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Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys.

Jolly, Christopher J. and Lee, Quintin and Padula,, Matthew P. and Pinello, Natalia and O'Rourke, Matthew B. and Williams, Simon and de Souza, William Marciel and Orkin, Joseph and Melin, Amanda and Shaban, Babak and Weninger, Wolfgang and Wong, Justin J.-L. and Crim, Marcus and Monette , Sébastien and Roediger, Ben and Fumagalli, Marcilio Jorge and Song, Renhua and Brenner, Ori and Pimanda, John E. (2020) Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys, 16 (1). ISSN 1553-7366

Abstract

Mouse kidney parvovirus (MKPV) is a member of the provisional genus Chapparvovirus that causes renal disease in immune-compromised mice, with a disease course reminiscent of polyomavirus-associated nephropathy in immune-suppressed kidney transplant patients. Here we map four major MKPV transcripts, created by alternative splicing, to a common initiator region, and use mass spectrometry to identify "p10" and "p15" as novel chapparvovirus accessory proteins produced in MKPV-infected kidneys. p15 and the splicing-dependent putative accessory protein NS2 are conserved in all near-complete amniote chapparvovirus genomes currently available (from mammals, birds and a reptile). In contrast, p10 may be encoded only by viruses with >60% amino acid identity to MKPV. We show that MKPV is kidney-tropic and that the bat chapparvovirus DrPV-1 and a non-human primate chapparvovirus, CKPV, are also found in the kidneys of their hosts. We propose, therefore, that many mammal chapparvoviruses are likely to be nephrotropic.

Item Type: Article
Keywords: Mouse kidney parvovirus
Date Deposited: 17 Mar 2020 00:45
Last Modified: 17 Mar 2020 00:45
URI: https://oak.novartis.com/id/eprint/40619

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