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Simple synthesis of amides via their acid chloride in aqueous TPGS-750-M

Shi, Min, Ye, Ning, Chen, Wei, Wang, Hui, Cheung, Chi Ming, Parmentier, Michael, Gallou, Fabrice and Wu, Bin (2020) Simple synthesis of amides via their acid chloride in aqueous TPGS-750-M. Organic Process Research & Development, 24 (8). pp. 1543-1548.

Abstract

The technology of surfactant chemistry is employed for amide bond construction via the reaction of acyl chlorides
with amines in 2 wt % TPGS-750-M aqueous solution. Specifically, this highly efficient method enables a chromatography-free scalable process and recycling of the TPGS-750-M solution.

Item Type: Article
Date Deposited: 02 Apr 2024 00:46
Last Modified: 02 Apr 2024 00:46
URI: https://oak.novartis.com/id/eprint/42522

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