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Number of items: 273.


Abdollahi-Roodsaz, Shahla, van de Loo, Fons, Koenders, Marije, Helsen, Monique, Walgreen, Brigitte, van den Bersselaar, Leduine, Arntz, Onno, Takahashi, Nozomi, Joosten, Leo and van den Berg, Wim (2011) Destructive Role of Myeloid Differentiation Factor 88 and Protective Role of TIR-Containing Adaptor Inducing Interferon β in IL-17-Dependent Arthritis. Arthritis & Rheumatism. ISSN 0004-3591

Abraham, Jinu, Prajapati, Suresh, Nishijo, Koichi, Schaffer, Beverly S, Taniguchi, Eri, Kilcoyne, Aoife, McCleish, Amanda T, Zarzabal, Lee Ann, Michalek, Joel E, Nelon, Laura D, Giles, Francis G, Efstratiadis, Argiris, LeGallo, Robin D, Nowak, Brent M, Rubin, Brian P, Keller, Charles and Jeay, Sebastien (2011) Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. Molecular Cancer Therapeutics, 10 (4). pp. 697-707. ISSN 1535-7163

Agarwal, Abhiruchi, Boettcher, Andreas, Kneuer, Rainer, Sari-Sarraf, Farid, Donovan, Adriana, Woelcke, Julian and Krucker, Thomas (2011) Quantitative and functional assessment of treatment strategies for acute pancreatitis with optical fluorescence imaging in rats. Plos, 8 (2). e55959. ISSN 1932-6203

Allyson, Julie, Dontigny, Eve, Cyr, Michel, Massicotte, Guy and Auberson, Yves (2011) Blockade of NR2A-containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices. Neural Plasticity. p. 340168. ISSN 0792-8483

Anders, Lars, Ke, Nan, Hydbring, Per, Zhai, Huili, Choi, Yoon, Braun, Pascal, Vidal, Marc and Sicinski, Peter (2011) a systematic substrate screen links CDK4/6 to senescence suppression through FOXM1. Cancer Cell, 20 (5). pp. 620-634. ISSN 1535-6108

Anemona, Alessandra, Basile, Venere, Hilbert, Anne-Katrin, Rondini, Simona, Micoli, Francesca, Marchetti, Elisa, Di Cioccio, Vito, Saul, Allan, Martin, Laura, Podda, Audino, Khan, Rana M. Qasim, Van Damme, Pierre, Kafeja, Froukje and De Coster, Ilse (2011) Safety, immunogenicity and dose ranging of a new Vi-CRM197 conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. PLoS ONE, 6 (9). e2539. ISSN 1932-6203

Argikar, Upendra, Liang, Guiqing, Bushee, Jennifer, Hosagrahara, Vinayak and Lee, Wendy (2011) Evaluation of pharmaceutical excipients as cosolvents in 4-methyl umbelliferone glucuronidation in human liver microsomes: An application for compounds with low solubility. Drug Metabolism and Pharmacokinetics.

Argikar, Upendra, Mangold, James and Harriman, Shawn (2011) Strategies and Chemical Design Approaches to Reduce the Potential for Formation of Reactive Metabolic Species. Current Topics in Medicinal Chemistry.

Arias, Hugo R, Gu, Ruo-Xu, Feuerbach, Dominik, Guo, Bao-Bao, Ye, Young and Wei, Dong-Qing (2011) Novel Positive Allosteric Modulators of the Human α7 Nicotinic Acetylcholine Receptor. Biochemistry.

Attias-Geva, Zohar, Bentov, Itay, Fishman, Ami, Werner, Haim, Bruchim, Ilan and Jeay, Sebastien (2011) Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometroid and serous papillary endometrial cancer cell lines. Gynecologic Oncology. ISSN 0090-8258


Baettig, Urs, Akhlaq, Mohammed, Beer, David, Charlton, Steven, Dunstan, Andrew, Bradley, Michelle, Gedeck, Peter, Owen, Charles, Nicklin, Paul, Rosethorne, Elizabeth and Bhalay, Gurdip (2011) Design and synthesis of a library of chemokine antagonists. Bioorganic & Medicinal Chemistry Letters, 21 (21). pp. 6249-6252. ISSN 0960-894X

Baldanzi, Gianluca, Rainero, Elena, Filigheddu, Nicoletta, Mesturini, Riccardo, Song, Shuping, Patrussi, Laura, Zhong, Xiao-Ping, van Blitterswijk, Wim J., Sinigaglia, Fabiola, Nichols, Kim E., Rubio, Ignacio, Pighini, Andrea, Schweighoffer, Tamas, Parolini, Ornella, Graziani, Andrea, Bettio, Valentina, Traini, Sara, Chianale, Federica and Porporato, Paolo E. (2011) SAP-Mediated Inhibition of Diacylglycerol Kinase alpha Regulates TCR-Induced Diacylglycerol Signaling. Journal of Immunology, 187 (11). pp. 5941-5951. ISSN 0022-1767

Baldo, Barbara, Weiss, Andreas, Parker, Christian, Bibel, Miriam, Paganetti, Paolo and Kaupmann, Klemens (2011) A screen for enhancers of clearance identifies huntingtin as an heat shock protein 90 (Hsp90) client protein. Journal of Biological Chemistry, http:/. ISSN 0021-9258

Balibar, Carl, Hollis-Symynkywicz, Micah and Tao, Jianshi (2011) Pantethine Rescues Phosphopantothenoylcysteine Synthetase and Phosphopantothenoylcysteine Decarboxylase Deficiency in Escherichia coli but Not in Pseudomonas aeruginosa. Journal of Bacteriology, 193 (13). pp. 3304-3312. ISSN 0021-9193

Baltus, Christine, Spencer, John, Clegg, William, Press, Neil and Harrington, Ross (2011) Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings. Tetrahedron Letters, 52 (31). pp. 3963-3968. ISSN 0040-4039

Bassat, Quique, Gonzalez, Raquel, Machevo, Sonia, Nahum, Alain, Lyimo, John, Maiga, Hamma, Martensson, Andreas, Bashraheil, Mahfudh, Ouma, Peter, Ubben, David, Walter, Verena, Nwaiwu, Obiyo, Kipkeu, Chemtai, Lefevre, Gilbert, Ogutu, Bernhards and Menendez, Clara (2011) Similar efficacy and safety of artemether-lumefantrine (Coartem(R)) in African infants and children with uncomplicated falciparum malaria across different body weight ranges. Malaria journal, 10 (1). p. 369. ISSN 1475-2875

Bello, Claudia, Dal Bello, Giovanna, Grossi, Francesco, Patrone, Franco, Ballestrero, Alberto, Dupuis, Marc, Sordat, Bernard, Nencioni, Alessio, Zimmermann, Kaspar, Loretan, Jacqueline, Wartmann, Markus, Vogel, Pierre, Cea, Michele, Motta, Giulia, Moran, Eva, Aubry, Dominique, Nahimara, Aimable, Duchosal, Michel A., Fruscione, Floriana and Pronzato, Paolo (2011) Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. BIOORGANIC & MEDICINAL CHEMISTRY, 19 (24). pp. 7720-7727. ISSN 0968-0896

Benoit, Roger and Auer, Manfred (2011) A direct way of redox sensing. RNAbiology, 8 (1). pp. 1-6. ISSN 1547-6286

Bielen, Aleksandra, Perryman, Lara, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Martins, Vanessa, Jury, Alexa, Popov, Sergey, Jeay, Sebastien, Raynaud, Florence, Hofmann, Francesco, Hargrave, Darren, Eccles, Sue and Jones, Chris (2011) Enhanced efficacy of IGF1R inhibition in paediatric glioblastoma by combinatorial targeting of PDGFRa/b. Molecular Cancer Therapeutics, 10 (8). pp. 1407-1418. ISSN 1535-7163

Bifani, Juan Pablo, Lefèvre, Philippe, Wang, Xiao-Ming, Karine, Soetaert, Rens, Céline, De Bruyn, Jacqueline, Lanéelle, Marie-Antoinette, Houyoux, Nicolas, Laval, Françoise, Lemassu, Anne, Wattiez, Ruddy, Daffé, Mamadou and Fontaine, Véronique (2011) Cpn60.1/GroEL-1/Hsp60-1, a New Potential Antimycobacterial Drug Target Involved in Antibiotics Resistance. Microbiology, 157 (4). pp. 1205-1219. ISSN 1608-3237; 0026-2617

Block, Stan L, Yogev, Ram, Waldmeier, Felix and Hamed, Kamal (2011) Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis. The Pediatric infectious disease journal, 30 (6). pp. 525-528. ISSN 1532-0987

Bonavia, Aurelio, Franti, Michael, Keaney, Erin, Kuhen, Kelli, Seepersaud, Mohindra, Radetich, Branko, Shao, Jian, Honda, Ayako, Dewhurst, Janetta, Balabanis, Kara, Monroe, James, Wolff, Karen, Osborne, Colin, Bourque, Leanne, Hoffmaster, Keith, Amin, Jakal, Markovits, Judit, Broome, Michelle, Skuba, Elizabeth, Cornella-Taracido, Ivan, Joberty, Gerard, Bouwmeester, Antonius, Hamann, Lawrence, Tallarico, John, Tommasi, Ruben, Compton, Teresa and Bushell, Simon (2011) Identification of Pyrimidine Biosynthesis Inhibitors with Broad Spectrum Antiviral Activity and Assessment of the Druggability of this Pathway for Efficacy against RSV. Proceedings of the National Accademy of Sciences USA, 108 (17). pp. 6739-6744. ISSN 0027-8424

Bornancin, Frederic (2011) Ceramide kinase: The first decade. Cellular Signalling, 23 (6). pp. 999-1008. ISSN 0898-6568

Boulton, Craig, Meiser, Karin, David, Olivier J and Schmouder, Robert (2011) Pharmacodynamic Effects of Steady-State Fingolimod on Antibody Response in Healthy Volunteers: A 4-Week, Randomized, Placebo-Controlled, Parallel-Group, Multiple-Dose Study. Journal of clinical pharmacology. ISSN 0091-2700

Brennan, Orlaith, Kennedy, OD, Lee, TC, Rackard, SM, O'Brien, FJ, McNamara, LM and Gasser, Juerg Andreas (2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Journal of Biomechanics or Bone, 44 (3). pp. 386-390. ISSN 0021-9290

Brocklehurst, Cara, Laumen, Kurt, La Vecchia, Luigi, Shaw, Duncan and Voegtle, Markus (2011) Diasteroisomeric Salt Formation and Enzyme-Catalyzed Kinetic Resolution as Complimentary Methods for the Chiral Separation of cis/trans-Enantiomers of 3-Aminocyclohexanol. Organic Process Research and Development, 15 (1). pp. 294-300. ISSN 1083-6160

Brocklehurst, Cara, Lehmann, Hansjoerg and La Vecchia, Luigi (2011) Nitration Chemistry in Continuous Flow using Fuming Nitric acid in a Commercially Available Flow Reactor. Organic Process Research and Development. ISSN 1083-6160

Burger, Matthew, Pecchi, Sabina, Wagman, Allan, Ni, Zhijie, Knapp, Mark, Hendrickson, Thomas, Atallah, Gordana, Pfister, Keith, Zhang, Yanchen, Bartulis, Sarah, Ng, Simon, Verhagen, Joelle, Huh, Kay, Iwanowicz, Edwin, Menezes, Daniel, Merritt, Hanne, Lee, Isabelle, Weismann, Marion, Kaufman, Susan, Crawford, Kenneth, Chin, Michael, Bussiere, Dirksen, Shoemaker, Kevin, Verhagen, Joelle, Frazier, Kelly, Xin, Xiaohua, Haznedar, Joshua, Zaror, Isabel, Maira, Sauveur-Michel and Voliva, Charles (2011) Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Medicinal Chemistry Letters, 2 (10). pp. 774-779. ISSN 1948-5875

Burton, Victoria, Holmes, Alan, Ciuclan, Loredana, Robinson, Alexander, Roger, Jan, Jarai, Gabor, Pearce, Andrew and Budd, David (2011) Attenuation of leukocyte recruitment via inhibition of CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II. Blood, 118 (17). pp. 4750-4758. ISSN 0006-4971

Bushee, Jennifer and Argikar, Upendra (2011) An experimental approach to enhance parent ion fragmentation for metabolite identification studies: Application of dual collision cells in an orbital trap. Rapid Communications in Mass Spectrometry, 25 (10). pp. 1356-1362. ISSN 1097-0231

beeh, kai, wagner, frank, Khindri, Sanjeev and Drollmann, Anton Franz (2011) Effect of indacaterol on dynamic lung hyperinflation and breathlessness in patients with COPD. COPD, 8 (5). pp. 340-345. ISSN 1541-2555


Cao, Xueying, Erdemli, Gul, Urban, Laszlo, Lee, Yan, Golden, Andrew, Holmqvist, Mats, Li, Nianzhen, Chen, Quin, Nevill, Tanner, Johnson, Juliette and Ionescu-Zanetti, Christian (2011) IonFlux, a Microfluidic Patch Clamp System Evaluated with hERG Channel Physiology and Pharmacology. Assay and Drug Development Technologies.

Cao, Yiqun and Landrum, Gregory (2011) Inchi wrappers for the RDKit. RDKit: open source cheminformatics.

Carcache, David, Vranesic, Ivan-Toma, Blanz, Joachim, Desrayaud, Sandrine, Fendt, Markus and Glatthar, Ralf (2011) Benzimidazoles as potent and orally active mGlu5 receptor antagonists with an improved PK profile. ACS Medicinal Chemistry Letters, 2 (1). pp. 58-62. ISSN 1948-5875

Caughlan, Ruth, Jones, Adriana, Delucia, Angela, Woods, Angela, Xie, Lili, Ma, Bing, Barnes, Whitney, Walker, John, Sprague, Elizabeth, Yang, Xia and Dean, Charles (2011) Mechanisms decreasing in vitro susceptibility to the LpxC inhibitor CHIR-090 in the Gram negative pathogen Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804

Chapelat, Julien, Berst, Frederic, Marzinzik, Andreas, Moebitz, Henrik, Drueckes, Peter, Fabbro, Doriano, Trappe, Joerg and Seebach, Dieter (2011) Substrate profiling of IGF-1R and InsR: Identification of a potent pentamer substrate. Bioorganic and Medicinal Chemistry Letters.

Chen, Jian, Shen, Qiong, Labow, Mark and Gaither, L Alex (2011) Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer research, 71 (12). pp. 4280-4291. ISSN 1538-7445

Chen, Xiao-Hui, Zhao, Hongjuan, Hatsis, Panagiotis and Amin, Jakal (2011) Investigation of Dried Blood Spot Card-Induced Interferences in Liquid Chromatography/Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085

Chiong, Edmund, Lee, I-Ling, Dadbin, Ali, Sabichi, Anita L, Harris, Loleta, Urbauer, Diana, McConkey, David, Grossman, H Barton and Imark, Esther (2011) Effects of mTOR Inhibitor Everolimus (RAD0011) On Bladder Cancer Cells. Clinical Cancer Research, 17 (9). pp. 2863-2873. ISSN 1078-0432

Christen, Selina, Holdener, Martin, Beerli, Christian, Thoma, Gebhard, Bayer, Monika, Pfeilschifter, Josef, Hintermann, Edith, Zerwes, Hans-Guenter and Christen, Urs (2011) Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model. Clinical and experimental immunology, 165 (3). pp. 318-328. ISSN 0009-9104

Ciuclan, Loredana, Bonneau, Olivier, Hussey, Martin, Duggan, Nicholas, Holmes, Alan, Good, Robert, Stringer, Rowan, Jones, Peter, Morrell, Nicholas W., Jarai, Gabor, Walker, Christoph, Westwick, John and Thomas, Matthew (2011) A Novel Murine Model of Severe Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X

Coan, Kristin, Ottl, Johannes and Klumpp, Martin (2011) Non-stoichiometric Inhibition in High-Throughput Screening. Expert Opinion on Drug Discovery.

Collingwood, Steve, Ratcliffe, Andrew and Allen, Jack (2011) Kinase Inhibitors from Early Research to Clinic. Drugs of the Future, 36 (3). pp. 249-263. ISSN 0377-8282

Commerford, Susan, He, Xiaohui, Liu, Hong, Seidel, Martin, Jaton, Anne-Lise, Gromada, Jesper, Teixeira, Sandra, Gerber, Sarah, Chen, Alice, Dardik, Beatriz, Chaperon, Frederique, Schwartzkopf, Chad, Nguyen-Tran, Van, Hollenbeck, Thomas and Mcnamara, Peter (2011) Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 384 (6). pp. 565-581. ISSN 0028-1298

Connolly, Michael K., Ayo, Diego, Hackman, Michael, Malhotra, Ashim, Bedrosian, Andrea S., Ibrahim, Junaid, Cieza-Rubio, Napoleon E., Nguyen, Andrew H., Henning, Justin R., Pachter, H. Leon and Miller, George (2011) Dendritic Cell Depletion Exacerbates Acetaminophen Hepatotoxicity. Hepat0logy, 54 (3). pp. 959-968. ISSN 0270-9139

Cottens, Sylvain and Cottens, Sylvain (2011) Perspective on Future Medicinal Chemistry. Futurescience, 3 (15). pp. 1863-1872. ISSN 1759-6180

Craig, Ian (2011) PocketAnalyzerPCA. Project is software (source code) to be "published" as download from a website.

Craig, Ian, Pfleger, Christopher, Gohlke, Holger, Essex, Jonathan and Spiegel, Katrin (2011) Pocket-space maps to identify novel binding-site conformations in proteins. Journal of Chemical Information and Modeling.

Curtis, Allison, Calabro, Katherine, Galarneau, Jean-Rene, Bigio, Irving and Krucker, Thomas (2011) Temporal Variations in Skin Pigmentation of C57Bl/6 Mice Affect Optical Bioluminescence Quantitation. Molecular Imaging and Biology, 13 (6). pp. 1114-1123. ISSN 1536-1632


Dalvit, Claudio and Vulpetti, Anna (2011) Fluorine-Protein Interactions and 19F NMR Isotropic Chemical Shift: An Empirical Correlation. ChemMedChem, 6 (1). pp. 104-114. ISSN 1860-7179

Delucia, Angela, Six, David, Caughlan, Ruth, Gee, Patricia, Hunt, Ian, Lam, Joseph and Dean, Charles (2011) Lipopolysaccharide inner-core phosphates are required for complete LPS synthesis and transport to the outer membrane in Pseudomonas aeruginosa PAO1. mBio, 2 (4). pii: e00142. ISSN 2150-7511

Deng, Gejing, Lee, Lac, Chenail, Gregg, Palestrant, Deborah, Whitehead, Lewis, Sachdeva, Meena, Dzink-Fox, Joann, Lamarche, Matthew and Leeds, Jennifer (2011) In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy, 55 (11). pp. 5277-5283. ISSN 0066-4804

Deng, Gejing, Lee, Lac, Chenail, Gregg, Palestrant, Deborah, Whitehead, Lewis, Sachdeva, Meena, Lamarche, Matthew and Leeds, Jennifer (2011) In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy, 55 (11). pp. 5277-5283. ISSN 0066-4804

Dertinger, Stephen D., Phonethepswath, Souk, Weller, Pamela, Nicolette, John, Murray, Joel, Sonders, Paul, Vohr, Hans-Werner, Shi, Jing, Krsmanovic, Ljubica, Gleason, Carol, Custer, Laura, Henwood, Andrew, Sweder, Kevin, Stankowski Jr, Leon F., Roberts, Daniel J., Giddings, Amanda, Kenny, Julia, Lynch, Anthony M., Defrain, Céline, Nesslany, Fabrice, van der Leede, Bas-jan M., Van Doninck, Terry, Schuermans, Ann, Tanaka, Kentaro, Hiwata, Yoshie, Tajima, Osamu, Eleanor, Wilde, Elhajouji, Azeddine, Gunther, William C., Thiffeault, Catherine J., Shutsky, Thomas J., Fiedler, Ronald D., Kimoto, Takafumi, Bhalli, Javed A., Heflich, Robert H. and MacGregor, James T. (2011) International Pig-a gene mutation assay trial: Evaluation of transferability across fourteen laboratories. Environmental and Molecular Mutagenesis, 52 (9). pp. 690-698. ISSN 0893-6692

Deschwanden, Alexandra, Karolewicz, Beata, Feyissa, Anteneh, M, Treyer, Valerie, Ametamey, Simon, M, Johayem, Annas, Burger, Cyrill, Auberson, Yves, Sovago, Judit, Stockmeier, Craig, A, Buck, Alfred and Hasler, Gregor (2011) Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 Positron Emission Tomography and Postmortem Study. American Journal of Psychiatry, 168 (7). pp. 727-734. ISSN 0002-953X

Didiot, Marie-Cecile, Serafini, Sergio, Pfeifer, Martin, King, Frederick and Parker, Christian (2011) Multiplexed Reporter Gene Assays: Monitoring the cell viability and the compound kinetics on luciferase activity. Journal of Biomolecular Screening, 16 (7). pp. 786-793. ISSN 1087-0571

Djimdé, Abdoulaye A, Tekete, Mamadou, Abdulla, Salim, Lyimo, John, Bassat, Quique, Mandomando, Inacio, Lefèvre, Gilbert and Borrmann, Steffen (2011) Pharmacokinetic and pharmacodynamic characteristics of a new pediatric formulation of artemether-lumefantrine in African children with uncomplicated Plasmodium falciparum malaria. Antimicrobial agents and chemotherapy, 55 (9). pp. 3994-3999. ISSN 1098-6596

Doghman, Mabrouka, Axelson, Magnus and Lalli, Enzo (2011) Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation. American journal of cancer research, 1 (3). pp. 356-361. ISSN 2156-6976

Drollmann, Anton Franz, Crane, Helen, Di Scala, Lilla and Fogarty, Charles (2011) Bronchodilatory effects of NVA237, a once daily long-acting muscarinic antagonist, in COPD patients. Respiratory Medicine, 105 (3). pp. 337-342. ISSN 0954-6111

Duttaroy, Alokesh, Voelker, Frank, Merriam, Kimberly, Zhang, Xia, Ren, Xianglin, Subramanian, Kala, Hughes, Thomas and Burkey, Bryan (2011) The DPP-4 Inhibitor Vildagliptin Increases Pancreatic Beta Cell Mass In Neonatal Rats. European Journal of Pharmacology, 650 (2-3). pp. 703-707. ISSN 0014-2999

de backer, jan, de backer, wilhelm, vos, w. g., vinchurkar, s., claes, r., wulfrank, p., parizel, p., germonpre, p. and Drollmann, Anton Franz (2011) Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology, 257 (3). pp. 854-862. ISSN 0033-8419


Emotte, Corinne, Deglave, Fanny, Heudi, Olivier, Picard, Franck and Kretz, Olivier (2011) Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with tandem liquid chromatography mass spectrometry. Journal of Pharmaceutical and biomedical analysis, 58. pp. 102-112. ISSN 0731-7085

Ettenger, R, Schmouder, R, Kovarik, J M, Bastien, M C and Hoyer, P F (2011) Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose fingolimod (FTY720) in adolescents with stable renal transplants. Pediatric transplantation, 15 (4). pp. 406-413. ISSN 1399-3046

Eucker, Tyson P. and Konkel, Michael E. (2011) The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling. Cellular Microbiology. ISSN 1462-5814


Faller, Bernard, Berellini, Giuliano, Ertl, Peter, Ottaviani, Giorgio and Collis, Alan (2011) Can History Foretell Future ? Drug Discovery Today, 16 (21-22). pp. 976-984. ISSN 1359-6446

Ferrand, Sandrine, Tao, Jianshi, Shen, Xiaoyu, Mcguire, Dorothy, Schmid, Andres, Glickman, Fraser and Schopfer, Ulrich (2011) Screening for Mevalonate Pathway Inhibitors using sensitized bacteria strains. Journal of Biomolecular Screening, 16 (6). pp. 637-646. ISSN 1087-0571

Ferreira, I.L., Bajouco, L.M., Oliveira, C.R., Auberson, Yves, Rego, A.C. and Mota, S.I. (2011) Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-D-aspartate receptors in cortical cultures. Cell Calcium. ISSN 0143-4160

Fetar, Hossam, Christie, Gilmour, Rachel, Klinoski, Daigle, Denis, Dean, Charles and Poole, Keith (2011) The mexEF-oprN multidrug efflux operon of P. aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol. Antimicrobial Agents and Chemotherapy, 55 (2). pp. 508-514. ISSN 0066-4804

Fiorina, Paolo, Pietramaggiori, Giorgio, Scherer, Saja, Jurewicz, Mollie, Mathews, Jasmine, Vergani, Andrea, Thoma, Gebhard, Orsenigo, Elena, Staudacher, Carlo, La Rosa, Stefano, Capella, Carlo, Carothers, Adelaide, Zerwes, Hans-Guenter, Luzi, Livio, Abdi, Reza and Orgill, Dennis (2011) The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Cell Transplantation, 19 (11). pp. 1369-1386. ISSN 0963-6897

Fonseca, Sonya, Gromada, Jesper and Urano, Fumihiko (2011) ER stress: The link between pancreatic beta cell dysfuntion and death. Trends in Endocrinology and Metabolism.

Fonseca, Sonya, Urano, Fumihiko, Burcin, Mark and Gromada, Jesper (2011) Stress HypERactivation in the Beta Cell. Islets, 2 (1). pp. 1-9. ISSN 1938-2014

Forbes, Ben, Asgharian, Bahman, Dailey, Lea Ann, Ferguson, Douglas, Gerde, Per, Gumbleton, Mark, Gustavsson, Lena, Hardy, Colin, Hassall, David, Jones, Rhys, Lock, Ruth, Maas, Janet, McGovern, Tim, Pitcairn, Gary R, Somers, Graham and Wolff, Ron K (2011) Challenges in inhaled product development and opportunities for open innovation. Advanced drug delivery reviews, 63 (1-2). pp. 69-87. ISSN 1872-8294

Freeman, Mark, Hardaker, Liz, Banner, Kathy, Poll, Christopher, Coulthard, Alex and Dewhurst, Jennifer (2011) Effects of a combination of subchronic tobacco smoke exposure and lipopolysaccharide administration on pulmonary inflammation in the mouse. British Journal of Pharmacology, 8 (1). 132P.

Fu, Qiang, Berbee, Maaike, Wang, Wenze, Boerma, Marjan, Schmid, Herbert and Hauer-Jensen, Martin (2011) Preclinical evaluation of SOM230 as a radiation mitigator in a mouse model: post-exposure time window and mechanisms of action. Radiation Research, 175 (6). pp. 728-735. ISSN 0033-7587

Fu, Yunlin, Li, Wenkui, Smith, Harold and Tse, Francis (2011) A practical approach to address the issue of analyte nonspecific binding in quantitative analysis of untreated and transferred urine samples. Bioanalysis, 3 (9). pp. 967-972. ISSN 1757-6180


Garofalo, Cecilia, Manara, Maria Christina, Nicoletti, Giordano, Marino, Maria Theresa, Nanni, Patrizia, Lollini, Pier-Luigi, Prandini, Giuseppe, Lopez-Guerrero, José Antonio, Schaefer, Karl-Ludwig, Belfiore, Antonino, Picci, Piero and Scotlandi, Katia (2011) Efficacy of and resistance to anti‐IGF‐1R therapies in sarcomas is dependent on Insulin Receptor signaling. Oncogene, 30 (24). pp. 2730-2740. ISSN 0950-9232

Garofolo, Fabio, Rocci Jr., Mario, Dumont, Isabelle, Martinez, Suzanne, Lowes, Steve, Woolf, Eric, van Amsterdam, Peter, Bansal, Surendra, Gomes Barra, Airadna, Bauer, Ronald, Booth, Brian, Carrasco-Triguero, Montserrat, DeSilva, Binodh, Dunn, John, Gallicano, Keith, Gouty, Dominique, Ho, Stacy, Hucker, Richard, Jemal, Mohammed, Katori, Noriko, Le Blaye, Olivier, Lee, Jean, Li, Wenkui, Michael, Steve, Nehls, Corey, Nicholson, Robert, Ormsby, Eric, Tang, Daniel, Viswanathan, C, Wiener, Russel and Young, Graeme (2011) 2011 White Paper on Recent Issues in Bioanalysis & Regulatory Findings from Audits and Inspections. Bioanalysis, 3 (18). pp. 2081-2096. ISSN 1757-6180

Giovannoni, Jerome and Peltier, John (2011) Implementation of high-throughput quality control processes within Compound Management. European Pharmaceutical Review, 16 (4). pp. 49-52.

Glick, Meir and Jacoby, Edgar (2011) The Role of Computational Methods in the Identification of Bioactive Compounds. Current Opinion in Chemical Biology. ISSN 1367-5931

Glowienke, Susanne (2011) Practical experience of in silico assessment for genotoxic impurities. Regul Pharm Tox.

Gomez-Mancilla, Baltazar (2011) Challenges and opportunities of criteria alignment regarding Neurodegenerative Diseases. World Health Summit.

Gossert, Alvar, Hinniger, Alexandra, Gutmann, Sascha, Jahnke, Wolfgang, Strauss, Andre and Fernandez, Cesar (2011) A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility. Journal of Biomolecular NMR.

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Morawska, Marta Magdalena, Buchi, Melanie and Fendt, Markus (2011) Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors. Behavioural Brain Research, 222 (2). pp. 397-400. ISSN 0166-4328

Moussaoui, Saliha (2011) Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease. The Journal of Clinical Investigation, 121 (8). pp. 3306-3319. ISSN 0021-9738

Moussaoui, Saliha (2011) Butyrylcholinesterase inhibition (MoA of Exelon) ameliorates cognitive dysfunction induced by amyloid-ß peptide in mice. Behavioural Brain Research, 225 (1). pp. 222-229. ISSN 0166-4328


Nigsch, Florian, Lounkine, Eugen, Mccarren, Patrick, Cornett, Allen, Glick, Meir, Azzaoui, Kamal, Urban, Laszlo, Marc, Philippe, Mueller, Arne, Hahne, Florian, Heard, David and Jenkins, Jeremy (2011) Computational methods for early predictive safety assessment from biological and chemical data. Expert Opinion on Drug Metabolism and Toxicology, 7 (12). pp. 1497-1511. ISSN 1742-5255

Nishiguchi, Gisele, Atallah, Gordana, Bellamacina, Cornelia, Burger, Matthew, Feucht, Paul, Garcia, Pablo, Han, Wooseok, Klivansky, Liana, Ding, Yu and Lindvall, Mika (2011) Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2 and Pim-3 protein kinases. Bioorganic and Medicinal Chemistry Letters, 21 (21). pp. 6366-6369.

Nyfeler, Beat, Bergman, Phillip, Triantafellow, Ellen, Wilson, Christopher, Zhu, Yanyi, Radetich, Branko, Finan, Peter, Klionsky, Daniel and Murphy, Leon (2011) Relieving autophagy and 4EBP1 from rapamycin resistance. Molecular and Cellular Biology, 31 (14). pp. 2867-2876. ISSN 0270-7306


O'Reilly, Terence, Mcsheehy, Paul M.J., Wartmann, Markus, Lassota, Peter, Brandt, Ralf and Lane, Heidi (2011) Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic anti-tumor agents using human tumor models in vitro and in vivo. Anticancer Drugs, 22 (1). pp. 58-78. ISSN 0959-4973

Orain, David, Beerli, Christian, Billich, Andreas, Streiff, Markus, Bigaud, Marc, Auberson, Yves and Briard, Emmanuelle (2011) BZM055, a SPECT tracer candidate for studying FTY720 brain distribution and myelin imaging. ChemMedChem, 6 (4). pp. 667-677.


Pascoe, S, Reynolds, Christine, Pleskow, W, Perry, Sheryl, Hmissi, Abdel, Kaiser, Guenther and Brookman, Laurence (2011) Safety, tolerability and pharmacokinetics of single escalating doses of indacaterol, a once-daily beta2-agonist bronchodilator, in subjects with COPD. International Journal of Clinical Pharmacology and Therapeutics, 49 (2). pp. 153-161. ISSN 0946-1965

Pecchi, Sabina, Renhowe, Paul, Taylor, Clarke, Kaufman, Susan, Merritt, Hanne, Wiesmann, Marion, Shoemaker, Kevin, Knapp, Mark, Hendrickson, Thomas, Fantl, Wendy and Voliva, Charles (2011) Identification and Structure-Activity Relationship of 2-Morpholino 6-(3-Hydroxyphenyl) Pyrimidines, a Class of Potent and Selective PI3-Kinase Inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (23). pp. 6895-6898. ISSN 0960-894X

Petrone, Paula, Whitehead, Lewis, Dewhurst, Janetta, Tommasi, Ruben and Pomerantz, Andrea (2011) Atomic-Scale Characterization of Conformational Changes in the PreQ1 Riboswitch Aptamer upon Ligand Binding. Journal of Molecular Graphics and Modeling. ISSN 1093-3296

Peukert, Stefan, Nunez, Jill, He, Feng, Dai, Miao, Yusuff, Naeem, Dipesa, Alan, Miller-Moslin, Karen, Karki, Rajesh, Lagu, Bharat, Harwell, Chris, Zhang, Yalin, Bauer, Daniel, Kelleher Iii, Joseph and Egan, William (2011) A method for estimating the risk of drug-induced phototoxicity and its application to Smoothened inhibitors. MedChemComm, 2. pp. 973-976. ISSN 2040-2511

Pilote, Natalie, Endacott, John, Miller, Kimberly, Peterson, Gretchen and Poolman, Robert (2011) Creation and implementation of a customized patent information training program for chemists in a global company. World Patent Information, 33 (4). pp. 340-344. ISSN 01722190

Pirard, Bernard (2011) The quest for novel chemical matter. Expert Opinion in Drug Discovery, 6 (3). pp. 226-231. ISSN 1746-0441

Poellinger, Bernadette (2011) IL-17 producing T cells in mouse models of Multiple Sclerosis and Rheumatoid Arthritis. IL-17 producing T cells in mouse models of Multiple Sclerosis and Rheumatoid Arthritis.

Poellinger, Bernadette, Junt, Tobias, Metzler, Barbara, Ulrich, Walker, Alan, Tyndall, Allard, Cyril, Bay, Serkan, Keller, Roland, Raulf, Friedrich, Patel, Dhavalkumar and Littlewood-Evans, Amanda (2011) Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans. Journal of Immunology, 186 (4). pp. 2602-2612. ISSN 0022-1767

Pritz, Stephan, Doering, Klaus, Woelcke, Julian and Hassiepen, Ulrich (2011) Fluorescence Lifetime Assays – Current Advances and Applications in Drug Discovery. Expert Opinion on Drug Discovery, 6 (6). pp. 663-670. ISSN 1746-045X

Pritz, Stephan, Meder, Gabriele, Doering, Klaus, Drueckes, Peter, Woelcke, Julian, Mayr, Lorenz and Hassiepen, Ulrich (2011) A Fluorescence Lifetime-Based Assay for Abelson Kinase. JOURNAL OF BIOMOLECULAR SCREENING, 16 (1). pp. 65-72. ISSN 1087-0571


Raghunathan, Dhaarini, Wells, Timothy J, Morris, Faye C, Shaw, Robert K, Bobat, Saeeda, Peters, Sarah E, Paterson, Gavin K, Jensen, Karina Tveen, Leyton, Denisse L, Blair, Jessica M A, Browning, Douglas F, Pravin, John, Flores-Langarica, Adriana, Hitchcock, Jessica R, Moraes, Claudia T P, Piazza, Roxane M F, Maskell, Duncan J, Webber, Mark A, May, Robin C, Maclennan, Calman A, Piddock, Laura J, Cunningham, Adam F and Henderson, Ian R (2011) SadA, a Trimeric Autotransporter from Salmonella enterica Serovar Typhimurium, Can Promote Biofilm Formation and Provides Limited Protection against Infection. Infection and immunity, 79 (11). pp. 4342-4352. ISSN 0019-9567

Rakhilin, Sergey, Turner, Gordon, Katz, Mark, Warden, Robert, Irelan, Jeffrey, Abassi, Yama and Glass, David (2011) Electrical Impedance as a Novel Biomarker of Myotube Atrophy and Hypertrophy. Journal of Biomolecular Screening. ISSN 1087-0571

Ramurthy, Savithri, Costales, Abran, Aikawa, Mina, Amiri, Payman, Jansen, Johanna, Lin, Song, Ma, Sylvia, Renhowe, Paul, Shafer, Cynthia, Subramanian, Sharadha, Sung, L and Verhagen, J (2011) Design and Synthesis of 5,6-fused Heterocyclic Amides as Raf Kinase Inhibitors. Bioorganic Medicinal Chemistry Letters, 21 (11). pp. 3286-3289. ISSN 0960-894X

Rebello, Sam, Zhao, Sally, Hariry, Sam, Dahlke, Marion, Alexander, Natalya, Vapurcuyan, Arpine, Hanna, Imad and Jarugula, Venkateswar (2011) Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects. European journal of clinical pharmacology. ISSN 0031-6970

Reiss, Simon, Rebhan, Ilka, Backes, Perdita, Romero-Brey, Ines, Erfle, Holger, Matula, Petr, Kaderali, Lars, Poenisch, Marion, Blankenburg, Hagen, Hiet, Marie-Sophie, Longerich, Thomas, Diehl, Sarah, Ramirez, Fidel, Rohr, Karl, Kaul, Artur, Buehler, Sandra, Pepperkok, Rainer, Lengauer, Thomas, Albrecht, Mario, Eils, Roland, Schirmacher, Peter, Lohmann, Volker and Bartenschlager, Ralf (2011) Recruitment and activation of a lipid kinase by NS5A of the hepatitis C virus is essential for integrity of the membranous replication compartment. Cell Host & Microbe, 9 (1). pp. 32-45. ISSN 19313128

Renner, Steffen, Bajorath, Jürgen, Barreca, Maria, Bender, Andreas, Bryce, Richard, Hutter, Michael, Laggner, Christian, Laughton, Charles, Martin, Yvonne, Mitchell, John, Padova, Alessandro, Selzer, Paul, Sherman, Woody, Sippl, Wolfgang, Taft, C and Tuccinardi, Tiziano (2011) Ask the experts: focus on computational chemistry. Future Medicinal Chemistry, 3 (8). pp. 909-921. ISSN 1756-8919

Renner, Steffen, Popov, Maxim, Schuffenhauer, Ansgar, Roth, Hans-Joerg, Breitenstein, Werner, Marzinzik, Andreas, Lewis, Ian, Krastel, Philipp, Nigsch, Florian, Jenkins, Jeremy and Jacoby, Edgar (2011) Recent Trends and Observations in the Design of High Quality Screening Collections. Future Medicinal Chemistry, 3 (6). pp. 751-766.

Ritchie, Timothy J., Ertl, Peter and Lewis, Richard (2011) The graphical representation of ADME-related molecular properties for medicinal chemists - an overview. Drug Discovery Today, 16 (1-2). pp. 65-72. ISSN 1359-6446

Riviere, Gilles-Jacques, Yeh, Ching-Ming, Reynolds, Christine, Brookman, Laurence and Kaiser, Guenther (2011) Bioequivalence of a novel omalizumab solution for injection compared with the standard lyophilized powder formulation. Journal of Bioequivalence & Bioavailability, 3 (6). pp. 144-150. ISSN 0975-0851

Rolan, Paul, MacLeod, Catherine, Bracken, Kathryn, Sun, Haiying and Evans, Thomas George (2011) Pharmacokinetics and unexpected safety issues of LBM415, a novel oral peptide deformylase inhibitor. Clinical Pharmacology and Therapeutics, 90 (2). pp. 256-262. ISSN 0009-9236

Rondini, Simona, Micoli, Francesca, Lanzilao, Luisa, Hale, Christine, Saul, Allan and Martin, Laura (2011) Evaluation of the Immunogenicity and Biological Activity of the Citrobacter freundii Vi-CRM197 Conjugate as a Vaccine for Salmonella enterica Serovar Typhi. CLINICAL AND VACCINE IMMUNOLOGY, 18 (3). pp. 460-468. ISSN 1556-6811

Rondini, Simona, Micoli, Francesca, Lanzilao, Luisa, Hale, Christine, Saul, Allan and Martin, Laura (2011) Evaluation of the Immunogenicity and Biological Activity of the Citrobacter freundii Vi-CRM197 Conjugate as a Vaccine for Salmonella enterica Serovar Typhi. Clinical and Vaccine Immunology, 18 (3). pp. 460-468. ISSN 1556-6811

Roscic, Ana, Baldo, Barbara, Crochemore, Christophe, Marcellin, David and Paganetti, Paolo (2011) Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model. Journal Neurochemistry, 119 (2). pp. 398-407. ISSN 0022-3042

Rosethorne, Liz and Charlton, Steven (2011) Agonist-biased signalling at the histamine H4 receptor: JNJ7777120 recruits beta-arrestin without activating G proteins. Molecular Pharmacology, 79 (4). pp. 749-757. ISSN 0026-895X

Rubert, Joelle, Qian, Zhiyan, Andraos, Rita, Guthy, Daniel Alexander and Radimerski, Thomas (2011) Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. BMC Cancer, 11. p. 24. ISSN 1471-2407

Rueeger, Heinrich, Rondeau, Jean-Michel, Mccarthy, Clive, Moebitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf and Desrayaud, Sandrine (2011) Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 21 (7). pp. 1942-1947. ISSN 0960-894X

Rueeger, Heinrich, Rondeau, Jean-Michel, Mccarthy, Clive, Moebitz, Henrik, Tintelnot-Blomley, Marina, Neumann, Ulf and Desrayaud, Sandrine (2011) Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 21 (7). pp. 1942-1947. ISSN 0960-894X

Russo, Carla, Cornella-Taracido, Ivan, Galli-Stampino, Luisa, Jain, Rishi, Harrington, Edmund, Isome, Yuko, Tavarini, Simona, Sammicheli, Chiara, Nuti, Sandra, Mbow, Lamine, Valiante, Nicholas M., Tallarico, John, De Gregorio, Ennio and Soldaini, Elisabetta (2011) Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. Blood Journal, 117 (21). pp. 5683-5691. ISSN 0006-4971


Sampath, Shruthi, Mc Lean, Leeanne, Buono-Dalton, Chiara, Richards, Virgile, Moulin, Pierre, Wolf, Armin, Chibout, Salah-Dine, Pognan, Francois and Shangari, Nandita (2011) The Use of Rat Lens Explant Cultures to Study the Mechanism of Drug-induced Cataractogenesis. Toxicological Sciences. ISSN 1096-6080

Saul, Allan (2011) Vaccines for Neglected Diseases. In: Vaccine Design: Innovative Approaches and Novel Strategies. Caister Academic Press, pp. 243-252. ISBN 978-1-904455-74-5

Schaefer, Michael and Koppole, Sampath (2011) A Discriminative Ramachandran Potential of Mean Force Aimed at Minimizing Secondary Structure Bias. Journal of Computational Chemistry. ISSN 0192-8651

Schiering, Nikolaus, D'Arcy, Allan, Villard, Frederic, Simic, Oliver, Kamke, Marion, Monnet, Gabriela, Hassiepen, Ulrich, Svergun, Dmitri, Pulfer, Ruth, Eder, Joerg, Raman, Prakash and Bodendorf, Ursula (2011) A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target. Proceedings of the National Academy of Sciences, USA. ISSN 0027-8424

Schmid, Herbert, Lambertini, Chiara, Van Vugt, Harmke, Barzaghi-Rinaudo, Patrizia, Schaefer, Judith, Stumm, Michael, Sailer, Andreas, Kaufmann, Martina and Nuciforo, Paolo (2011) Monoclonal antibodies against the human somatostatin receptor subtypes 1–5: Development and immunohistochemical application in neuroendocrine tumors. Neuroendocrinology. ISSN 0028-3835

Schmitt, Esther, Moore, Charles, Krastel, Philipp and Petersen, Frank (2011) Natural products as catalysts for innovation: a pharmaceutical industry perspective. Current Opinion in Chemical Biology.

Schmitt, Esther, Roggo, Silvio, Miault, Charlotte, Krastel, Philipp, Noble, Christian, Beer, David, Rao, Srinivasa, Au, Melvin, Niyomrattanakit, Pornwaratt, Zheng, Jun, Jeffery, Douglas, Pethe, Kevin and Camacho, Luis (2011) The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease. Angewandte.

Schmouder, Robert, Hariry, Sam and David, Olivier J (2011) Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers. European journal of clinical pharmacology. ISSN 0031-6970

Schuffenhauer, Ansgar and Varin, Thibault (2011) Rule-Based Classification of chemical structures by scaffold. Molecular informatics, 30 (8). ISSN 1868-1751

Sheng, Qing and liu, joyce (2011) The therapeutic potential of targeting the EGFR family in epithelial ovarian cancer. British Journal of Cancer, 104 (8). pp. 1241-1245. ISSN 0007-0920

Shi, Jun and Glass, David (2011) The E3 ubiquitin ligase Fbxo40 targets IRS1 for degradation upon IGF1 treatment in skeletal myotubes, controlling muscle cell size. Developemental Cell, 21 (5). pp. 835-847. ISSN 1534-5807

Shultz, Michael, Cao, Xueying, Chen, Christine, Cho, Young, Davis, Nicole, Eckman Iii, Joseph, Growney, Joseph, Holmqvist, Mats, Hsu, Meier, Jansson, Daniel, Jiang, Lei, Kwon, Paul, Liu, Gang, Lombardo, Franco, Lu, Qiang, Majumdar, Dyuti, Meta, Christopher, Pu, Minying, Ramsey, Timothy, Remiszewski, Stacy, Traebert, Martin, Urban, Laszlo, Uttamsingh, Vinita, Wang, Ping, Whitebread, Steven, Whitehead, Lewis, Yan-Neale, Yan, Yao, Megan, Zhou, Liping and Atadja, Peter (2011) Optimization of the in vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors. Journal of Medicinal Chemistry, 54 (13). pp. 4752-4772. ISSN 0022-2623

Shultz, Michael, Fan, Jianmei, Chen, Christine, Cho, Young, Davis, Nicole, Bickford, Shari, Buteau, Kristen, Cao, Xueying, Holmqvist, Mats, Hsu, Meier, Jiang, Lei, Liu, Gang, Lu, Qiang, Patel, Chetan, Suresh, Joghee, Selvaraj, Mannangatti, Urban, Laszlo, Wang, Ping, Yan-Neale, Yan, Whitehead, Lewis, Zhang, Haiyan, Zhou, Liping and Atadja, Peter (2011) The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters, 21 (16). pp. 4909-4912. ISSN 0960-894X

Siehler Wagner, Sandra and Jacob, Sandra (2011) Lead Discovery for Targeting G Protein-coupled Receptors. European Pharmaceutical Review, 16 (5). pp. 45-51. ISSN 1360-8606

Siggins, Matthew K, Cunningham, Adam F, Marshall, Jennifer L, Chamberlain, Jayne L, Henderson, Ian R and MacLennan, Calman A (2011) Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody. Journal of immunology, 186 (4). pp. 2365-2371. ISSN 1550-6606

Sivak, Jeremy, Cherry, Allison, Demirs, John, Cepeda, Rosemarie, Long, Debby, Anderson, Karen and Jaffee, Bruce (2011) PATHOLOGICAL ANGIOGENESIS IS COORDINATED BY REPAIR EPITHELIAL CELLS IN THE CORNEA DISTINCTLY FROM INTERACTIONS WITH INFLAMMATORY INFILTRATES. Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization.

Skvara, Hans, Kalthoff, Frank, Meingassner, Josef G, Wolff-Winiski, Barbara, Aschauer, Heinrich, Kelleher, Joseph F, Wu, Xu, Pan, Shifeng, Mickel, Lesanka, Schuster, Christopher, Stary, Georg, Jalili, Ahmad, David, Olivier J, Emotte, Corinne, Antunes, Ana Monica Costa, Rose, Kristine, Decker, Jeremy, Carlson, Ilene, Gardner, Humphrey, Stuetz, Anton, Bertolino, Arthur P, Stingl, Georg and De Rie, Menno A (2011) Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. The Journal of investigative dermatology, 131 (8). pp. 1735-1744. ISSN 1523-1747

Smith, Nichola, Galan, M. Carmen, Tran, Anh-Tuan, Jones, Rachel A., Pastor, Julien and Boisson, Julien (2011) Copper (II) triflate: a versatile catalyst for the one-pot preparation of orthogonally protected glycosides. Advanced Synthesis and catalysis, 353 (14/15). pp. 2593-2598. ISSN 1615-4169

Souza, Sandra/C, Chau, Mary/DL, Yang, Qing, Gauthier, Marie-Soleil, Clairmont, Kevin, Wu, Zhidan, Gromada, Jesper and Dole, William (2011) Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in isolated human adipocytes by activating AMPK. Biochemical and Biophysical Research Communications, 410 (3). pp. 398-403. ISSN 0006-291X

Stadler, Michael, Murr, Rabih, Wirbelauer, Christiane, Burger, Lukas, Ivanek, Robert, Lienert, Florian, Schoeler, Anne, Oakeley, Edward James, Gaidatzis, Dimosthenis, Tiwari, Vijay and Schuebeler, Dirk (2011) DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature, 480 (7378). pp. 490-495. ISSN 0028-0836

Stamp, Craig and Riddy, Darren (2011) Characterisation of hS1P3 Receptor Expression Levels: Their Impact on Recruitment of β-arrestin within the DiscoveRx Assay. Univeristy of York Placement Report.

Stoop, Chatanika and Daniels, Anne (2011) Job Disovery Initiative at NIBR. Novartis Live Magazine, August (4/2011). pp. 28-29.

Stöcklin, Reto and Vorherr, Thomas (2011) Future perspectives of venoms for drug discovery. PharManufacturing.

Stühmer, Thorsten, Iskandarov, Karmol, Gao, Zhenhai, Bumm, Thomas, Grella, Evelyn, Jensen, Michael Rugaard, Einsele, Hermann, Chatterjee, Manik and Bargou, Ralf C. (2011) Preclinical Activity of the Novel Orally Bioavailable HSP90 Inhibitor NVP-HSP990 against Multiple Myeloma Cells. Anticancer Res, 32 (2). pp. 453-462. ISSN 0250-7005

Sutton, J, Clark, D, Dunsdon, J, Fenton, G, Fillmore, A, Harris, N, Higgs, C, Hurley, C, Krintel, S, MacKenzie, R, Duttaroy, Alokesh, Gangl, Eric, Maniara, Wieslawa, Sedrani, Richard, Namoto, Kenji, Ostermann, Nils, Sirockin, Finton, Trappe, Joerg, Hassiepen, Ulrich and Baeschlin, Daniel (2011) Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes II: Optimisation of the PK profile. Bioorganic and medicinal chemistry letters, 22 (3). pp. 1464-1468. ISSN 0960-894X


Tanii, Hiromi, Shitara, Yoshihisa and Horie, Toshiharu (2011) Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women. European Journal of Clinical Pharmacology, 67 (10). pp. 1017-1025. ISSN 0031-6970

Terranova, Remi (2011) Novartis: Genedata Expressionist® for Genomic Profiling used to predict effects of non-genotoxic carcinogens. Case study document from genedata company.

Terranova, Remi (2011) Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice. PLoS ONE, 6 (3). e118216-e18216. ISSN 1932-6203

Testa, Lisa, Rosser, Paula and Novo, Alfredo (2011) Rodent Duplex. Rodent Duplex.

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Tetko, Igor V, Sushko, Iurii, Gasteiger, Johann, Todeschini, Roberto and Ertl, Peter (2011) Online Chemical Modeling Environment (OCHEM): Web Platform for Data Storage, Model Development and Publishing of Chemical Information. Journal of Computer Aided Molecular Design, 25 (6). pp. 533-554. ISSN 0920-654X

Thoma, Gebhard, Baenteli, Rolf, Lewis, Ian, Jones, Darryl, Kovarik, Jiri, Streiff, Markus and Zerwes, Hans-Guenter (2011) Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood. Bioorganic & Medicinal Chemistry Letters.

Thoma, Gebhard, Nuninger, Francois, Falchetto, Rocco Angelo, Hermes, Erwin, Tavares, Gisele, Vangrevelinghe, Eric and Zerwes, Hans-Guenter (2011) Identification of a potent Jak3 inhibitor with high selectivity within the Jak kinase family. The Journal of Medicinal Chemistry, 54 (1). pp. 284-288. ISSN 0022-2623

Thomson, Christopher, Reilly, John and Sandham, David (2011) Synthesis of useful fragments in drug discovery: 2-amino-5-tert-butylpyridine and its oxidised analogues. Bioorganic and Medicinal Chemistry Letters, 21 (14). pp. 4281-4283. ISSN 0960-894X

Thrum, Stephan, Lorenz, Jana, Mössner, Joachim and Wiedmann, Marcus (2011) Polo-like Kinase 1 Inhibition as a New Therapeutic Modality in Therapy of Cholangiocarcinoma. Anticancer Research, 31 (10). pp. 3289-3300. ISSN 0250-7005

Tiedt, Ralph, Degenkolbe, Elisa, Furet, Pascal, Appleton, Brent, Schoepfer, Joseph, Ruddy, David, Monahan, John, Blank, Jutta, Haasen, Dorothea, Drueckes, Peter, Wartmann, Markus, Mccarthy, Clive and Hofmann, Francesco (2011) A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Research, 71 (15). pp. 5255-5264. ISSN 0008-5472

Tommasi, Ruben, Weiler, Sven, Mc Quire, Leslie, Rogel, Olivier, Chambers, Mark, Clark, Kirk, Doughty, John, Fang James, -, Ganu, Vishwas, Goldberg, Ronald, Goldstein, Robert, Lavoie, Stacey, Grob, Jonathan, Kulathila, Raviraj, Macchia, William, Melton, Richard, Springer, Clayton, Walker, Marc, Zhang, Jing, Zhu, Lijuan and Shultz, Michael (2011) Potent and Selective 2-Naphthylsulfonamide Substituted Hydroxamic Acid Inhibitors of Matrix Metalloproteinase-13. Bioorganic and Medicinal Chemistry Letters, 21 (21). pp. 6440-6445. ISSN 0960-894X

Trowitzsch, Simon, Klumpp, Martin, Thoma, Ralf, Carralot, Jean-Philippe and Berger, Imre (2011) Light it up: Highly Efficient Multigene Delivery in Mammalian Cells. Bioessays, 33 (12). pp. 946-955. ISSN 0265-9247

Tsukamoto, Naoko, Otsuka, Fumio, Miyoshi, Tomoko, Inagaki, Kenichi, Nakamura, Eri, Suzuki, Jiro, Ogura, Toshio, Makino, Hiofumi and Ritson, Margaret (2011) Activities of bone morphogenetic proteins in prolactin regulation by somatostatin analogs in rat pituitary GH3 cells. Molecular and cellular endocrinology, 332 (1-2). pp. 163-169. ISSN 0303-7207

Turner, Jonathan, Roger, Jan, Fitau, Juliette, Combe, Delphine, Giddings, June, Van Heeke, Gino and Jones, Carol (2011) Goblet Cells are Derived from a FOXJ1-Expressing Progenitor in a Human Airway Epithelium. American Journal of Respiratory Cell and Molecular Biology, 44 (3). pp. 276-284. ISSN 1535-4989

Turner, Oliver, Colman, Karyn, Potenta, Daniel, Sistare, F.D., Morton, D., Alden, C., Christensen, J., Keller, D., Jonghe, S.D., Storer, R.D., Reddy, M.V., Kraynak, A., Trela, B., Bienvenu, J.G., Bjurström, S., Bosmans, v., Dominick, M., Evans, J., Hailey, J.R., Kinter, L., Liu, M., Mahrt, C., Marien, D, Myer, J., Perry, R., Roth, A., Sherratt, P., Singer, T., Slim, r., Soper, K., Fransson-Stehn, R., Stoltz, J., Turnquist, S., vanHeerden, M., Woicke, J. and Degeorge, J.J. (2011) An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing: Support for a Proposal to Modify Current Regulatory Guidelines. Toxicologic Pathology, 39 (4). pp. 716-744. ISSN 0192-6233


Umehara, Ken-Ichi and Camenisch, Gian P. (2011) Novel in vitro-in vivo Extrapolation (IVIVE) Method to Predict Hepatic Organ Clearance in Rat. Pharmaceutical Research. ISSN 0724-8741


Valentin, Marie-Anne, Ma, Shenglin, Zhao, An, Legay, Francois and Avrameas, Alexandre (2011) VALIDATION OF IMMUNOASSAY FOR PROTEIN BIOMARKERS: BIOANALYTICAL STUDY PLAN IMPLEMENTATION TO SUPPORT PRE-CLINICAL AND CLINICAL STUDIES. Journal of Pharmaceutical and Biomedical Analysis, 55 (5). pp. 869-877. ISSN 0731-7085

Van Eis, Maurice, Evenou, Jean-Pierre, Floersheim, Philipp, Gaul, Christoph, Jacob, Sandra, Monovich, Lauren, Rummel, Gabriele, Schuler, Walter, Stark, Wilhelm, Strauss, Andre, Von Matt, Anette, Vangrevelinghe, Eric, Wagner, Juergen and Soldermann, Nicolas (2011) 2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes. Bioorganic & Medicinal Chemistry Letters, 21 (24). pp. 7367-7372. ISSN 0960-894X

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Velcicky, Juraj, Soicke, Arne, Steiner, Roland and Schmalz, Hans-Günther (2011) Palladium-Catalyzed Cyanomethylation of Aryl Halides through Domino Suzuki Coupling-Isoxazole Fragmentation. Journal of the American Chemical Society, 133 (18). pp. 6948-6951. ISSN 1520-5126

Voedisch, Bernd, Patoux, Agnes, Sterkenburgh, Jildou, Buchs, Mirjam, Barry, Emily, Allard, Cyril and Geisse, Sabine (2011) About making a CHO production cell line “research-friendly” by genetic engineering - Extended abstract. BMC Proceedings, 5 (Suppl.). P132. ISSN 0002-9440

Vulpetti, Anna and Dalvit, Claudio (2011) Fluorine Local Environment: From Screening to Drug Design. Drug Discovery Today, 17 (15-16). pp. 890-897. ISSN 1359-6446

Vulpetti, Anna and Dalvit, Claudio (2011) Intermolecular and intramolecular hydrogen bonds involving shielded fluorine atoms: implications for recognition, selectivity and chemical properties. ChemMedChem, 7 (2). pp. 262-272. ISSN 1860-7179

van Damme, Pierre, Kafeja, Froukje, Anemona, Alessandra, Basile, Venere, Hilbert, Anne Katrin, De Coster, Ilse, Rondini, Simona, Micoli, Francesca, Qasim Khan, Rana M, Marchetti, Elisa, Di Cioccio, Vito, Saul, Allan, Martin, Laura B and Podda, Audino (2011) Safety, immunogenicity and dose ranging of a new Vi-CRM₁₉₇ conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. PloS one, 6 (9). e25398. ISSN 1932-6203


Wagner, Juergen, Von Matt, Peter, Faller, Bernard, Cooke, Nigel Graham, Albert, Rainer, Sedrani, Richard, Beerli, Christian, Weckbecker, Gisbert, Evenou, Jean-Pierre, Zenke, Gerhard and Cottens, Sylvain (2011) SAR and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine to Prevent Graft Rejection and Treat Psoriasis. Journal of Medicinal Chemistry, 54 (17). pp. 6028-6039. ISSN 0022-2623

Wang, Jianling and Collis, Alan (2011) Maximizing the Outcome of Early ADMET Models: Strategies to Win the Drug Hunting Battles? Expert Opinion in Drug Metabolism and Toxicity, 7 (4). pp. 381-386. ISSN 1742-5255

Wang, Tao, Papoutsi, Maria, Decristofaro, Marc, Keselica, Michael, Skuba, Elizabeth, Spaet, Robert, Markovits, Judit, Wolf, Armin, Moulin, Pierre, Pognan, Francois, Vancutsem, Paul, Petryk, Lew and Kluwe, William (2011) Investigation of Correlation between safety biomarkers in serum, histopathological examination and toxicogenomics. International Journal of Toxicology. ISSN 1091-5818

Weber, Christian, Meiler, Svenja, Doering, Yvonne, Koch, Miriam, Drechsler, Maik, Megens, Remco T.A., Rowinska, Zuzanna, Bidzhekov, Kiril, Ribechini, Eliana, van Zandvoort, Marc A.M.J., Binder, Christoph J., Jelinek, Ivett, Hristov, Mihail, Boon, Louis, Jung, Steffen, Korn, Thomas, Lutz, Manfred, Foerster, Irmgard, Zenke, Martin, Hieronymus, Thomas, Junt, Tobias and Zernecke, Alma (2011) CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T-cell homeostasis in mice. Journal of Clinical Investigation, 121 (7). pp. 2898-2910. ISSN 0021-9738

Wedehase, Thomas (2011) Lab logistics for Novartis. Internet.

Weiss, Tilla and Bürge, Thomas (2011) Handling and Restraint. In: The Laboratory Mouse. ELSEVIER Academic Press.

White, John/P/M, Urban, Laszlo and Nagy, Istvan (2011) Molecular structure of the Trnasient Receptor Potential Vanilloid Type 1 (TRPV1). Current Pharmaceutical Biotechnology.

Whitehead, Lewis, Deng, Gejing, Lee, Lac, Chenail, Gregg, Leeds, Jennifer, Luu, Catherine, Palestrant, Deborah, Sachdeva, Meena, Yu, Robert and Lamarche, Matthew (2011) In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy, 55 (11). pp. 5277-5283. ISSN 0066-4804

Whitehead, Lewis, Vash, Brian, Dobler, Markus, Radetich, Branko, Grob, Jonathan, Mcriner, Andrew, Pancost, Margaret, Patnaik, Anup, Shao, Wenlin, Shultz, Michael, Tichkule, Ritesh, Tommasi, Ruben, Zhu, Yanyi, Wang, Ping, Atadja, Peter, Stams, Travis and Claiborne, Tavina (2011) Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorganic and Medicinal Chemistry.

Widler, Leo (2011) Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis. Future Medicinal Chemistry, 3 (5). pp. 535-547. ISSN 1756-8919

Wiessner, Christoph, Wiederhold, Karl-Heinz, Tissot, Alain C, Frey, Peter, Danner, Simone, Jacobson, Laura, Jennings, Gary T, Lueoend, Rainer Martin, Ortmann, Rainer, Reichwald, Julia, Zurini, Mauro, Mir, Anis Khusro, Bachmann, Martin F and Staufenbiel, Matthias (2011) The second generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. The Journal of Neuroscience, 31 (25). pp. 9323-9331. ISSN 0270-6474

Wirth, Urs, Bouwmeester, Antonius, Bauer, Andreas, Thoma, Nicolas, Schmidges, Frank W., Prusty, Archana B., Faty, Mahamadou, Stützer, Alexandra, Lingaraju, Gondihcathhanlli M., Aiwazian, Jonathan, Sack, Ragna, Hess, Daniel, Li, ling, Zhou, Shalolian, Bunker, Richard D., Wirth, Urs, Ly-Hartig, Nga, Zhao, Kehao, Chan, Homan, Gu, Justin, Gut, Heinz, Fischle, Wolfgang, Müller, Jürg and Thomä, Nicolas H. (2011) Histone methylation by PRC2 is inhibited by active chromatin marks. Molecular Cell, 42 (3). pp. 330-341. ISSN 1097-2765

Woehrle, Simon, Bonny, Olivier, Beluch, Noemie, Gaulis, Swann, Stamm, Christelle, Scheibler, Marcel, Mueller, Matthias, Kinzel, Bernd, Thuery, Anne, Brueggen, Josef, Hynes, Nancy, Sellers, William, Hofmann, Francesco and Graus Porta, Diana (2011) FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF23 signaling and regulating FGF23 expression in bone. Journal of Bone and Mineral Research. ISSN 0884-0431

Wolf, Romain (2011) AMBER "Lite": Some AMBER-Tools-Based Utilities. Amber Home Page.

Wu, Kai, Mercier, Francois, David, Olivier J, Schmouder, Robert L and Looby, Michael (2011) Population Pharmacokinetics of Fingolimod Phosphate in Healthy Participants. Journal of clinical pharmacology. ISSN 0091-2700


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Zhang, Yun, Mainolfi, Nello, Patel, Sejal and Timothy, Jamison/F (2011) Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing. Journal of Organic Letters, 13 (2). pp. 280-283. ISSN 1523-7060

Zhou, Hui, Rao, Jing, Lin, Jian, Yin, Bo, Sheng, Hansong, Lin, Fengchun, Zhang, Nu and Yang, Lin (2011) The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes medulloblastoma to the Effects of Chemotherapy. Oncology Reports, 25 (6). pp. 1565-1571. ISSN 1021-335X

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This list was generated on Tue Apr 16 22:40:54 2024 UTC.


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