interview Series. RADAR-AD Project Website.

Erklavec Zajec, Vivian, Pohar, Andrej, Kastelic, Miha, Novak, Uroš, Japelj, Bostjan, Lah, Ljerka and Likozar, Blaž (2020) Dynamic metabolic modeling of CHO cell metabolism coupled with N-glycosylation in the industrial pharmaceutical production. Biotechnology and bioengineering. pp. 1-15. ISSN 1097-0290; 0006-3592

Ertl, Peter (2020) Craig plot 2.0 - An interactive navigation in the substituent bioisosteric space. Journal of Cheminformatics, 12 (2020). ISSN 1758-2946

Ertl, Peter (2020) Identification of bioisosteric analogs by deep neural network. Journal of Chemical Information and Modeling, 60 (7). pp. 3369-3375. ISSN 1549-95961549-960X

Ertl, Peter, Altmann, Eva and McKenna, Jeffrey (2020) The Most Common Functional Groups in Bioactive Molecules and How Their Popularity Has Evolved over Time. Journal of medicinal chemistry, 63 (15). 8408-8418.

Ertl, Peter and Schuhmann, Tim (2020) Cheminformatics Analysis of Natural Product Scaffold Space - Comparison of Scaffolds Produced by Animals, Plants, Fungi and Bacteria. Molecular informatics, 11. pp. 1-6.

Espay, Alberto J, Marsili, Luca, Mahajan, Abhimanyu, Sturchio, Andrea, Pathan, Rashid Khan, Pilotto, Andrea, Solai Elango, Damodaran, Pezous, Nicole, Masellis, Mario and Gomez-Mancilla, Baltazar (2020) Rivastigmine in Parkinson's Disease Dementia with Orthostatic Hypotension. Annals of Neurology. ISSN 1531-8249

Fairhurst, Robin, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Joerg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Joerg, Del Rio Espinola, Alberto, Jahnke, Wolfgang and Furet, Pascal (2020) Discovery of roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4. Journal of medicinal chemistry, 63 (21). pp. 12542-12573. ISSN 0022-2623

Fanous, Marina, Gold, Sarah, Hirsch, Stefan, Ogorka, Joerg and Imanidis, Georgios (2020) Development of Immediate Release (IR) 3D-printed oral dosage forms with focus on industrial relevance. Development of Immediate Release (IR) 3D-printed oral dosage forms with focus on industrial relevance, 105558. ISSN 0928-0987

Fanous, Marina, Gold, Sarah, Muller, Silvain, Hirsch, Stefan, Ogorka, Joerg and Imanidis, Georgios (2020) Simplification of FDM 3D-Printing paradigm: feasibility of 1-step Direct Powder Printing for Immediate Release dosage forms production. International journal of pharmaceutics. ISSN 1873-3476; 0378-5173

Fernandez Vallone, Valeria, Leprovots, Morgane, Gerbier, Romain, Ribatallada-Soriano, Didac, Lefort, Anne, Libert, Frederick, Vassart, Gilbert and Garcia, Marie-Isabelle (2020) LGR5 controls extracellular matrix production by stem cells in the developing intestine. EMBO Reports. ISSN 14693178

Fernandez Vallone, Valeria, Leprovots, Morgane, Gerbier, Romain, Ribatallada-Soriano, Didac, Lefort, Anne, Libert, Frederick, Vassart, Gilbert and Garcia, Marie-Isabelle (2020) LGR5 controls extracellular matrix production by stem cells in the developing intestine. EMBO Reports, 21 (7). ISSN 14693178

Fisher, Benjamin A, Szanto, Antonia, Ng, Wan-Fai, Bombardieri, Michele, Posch, Maximilian, Papas, Athena S, Farag , Arwa S, Daikeler, Tomas, Bannert, Bettina, Kyburz, Diego, Kivitz, Alan J, Carsons, Steven E, Isenberg, David, Barone, Francesca, Bowman, Simon J, Espie, Pascal, Floch, David, Dupuy, Cyrielle, Farber, Petra, Ren, Xiaohui, Wright, Andrew, Hockey, Hans-Ulrich, Rotte, Michael, Milojevic, Julie, Avrameas, Alexandre, Valentin, Marie-Anne, Rush, James and Gergely, Peter (2020) Assessment of the anti-CD40 antibody iscalimab in patients with primary Sjögren’s syndrome: a multicentre, randomised, double-blind, placebo-controlled, proof-of-concept study. The Lancet Rheumatology, 2 (3). pp. 142-152. ISSN 2665-9913

Flandre, Thierry, Hey, Adam and Spence, Fiona (2020) Nonclinical safety assessment of an inhaled formulation of serelaxin, a recombinant human protein, in rats and cynomolgus monkeys (Macaca fascicularis). Experimental and Toxicologic Pathology. ISSN 0192-62331533-1601

Flannery, Erika (2020) MAM 2020: Growing Strong on the 20th Anniversary. Trends in Parasitology, 36 (6). pp. 487-494. ISSN 14715007

Folkerts, Jelle, Redegeld, Frank, Folkerts, Gert, Blokhuis, Bart, van den Berg, Mariska P.M., Marjolein J.W., de Bruijn, Wilfred F.J., van Ijcken, Junt, Tobias, Tam, See-ying, Galli, Stephen J., Hendriks, Rudi W., Stadhouders, Ralph and Maurer, Marcus (2020) Butyrate inhibits human mast cell activation via epigenetic regulation of FcεRI-mediated signaling. Allergy: European Journal of Allergy and Clinical Immunology. ISSN 13989995

Fu, Yue, Estoppey, David, Roggo, Silvio, Pistorius, Dominik, Fuchs, Florian, Studer, Christian, Ibrahim, Ashraf S, Aust, Thomas, Grandjean, Frederic, Mihalic, Manuel, Memmert, Klaus, Prindle, Vivian, Richard, Etienne, Riedl, Ralph, Schuierer, Sven, Weber, Eric, Hunziker, Juerg, Petersen, Frank, Tao, Jianshi and Hoepfner, Dominic (2020) Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol. Nature Communications, 11 (1). ISSN 20411723

Fuchs, Florian, Marx, Uwe, Akabane, Takafumi, Andersson, Tommy, Baker, Elizabeth, Beilmann, Mario, Beken, Sonja, Brendler-Schwab, Susanne, Cirit, Murat, David, Rhiannon, Dehne, Eva-Maria, Durieux, Isabell, Ewart, Lorna, Fitzpatrick, Suzanne, Frey, Olivier, Griffith, Linda, Hamilton, Geraldine, Hartung, Thomas, Hoeng, Julia, Hogberg, Helena, Hughes, David, Ingbar, Donald, Iskandar, Anita, Kanamori, Toshiyuki, Kojima, Hajime, Kuehnl, Jochen, Leist, Marcel, Li, Bo, Loskill, Peter, Mendrick, Donna, Neumann, Thomas, Pallocca, Giorgia, Rusyn, Ivan, Smirnova, Lena, Steger-Hartmann, Thomas, Tagle, Danilo, Tonevitsky, Alexander, Tsyb, Sergej, Trapecar, Martin, van de Water, Bob, van den Eijnden-van Raaij, Janny, Vulto, Paul, Watanabe, Kengo, Wolf, Armin, Zhou, Xiaobing and Roth, Adrian (2020) Biology-Inspired Microphysiological Systems to Advance Medicines for Patients Benefit. Biology-Inspired Microphysiological Systems to Advance Medicines for Patients Benefit and Animal Welfare.

Furegati, Markus, Nocito, Sandro, Reck, Folkert, Casarez, Anthony, Simmons, Robert, Koch, Guido and Schuetz, Heiner (2020) Scale up synthesis of IID572: A new β-lactamase inhibitor. Organic process research & development, 24. pp. 1244-1253.

Gajewska, Monika, Blumenstein, Lars, Kourentas, Alexandros, Mueller-Zsigmondy, Martin, Lorenzo, Sebastien, Heimbach, Tycho, Angela, Sinn and Maria, Velinova (2020) Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection. AAPS Journal, 22 (6). ISSN 15507416

Gallou, Fabrice (2020) Continuous Flow Suzuki-Miyaura Couplings Under Aqueous Micellar Conditions in a CSTR Cascade Catalyzed by Fe/ppm Pd Nanoparticles. Green chemistry, 22. pp. 3441-3444. ISSN 1463-9270; 1463-9262

Gallou, Fabrice (2020) Development of a robust protocol for the synthesis of 6-hydroxybenzofuran-3-carboxylic acid. Organic process research & development, 24 (5). pp. 861-866. ISSN 1520-586X; 1083-6160

Gallou, Fabrice (2020) N2Phos. An easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki-Miyaura cross couplings in water. Chemical science, 11. pp. 5205-5212.

Gallou, Fabrice (2020) Sustainability as a trigger for innovation ! Chimia., 74. pp. 538-548.

Gallou, Fabrice (2020) Sustainable ppm Palladium-Catalyzed Tsuji-Trost Reactions Enabled by Aqueous Micellar Catalysis. Organic letters, 22 (13). pp. 4949-4954.

Gallou, Fabrice (2020) A sustainable 1-pot, 3-step synthesis of boscalid using ppm level Pd catalysis in water. Organic process research & development, 24. pp. 101-105.

Gallou, Fabrice, Buescher, Klaus, Schreiber, Robert, Durano, Corinne, Parmentier, Michael, Ye, Ning, Wu, Bin, Yang, Hongwei and Shi, Min (2020) Surfactant technology: to new rules, new design required ! Organic process research & development, 24. pp. 841-849.

Gallou, Fabrice, Robinson, Richard and Parmentier, Michael (2020) Computer Aided Synthesis Planning: ASKCOS. Journal of medicinal chemistry.

Gintant, Gary, Pfeiffer, Emily, Feaster, Tromondae, Stoelzle-Feix, Sonja, Kanda, Yasunari, Osada, Tomoharu, Smith, Godfrey, Kettenhofen, Ralf, Lu, Hua Rong, Cei, Beibei, Hong, Shi, Todd, Herron, Qianju, Dang, Burton, Francis, Pang, Li, Traebert, Martin, Abassi, Yama, Millard, Daniel, Pierson, Jennifer and Blinova, Ksenia (2020) Repolarization Studies using Human Stem Cell-Derived Cardiomyocytes: Validation Studies and Best Practice Recommendations. Regulatory toxicology and pharmacology, 117. ISSN 02732300

Gintant, Gary and Traebert, Martin (2020) The roles of human induced pluripotent stem cell-derived cardiomyocytes in drug discovery: managing in vitro safety study expectations. Expert Opinion on Drug Discovery. ISSN 1746045X

Glaenzel, Ulrike, Jin, Yi, Hansen, Regine, Schroer, Kirsten, Rahmanzadeh, Gholamreza, Pfaar, Ulrike, van Lier, Jan Jaap, Borell, Hubert, Meissner, Axel, Camenisch, Gian P. and Zhao, Sylvia (2020) Absorption, Distribution, Metabolism, and Excretion (ADME) of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite. Drug Metabolism and Disposition, 48 (10). pp. 873-885. ISSN 0090-95561521-009X

Glowienke, Susanne (2020) Management of pharmaceutical ICH M7 (Q)SAR predictions – The impact of model updates. Regulatory Toxicology and Pharmacology, 118. ISSN 10960295

Glowienke, Susanne (2020) Qualification of impurities based on metabolite data. Regulatory Toxicology and Pharmacology, 110. ISSN 10960295

Goepfert, Arnaud, Lehmann, Sylvie, Blank, Jutta, Kolbinger, Frank and Rondeau, Jean-Michel (2020) Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. Immunity, 52 (3). 499-512.e5. ISSN 10974180

Goncharenko, Kristina, Mari, Michele, Auberson, Yves and Matagne, Brieuc (2020) The Young Scientists Network – How the European Federation for Medicinal Chemistry (EFMC) became young again. ChemMedChem : chemistry enabling drug discovery. ISSN 1860-71791860-7187

González Medina, Mariana, Miljković, Filip, Haase, Gernot S., Drueckes, Peter, Trappe, Joerg, Laufer, Stefan and Bajorath, Jürgen (2020) Promiscuity analysis of a kinase panel screen with designated p38 alpha inhibitors. European Journal of Medicinal Chemistry, 187. ISSN 17683254

Gorovits, Boris, Fiscella, Michele , Havert, Mike, Koren, Eugen, Long, Brian, Milton, Mark and Purushothama , Shobha (2020) Recommendations for the Development of Cell-Based Anti-Viral Vector Neutralizing Antibody Assays. AAPS Journal, 22 (2). ISSN 15507416

Grande, Enrique, Giovannini, Monica, Marriere, Eddie, Pultar, Philippe, Quinlan, Michelle, Chen, Heller, Curigliano, Giuseppe and Cui, Xiaoming (2020) Effect of capmatinib on the pharmacokinetics of digoxin and rosuvastatin administered as a two-drug cocktail in patients with MET-dysregulated advanced solid tumors: A phase I, multicenter, open-label, single-sequence drug-drug interaction study. British Journal of Clinical Pharmacology.

Growcott, Ellena, Gamboa, Luis, Roth, Theresa, Lopez, Sara and Osborne, Colin (2020) Efficacy of piperacillin in combination with novel β-lactamase inhibitor IID572 against β-lactamase-producing strains of Enterobacteriaceae and Staphylococcus aureus in murine neutropenic thigh infection models. Journal of Antimicrobial Chemotherapy. ISSN 0305-74531460-2091

Gu, Ennan, Zhang, Jiajia, Lu, Wenbin, Wang, Lianming and Felizzi, Federico (2020) Semiparametric estimation of the cure fraction in population‐based cancer survival analysis. Statistics in Medicine, 39 (26). pp. 3787-3805. ISSN 0277-6715

Gu, Wayne, Zhao, Jibin, Li, Yunzhong, Yu, Bo, Tian, Xiangguang, Min, Jacob, Xu, Su, Gu, Huijuan, Sun, Junjie, Wang, Xufan, Ye, Shengqing, Yang, Hongwei, Tian, Yingtao, Gao, Feng, Gai, Yu, Wang, Yan, Zhang, Xuesong, Luo, Xi, Schenkel, Berthold, Venturoni, Francesco, Filipponi, Paolo, Guelat, Bertrand, Allmendinger, Thomas, Hoehn, Pascale, Kovacic, Nikola, Hermann, Luca, Schlama, Thierry, Ruch, Thomas, Derrien, Nadine, Piechon, Philippe, Kleinbeck-Riniker, Florian, Chen, Like, Wang, Huaimin, Wietfeld, Bernhard, Zhao, Stephen, Chang, Tommy, Lu, Xiaoquan, Zhang, Jianghua, Wu, Jingjing, Jia, Guanghua, Liu, Weichun, Gu, Xin and Hai, Dong (2020) Application of Transition-Metal Catalysis, Biocatalysis and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696. The Journal of Organic Chemistry. ISSN 0022-32631520-6904

Guedan, Sonia, Madar, Aviv, Casado-Medrano, Victoria, Shaw, Carolyn, Wing, Anna, Liu, Feng, Young, Regina, June, Carl H. and Posey, Avery D. Jr. (2020) Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability. Journal of Clinical Investigation. ISSN 0021-97381558-8238

Haefliger, Simon, Marston, Katharina, Juskevicius, Darius, Meyer-Schaller, Nathalie, Forster, Anja, Nicolet, Stefan, Komminoth, Paul, Stauffer, Edouard, Cathomas, Gieri, Hoeller, Sylvia, Tornillo, Luigi, Dirnhofer, Stefan, Terracciano, Luigi M, Bihl, Michel and Matter, Matthias S (2020) Molecular Profile of Gastrointestinal Stromal Tumors in Sixty-Eight Patients from a Single Swiss Institution. Pathobiology : journal of immunopathology, molecular and cellular biology. pp. 1-8. ISSN 1423-0291

Hardegger, Leo, Beney, Pascal, Bixel, Dominique, Fleury, Christian, Gao, Feng, Grand-Guillaume-Perrenoud, Alexandre, Gu, Wayne, Haber, Julien, Hong, Tao, Humair, Roger, Kaegi, Andreas, Kibiger, Michael, Kleinbeck-Riniker, Florian, Luu, Van Tong, Padeste, Lukas, Rampf, Florian, Ruch, Thomas, Schlama, Thierry, Sidler, Eric, Udvarhelyi, Aniko, Wietfeld, Bernhard and Yang, Yao (2020) Toward a scalable synthesis and process for EMA401. Part III: Using an engineered phenylalanine ammonia lyase enzyme to synthesize a non-natural phenylalanine derivative. Organic Process Research & Development, 24 (9). pp. 1763-1771. ISSN 1083-61601520-586X

Hardegger, Leo, Mallet, Franck, Bianchi, Barbara, Cai, Chunlong, Grand-Guillaume-Perrenoud, Alexandre, Humair, Roger, Kaehny, Richard, Lanz, Stephan, Li, Cheng, Li, Eddie, Rampf, Florian, Shi, Lei, Spoendlin, Christoph, Teng, Shangjun, Staeuble, Jeannine, Tian, Xiangguang, Wietfeld, Bernhard, Yang, Yao, Yu, Bo, Zepperitz, Christine, Zhang, Xuesong and Zhang, Yong (2020) Toward a Scalable Synthesis and Process for EMA401. Part I: Late Stage Process Development, Route Scouting and ICH M7 Assessment. Organic Process Research & Development, 24 (9). pp. 1743-1755. ISSN 1083-61601520-586X

Hayden, Chris and Meseck, Emily (2020) Transmission Electron Microscopy of the Retina: A Method for Sample Preparation and Evaluation. Toxicologic Pathology. ISSN 15331601

Hayden, Chris and Meseck, Emily (2020) Transmission Electron Microscopy of the Retina: A Method for Sample Preparation and Evaluation. Toxicologic Pathology. ISSN 15331601

He, Yingfang, Whitehead, David, Briard, Emmanuelle, Numao, Shin, Mu, Linjing, Schibli, Roger, Ametamey, Simon and Auberson, Yves (2020) Evaluation of 5H-thiazolo[3,2-alpha]pyrimidin-5-ones as potential GluN2A PET tracers. ChemMedChem : chemistry enabling drug discovery, 15 (24). pp. 2448-2461. ISSN 1860-71791860-7187

Hinder, Markus, Alexander, Schuhmacher, Michael, Kuss, Oliver , Gassmann and Alexander, Gatto (2020) The upside of being a digital pharma player. Drug Discovery Today.

Hollenbeck, Thomas, Thibodeaux, Stefan, White, Patrick, Westling, Lucas, Chong, Ashley and Isbell, John (2020) Acoustic Droplet Ejection and Open Port Interface for Rapid Analysis of Metabolic Stability Assays. Journal of Pharmaceutical Sciences, 109 (11). pp. 3285-3291. ISSN 15206017

Huppertz, Christine, Wieczorek, Grazyna, Littlewood-Evans, Amanda, Oliver, Stephen, Jaeger, Benedikt, Engelhard, Peggy, Bauernfeind, Franz-Georg, Welte, Tobias, Hornung, Veit and Prasse, Antje (2020) The NLRP3 inflammasome pathway is activated in sarcoidosis and involved in granuloma formation. The European respiratory journal. ISSN 13993003

Isalomboto Nkanga, Christian , Fisch, Andreas, Rad-Malekshahi, Mazda , Duvnjak Romic, Marieta, Kittel, Birgit, Ullrich, Thomas, Wang, Jing, Werner Maçedo Krause, Rui, Adler, Sabine, Lammers, Twan, Hennink, Wim and Ramazani, Farshad (2020) Clinically established biodegradable long acting injectables: An industry perspective. Advanced drug delivery reviews, 167. pp. 19-46. ISSN 33202261

Isobe, Yosuke, Okumura, Mikiko, McGregor, Lynn, Brittain, Scott, Jones, Michael, Liang, Xiaoyou, White, Ross, Forrester, William, McKenna, Jeffrey, Tallarico, John, Schirle, Markus, Maimone, Thomas and Nomura, Daniel (2020) Manumycin polyketides act as molecular glues between UBR7 and P53. Nature chemical biology. ISSN 1552-4469; 1552-4450

Jahnke, Wolfgang, Erlanson, Daniel A, de Esch, Iwan JP, Johnson, Christopher N, Mortenson, Paul N, Ochi, Yuji and Urushima, Tatsuya (2020) Fragment-to-Lead Medicinal Chemistry Publications in 2019. Journal of Medicinal Chemistry, 63 (24). pp. 15494-15507. ISSN 15204804

James, Alexander David, Schiller, Hilmar, Marvalin, Cyrille, Jin, Yi, Borell, Hubert, Roffel, Ad , Glaenzel, Ulrike, Ji, Yan and Camenisch, Gian P. (2020) An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo and human ADME data. Pharmacology Research & Perspectives, 8 (3). ISSN 2052-17072052-1707

Jayawardena, Asitha, Liu, Tingyu, Pereira, Bernard, Wang, Ye, Baker, Lisa, Leary, Rebecca, Sabatos-Peyton, Catherine and Hartnick, Christopher (2020) Genetic variation in twins with vastly different phenotypical expression of recurrent respiratory papillomatosis. The Laryngoscope. ISSN 1531-4995

Jentsch, Marcel, Snyder, Petra, Sheng, Caibin, Cristiano, Elena and Loewer, Alexander (2020) p53 dynamics in single cells are temperature-sensitive. Scientific reports, 10 (1). p. 1481. ISSN 2045-2322

Ji, Yan, Abozeid, Ahmed M, Samant, Tanay, Yang, Shu and Rodriguez Lorenc, Cristina (2020) Evaluation of Absolute Oral Bioavailability and Bioequivalence of Ribociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, in Healthy Subjects. Clinical Pharmacology in Drug Development. ISSN 21607648

Jin, Xi-Feng, Spöttl, Gerald, Maurer, Julian, Nölting, Svenja and Auernhammer, Christoph J. (2020) Inhibition of wnt/β-catenin signaling in neuroendocrine tumors in vitro: Antitumoral effects. Cancers, 12 (2). p. 345. ISSN 20726694

Johnson, Erik C. B., Ho, Kaitlyn, Das, Melanie, Sanchez , Pascal, Djukic, Biljana, Yu, Xinxing, Lopez, Isabel, Gill, Michael, Paz, Jeanne, Palop, Jorge and Mucke, Lennart (2020) Behavioral and neural network abnormalities of human APP transgenic mice resemble those of App knockin mice but are not prevented by early inhibition of BACE1. Molecular neurodegeneration, 15 (1).

Jolly, Christopher J. , Lee, Quintin, Padula,, Matthew P. , Pinello, Natalia, O'Rourke, Matthew B. , Williams, Simon , de Souza, William Marciel , Orkin, Joseph, Melin, Amanda, Shaban, Babak, Weninger, Wolfgang, Wong, Justin J.-L. , Crim, Marcus, Monette , Sébastien, Roediger, Ben, Fumagalli, Marcilio Jorge, Song, Renhua, Brenner, Ori and Pimanda, John E. (2020) Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys, 16 (1). ISSN 1553-7366

Jones, Graham, Chirino Chace, Bernardita and Wright, Justin (2020) Cultural diversity drives innovation: empowering teams for success. International Journal of Innovation Science, 12 (3). pp. 323-343. ISSN 1757-2223

Jones, Graham and Wright, Justin (2020) Let Culture Drive Online Innovation Teams. Innovation Management, 2020 (May 13).

Jordan, Stanley / SCJ, Kucher, Klaus, Bagger, Morten, Hockey, Hans-Ulrich / HUH, Wagner, Kristina, Ammerman, Noriko / NA and Vo, Ashley / AV (2020) Intravenous immunoglobulin significantly reduces exposure of concomitantly administered anti-C5 monoclonal antibody tesidolumab. American Journal of Transplantation. ISSN 16006143

Junker Walker, Ursula (2020) Histological thymus alterations in rats treated with a S1P receptor agonist. European society of toxicologic pathology website: "Guess what" the diagnotic cases of the ESTP.

Kang, Zhao Bin, Moutsatsos, Ioannis, Moretti, Francesca, Bergman, Phil, Zhang, Xian, Nyfeler, Beat and Antczak, Christophe (2020) Fluopack screening platform for unbiased cellular phenotype profiling. Scientific reports, 10. p. 2097. ISSN 2045-2322

Karle, Anette (2020) Applying MAPPs assays to assess immunogenicity. Frontiers in immunology, 11. ISSN 1664-3224

Karuna, Ratna, Yokokawa, Fumiaki, Wang, Keshi, Zhang, Jin, Xu, Haoying, Wang, Gang, Ding, Mei, Chan, Wai Ling, Abdul Ghafar, Nahdiyah, Leonardi, Andrea, Seh, Cheah Chen, Seah, Peck Gee, Liu, Wei, Rao, Srinivasa, Lim, Siew Pheng, Lakshminarayana, Suresh, Growcott, Ellena, Babu, Sreehari, Fenaux, Martijn, Zhong, Weidong, Gu, Feng, Shi, Pei-Yong, Blasco, Francesca and Chen, Yen-Liang (2020) A Cyclic Phosphoramidate Prodrug of 2'-deoxy-2'-fluoro-2'-C-methylguanosine for the Treatment of Dengue Infection. Antimicrobial agents and chemotherapy, 64 (12). pp. 1-17. ISSN 1098-6596

Kaul, Martin, Jarvis, Philip, Rozenberg, Izabela, Kolbinger, Frank, Di Padova, Franco E., Calonder, Claudio, Espie, Pascal, Rondeau, Jean-Michel, Cebe, Regis, Huber, Thomas, Mussmann, Rainer and Aassi, Maher (2020) First-in-human study demonstrating the safety and clinical efficacy of novel anti-IL-17A monoclonal antibody CJM112 in moderate to severe plaque psoriasis. Journal of the European Academy of Dermatology and Venereology, 2020 (4). pp. 1-9. ISSN 14683083

Kaur, Surinder, Bateman, Kevin, Glick, Jim, Jairaj, Mark, Kellie, John, Sydor, Jens and Zeng, Jianing (2020) Industry Perspective of International Consortium for Innovation through Quality in Pharmaceutical Development: Complementary LBA and LC-MS Strategies for Large Molecule Protein Bioanalysis and Biotransformation. Bioanalysis, 12 (4). ISSN 1757-6180

Kawanami, Toshio, Karki, Rajeshri, Cody, Emma, Liu, Qian, Liang, Guiqing, Ksander, Gary, Schiering, Nikolaus, Gong, Yongjin, Coppola, Gary, Iwaki, Yuki, Sun, Robert, Neubert, Alan, Fan, Li, Ingles Ginesta, Sara, D'Arcy, Allan, Villard, Frederic, Ramage, Paul, Jeng, Arco, Leung-Chu, Jennifer, Liu, Jing, Beil, Michael, Fu, Fumin, Chen, Wei, Rigel, Dean, Cumin, Frederic, Wiesmann, Christian and Mogi, Muneto (2020) Structure-guided design of substituted biphenyl butanoic acid derivatives as Neprilysin inhibitors. ACS Medicinal Chemistry Letters, 11 (2). pp. 188-194. ISSN 1948-58751948-5875

Kawanami, Toshio, La Bonte, Laura, Amin, Jakal, Thibodeaux, Stefan, Lee, Cameron, Argintaru, Andreea and Adams, Christopher (2020) A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers. International journal of pharmaceutics, 585. p. 119519. ISSN 03785173

Kennedy, Ryan, Yung, Christina and Luzzi Castro, Nazarena (2020) How design systems help teams build faster and create better experiences for users. PISTOIA Alliance Blog.

Kim, Myong-Jin and Jarugula, Venkateswar (2020) Clinical Pharmacology in Women's Health: Current Status and Opportunities. Journal of Clinical Pharmacology, 60 (S2). S7-S10. ISSN 15524604

Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sebastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phillip, Michellys, Pierre, Deane, Jonathan, Junt, Tobias, Collignon Zipfel, Geraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland and Betschart, Claudia (2020) Target-Based Identification and Optimization of 5-Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists using a Biochemical TLR8 Antagonist Competition Assay. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Kohlberger, Michael, Wildner, Sabrina, Regl, Christof, Huber, Christian G. and Gadermaier, Gabriele (2020) Rituximab-specific DNA aptamers are able to selectively recognize heat-treated antibodies. PLoS ONE, 15 (11 Nov). ISSN 19326203

Kourentas, Alexandros and Beato, Stefania (2020) The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation. European journal of pharmaceutical sciences , 151. ISSN 18790720

Kramlinger, Valerie, Argikar, Upendra, Khojasteh, Cyrus , Driscoll, James, Heck, Carley, Llyod, King, Jackson, Klarissa, Jian, Wenying, Kalgutkar, Amit, Miller, Grover, Rietjens, Ivonne, Teitelbaum, Aaron, Wang, Kai and Wei, Cong (2020) Novel advances in biotransformation and bioactivation research—2019 year in review*. Drug Metabolism Reviews. pp. 1-33. ISSN 10979883

Krantz, Carsten (2020) Ask the Experts: biologics by LC–MS. Bioanalyis Zone Interview Ask the Esperts.

Krewson, Elizabeth A. , Sanderlin, Edward J. , Marie, Mona , Velcicky, Juraj, Loetscher, Pius and Yang, Li V. (2020) The proton-sensing GPR4 receptor regulates paracellular gap formation and permeability of vascular endothelial cells. iScience, 23 (2). ISSN 25890042

Kublin, James G., Murphy, Sean C., Maenza, Janine, Seilie, Annette M., Jain, Jay Prakash, Goswami, Budhaditya, Berger, David, Spera, Danielle, Stein, Daniel S., Zhao, Rong, Pertel, Peter and Prince, William (2020) Causal prophylactic efficacy of ganaplacide (KAF156) in a controlled human malaria infection model. Clinical Infectious Diseases, Clin I. ISSN 1058-48381537-6591

Lamb, John R, Jennings, Lori, Gudmundsdottir, Valborg, Gudnason, Vilmundur and Emilsson, Valur (2020) It's in Our Blood: A Glimpse of Personalized Medicine. Trends in Molecular Medicine. ISSN 1471499X

Lamb, John R, Jennings, Lori, Gudmundsdottir, Valborg, Gudnason, Vilmundur and Emilsson, Valur (2020) It’s in Our Blood: A Glimpse of Personalized Medicine. Trends in molecular medicine. ISSN 1471-499X; 1471-4914

Langlois, Jean-Baptiste (2020) Stabilizing inactive conformations of the paracaspase MALT1 as an effective approach to inhibit its protease activity. Advanced Therapeutics, 3 (6).

Lawson, Kaycie S, Prasad, Anil and Groopman, Jerome E (2020) Methamphetamine Enhances HIV-1 Replication in CD4 T-Cells via a Novel IL-1β Auto-Regulatory Loop. Frontiers in immunology, 11. ISSN 1664-3224

Leeds, Jennifer, Sachdeva, Meena, Wang, Jia, Yi, Xiaoping, Yang, Xiaohan, Cai, Youyan, Hu, Wenhao and Yuan, Yanqiu (2020) Discovery of Novel Antibiotics as Covalent Inhibitors of Fatty Acid Synthesis. ACS chemical biology, 15 (7). pp. 1826-1834. ISSN 15548937

Leemans Martin, Laura, Peschke, Theo, Venturoni, Francesco and Mostarda, Serena (2020) Pharmaceutical industry perspectives on flow chemocatalysis and biocatalysis. Current Opinion in Green and Sustainable Chemistry, 25. ISSN 24522236

Li, Leon (2020) Strategies to Prevent and Elimination of Corynebacterium bovis from Animal Research Facility. Laboratory Animal and Comparative Medicine.

Li, Lujin and Ding, Junjie (2020) General considerations of model-based meta-analysis. Chinese Journal of Clinical Pharmacology and Therapeutics, 25 (11). pp. 1250-1267. ISSN 10092501

Lim, Yun-Sung , You, Byung Hoon , Kim, Hee-Bok , Lim, So Hyun , Song, Jae Geun , Bae, Min Goo, Han, Hyo-Kyung , Choi, Young Hee and Choi, Han Seok (2020) A New Therapeutic Approach Using a Calcilytic (AXT914) for Postsurgical Hypoparathyroidism in Female Rats. Endocrinology, 161. ISSN 1945-7170

Lima, Fabio, Andre, Jerome, Marziale, Alexander, Greb, Andreas, Glowienke, Susanne, Meisenbach, Mark, Schenkel, Berthold, Martin, Benjamin and Sedelmeier, Joerg Mathias (2020) Continuous Flow as Enabling Technology: Synthesis of Heteroaromatic Sulfinates as Bench Stable Cross-Coupling Partners. Organic Letters. ISSN 1523-70601523-7052

Lin, Fallon, Stockwell, Brent, deCarvalho, Ana, Ye, Ling, Yang, Guizhi, Pagliarini, Raymond, Malesky, Kimberly, Gao, Hui and Korn, Joshua (2020) Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery. Oncotarget, 11 (4). pp. 443-451. ISSN 1949-2553

Lingel, Andreas, Vulpetti, Anna, Reinsperger, Tony, Proudfoot, Andrew, Denay, Regis, Frommlet, Alexandra, Gossert, Alvar, Henry, Christelle, Hommel, Ulrich, Luy, Burkhard and Frank, Andreas (2020) Comprehensive and High-Throughput Exploration of Chemical Space Using Broadband 19F NMR Based Screening. Angewandte Chemie International Edition. ISSN 1433-78511521-3773

Liu, Ge, Zeng, Haoyang, Mueller, Jonas, Carter, Brandon, Wang, Ziheng, Schilz, Jonas, Horny, Geraldine, Birnbaum, Michael, Ewert, Stefan and Gifford, David (2020) Antibody complementarity determining region design using high-capacity machine learning. Bioinformatics (Oxford, England), 36 (7). pp. 2126-2133. ISSN 13674811

Liu, MM, Fields, FO, Prescott, JS, Bello, A, Bower, N, Hartke, J, Kadambi, V, Lapadula, Daniel, Stoch, A and Derzi, M (2020) Evaluation of Therapeutics for Severely Debilitating or Life-Threatening Diseases or Conditions: Defining Scope to Enable Global Guidance Development. Clinical Pharmacology and Therapeutics, 107 (3). pp. 514-520. ISSN 15326535

Liu, Yahu, Chen, Hui and Liao, Xuebin (2020) Recent Progress in Radical Decarboxylative Functionalizations Enabled by Transition-Metal (Ni, Cu, Fe, Co or Cr) Catalysis. Synthesis (Germany), 53 (1). pp. 1-29. ISSN 1437210X

Liu, Yahu, Jin, Qihui, Ding, Qiang, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Zou, Yefen, Huang, Zhihong, Zhang, Xiaoyue, Gao, Wenqi, Wu, Tom Y.-H., Li, Chun, Bursulaya, Badry, DiDonato, Michael, Zhang, You-Qing, Deaton, Lisa, Shen, Weijun, Taylor, Brandon, Kamireddy, Anwesh , Harb, George , Li, Jing, Jia, Yong, Schumacher, Andrew, Laffitte, Bryan , Glynne, Richard , Pan, Shifeng, McNamara, Peter, Molteni, Valentina and Loren, Jon (2020) A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877. ChemMedChem, 15. ISSN 18607187

Liu, Yahu, Zou, Yefen, Yan, Shanshan, Wang, Zhicheng, Hao, Xueshi, Nguyen, Bao, Zhang, Xiaoyue, Bursulaya, Badry, DiDonato, Michael, Gordon, William, Baaten, Janine, Hill, Robert, Qiu, Minhua, Zhang, You-Qing, Espinola, Sheryll, Deaton, Lisa, Ha, Sukwon, Jia, Yong, Schumacher, Andrew, Colman, Karyn, Pan, Shifeng, McNamara, Peter, Meeusen, Shelly, Molteni, Valentina, Loren, Jon, Jin, Qihui , Ding, Qiang , Pan, Jianfeng , Mo, Tingting , Jacobsen, Kate , Lam, Thanh , Wu, Tom Y.-H. , Petrassi, Hank Michael , Liu, Bo , Nguyen-Tran, Vân , Kamireddy, Anwesh , Harb, George , Li, Jing , Shen, Weijun , Glynne, Richard and Laffitte, Bryan (2020) Selective DYRK1A inhibitor for the treatment of Type 1 Diabetes: Discovery of 6-azaindole derivative GNF2133. Journal of Medicinal Chemistry, 63 (6). pp. 2958-2973. ISSN 0022-26231520-4804

Liu, Zichuan, Tardat, Mathieu, Gill, Mark E, Royo, Helene, Thierry, Raphael, Ozonov, Evgeniy A and Peters, Antoine HFM (2020) SUMO ylated PRC 1 controls histone H3.3 deposition and genome integrity of embryonic heterochromatin. The EMBO Journal. pp. 1-24. ISSN 0261-4189

Lopez, John, Kumar, Ashish, Mahama , Alhassan, Fernando , Albericio and Beatriz , G. de la Torre (2020) N-Butylpyrrolidinone for Solid-Phase Peptide Synthesis is Environmentally Friendlier and Synthetically Better than DMF. ChemSusChem, 13 (19). pp. 5288-5294. ISSN 1864564X

Lopez, John, Bucher, Christoph, Albericio, Fernando, Garcia de la Torre, Beatriz, Kumar, Ashish and Alhassan, Mahama (2020) Successful Development of a Method for the Incorporation of Fmoc-Arg(Pbf)-OH in Solid-Phase Peptide Synthesis using N Butylpyrrolidinone (NBP) as a Green Solvent. Current Green Chemistry, 22 (10). pp. 3162-3169. ISSN 1463-92621463-9270

Lopez, John, Mahama , Alhassan, Kumar, Ashish , Albericio, Fernando and G. de la Torre, Beatriz (2020) Revisiting NO2 as Protecting group of Arginine in Solid-Phase Peptide Synthesis. International journal of molecular sciences, 21 (12). pp. 1-12. ISSN 1422-0067

Lorthiois, Edwige, Roache, James, Barnes, David, Altmann, Eva, Hassiepen, Ulrich, Turner, Gordon, Duvadie, Rohit, Hornak, Viktor, Karki, Rajeshri, Schiering, Nikolaus, Weihofen, Wilhelm, Perruccio, Francesca, Calhoun, Amy, Fazal, Tanzina, Dedic, Darija, Durand, Corinne, Dussauge, Solene, Fettis, Kamal, Tritsch, Fabien, Dentel, Celine, Druet, Adelaide, Liu, Donglei, Kirman, Louise, Lachal, Julie, Namoto, Kenji, Bevan Jr, Doug, Mo, Ruowei, Monnet, Gabriela, Muller, Lionel, Zessis, Richard, Huang, Xueming, Lindsley, Loren, Currie, Treeve, Chiu, Yu-Hsin, Fridrich, Cary, Delgado, Pete, Wang, Shuangxi, Hollis-Symynkywicz, Micah, Berghausen, Joerg, Williams, Eric, Liu, Hong, Liang, Guiqing, Kim, Hyungchul, Hoffmann, Peter, Hein, Andreas, Ramage, Paul, D'Arcy, Allan, Harlfinger, Stephanie, Renatus, Martin, Ruedisser, Simon, Feldman, David, Elliott, Jason, Sedrani, Richard, Maibaum, Juergen Klaus and Adams, Christopher (2020) Structure-based design and pre-clinical characterization of selective and orally bioavailable Factor XIa inhibitors: Demonstrating the power of an integrated S1 protease family approach. Journal of medicinal chemistry, 63 (15). pp. 8088-8113. ISSN 1520-4804; 0022-2623

Lu, Haihui, Molony, Ryan, Chen, Dongshu, Jang, Sunyoung, Wolf, Babette, Ewert, Stefan, Meghan , Flaherty, Xu, Fangmin, Isim, Sinan, Shim, Yeonju, Dornelas, Christina, Balke, Nicole, Leber, Xavier Charles, Scharenberg, Meike, Koelln, Johanna, Choi, Eugene, Ward, Rebecca, Johnson, Jennifer, Calzascia, Thomas, Isnardi, Isabelle, Williams, Juliet, Van de Donk, Niels, Mutis, Tuna, Huet, Heather, Lees, Emma and Meyer, Matthew (2020) Development of anti-CD32b antibodies with enhanced Fc function for the treatment of B and plasma cell malignancies. Molecular cancer therapeutics, 19 (10). pp. 2089-2104. ISSN 1538-8514

Lu, Henry, Liu, Chen, Huynh, Hung, Le, Thi Bich Uyen, LaMarche, Matthew, Mohseni, Mori, Engelman, Jeffrey, Hammerman, Peter, Caponigro, Giordano and Hao, Huaixiang (2020) Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR. Oncotarget, 11 (3). pp. 265-281. ISSN 1949-2553

Luo, Hongyu, Lee, Pierre-Alexandre, Clay, Ieuan, Jaggi, Martin and De Luca, Valeria (2020) Assessment of Fatigue Using Wearable Sensors: A Pilot Study. Digital Biomarkers, 4 (1). pp. 59-72. ISSN 2504-110X

Luo, Wen, Xu, Changxin, Phillips, Sarah, Gardenswartz, Aliza, Rosenblum, Jeremy M., Ayello, Janet, Lessnick, Stephen L., Hao, Huaixiang and Cairo, Mitchell S. (2020) Protein phosphatase 1 regulatory subunit 1A regulates cell cycle progression in Ewing sarcoma. Oncotarget, 11 (19). ISSN 1949-2553

Ma, Eric and Kummer, Arkadij (2020) Reimplementing Unirep in JAX. Reimplementing Unirep in JAX.

Ma, Xiaolei, Han, Wooseok, Benson, Timothy, Brenton, Bret, Berminghan, Alun, Casey, Fergal, Chiu, Chun-Hao, Cook, Kim, Frank, Andreas, Frommlet, Alexandra, Ho, Chi-Min, Jansen, Hanneke, Lee, Patrick, Chie Leon, Barbara, Li, Min, Cho, Min-Kyu, Lingel, Andreas, Ma, Sylvia, Merritt, Hanne, Ornelas, Elizabeth, De Pascale, Gianfranco, Prathapam, Ramadevi, Prosen, Katie, Rasper, Dita, Rath, Christopher, Sawyer, William, Shaul, Jacob, Shia, Steven, Steffek, Micah, Smith, Thomas, Subramanian, Sharadha, Vo, Jason, Wang, Feng, Wartchow, Charles and Uehara, Tsuyoshi (2020) Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis. Journal of the American Chemical Society JACS., 142 (9). pp. 4445-4455. ISSN 0002-78631520-5126

Ma, Xiaolei, Han, Wooseok, Benson, Timothy, Brenton, Bret, Berminghan, Alun, Casey, Fergal, Chiu, Chun-Hao, Cook, Kim, Frank, Andreas, Frommlet, Alexandra, Ho, Chi-Min, Jansen, Hanneke, Lee, Patrick, Chie Leon, Barbara, Li, Min, Cho, Min-Kyu, Lingel, Andreas, Ma, Sylvia, Merritt, Hanne, Ornelas, Elizabeth, De Pascale, Gianfranco, Prathapam, Ramadevi, Prosen, Katie, Rasper, Dita, Rath, Christopher, Sawyer, William, Shaul, Jacob, Shia, Steven, Steffek, Micah, Smith, Thomas, Subramanian, Sharadha, Vo, Jason, Wang, Feng, Wartchow, Charles and Uehara, Tsuyoshi (2020) Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis. Journal of the American Chemical Society. ISSN 15205126

Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri, Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra, Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel, Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas, Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ramage, Paul, Gerhartz, Bernd, Ostermeier, Daniela, Schubart Wellensiek, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Juergen Klaus, Eder, Joerg, Sedrani, Richard, Harrison, Richard, Mogi, Muneto, Jaffee, Bruce and Adams, Christopher (2020) The discovery of 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid (LNP023), a Factor B inhibitor, specifically designed to be applicable to treating a diverse array of complement mediated diseases. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Mann, Greg and Stanger, Frederic (2020) A Bio-logical Approach to Catalysis in the Pharmaceutical Industry. Chimia, 74 (5). pp. 407-417. ISSN 00094293

Mannschott, Thomas, Krumme, Markus, Zettl, Manuel, Kreimer, Manuel, Aigner, Isabella, van der Wel, Peter and Khinast, Johannes G. (2020) Runtime Maximization of Continuous Precipitation in an Ultrasonic Process Chamber. Organic Process Research & Development, 24 (4). pp. 508-519. ISSN 1083-61601520-586X

Marchand, Jean-Rémy, Knehans, Tim, Caflisch, Amedeo and Vitalis, Andreas (2020) An ABSINTH-Based Protocol for Predicting Binding Affinities Between Proteins and Small Molecules. Journal of Chemical Information and Modeling. ISSN 1549-9596

Marie-Gabrielle , Braun, Jonathan, Latham, Louis, Diorazio, Kenneth, Fraunhoffer , John, Hayler, Matthew, Hickey, Lovelle, Lucie, Mark, McLaws, Andrew, Parsons, Paul, Richardson, Doru, Roiban, Philipp, Roosen, Alan, Steven , Jack, Terrett, Timothy, White and Jingjun, Yin (2020) Green Chemistry Articles of Interest to the Pharmaceutical Industry (24). Organic Process Research & Development, 24 (3). pp. 334-346. ISSN 1083-61601520-586X

Martin, Benjamin, Schenkel, Berthold, Ganiek, Maximilian, Djukanovic, Dimitrije, Knochel, Paul and Heinz, Benjamin (2020) Selective Acylation of Aryl- and Heteroarylmagnesium Reagents with Esters in Continuous Flow. Organic Letters, 22 (2). pp. 493-496. ISSN 1523-70601523-7052

Martin, Eric and Jansen, Hanneke (2020) Biased Diversity for Effective Virtual Screening. Journal of Chemical Information and Modeling, 60 (9). pp. 4116-4119. ISSN 1549-95961549-960X

Maser, Tyler, Zagorski, Joseph, Kelly, Shannon, Ostrander, Anna, Goodyke, Austin, Nagulapally, Abhinav, Bond, Jeffrey and Sholler, Giselle Saulnier (2020) The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma. Cancer Medicine. ISSN 2045-76342045-7634

Matafora, Vittoria, Restuccia, Umberto, Tamburri, Simone, Martano, Giuseppe, Farris, Francesco, Pisati, Federica, Bernadelli, Clara, Lazzari, Luca, Marsoni, Silva, Bonoldi, Emanuela and Bachi, Angela (2020) Targeting BACE to remodel tumor microenvironment and enhance chemo-sensitivity in metastatic melanoma. EMBO reports. ISSN 1469-221X1469-3178

Mathison, Casey, Chianelli, Donatella, Rucker, Paul, Nelson, John, Roland, Jason, Huang, Zhihong, Yang, Yang, Jiang, Jiqing, Yun Feng, Xie, Epple, Robert, Bursulaya, Badry, Lee, Christian, Gao, Mu-Yun, Shaffer, Jennifer, Briones, Sergio, Sarkisova, Yelena, Galkin, Anna, Li, Lintong, Li, Nanxin, Li, Chun, Hua, Su, Kasibhatla, Shailaja, Kinyamu-Akunda, Jacqueline, Kikkawa, Rie, Tellew, John and Molteni, Valentina (2020) Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma. ACS Medicinal Chemistry Letters, 11 (4). pp. 558-565. ISSN 1948-58751948-5875

McKenna, Jeffrey, Tallarico, John, Schirle, Markus, Tong, Bingqi, Luo, Mai, Xie, Yi, Spradlin, Jessica, Maimone, Thomas and Nomura, Daniel (2020) Targeted Protein Degradation via a Covalent Reversible Degrader Based on Bardoxolone. Sci Rep.

Meseck, Emily (2020) Summer 2020 STP President's Report. Scope Newsletter of the STP, NA (NA).

Meyer-Schaller, Nathalie, Tiede, Stefanie, Ivanek, Robert, Diepenbruck, Maren and Christofori, Gerhard (2020) A dual role of Irf1 in maintaining epithelial identity but also enabling EMT and metastasis formation of breast cancer cells. Oncogene. ISSN 1476-5594

Meyers-Normand, Guillaume, Maker, Michael, Penraat, Jan, Kovach, Kellyann, Ghosh, Joy, Grosskreutz, Cyndy and Chandra, Sudeep (2020) Non-invasive molecular tracking method that measures ocular drug distribution in non-human primates. Communications biology, 3 (1). ISSN 23993642

Middleton, Gary, Yang, Yiqun, Campbell, Katie, Millholland, John, Rangwala, Fatima and Corcoran, Ryan (2020) BRAF-mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade With Dabrafenib, Trametinib, and Panitumumab in Patients With Colorectal Cancer. Clinical cancer research. ISSN 1078-0432

Minami, Hironobu, Doi, Toshihiko, Toyoda, Masanori, Imamura, Yoshinori, Kiyota, Naomi, Mitsuma, Awake, Shimokata, Tomoya, Naito, Yoichi, Matsubara, Nobuaki, TAJIMA, TAKESHI, TOKUSHIGE, KOTA, ISHIHARA, KAE, Cameron, Scott and Ando, Yuichi (2020) Phase I study of the antiprogrammed cell death-1 Ab spartalizumab (PDR001) in Japanese patients with advanced malignancies. Cancer Science, 00. pp. 1-9. ISSN 13497006

Misselwitz, Benjamin, Wyss, Annika, Raselli, Tina, Cerovic, Vuc, Sailer, Andreas, Krupka, Niklas, Ruiz, Florian, Pot, Caroline and Papst, Oliver (2020) The oxysterol receptor GPR183 in inflammatory bowel diseases. British Journal of Pharmacology. pp. 1-17. ISSN 14765381

Monaco, Kelli-Ann, Delach, Scott, Yuan, Jing, Mishina, Yuji, Fordjour, Paul, Labrot, Emma, Parikh, Salonee, Jaskelioff, Mariela, Mathews Griner, Lesley, McKay, Daniel, Aspesi Jr, Peter, Ambrose, Jessi, Mapa, Felipa, Fuller, John, Crawford, Kenneth, Pardee, Gwynn, Widger, Stephania, Hammerman, Peter, Engelman, Jeffrey, Stuart, Darrin, Cooke, Vesselina and Caponigro, Giordano (2020) LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors. Clinical cancer research. ISSN 1557-3265; 1078-0432

Montis, Riccardo, Davey, Roger J., Wright, Sarah E., Woollam, Grahame and Cruz-Cabeza, Aurora J. (2020) Transforming Computed Energy Landscapes into Experimental Realities - the Role of Structural Rugosity. Angewandte Chemie (International ed. in English). ISSN 15213773

Moreton, Dean, Donnelly, Charles, Lanham, Austin, Morrison, Julie and Baran, Szczepan (2020) “Stop, Collaborate, and Listen”: A Model for Successful Pharma and Vendor Engagement. Drug Discovery World, digita (digita). NA-NA. ISSN NA

Mortzfeld, Frederik, Polenk, Jutta, Guelat, Bertrand, Venturoni, Francesco, Schenkel, Berthold and Filipponi, Paolo (2020) Reaction Calorimetry in continuous flow mode. A new approach for the thermal characterization of high energetic and fast reactions. Organic Process Research & Development. ISSN 1083-61601520-586X

Mow, Tomas, Andersen, Nidette, Dragsted, Nils, Lassen, Anders B., Laursen, Morten, Bass, Alan, Valentin, Jean-Pierre, Markgraf, Carrie, Authier, Simon, Baird, Ted, Bhatt, Siddhartha, Traebert, Martin, Leishman, Derek J, Jones, David and Curtis, Michael J (2020) Is there a role for the No Observed Adverse Effect Level in safety pharmacology? Journal of pharmacological and toxicological methods. ISSN 10568719

Mueller, Rufolf, Reddy, Virsinha, Nchinda, Aloysius, Mebrahtu, Fanuel, Taylor, Dale, Lawrence, Nina, Tanner, Lloyd, Barnabe, Marine, Eyermann, Charles, Zou, Bin, Kondireddi, Ravinder, Lakshminarayana, Suresh, Rottmann, Matthias, Street, Leslie and Chibale, Kelly (2020) Lerisetron Analogues with Antimalarial properties - Synthesis, Structure-Activity Relationship (SAR) studies and Biological Assessment. ACS Omega, 5 (12). pp. 6967-6982. ISSN 2470-13432470-1343

Mueller-Zsigmondy, Martin and Limoncini, Fedra Maria (2020) White Paper - Biopharmaceutics Modelling as a Fundamental Tool to Support Accelerated Access. efpia Website, n/a (n/a). n/a-n/a. ISSN n/a

Muthuswamy, Anantharaman, Hu, Ying , Chen, Henry, Turner, Oliver and Aina, Olulanu (2020) Mammalian Retinal Cell Quantification. Toxicologic Pathology. ISSN 15331601

Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, caridha, Diana, Sciotti, Richard, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin, Gao, Mu-Yun, Liang, Fang, Mathison, Casey, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Isabelle, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick, Rao, Srinivasa, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard, Supek, Frantisek, Wiesmann, Christian and Molteni, Valentina (2020) Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Naing, Aung , Gainor, Justin F., Gelderblom, Hans, Forde, Patrick M., Butler , Marcus O., Lin, Chia-Chi, Sharma, Sunil, Ochoa del Olza, Maria, Varga, Andreea, Taylor, Matthew, Schellens, Jan HM, Wu, Hongqian, Sun, Haiying, Silva, Antonio, Faris, Jason, Mataraza, Jennifer, Cameron, Scott and Bauer, Todd M. (2020) A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti-PD-1 antibody, in patients with advanced solid tumors. Journal for ImmunoTherapy of Cancer, 8 (1). pp. 1-9. ISSN 20511426

Naing, Aung , Gainor, Justin F., Gelderblom, Hans, Forde, Patrick M., Butler , Marcus O., Lin, Chia-Chi, Sharma, Sunil, Ochoa del Olza, Maria, Varga, Andreea, Taylor, Matthew, Schellens, Jan HM, Wu, Hongqian, Sun, Haiying, Silva, Antonio, Faris, Jason, Mataraza, Jennifer, Cameron, Scott and Bauer, Todd M. (2020) A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti-PD-1 antibody, in patients with advanced solid tumors. Journal for ImmunoTherapy of Cancer, 8 (1). ISSN 20511426

Nienhold, Ronny, Ciani, Yari, Koelzer, Viktor H., Tzankov, Alexandar, Haslbauer, Jasmin D., Menter, Thomas, Schwab, Nathalie, Henkel, Maurice, Frank, Angela, Zsikla, Veronika, Willi, Niels, Kempf, Werner, Hoyler, Thomas, Barbareschi, Mattia, Moch, Holger, Tolnay, Markus, Cathomas, Gieri, Demichelis, Francesca, Junt, Tobias and Mertz, Kirsten (2020) Two distinct immunopathological profiles in autopsy lungs of COVID-19. Nature Communications, 11 (1). pp. 1-13. ISSN 20411723

Nusinow, David, Gygi, Steven, Golji, Javad, Rejtar, Tomas, Wang, Yingqi and McDonald III, Earl (2020) Quantitative Proteomics of the Cancer Cell Line Encyclopedia Reveals Coordinated Post-Transcriptional Pathway Regulation. Cell.

Nutiu, Razvan and Ma, Eric (2020) Functional atlas of primary miRNA maturation by the Microprocessor. Molecular cell. ISSN 10972765

Olsen, Oddrun Elise, Hella, Hanna, Elsaadi, Samah, Jacobi, Carsten and Holien, Toril (2020) Activins as dual specificity TGF-β family molecules: SMAD-activation via activin- and BMP-type I receptors. Biomolecules, 10 (4). p. 519. ISSN 2218-273X

Parmentier, Michael, Gallou, Fabrice, Wickendick, Regina, Wagner, Mona, Langlois, Audrey and Baenziger, Markus (2020) A general kilogram scale protocol for Suzuki-Miyaura cross-coupling in water with TPGS-750-M surfactant. Organic Process Research & Development. ISSN 1083-61601520-586X

Parmentier, Michael, Hoehn, Pascale, Lanz, Marian and Gallou, Fabrice (2020) Synthesis of 5-iodo-7-aza-indazole by Diels–Alder cascade and se-lected examples of C–C and C–N cross-coupling reactions. Organic process research & development.

Patnaik, Anup, Axford, Laura, Deng, Lin, Ren, Xianglin, Kecman, Sam, Hollis-Symynkywicz, Micah, Harrison, Tyler, Papillon, Julien, Dales, Natalie, Lee, Lac, Regard, Jean, Marcinkeviciene, Jovita, Marro, Martin and Patterson, Andrew (2020) Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO). Bioorganic and Medicinal Chemistry, 28 (12). ISSN 14643391

Pauli, Victoria Isabell, Krumme, Markus and Kleinebudde, Peter (2020) From powder to tablets: Investigation of Residence Time Distributions in a Continuous Manufacturing Process Line as Basis for Continuous Process Verification. European journal of pharmaceutics and biopharmaceutics, 153. pp. 200-210. ISSN 09396411

Pauli, Victoria Isabell, Krumme, Markus and Kleinebudde, Peter (2020) Predictive model-based process start-up in pharmaceutical continuous manufacturing. Pharmaceutics, 12 (1). p. 67. ISSN 1999-4923

Pedro, Liliana and Rudewicz, Patrick (2020) Analysis of Live Single Cells by Confocal Microscopy and High-Resolution Mass Spectrometry to Study Drug Uptake, Metabolism, and Drug-Induced Phospholipidosis. Analytical Chemistry, 92 (24). pp. 16005-16015. ISSN 0003-27001520-6882

Perner, Florian, Gadrey, Jayant Y, Xiong, Yijun , Hatton, Charles, Eschle, Benjamin K, Stauffer, Frederic, Gaul, Christoph, Tiedt, Ralph, Perry, Jennifer A, Armstrong, Scott A and Krivtsov, Andrei V (2020) Novel Inhibitors of the Histone-Methyltransferase DOT1L Show Potent Antileukemic Activity in Patient-derived Xenografts. Blood, 136 (17). pp. 1983-1988. ISSN 15280020

Pettus, Liping H., Bourbeau, Matthew P., Bradley, Jodi, Bartberger, Michael D., Chen, Kui, Hickman, Dean, Johnson, Michael, Liu, Qingyian, Manning, James, Nanez, Adrian, Siegmund, Aaron C., Wen, Paul H., Whittington, Douglas A., Allen, Jennifer R. and Wood, Stephen (2020) Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. Journal of Medicinal Chemistry, 63 (5). pp. 2263-2281. ISSN 0022-2623

Pinch, Benika, McGregor, Lynn, Dovala, Dustin, Thoma, Claudio, Sprague, Elizabeth, Gleim, Scott, Forrester, William, Brittain, Scott, Buckley, Dennis, D'Alessandro, Pier Luca, Tandeske, Laura, Edward, Harvey and Zachary, Hauseman (2020) A Strategy to Assess the Cellular Activity of E3 Ligases against Neo-Substrates using Electrophilic Probes. BioRXiv.

Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, Mcsheehy, Paul M.J., Endres, Ralf, Fernandes Gomes Dos Santos, Paulo Antonio, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frederic, Radimerski, Thomas and Regnier, Catherine (2020) Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing. Journal of medicinal chemistry. pp. 14576-14583.

Pottel, Joshua, Armstrong, Duncan, Zou, Ling, Fekete, Alexander, Huang, Xi-Ping, Torosyan, Hayarpi, Bednarczyk, Dallas, Whitebread, Steven, Bhhatarai, Barun, Liang, Guiqing, Jin, Hong, Ghaemi, Nassir, Slocum, Samual, Lukacs, Katalin, Irwin, John, Berg, Ellen, Giacomini, Kathleen, Roth, Brian, Shoichet, Brian and Urban, Laszlo (2020) The activities of drug inactive ingredients on biological targets. Science, 369 (6502). pp. 403-413. ISSN 1095-9203

Potthoff, Bernd, McBlane, Fraser, Spindeldreher, Sebastian and Sickert, Denise (2020) A cell-based immunogenicity assay to detect antibodies against chimeric antigen receptor expressed by tisagenlecleucel. Journal of immunological methods, 476. ISSN 00221759

Press, Neil, Carmalt, Claire, J., Tocher, Derek, A. and Faizer, Habib (2020) Structure Determination of Terpenes by The Crystalline Sponge Method. Microporous and Mesoporous Materials.

Pruteanu-Malinici, Iulian, Sharma, Sujata, Quinn, David and Melenhorst, Jos (2020) High-dimensional immune monitoring for chimeric antigen receptor T cell therapies. Springer-Nature's Current Hematologic Malignancy Reports. ISSN Current Hematologic Malignancy Reports

Qiu, Minhua, Chyba, Jason, Zhou, Bin, Lo, Frederick, Quackenbush, Doug, Li, Zhizhong, Chen, Kaisheng, Zhou, Yingyao and Cook, Steven (2020) A cell-level quality control workflow for high-throughput image analysis. BMC bioinformatics, 21 (1). ISSN 14712105

Quancard, Jean, Simic, Oliver, Pissot Soldermann, Carole, aichholz, reiner, Blatter, Markus, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Endres, Ralf, Sorge, Mickael, Kieffer, Laurence, Wagner, Beatrix, Beltz, Karen, mcsheehy, paul, Wartmann, Markus, Regnier, Catherine, Calzascia, Thomas, radimerski, thomas, Bigaud, Marc, Weiss, Andreas, Bornancin, Frederic and Schlapbach, Achim (2020) Optimization of the in vivo potency of pyrazolopyrimidine MALT1 protease inhibitors by reducing metabolism and increasing potency in whole blood. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Quancard, Jean, cox, brian, finsinger, dirk, Gueret, Stefanie, Hartung, ingo, koolman, hannes, messinger, josef, sbardela, gianluca and laufer, stefan (2020) The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes. ChemMedChem. ISSN 18607187

Quinlan, Michelle, Forenzo, Patrick, James, Schwenke and Walter, Stroup (2020) Estimating Shelf Life Through Tolerance Intervals. AAPS PharmSciTech, 21 (290). pp. 1-22. ISSN 10.1208/s12249-020-01800-2

Rago, Florencia, Elliott, Ginell, Li, Ailing, Sprouffske, Kathleen, Kerr, Grainne, Desplat, Aurore, Abramowski, Dorothee, Golji, Javad, Farsidjani, Alireza, Xiang, Xiaoqin, Bushold, Geoffrey, Chung, Franklin, Feng, Yun, Shirley, Matt, Bric, Anka, Vattay, Anthony, Moebitz, Henrik, Nakajima, Katsumasa, Adair, Chris, Mathieu, Simon, Ntaganda, Rukundo, Smith, Troy, Papillon, Julien, Kauffmann, Audrey, Ruddy, David, Bhang, Hyo-eun, Castelletti, Deborah and Jagani, Zainab (2020) The discovery of SWI/SNF chromatin remodeling activity as a novel and targetable dependency in uveal melanoma. Molecular cancer therapeutics. ISSN 1538-8514

Rajman, Iris, Hanna, Imad and Knapp, Laura (2020) Genetic Diversity in Drug Transporters: Impact in African Populations. Clinical and Translational Science. ISSN 17528062

Reddy, Joseph, Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Johnson, Theresa, Cross, Vicky, Westrick, Elaine, Qi, LongWu, Hahn, Spencer, Santhapuram, Hari Krishna, Parham, Garth, Wang, Kevin, Vaughn, Jeremy F, Pugh, Michael, Lu, June, Klein, Pat, Vlahov, Iontcho and Leamon, Christopher (2020) Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent. Scientific reports, 10 (1). ISSN 20452322

Ren, Xiaojun and Dodd, Stephanie (2020) Use of PBPK Modeling for Predicting Drug-Food Interactions: An Industry Perspective. The AAPS journal, 22 (Theme:). pp. 123-138. ISSN 1550-7416

Renner, Steffen, Bergsdorf, Christian, Bouhelal, Rochdi, Koziczak-Holbro, Magdalena, Amati, Andrea Marco, Techer-Etienne, Valerie, FLOTTE, Ludivine, Reymann, Nicole, Kapur, Karen, Hoersch, Sebastian, Oakeley, Edward James, Schuffenhauer, Ansgar, Gubler, Hanspeter, Lounkine, Eugen and Farmer, Pierre (2020) Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes. Scientific reports, 10 (1). ISSN 2045-2322

Robichon, Katharina, Maiwald, Tim, Schilling, Marcel, Schneider, Annette, Willemsen, Joschka, Salopiata, Florian, Teusel, Melissa, Kreutz, Clemens, Ehlting, Christian, Huang, Jun, Chakraborty, Sajib, Huang, Xiaoyun, Damm, Georg, Seehofer, Daniel, Lang, Philipp A, Bode, Johannes G, Binder, Marco, Bartenschlager, Ralf, Timmer, Jens and Klingmüller, Ursula (2020) Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses. PLoS pathogens, 16 (10). e1008461. ISSN 1553-7374

Robinson, T.R., Goris, M.L., Moss, R.B., Tian, L., Kan, P., Yilma, M., McCoy, K.S., Newman, B., deJong, P.A., Long, F.R., Brody, A., Bherje, R., Yates, Denise and Cornfield, D.N. (2020) Mucus plugging, air trapping, and bronchiectasis are important outcome measures in assessing progressive childhood cystic fibrosis lung disease. Pediatric Pulmonology, 55 (4). pp. 929-938. ISSN 10990496

Rochester, Lynn, Mazza, Claudia, Caulfield, Brian, McCarthy, Marie, Becker, Clemens, Miller, Ram, Praino, Paulo, Dartee, Wim, Treubel, Hubert, Garcia-Aymerich, Judith, Aydemir, AA, Vereijken, Beatrice, Arnera, Valdo, Ammour, Nadir, Jackson, Mike, Hache, Tilo and Roubenoff, Ronenn (2020) A Roadmap to Inform Development, Validation and Approval of Digital Mobility Outcomes: The Mobilise-D Approach. Digital Biomarkers, 4 (1). pp. 13-27. ISSN 2504-110X

Roggo, Yves, Jelsch, Morgane, Heger, Philipp, Ensslin, Simon and Krumme, Markus (2020) Deep learning for continuous manufacturing of pharmaceutical solid dosage form. European journal of pharmaceutics and biopharmaceutics. ISSN 1873-3441; 0939-6411

Rohall, Steven, Gable, Jonathan, Gora, Jacob, Jansen, Hanneke, Lu, Yipin, Martin, Eric, Pancost-Heidebrecht, Margaret, Stiefl, Nikolaus, Mika, Lindvall, Lydia, Auch and Bill, Shirley (2020) An Artificial Intelligence Approach to Proactively Inspire Drug Discovery with Recommendations. Journal of medicinal chemistry, 63 (16). pp. 8824-8834. ISSN 1520-4804

Rooks, Daniel, Swan, Therese, Filosa, Lee Anne, Bunte, Ola, Panchaud, Nicolas, Coleman, Laura, Miller, Ram, Garcia Garayoa, Elisa, Praestgaard, Jens, Laurent, Didier, Petricoul, Olivier, Trifilieff, Estelle, Papanicolaou, Dimitris and Roubenoff, Ronenn (2020) Bimagrumab for treatment of sarcopenia in community-dwelling older adults: a phase II, randomized, controlled trial. JAMA Network Open, 3 (10). ISSN 2574-3805

Ruff, Yves, Martinez, Roberto, Pelle, Xavier, Nimsgern, Pierre, Berst, Frederic and Ratnikov, Max (2020) An amphiphilic polymer-supported strategy enables chemical transformations under anhydrous conditions for DNA-encoded library synthesis. ACS Combinatorial Science, 22 (3). pp. 120-128. ISSN 2156-89522156-8944

Ruffner, Heinz and Aebi, Alexandra (2020) PhD Thesis: Technologies for Vascularized Skin Equivalents to Study Cutaneous Wound Healing in Vitro. PhD Thesis. ISSN NA

Sahasrabudhe, Pranav, Banks, Angela and Rice, Dennis (2020) Internship Report for Summer-Pranav Sahasrabudhe. Internship Report for Summer-Pranav Sahasrabudhe .

Saldivia Concepcion, Manuel Alejandro (2020) Divide et impera: targeting kinetoplastid cell cycle. Nature Research Microbiology Community, 5. pp. 1207-1216.

Sanchez-Felix, Manuel, Burke, Matt, Chen, Hunter, Mittal, Sachin and Patterson, Claire (2020) Predicting Bioavailability of Monoclonal Antibodies after Subcutaneous Administration: Open Innovation Challenge. Advanced drug delivery reviews.

Sanchez-Felix, Manuel, Collins, David, Badkar, Advait and Mrsny, Randall (2020) Accelerating the Development of Novel Technologies and Tools for the Subcutaneous Delivery of Biotherapeutics. Journal of controlled release, 321. pp. 475-482. ISSN 01683659

Sanchez-Felix, Manuel, Tomic, Ivana, Duvnjak Romic, Marieta, Yang, Wenzhan, Bhattachar, Shobha, Landis, Margaret, Patel, Dipal, Reid, Darren and Phenil , Patel (2020) Modulating Target Engagement of Small Molecules Via Drug Delivery – Approaches and Applications in Drug Discovery and Development. Drug discovery today. ISSN 13596446

Sanchez-Felix, Manuel, Yang, Wenzhan , Gadgil, Prajakta , Landis, Margaret , Mallick, Pankajini , Patel, Dipal , Patel, Phenil J. and Reid, Darren L. (2020) The Evolving Druggability and Developability Space Part One: Druggability Part Two: Developability. Pharmaceutical research.

Schirle, Markus (2020) Characterizing drug-target interactions in complex tissues. Trends in pharmacological sciences. ISSN 1873-3735

Schuffenhauer, Ansgar, Schneider, Nadine, Hintermann, Samuel, Auld, Douglas, Blank, Jutta, Cotesta, Simona, Engeloch, Caroline, Fechner, Nikolas, Gaul, Christoph, Giovannoni, Jerome, Jansen, Hanneke, Joslin, John, Krastel, Philipp, Lounkine, Eugen, Manchester, John, Monovich, Lauren, Pelliccioli, Anna, Schwarze, Manuel, Shultz, Michael, Stiefl, Nikolaus and Baeschlin, Daniel (2020) Evolution of Novartis' Small Molecule Screening Deck Design. Journal of Medicinal Chemistry. ISSN 0022-26231520-4804

Schuhmacher, Alexander, Gassmann, Oliver, Hinder, Markus and Kuss, Michael (2020) The present and future of project management in pharmaceutical R&D. Drug discovery today, epub a (epub a). pp. 1-12. ISSN PMID: 32745523

Schwarz, Jenny, Rosenthal, Katrin, Luetz, Stephan, Kittelmann , Mathias and Snajdrova, Radka (2020) The Development of Biocatalysis as a Tool for Drug Discovery. Chimia, 74 (5). pp. 368-377. ISSN 00094293

Senatore, Assunta, Frontzek, Karl, Emmenegger, Marc, Chincisan, Andra, Losa, Marco, Reimann, Regina, Horny, Geraldine, Guo, Jingjing, Fels, Sylvie, Sorce, Silvia, Zhu, Caihong, George, Nathalie, Ewert, Stefan, Pietzonka, Thomas, Hornemann, Simone and Aguzzi, Adriano (2020) Protective anti‐prion antibodies in human immunoglobulin repertoires. EMBO Molecular Medicine, 12 (9). pp. 1-19. ISSN 1757-46761757-4684

Shi, Min, Ye, Ning, Chen, Wei, Wang, Hui, Cheung, Chi Ming, Parmentier, Michael, Gallou, Fabrice and Wu, Bin (2020) Simple synthesis of amides via their acid chloride in aqueous TPGS-750-M. Organic Process Research & Development, 24 (8). pp. 1543-1548.

Shirley, Matt, Krishnamurthy Radhakrishna, Vivek, Golji, Javad and Korn, Joshua (2020) PISCES: a package for rapid quantitation and quality control of large scale mRNA-seq datasets. bioRxiv.

Sidler, Eric, Humair, Roger and Hardegger, Leo (2020) Toward a Scalable Synthesis and Process for EMA401. Part II: Development and Scale-up of a Pyridine- and Piperidine-free Knoevenagel-Doebner Condensation. Organic Process Research & Development, 24 (9). pp. 1756-1762. ISSN 1083-61601520-586X

Sink, Roman, Brovč, Ema Valentina, Pajk, Stane and Mravljak, Janez (2020) Protein formulations containing polysorbates: are metal chelators needed at all? Antioxidants., 9 (5). ISSN 2076-3921

Sivakumar, Kumaraswamy, Cochrane, Thomas I., Sloth, Birgitte, Ashar, Hardik, Laurent, Didier, Tanko, Laszlo and Amato, Anthony A. (2020) Long-term Safety, Tolerability, and Efficacy of Bimagrumab (BYM338) in Sporadic Inclusion Body Myositis: Results of an Open-label Extension Study. Neurology, 95. ISSN 1526-632X

Skepper, Colin, Armstrong, Duncan, Balibar, Carl, Bauer, Daniel, Bellamacina, Cornelia, Benton, Bret, Bussiere, Dirksen, Holder, Lauren, Dangi, Veer, De Pascale, Gianfranco, De Vicente Fidalgo, Javier, Dean, Charles, Dhumale, Bhavesh, Mark, Fisher, Fuller, John, Fulsunder, Mangesh, Hu, Cheng, Kantariya, Bhavin, Lapointe, Guillaume, Leeds, Jennifer, Li, Xiaolin, Lu, Peichao, Lvov, Anatoli, Ma, Sylvia, Madhavan, Shravanthi, Malekar, Swapnil, Mckenney, David, Mergo, Wosenu, Metzger Iv, Louis, Moser, Heinz, Mutnick, Daniel, Noeske, Jonas, Osborne, Colin, Pal, Arani, Patel, Ashish, Patel, Darshit, Patel, Tushar, Prajapati, Krunal, Prosen, Katie, Reck, Folkert, Richie, Daryl, Rico, Alice, Sanderson, Mark, Satasia, Shailesh, Sawyer, William, Selvarajah, Jogitha, Shafer, Cynthia, Shah, Nirav, Shangavi, Kartik, Shu, Wei, Thompson, Katherine, Vala, Anand, Veselkov, Dennis, Vo, Jason, Wang, Michael, Widya, Marcella, Williams, Sarah, Xu, Yongjin, Yue, Qin, Zhang, Richard, Zhou, Bo and Rivkin, Alexey (2020) Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria. Journal of Medicinal Chemistry, 63 (14). pp. 7773-7816. ISSN 0022-26231520-4804

Snajdrova, Radka, Wu, Shuke, Moore, Jeffrey, Baldenius, Kai and Bornscheuer, Uwe (2020) Biocatalysis: Enzymatic Synthesis for Industrial Applications. Angewandte Chemie (International ed. in English). ISSN 15213773

Sommer, Ulrike, Eck, Steven, Marszalek , Laura, Stewart, Jennifer J. , Bradford, Jolene , McCloskey, Thomas W. , Green, Cherie , Vitaliti Garami, Alessandra, Oldaker, Teri and Litwin, Virginia (2020) High-sensitivity Flow Cytometric Assays: Considerations for Design Control and Sensitivity Validation for Identification of Rare Events. Cytometry Part B: Clinical Cytometry, Online (Online). ISSN 1552-49491552-4957

Sorden, Steven, Larsen, Thomas, McPherson, Leslie, Turner, Oliver, Carroll, Erica and Sharma, Alok (2020) Spontaneous background and procedure-related microscopic findings and common artefacts in ocular tissues of laboratory animals in ocular studies. Toxicologic pathology (Articl).

Soto, Jessica (2020) Multi-Methodological Quantitative Taste Assessment of Anti-Tuberculosis Drugs to Support the Development of Palatable Paediatric Dosage Forms. Pharmaceutics, 12 (4). p. 369. ISSN 1999-4923

Spieler, Valerie, Ludwig, Marie-Gabrielle, Dawson King, Janet, Tigani, Bruno, Littlewood-Evans, Amanda, Raschig, Martina , ter Mors, Björn, Müller, Thomas, Meinel, Lorenz and Lühmann, Tessa (2020) Targeting interleukin-4 to the arthritic joint. Journal of controlled release, 326. pp. 172-180. ISSN 1873-4995

Spindeldreher, Sebastian, Karle, Anette, Correia, Evelyne, Tenon, Maxime, Gottlieb, Sascha, Huber, Thomas, Maillere, Bernard and Kolbinger, Frank (2020) T cell epitope mapping of secukinumab and ixekizumab in healthy donors. mAbs, 12 (1). ISSN 19420870

Steger-Hartmann, Thomas, Kreuchwig, Annika, Vaas, Lea, Wichard, Joerg, Bringezu, Frank, Amberg, Alexander, Muster, Wolgang, Pognan, Francois and Barber, Chris (2020) Introducing the concept of virtual control groups into preclinical toxicology testing. ALTEX, 37 (3). pp. 343-349. ISSN 1868-596X

Stoecklin, Stefan (2020) Fokus: Wissenschaftliche Karrierepfade Stefan Ewert: Forschen für die Gesundheit. Journal der Universität Zürich.

Stojković, Vanja, Myasnikov, Alexander G, Young, Iris D, Frost, Adam, Fraser, James S and Fujimori, Danica Galonić (2020) Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit. Nucleic acids research, 48 (5). pp. 2723-2732. ISSN 1362-4962

Straube, Frank and Kress, Wolfgang (2020) Understanding the adsorption and potential tear film stability properties of recombinant human lubricin and bovine submaxillary mucins in an in vitro tear film model. Colloids and surfaces, series B : biointerfaces, 195. ISSN 111257

Tang, Ran and Xu, Zhigang (2020) Gene therapy: a double-edged sword with great powers. Molecular and cellular biochemistry, 474 (1-2). pp. 73-81. ISSN 1573-4919

Tanriöver, Gaye, Bacioglu, Mehtap, Schweighauser, Manuel, Mahler, Jasmin, Wegenast-Braun, Bettina, Skodras, Angelos, Barth, Melanie, Kronenberg-Versteeg, Deborah, Nilsson, Peter, Shimshek, Derya, Kahle, Philipp, Eisele, Yvonne and Jucker, Mathias (2020) Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions. Acta neuropathologica communications., 8. p. 133. ISSN 2051-5960

Thomson, Christopher, Le Grand, Darren, Dowling, Mark, Beattie, David, Elphick, Lucy, Faller, Michael, Freeman, Mark, Hardaker, Elizabeth, Head, Victoria, Hemmig, Rene, Hill, Johan, Lister, Andrew, Pascoe, David, Rieffel, Sebastien, Shresta, Binesh, Steward, Oliver and Zink, Florence (2020) Development of autotaxin inhibitors: A series of tetrazole cinnamides. Bioorganic and medicinal chemistry letters. ISSN 0960894X

Tian, Yingtao, Zhang, Xingmin, Yu, Bo, Bai, Yingjun, Guan, Limin, Teng, Shangjun, Li, Jun, Huang, Chen, Lanz, Marian and Hoehn, Pascale (2020) Case-Based Thermal Safety Evaluation on a Pharmaceutical Process Using Dimethyl Sulfoxide as a Solvent. Organic Process Research & Development, 24 (12). pp. 2927-2934. ISSN 1083-61601520-586X

Tietsch, Matthias, Muaremi, Amir, Ieuan, Clay, Kluge, Felix, Hoefling, Holger, Kluge, Felix, Kuederle, Arne, Ulrich, Martin, Eskofier, Bjoern and Mueller, Arne (2020) Robust step detection from different waist-worn sensor positions – implications for clinical studies. Digital biomarkers, 4 (suppl.). pp. 50-58. ISSN 2504-110X

Tjhung, Katrina, Sczepanski, Jonathan, Murtfeldt, Eric and Joyce, Gerald (2020) RNA-Catalyzed Cross-Chiral Polymerization of RNA. Journal of the American Chemical Society JACS., 142 (36). pp. 15331-15339. ISSN 0002-78631520-5126

Tjhung, Katrina, Shokhirev, Maxim N., Horning, David P. and Joyce, Gerald F. (2020) An RNA polymerase ribozyme that synthesizes its own ancestor. Proceedings of the National Academy of Sciences. ISSN 0027-84241091-6490

Tong, Bingqi, Spradlin, Jessica, Novaes, Luiz, Zhang, Erika, Hu, Xirui, Moeller, Malte, Brittain, Scott, McGregor, Lynn, McKenna, Jeffrey, Tallarico, John, Schirle, Markus, Maimone, Tom and Nomura, Dan (2020) A Nimbolide-Based Kinase Degrader Preferentially Degrades Oncogenic BCR-ABL. ACS chemical biology. ISSN 1554-8937

Trnovec, Helena (2020) Characterization of membrane adsorbers used for impurity removal during the continuous purification of monoclonal antibodies. Journal of chromatography A, 1609 (460518). ISSN 1873-3778; 0021-9673

Vargas, Hugo M, Rolf, Mike, Wisialowski, Todd A, Anchazar, William, Bahinski, Anthony, Bass, Alan, Benson, Charles, Chaudry, Khuram W, Couvreur, Nicolas, Dota, Carina, Mike, Engwall, Gallacher, David, Greiter-Wilke, Andrea, Guillon, Jean-Michel, Guth, Brian, Herbert, Himmel, Ito, Maki, Jenkinson, Stephen, Katsuyoshi, Chiba, Kochihoro, Ogata, Taeko, Kubo, Armando, Lagrutta, Paul, Levesque, Eric, Martel, Yoshiko, Okai, Ravi, Peri, Ami, Pointon, Yusheng, Qu, Teisman, Ard, Traebert, Martin, Takashi, Yoshinaga, Gary, Gintant, Derek, Leishman and Derek, Valentin (2020) Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QTc Prolongation Liability Determinations: A Pharma Perspective. Clinical Pharmacology & Therapeutics. ISSN 0009-92361532-6535

Velcicky, Juraj, Wilcken, Rainer, Cotesta, Simona, Janser, Philipp, Schlapbach, Achim, Piechon, Philippe, Villard, Frederic, Bouhelal, Rochdi, Piller, Fabian, Harlfinger, Stephanie, Stringer, Rowan, Fehlmann, Dominique, Kaupmann, Klemens, Littlewood-Evans, Amanda, Haffke, Matthias and Gommermann, Nina (2020) Discovery And Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with Salt-Bridge for Improvement of Oral Exposure. Journal of Medicinal Chemistry, 63 (17). pp. 9856-9875. ISSN 0022-26231520-4804

Vessillier, Sandrine, Fort, Madeline, O'Donnell, Lynn, Hinton, Heather, Nadwodny, Kimberly, Picotti, Joseph, Rigsby, Peter, Staflin, Karin, Stebbings, Richard, Weinstock, Daniel, Willingham, Aarron and Wolf, Babette (2020) Development of the first reference panel for qualification and validation of cytokine release assay platforms - Report of an international collaborative study. Cytokine.

Vogel, Jennifer, Yin, Jianning, Su, Liansheng, Wang-Gadient, Sharon, Zessis, Richard, Fowler, Sena, Chiu, Chun-Hao, Wilson , Aaron, Chen, Amy, Zecri, Frederic, Turner, Gordon, Smith, Thomas, DeChristopher, Brian, Xing, Heming, Rothman, Deborah, Cai, Xinming and Berdichevsky, Alina (2020) A phenotypic screen identifies calcium overload as a key mechanism of beta cell glucolipotoxicity. Diabetes.

Vollmer, Tom, Zhou, Enhua, Rice, Dennis, Prasanna, Ganesh, Chen, Amy and Wilson, Chris (2020) Application of Cell Impedance as a Screening Tool to Discover Modulators of Intraocular Pressure. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 36 (5). pp. 269-281. ISSN 15577732

Vorherr, Thomas, Lewis, Ian, Wille, Roman Mariano, Lochmann, Thomas, Berghausen, Joerg, Huth, Felix, Schroer, Kirsten, Blanz, Joachim, Aichholz, Reiner and Schaefer, Michael (2020) On the importance of metabolic stability to achieve high oral exposures for cyclic peptides. American Journal of Medicinal Chemistry.

Vulic, Katarina and Caralli, Lisa (2020) From Candidate to Clinic: Strategies to Accelerate you Molecule's Development Path. Candidate to Clinic Webinar Executive Summary, n/a (n/a). pp. 1-10. ISSN n/a

Wagner, Julia A, Wong, Pamela, Schappe, Timothy, Berrien-Elliott, Melissa M, Cubitt, Celia, Jaeger, Natalia, Lee, Madeline, Keppel, Cassie R, Marin, Nancy D, Foltz, Jennifer A, Marsala, Lynne, Neal, Carly C, Sullivan, Ryan, Schneider, Stephanie E, Keppel, Molly P, Saucier, Nermina, Cooper, Megan A and Fehniger, Todd A (2020) Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity. Cell reports, 31 (9). p. 107720. ISSN 2211-1247

Walles, Markus, End, Peter, Brown, Alan and Zimmerlin, Alfred Gilbert (2020) New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides. Chem res tox, 33 (7). pp. 1551-1560. ISSN doi: 10.1021/acs.chemrestox.0c00131.

Wang, Shirley, Kulldorff, Martin, Poor, Stephen, Rice, Dennis, Banks, Angela, Li, Ning, Lii, Joyce and Gagne, Joshua J (2020) Screening medications for association with progression to wet age-related macular degeneration (AMD). Ophthalmology. ISSN 01616420

Wang, Xiaoliang, Perozzo, Remo, Amirshahrokhi, Keyvan, Kuchen, Stefan, Yousefi, Shida, Simon, Hans-Uwe, Loetscher, Pius and Gessier, Francois (2020) RIPK3-MLKL – Mediated neutrophil death requires concurrent activation of fibroblast activation protein alpha (FAP-α). The Journal of Immunology. ISSN 0022-17671550-6606

Wang, Zhong-Yi, Leushkin, Evgeny, Liechti, Angélica, Ovchinnikova, Svetlana, Mößinger, Katharina, Brüning, Thoomke, Rummel, Coralie, Grützner, Frank, Cardoso-Moreira, Margarida, Janich, Peggy, Gatfield, David, Diagouraga, Boubou, de Massy, Bernard, Gill, Mark E, Peters, Antoine H F M, Anders, Simon and Kaessmann, Henrik (2020) Transcriptome and translatome co-evolution in mammals. Nature, 588 (7839). pp. 642-647. ISSN 1476-4687

Ward, Lesley A, Lee, Dennis SW, Sharma, Anshu, Wang, Angela, Naouar, Ikbel, Ma, Xianjie I, Pikor, Natalia, Nuesslein-Hildesheim, Barbara, Ramaglia, Valeria and Gommerman, Jennifer L (2020) A murine model of meningeal inflammation and subpial demyelination identifies an anti-MOG independent mechanism of cortical injury that is inhibited by Siponimod therapy. JCI insight.

Wartchow, Charles, Kane, Joshua, Shaul, Jacob, Frank, Andreas, Knapp, Mark, Bussiere, Dirksen, Ornelas, Elizabeth and Hyrina, Anastasia (2020) eLive revised manuscript: A POLYOMAVIRUS PEPTIDE BINDS TO THE CAPSID VP1 PORE AND HAS POTENT ANTIVIRAL ACTIVITY AGAINST BK AND JC POLYOMAVIRUSES. ELife., 9. ISSN 2050-084X

Wenzel, Jan, Richter, Marius, Bettoni, Carla, Vogt, Miriam A, Natsagdorj, Rentsenkhand, Huber, Gianna, Brands, Josefine, Assmann, Julian C, Lembrich, Beate, Stölting, Ines, Sedlacik, Jan, Fiehler, Jens, Ludewig, Peter, Wegmann, Michael, MüllerFielitz, Helge, Wlather, Thomas, Schmidt, Kjestine, König, Gabriele M, Kostenis, Evi, Raasch, Walter, deWit, Cor, Gass, Peter, Offermanns, Stefan, Wagner, Carsten A and Schwaninger, Markus (2020) Behavioral, respiratory and metabolic consequences of impaired cerebrovascular reactivity. Proceedings of the National Academy of Sciences of the United States of America PNAS.. ISSN 1091-6490; 0027-8424

Wewers, Martin, Czyz, Stefan, Finke, Jan, John, Edgar, Van Eerdenbrugh, Bernard, Juhnke, Michael, Bunjes, Heike and Kwade, Arno (2020) Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules Produced in a Fluidized Bed Process. Pharmaceutics, 12 (n/a). p. 363. ISSN 1999-4923

Widler, Leo, Amadeu, Nader, Augner, Sven, Janiak, Christoph and Hägele, Gerhard (2020) Symmetric Geminal Bisphosphinic Acids RR´C[P(CH3)(O)OH]2 - NMR and Analytical Studies. Phosphorus, Sulfur, and Silicon and the Related Elements. ISSN 1042-65071563-5325

Wilcken, Rainer, Rodde, Stephane and Udvarhelyi, Aniko (2020) ReSCoSS: A Flexible Quantum Chemistry Workflow Identifying Relevant Solution Conformers of Drug-like Molecules. Journal of computer-aided molecular design.

Wong, Connie, Baum, Jason, Beste, Michael, Bharani Dharan, Bharani, Wang, Amanda, Wang, Xiaoshan, Silvestro, Angela, Prescott, Margaret, Krajkovich, Lynne, Dugan, Margaret, Ridker, Paul, Martin, Ann Marie, Svensson, Eric and Xu, Siyan (2020) Inhibition of IL-1β by canakinumab may be effective against diverse molecular subtypes of lung cancer: An exploratory analysis of the CANTOS trial. Cancer research, 80. pp. 5597-5605. ISSN 1538-7445

Woollam, Grahame, Das, Partha P. , Mugnaioli, Enrico , Andrusenko, Iryna , Galanis, Athanassios S. , Jacco, Van De Streek (ext.), Nicolopoulos, Stavros , Gemmi, Mauro and Wagner, Beatrix (2020) Structural Analysis of Metastable Pharmaceutical Loratadine Form II, by 3D Electron Diffraction and DFT+D Energy Minimisation. CrystEngComm. ISSN 1466-8033

Wu, Bin, Zhang, Sisi, Hong, Tao, Zhou, Yizong, Wang, Hui, Shi, Min, Yang, Hongwei, Tian, Xiangguang, Guo, Jing, Bian, Jianwei, Roache, James, Delgado, Pete, Mo, Ruowei, Fridrich, Cary, Gao, Feng and Wang, Joseph (2020) Development of a Practical Synthesis of an FXI (Factor XI) Inhibitor. Organic process research & development, 24 (11). pp. 2780-2788.

Wu, Quanbing, Li, Lei, Li, Bin, Chen, Like, Wu, Bin, Wang, Xianwen and Guo, Tina (2020) Process Development for the Synthesis of a -monobactam antibiotic - LYS228. Organic Process Research & Development, 24 (3). pp. 363-370. ISSN 1083-61601520-586X

Wuersch, Kuno, Parrula, Cecilia, Dincer, Zuhal, de Vera Mudry, Maria Cristina, Geoly, Frank and Mysore, Jagannatha (2020) Toxicologic Pathology Forum: Opinion on Obligatory Microscopic Examination of Intermediate-Dose Groups in Toxicity Studies With Biotherapeutics in Cynomolgus Monkeys. Toxicologic Pathology, 48 (8). pp. 939-943. ISSN 15331601

Xing, Jimmy, Loureiro, Joe, Patel, Michael, Mikhailov, Dmitri and Gusev, Arkady (2020) Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis. Bioanalysis, 12. pp. 919-935. ISSN 1757-6199

Xue, J, Domingo-Almenara, X, Fuijas, C, Palermo, A, Rinschen, M, Benton, H P, Isbell, John and Siuzdak, G (2020) Enhanced electrospray in-source fragmentation for higher sensitivity data independent acquisition and autonomous METLIN molecular identification. Analytical Chemistry, 92 (8). pp. 6051-6059. ISSN 0003-27001520-6882

Yang, Haisheng, Büttner, Alexander, Albiol, Laia, Julien, Catherine, Thiele, Tobias, Figge, Christine, Kramer, Ina, Kneissel, Michaela, Duda, Georg N., Checa, Sara and Willie, Bettina M. (2020) Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice. Scientific reports, 10 (1). pp. 22299-22316.

Yang, J, Balog, B, Deng , K, Hanzlicek, B, Rietsch, A, Kuang, M, Hatakeyama, Shinji, Trifilieff, Estelle, Zhu, H and Damaser, MS (2020) Therapeutic potential of muscle growth promoters in a stress urinary incontinence model. American Journal of Physiology-Renal Physiology, 319 (3). F436-F446. ISSN 1931-857X1522-1466

Yi, John , Russo, Melissa, Raja, Shruti, Massey, Janice, Juel, Vern, Shin, Jay, Hobson-Webb, Lisa, Gable, Karissa and Guptill, Jeffrey (2020) Inhibition of the transcription factor ROR-γ reduces pathogenic Th17 cells in acetylcholine receptor antibody positive myasthenia gravis. Experimental Neurology, 325 (March ). pp. 1-8. ISSN 0014-4886

Yokokawa, Fumiaki (2020) Recent progress on phenotype-based discovery of dengue inhibitors. RSC Medicinal Chemistry.

Yuan, Xin, Sipe, Conor W., Suzawa, Miyuki, Bland, Michelle L. and Siegrist, Sarah E. (2020) Dilp-2–mediated PI3-kinase activation coordinates reactivation of quiescent neuroblasts with growth of their glial stem cell niche. PLOS Biology, 18 (5). e3000721. ISSN 1545-7885

Zaidman, Nathan A, Tomilin , Viktor, Damarla, Mahendra, Tidmore, Josephine, Capen , Diane, Brown, Dennis, Pochynyuk, Oleh and Pluznick, Jennifer L (2020) Adhesion-GPCR Gpr116 (ADGRF5) is a Regulator of Urine Acidification and Surface Expression of the Vacuolar-type H+-ATPase in Renal α-Intercalated Cells. Proceedings of the National Academy of Sciences of the United States of America PNAS..

Zhu, Liang, Glick, Jim and Flarakos, Jimmy (2020) Bioanalytical Challenges in Support of Complex Modalities of Antibody-Based Therapeutics. AAPS Journal, 22 (6). pp. 130-135. ISSN 15507416

chaudhury, anwesha, Zhu, Xu, Chu, Lulu, Goliaei, Ardeshir, Kearns, Jeff and Stein, Andrew (2020) Chimeric Antigen Receptor T Cell Therapies: A Review of Cellular Kinetic-Pharmacodynamic Modeling Approaches. Journal of Clinical Pharmacology, 60 (S1). S147-S159. ISSN 15524604

fassl, anne, lachowicz, iga, butter, deborah, Brain, Christopher, Sheng, Qing, Loo, Alice, michowski, wojciech, otto, tobias, abu-remaileh, monther, stepien, piotr, bergholtz, johann, jovanovic, bojana, nowak, karolina, erikson, maria, zhao, jean, sabatini, david, jeselson, rinath, brown, myles, polyak, kornelia and sicinski, piotr (2020) Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Science advances, 6 (25). ISSN 2375-2548

fassl, anne, lachowicz, iga, butter, deborah, Brain, Christopher, Sheng, Qing, Loo, Alice, michowski, wojciech, otto, tobias, abu-remaileh, monther, stepien, piotr, bergholtz, johann, jovanovic, bojana, nowak, karolina, erikson, maria, zhao, jean, sabatini, david, jeselson, rinath, brown, myles, polyak, kornelia and sicinski, piotr (2020) Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Science advances, 6 (25). ISSN 2375-2548

van Groen, Bianca D., Pilla Reddy, Venkatesh, Badee, Justine Marine, Olivares-Morales, Andrés, Johnson, Trevor N., Nicolaï, Johan, Annaert, Pieter, Smith, Anna, de Wildt, Saskia N., Knibbe, Catherijne A. J. and de Zwart, Loeckie (2020) Pediatric pharmacokinetics and dose predictions: a report of a satellite meeting to the 10th Juvenile Toxicity Symposium. Clinical and translational science. ISSN 1752-8062