Browse views: by Year, by Function, by GLF, by Subfunction, by Conference, by Journal

Items where Year is 2011

Up a level
Export as [feed] RSS
Group by: Creators | Item Type | No Grouping
Jump to: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | R | S | T | U | V | W | Z
Number of items: 273.


Abdollahi-Roodsaz, Shahla and van de Loo, Fons and Koenders, Marije and Helsen, Monique and Walgreen, Brigitte and van den Bersselaar, Leduine and Arntz, Onno and Takahashi, Nozomi and Joosten, Leo and van den Berg, Wim (2011) Destructive Role of Myeloid Differentiation Factor 88 and Protective Role of TIR-Containing Adaptor Inducing Interferon β in IL-17-Dependent Arthritis. Arthritis & Rheumatism. ISSN 0004-3591

Abraham, Jinu and Prajapati, Suresh and Nishijo, Koichi and Schaffer, Beverly S and Taniguchi, Eri and Kilcoyne, Aoife and McCleish, Amanda T and Zarzabal, Lee Ann and Michalek, Joel E and Nelon, Laura D and Giles, Francis G and Efstratiadis, Argiris and LeGallo, Robin D and Nowak, Brent M and Rubin, Brian P and Keller, Charles and Jeay, Sebastien (2011) Evasion mechanisms to Igf1r inhibition in rhabdomyosarcoma. Molecular Cancer Therapeutics, 10 (4). pp. 697-707. ISSN 1535-7163

Agarwal, Abhiruchi and Boettcher, Andreas and Kneuer, Rainer and Sari-Sarraf, Farid and Donovan, Adriana and Woelcke, Julian and Krucker, Thomas (2011) Quantitative and functional assessment of treatment strategies for acute pancreatitis with optical fluorescence imaging in rats. Plos, 8 (2). e55959. ISSN 1932-6203

Allyson, Julie and Dontigny, Eve and Cyr, Michel and Massicotte, Guy and Auberson, Yves (2011) Blockade of NR2A-containing NMDA Receptors Induces Tau Phosphorylation in Rat Hippocampal Slices. Neural Plasticity. p. 340168. ISSN 0792-8483

Anders, Lars and Ke, Nan and Hydbring, Per and Zhai, Huili and Choi, Yoon and Braun, Pascal and Vidal, Marc and Sicinski, Peter (2011) a systematic substrate screen links CDK4/6 to senescence suppression through FOXM1. Cancer Cell, 20 (5). pp. 620-634. ISSN 1535-6108

Anemona, Alessandra and Basile, Venere and Hilbert, Anne-Katrin and Rondini, Simona and Micoli, Francesca and Marchetti, Elisa and Di Cioccio, Vito and Saul, Allan and Martin, Laura and Podda, Audino and Khan, Rana M. Qasim and Van Damme, Pierre and Kafeja, Froukje and De Coster, Ilse (2011) Safety, immunogenicity and dose ranging of a new Vi-CRM197 conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. PLoS ONE, 6 (9). e2539. ISSN 1932-6203

Argikar, Upendra and Liang, Guiqing and Bushee, Jennifer and Hosagrahara, Vinayak and Lee, Wendy (2011) Evaluation of pharmaceutical excipients as cosolvents in 4-methyl umbelliferone glucuronidation in human liver microsomes: An application for compounds with low solubility. Drug Metabolism and Pharmacokinetics.

Argikar, Upendra and Mangold, James and Harriman, Shawn (2011) Strategies and Chemical Design Approaches to Reduce the Potential for Formation of Reactive Metabolic Species. Current Topics in Medicinal Chemistry.

Arias, Hugo R and Gu, Ruo-Xu and Feuerbach, Dominik and Guo, Bao-Bao and Ye, Young and Wei, Dong-Qing (2011) Novel Positive Allosteric Modulators of the Human α7 Nicotinic Acetylcholine Receptor. Biochemistry.

Attias-Geva, Zohar and Bentov, Itay and Fishman, Ami and Werner, Haim and Bruchim, Ilan and Jeay, Sebastien (2011) Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometroid and serous papillary endometrial cancer cell lines. Gynecologic Oncology. ISSN 0090-8258


Baettig, Urs and Akhlaq, Mohammed and Beer, David and Charlton, Steven and Dunstan, Andrew and Bradley, Michelle and Gedeck, Peter and Owen, Charles and Nicklin, Paul and Rosethorne, Elizabeth and Bhalay, Gurdip (2011) Design and synthesis of a library of chemokine antagonists. Bioorganic & Medicinal Chemistry Letters, 21 (21). pp. 6249-6252. ISSN 0960-894X

Baldanzi, Gianluca and Rainero, Elena and Filigheddu, Nicoletta and Mesturini, Riccardo and Song, Shuping and Patrussi, Laura and Zhong, Xiao-Ping and van Blitterswijk, Wim J. and Sinigaglia, Fabiola and Nichols, Kim E. and Rubio, Ignacio and Pighini, Andrea and Schweighoffer, Tamas and Parolini, Ornella and Graziani, Andrea and Bettio, Valentina and Traini, Sara and Chianale, Federica and Porporato, Paolo E. (2011) SAP-Mediated Inhibition of Diacylglycerol Kinase alpha Regulates TCR-Induced Diacylglycerol Signaling. Journal of Immunology, 187 (11). pp. 5941-5951. ISSN 0022-1767

Baldo, Barbara and Weiss, Andreas and Parker, Christian and Bibel, Miriam and Paganetti, Paolo and Kaupmann, Klemens (2011) A screen for enhancers of clearance identifies huntingtin as an heat shock protein 90 (Hsp90) client protein. Journal of Biological Chemistry, http:/. ISSN 0021-9258

Balibar, Carl and Hollis-Symynkywicz, Micah and Tao, Jianshi (2011) Pantethine Rescues Phosphopantothenoylcysteine Synthetase and Phosphopantothenoylcysteine Decarboxylase Deficiency in Escherichia coli but Not in Pseudomonas aeruginosa. Journal of Bacteriology, 193 (13). pp. 3304-3312. ISSN 0021-9193

Baltus, Christine and Spencer, John and Clegg, William and Press, Neil and Harrington, Ross (2011) Synthesis of a (piperazin-1-ylmethyl)biaryl library via microwave-mediated Suzuki–Miyaura cross-couplings. Tetrahedron Letters, 52 (31). pp. 3963-3968. ISSN 0040-4039

Bassat, Quique and Gonzalez, Raquel and Machevo, Sonia and Nahum, Alain and Lyimo, John and Maiga, Hamma and Martensson, Andreas and Bashraheil, Mahfudh and Ouma, Peter and Ubben, David and Walter, Verena and Nwaiwu, Obiyo and Kipkeu, Chemtai and Lefevre, Gilbert and Ogutu, Bernhards and Menendez, Clara (2011) Similar efficacy and safety of artemether-lumefantrine (Coartem(R)) in African infants and children with uncomplicated falciparum malaria across different body weight ranges. Malaria journal, 10 (1). p. 369. ISSN 1475-2875

Bello, Claudia and Dal Bello, Giovanna and Grossi, Francesco and Patrone, Franco and Ballestrero, Alberto and Dupuis, Marc and Sordat, Bernard and Nencioni, Alessio and Zimmermann, Kaspar and Loretan, Jacqueline and Wartmann, Markus and Vogel, Pierre and Cea, Michele and Motta, Giulia and Moran, Eva and Aubry, Dominique and Nahimara, Aimable and Duchosal, Michel A. and Fruscione, Floriana and Pronzato, Paolo (2011) Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. BIOORGANIC & MEDICINAL CHEMISTRY, 19 (24). pp. 7720-7727. ISSN 0968-0896

Benoit, Roger and Auer, Manfred (2011) A direct way of redox sensing. RNAbiology, 8 (1). pp. 1-6. ISSN 1547-6286

Bielen, Aleksandra and Perryman, Lara and Box, Gary and Valenti, Melanie and de Haven Brandon, Alexis and Martins, Vanessa and Jury, Alexa and Popov, Sergey and Jeay, Sebastien and Raynaud, Florence and Hofmann, Francesco and Hargrave, Darren and Eccles, Sue and Jones, Chris (2011) Enhanced efficacy of IGF1R inhibition in paediatric glioblastoma by combinatorial targeting of PDGFRa/b. Molecular Cancer Therapeutics, 10 (8). pp. 1407-1418. ISSN 1535-7163

Bifani, Juan Pablo and Lefèvre, Philippe and Wang, Xiao-Ming and Karine, Soetaert and Rens, Céline and De Bruyn, Jacqueline and Lanéelle, Marie-Antoinette and Houyoux, Nicolas and Laval, Françoise and Lemassu, Anne and Wattiez, Ruddy and Daffé, Mamadou and Fontaine, Véronique (2011) Cpn60.1/GroEL-1/Hsp60-1, a New Potential Antimycobacterial Drug Target Involved in Antibiotics Resistance. Microbiology, 157 (4). pp. 1205-1219. ISSN 1608-3237; 0026-2617

Block, Stan L and Yogev, Ram and Waldmeier, Felix and Hamed, Kamal (2011) Safety and pharmacokinetics of a single 1500-mg dose of famciclovir in adolescents with recurrent herpes labialis. The Pediatric infectious disease journal, 30 (6). pp. 525-528. ISSN 1532-0987

Bonavia, Aurelio and Franti, Michael and Keaney, Erin and Kuhen, Kelli and Seepersaud, Mohindra and Radetich, Branko and Shao, Jian and Honda, Ayako and Dewhurst, Janetta and Balabanis, Kara and Monroe, James and Wolff, Karen and Osborne, Colin and Bourque, Leanne and Hoffmaster, Keith and Amin, Jakal and Markovits, Judit and Broome, Michelle and Skuba, Elizabeth and Cornella-Taracido, Ivan and Joberty, Gerard and Bouwmeester, Antonius and Hamann, Lawrence and Tallarico, John and Tommasi, Ruben and Compton, Teresa and Bushell, Simon (2011) Identification of Pyrimidine Biosynthesis Inhibitors with Broad Spectrum Antiviral Activity and Assessment of the Druggability of this Pathway for Efficacy against RSV. Proceedings of the National Accademy of Sciences USA, 108 (17). pp. 6739-6744. ISSN 0027-8424

Bornancin, Frederic (2011) Ceramide kinase: The first decade. Cellular Signalling, 23 (6). pp. 999-1008. ISSN 0898-6568

Boulton, Craig and Meiser, Karin and David, Olivier J and Schmouder, Robert (2011) Pharmacodynamic Effects of Steady-State Fingolimod on Antibody Response in Healthy Volunteers: A 4-Week, Randomized, Placebo-Controlled, Parallel-Group, Multiple-Dose Study. Journal of clinical pharmacology. ISSN 0091-2700

Brennan, Orlaith and Kennedy, OD and Lee, TC and Rackard, SM and O'Brien, FJ and McNamara, LM and Gasser, Juerg Andreas (2011) The Effects of Estrogen Deficiency and Bisphosphonate Treatment on Tissue Mineralisation and Stiffness in an Ovine Model of Osteoporosis. Journal of Biomechanics or Bone, 44 (3). pp. 386-390. ISSN 0021-9290

Brocklehurst, Cara and Laumen, Kurt and La Vecchia, Luigi and Shaw, Duncan and Voegtle, Markus (2011) Diasteroisomeric Salt Formation and Enzyme-Catalyzed Kinetic Resolution as Complimentary Methods for the Chiral Separation of cis/trans-Enantiomers of 3-Aminocyclohexanol. Organic Process Research and Development, 15 (1). pp. 294-300. ISSN 1083-6160

Brocklehurst, Cara and Lehmann, Hansjoerg and La Vecchia, Luigi (2011) Nitration Chemistry in Continuous Flow using Fuming Nitric acid in a Commercially Available Flow Reactor. Organic Process Research and Development. ISSN 1083-6160

Burger, Matthew and Pecchi, Sabina and Wagman, Allan and Ni, Zhijie and Knapp, Mark and Hendrickson, Thomas and Atallah, Gordana and Pfister, Keith and Zhang, Yanchen and Bartulis, Sarah and Ng, Simon and Verhagen, Joelle and Huh, Kay and Iwanowicz, Edwin and Menezes, Daniel and Merritt, Hanne and Lee, Isabelle and Weismann, Marion and Kaufman, Susan and Crawford, Kenneth and Chin, Michael and Bussiere, Dirksen and Shoemaker, Kevin and Verhagen, Joelle and Frazier, Kelly and Xin, Xiaohua and Haznedar, Joshua and Zaror, Isabel and Maira, Sauveur-Michel and Voliva, Charles (2011) Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Medicinal Chemistry Letters, 2 (10). pp. 774-779. ISSN 1948-5875

Burton, Victoria and Holmes, Alan and Ciuclan, Loredana and Robinson, Alexander and Roger, Jan and Jarai, Gabor and Pearce, Andrew and Budd, David (2011) Attenuation of leukocyte recruitment via inhibition of CXCR1/2 inhibition stops the progression of PAH in mice with genetic ablation of endothelial BMPR-II. Blood, 118 (17). pp. 4750-4758. ISSN 0006-4971

Bushee, Jennifer and Argikar, Upendra (2011) An experimental approach to enhance parent ion fragmentation for metabolite identification studies: Application of dual collision cells in an orbital trap. Rapid Communications in Mass Spectrometry, 25 (10). pp. 1356-1362. ISSN 1097-0231

beeh, kai and wagner, frank and Khindri, Sanjeev and Drollmann, Anton Franz (2011) Effect of indacaterol on dynamic lung hyperinflation and breathlessness in patients with COPD. COPD, 8 (5). pp. 340-345. ISSN 1541-2555


Cao, Xueying and Erdemli, Gul and Urban, Laszlo and Lee, Yan and Golden, Andrew and Holmqvist, Mats and Li, Nianzhen and Chen, Quin and Nevill, Tanner and Johnson, Juliette and Ionescu-Zanetti, Christian (2011) IonFlux, a Microfluidic Patch Clamp System Evaluated with hERG Channel Physiology and Pharmacology. Assay and Drug Development Technologies.

Cao, Yiqun and Landrum, Gregory (2011) Inchi wrappers for the RDKit. RDKit: open source cheminformatics.

Carcache, David and Vranesic, Ivan-Toma and Blanz, Joachim and Desrayaud, Sandrine and Fendt, Markus and Glatthar, Ralf (2011) Benzimidazoles as potent and orally active mGlu5 receptor antagonists with an improved PK profile. ACS Medicinal Chemistry Letters, 2 (1). pp. 58-62. ISSN 1948-5875

Caughlan, Ruth and Jones, Adriana and Delucia, Angela and Woods, Angela and Xie, Lili and Ma, Bing and Barnes, Whitney and Walker, John and Sprague, Elizabeth and Yang, Xia and Dean, Charles (2011) Mechanisms decreasing in vitro susceptibility to the LpxC inhibitor CHIR-090 in the Gram negative pathogen Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804

Chapelat, Julien and Berst, Frederic and Marzinzik, Andreas and Moebitz, Henrik and Drueckes, Peter and Fabbro, Doriano and Trappe, Joerg and Seebach, Dieter (2011) Substrate profiling of IGF-1R and InsR: Identification of a potent pentamer substrate. Bioorganic and Medicinal Chemistry Letters.

Chen, Jian and Shen, Qiong and Labow, Mark and Gaither, L Alex (2011) Protein kinase D3 sensitizes RAF inhibitor RAF265 in melanoma cells by preventing reactivation of MAPK signaling. Cancer research, 71 (12). pp. 4280-4291. ISSN 1538-7445

Chen, Xiao-Hui and Zhao, Hongjuan and Hatsis, Panagiotis and Amin, Jakal (2011) Investigation of Dried Blood Spot Card-Induced Interferences in Liquid Chromatography/Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis. ISSN 0731-7085

Chiong, Edmund and Lee, I-Ling and Dadbin, Ali and Sabichi, Anita L and Harris, Loleta and Urbauer, Diana and McConkey, David and Grossman, H Barton and Imark, Esther (2011) Effects of mTOR Inhibitor Everolimus (RAD0011) On Bladder Cancer Cells. Clinical Cancer Research, 17 (9). pp. 2863-2873. ISSN 1078-0432

Christen, Selina and Holdener, Martin and Beerli, Christian and Thoma, Gebhard and Bayer, Monika and Pfeilschifter, Josef and Hintermann, Edith and Zerwes, Hans-Guenter and Christen, Urs (2011) Small molecule CXCR3 antagonist NIBR2130 has only a limited impact on type 1 diabetes in a virus-induced mouse model. Clinical and experimental immunology, 165 (3). pp. 318-328. ISSN 0009-9104

Ciuclan, Loredana and Bonneau, Olivier and Hussey, Martin and Duggan, Nicholas and Holmes, Alan and Good, Robert and Stringer, Rowan and Jones, Peter and Morrell, Nicholas W. and Jarai, Gabor and Walker, Christoph and Westwick, John and Thomas, Matthew (2011) A Novel Murine Model of Severe Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. ISSN 1073-449X

Coan, Kristin and Ottl, Johannes and Klumpp, Martin (2011) Non-stoichiometric Inhibition in High-Throughput Screening. Expert Opinion on Drug Discovery.

Collingwood, Steve and Ratcliffe, Andrew and Allen, Jack (2011) Kinase Inhibitors from Early Research to Clinic. Drugs of the Future, 36 (3). pp. 249-263. ISSN 0377-8282

Commerford, Susan and He, Xiaohui and Liu, Hong and Seidel, Martin and Jaton, Anne-Lise and Gromada, Jesper and Teixeira, Sandra and Gerber, Sarah and Chen, Alice and Dardik, Beatriz and Chaperon, Frederique and Schwartzkopf, Chad and Nguyen-Tran, Van and Hollenbeck, Thomas and Mcnamara, Peter (2011) Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 384 (6). pp. 565-581. ISSN 0028-1298

Connolly, Michael K. and Ayo, Diego and Hackman, Michael and Malhotra, Ashim and Bedrosian, Andrea S. and Ibrahim, Junaid and Cieza-Rubio, Napoleon E. and Nguyen, Andrew H. and Henning, Justin R. and Pachter, H. Leon and Miller, George (2011) Dendritic Cell Depletion Exacerbates Acetaminophen Hepatotoxicity. Hepat0logy, 54 (3). pp. 959-968. ISSN 0270-9139

Cottens, Sylvain and Cottens, Sylvain (2011) Perspective on Future Medicinal Chemistry. Futurescience, 3 (15). pp. 1863-1872. ISSN 1759-6180

Craig, Ian (2011) PocketAnalyzerPCA. Project is software (source code) to be "published" as download from a website.

Craig, Ian and Pfleger, Christopher and Gohlke, Holger and Essex, Jonathan and Spiegel, Katrin (2011) Pocket-space maps to identify novel binding-site conformations in proteins. Journal of Chemical Information and Modeling.

Curtis, Allison and Calabro, Katherine and Galarneau, Jean-Rene and Bigio, Irving and Krucker, Thomas (2011) Temporal Variations in Skin Pigmentation of C57Bl/6 Mice Affect Optical Bioluminescence Quantitation. Molecular Imaging and Biology, 13 (6). pp. 1114-1123. ISSN 1536-1632


Dalvit, Claudio and Vulpetti, Anna (2011) Fluorine-Protein Interactions and 19F NMR Isotropic Chemical Shift: An Empirical Correlation. ChemMedChem, 6 (1). pp. 104-114. ISSN 1860-7179

Delucia, Angela and Six, David and Caughlan, Ruth and Gee, Patricia and Hunt, Ian and Lam, Joseph and Dean, Charles (2011) Lipopolysaccharide inner-core phosphates are required for complete LPS synthesis and transport to the outer membrane in Pseudomonas aeruginosa PAO1. mBio, 2 (4). pii: e00142. ISSN 2150-7511

Deng, Gejing and Lee, Lac and Chenail, Gregg and Palestrant, Deborah and Whitehead, Lewis and Sachdeva, Meena and Dzink-Fox, Joann and Lamarche, Matthew and Leeds, Jennifer (2011) In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy, 55 (11). pp. 5277-5283. ISSN 0066-4804

Deng, Gejing and Lee, Lac and Chenail, Gregg and Palestrant, Deborah and Whitehead, Lewis and Sachdeva, Meena and Lamarche, Matthew and Leeds, Jennifer (2011) In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy, 55 (11). pp. 5277-5283. ISSN 0066-4804

Dertinger, Stephen D. and Phonethepswath, Souk and Weller, Pamela and Nicolette, John and Murray, Joel and Sonders, Paul and Vohr, Hans-Werner and Shi, Jing and Krsmanovic, Ljubica and Gleason, Carol and Custer, Laura and Henwood, Andrew and Sweder, Kevin and Stankowski Jr, Leon F. and Roberts, Daniel J. and Giddings, Amanda and Kenny, Julia and Lynch, Anthony M. and Defrain, Céline and Nesslany, Fabrice and van der Leede, Bas-jan M. and Van Doninck, Terry and Schuermans, Ann and Tanaka, Kentaro and Hiwata, Yoshie and Tajima, Osamu and Eleanor, Wilde and Elhajouji, Azeddine and Gunther, William C. and Thiffeault, Catherine J. and Shutsky, Thomas J. and Fiedler, Ronald D. and Kimoto, Takafumi and Bhalli, Javed A. and Heflich, Robert H. and MacGregor, James T. (2011) International Pig-a gene mutation assay trial: Evaluation of transferability across fourteen laboratories. Environmental and Molecular Mutagenesis, 52 (9). pp. 690-698. ISSN 0893-6692

Deschwanden, Alexandra and Karolewicz, Beata and Feyissa, Anteneh, M and Treyer, Valerie and Ametamey, Simon, M and Johayem, Annas and Burger, Cyrill and Auberson, Yves and Sovago, Judit and Stockmeier, Craig, A and Buck, Alfred and Hasler, Gregor (2011) Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 Positron Emission Tomography and Postmortem Study. American Journal of Psychiatry, 168 (7). pp. 727-734. ISSN 0002-953X

Didiot, Marie-Cecile and Serafini, Sergio and Pfeifer, Martin and King, Frederick and Parker, Christian (2011) Multiplexed Reporter Gene Assays: Monitoring the cell viability and the compound kinetics on luciferase activity. Journal of Biomolecular Screening, 16 (7). pp. 786-793. ISSN 1087-0571

Djimdé, Abdoulaye A and Tekete, Mamadou and Abdulla, Salim and Lyimo, John and Bassat, Quique and Mandomando, Inacio and Lefèvre, Gilbert and Borrmann, Steffen (2011) Pharmacokinetic and pharmacodynamic characteristics of a new pediatric formulation of artemether-lumefantrine in African children with uncomplicated Plasmodium falciparum malaria. Antimicrobial agents and chemotherapy, 55 (9). pp. 3994-3999. ISSN 1098-6596

Doghman, Mabrouka and Axelson, Magnus and Lalli, Enzo (2011) Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation. American journal of cancer research, 1 (3). pp. 356-361. ISSN 2156-6976

Drollmann, Anton Franz and Crane, Helen and Di Scala, Lilla and Fogarty, Charles (2011) Bronchodilatory effects of NVA237, a once daily long-acting muscarinic antagonist, in COPD patients. Respiratory Medicine, 105 (3). pp. 337-342. ISSN 0954-6111

Duttaroy, Alokesh and Voelker, Frank and Merriam, Kimberly and Zhang, Xia and Ren, Xianglin and Subramanian, Kala and Hughes, Thomas and Burkey, Bryan (2011) The DPP-4 Inhibitor Vildagliptin Increases Pancreatic Beta Cell Mass In Neonatal Rats. European Journal of Pharmacology, 650 (2-3). pp. 703-707. ISSN 0014-2999

de backer, jan and de backer, wilhelm and vos, w. g. and vinchurkar, s. and claes, r. and wulfrank, p. and parizel, p. and germonpre, p. and Drollmann, Anton Franz (2011) Validation of computational fluid dynamics in CT-based airway models with SPECT/CT. Radiology, 257 (3). pp. 854-862. ISSN 0033-8419


Emotte, Corinne and Deglave, Fanny and Heudi, Olivier and Picard, Franck and Kretz, Olivier (2011) Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with tandem liquid chromatography mass spectrometry. Journal of Pharmaceutical and biomedical analysis, 58. pp. 102-112. ISSN 0731-7085

Ettenger, R and Schmouder, R and Kovarik, J M and Bastien, M C and Hoyer, P F (2011) Pharmacokinetics, pharmacodynamics, safety, and tolerability of single-dose fingolimod (FTY720) in adolescents with stable renal transplants. Pediatric transplantation, 15 (4). pp. 406-413. ISSN 1399-3046

Eucker, Tyson P. and Konkel, Michael E. (2011) The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling. Cellular Microbiology. ISSN 1462-5814


Faller, Bernard and Berellini, Giuliano and Ertl, Peter and Ottaviani, Giorgio and Collis, Alan (2011) Can History Foretell Future ? Drug Discovery Today, 16 (21-22). pp. 976-984. ISSN 1359-6446

Ferrand, Sandrine and Tao, Jianshi and Shen, Xiaoyu and Mcguire, Dorothy and Schmid, Andres and Glickman, Fraser and Schopfer, Ulrich (2011) Screening for Mevalonate Pathway Inhibitors using sensitized bacteria strains. Journal of Biomolecular Screening, 16 (6). pp. 637-646. ISSN 1087-0571

Ferreira, I.L. and Bajouco, L.M. and Oliveira, C.R. and Auberson, Yves and Rego, A.C. and Mota, S.I. (2011) Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-D-aspartate receptors in cortical cultures. Cell Calcium. ISSN 0143-4160

Fetar, Hossam and Christie, Gilmour and Rachel, Klinoski and Daigle, Denis and Dean, Charles and Poole, Keith (2011) The mexEF-oprN multidrug efflux operon of P. aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol. Antimicrobial Agents and Chemotherapy, 55 (2). pp. 508-514. ISSN 0066-4804

Fiorina, Paolo and Pietramaggiori, Giorgio and Scherer, Saja and Jurewicz, Mollie and Mathews, Jasmine and Vergani, Andrea and Thoma, Gebhard and Orsenigo, Elena and Staudacher, Carlo and La Rosa, Stefano and Capella, Carlo and Carothers, Adelaide and Zerwes, Hans-Guenter and Luzi, Livio and Abdi, Reza and Orgill, Dennis (2011) The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Cell Transplantation, 19 (11). pp. 1369-1386. ISSN 0963-6897

Fonseca, Sonya and Gromada, Jesper and Urano, Fumihiko (2011) ER stress: The link between pancreatic beta cell dysfuntion and death. Trends in Endocrinology and Metabolism.

Fonseca, Sonya and Urano, Fumihiko and Burcin, Mark and Gromada, Jesper (2011) Stress HypERactivation in the Beta Cell. Islets, 2 (1). pp. 1-9. ISSN 1938-2014

Forbes, Ben and Asgharian, Bahman and Dailey, Lea Ann and Ferguson, Douglas and Gerde, Per and Gumbleton, Mark and Gustavsson, Lena and Hardy, Colin and Hassall, David and Jones, Rhys and Lock, Ruth and Maas, Janet and McGovern, Tim and Pitcairn, Gary R and Somers, Graham and Wolff, Ron K (2011) Challenges in inhaled product development and opportunities for open innovation. Advanced drug delivery reviews, 63 (1-2). pp. 69-87. ISSN 1872-8294

Freeman, Mark and Hardaker, Liz and Banner, Kathy and Poll, Christopher and Coulthard, Alex and Dewhurst, Jennifer (2011) Effects of a combination of subchronic tobacco smoke exposure and lipopolysaccharide administration on pulmonary inflammation in the mouse. British Journal of Pharmacology, 8 (1). 132P.

Fu, Qiang and Berbee, Maaike and Wang, Wenze and Boerma, Marjan and Schmid, Herbert and Hauer-Jensen, Martin (2011) Preclinical evaluation of SOM230 as a radiation mitigator in a mouse model: post-exposure time window and mechanisms of action. Radiation Research, 175 (6). pp. 728-735. ISSN 0033-7587

Fu, Yunlin and Li, Wenkui and Smith, Harold and Tse, Francis (2011) A practical approach to address the issue of analyte nonspecific binding in quantitative analysis of untreated and transferred urine samples. Bioanalysis, 3 (9). pp. 967-972. ISSN 1757-6180


Garofalo, Cecilia and Manara, Maria Christina and Nicoletti, Giordano and Marino, Maria Theresa and Nanni, Patrizia and Lollini, Pier-Luigi and Prandini, Giuseppe and Lopez-Guerrero, José Antonio and Schaefer, Karl-Ludwig and Belfiore, Antonino and Picci, Piero and Scotlandi, Katia (2011) Efficacy of and resistance to anti‐IGF‐1R therapies in sarcomas is dependent on Insulin Receptor signaling. Oncogene, 30 (24). pp. 2730-2740. ISSN 0950-9232

Garofolo, Fabio and Rocci Jr., Mario and Dumont, Isabelle and Martinez, Suzanne and Lowes, Steve and Woolf, Eric and van Amsterdam, Peter and Bansal, Surendra and Gomes Barra, Airadna and Bauer, Ronald and Booth, Brian and Carrasco-Triguero, Montserrat and DeSilva, Binodh and Dunn, John and Gallicano, Keith and Gouty, Dominique and Ho, Stacy and Hucker, Richard and Jemal, Mohammed and Katori, Noriko and Le Blaye, Olivier and Lee, Jean and Li, Wenkui and Michael, Steve and Nehls, Corey and Nicholson, Robert and Ormsby, Eric and Tang, Daniel and Viswanathan, C and Wiener, Russel and Young, Graeme (2011) 2011 White Paper on Recent Issues in Bioanalysis & Regulatory Findings from Audits and Inspections. Bioanalysis, 3 (18). pp. 2081-2096. ISSN 1757-6180

Giovannoni, Jerome and Peltier, John (2011) Implementation of high-throughput quality control processes within Compound Management. European Pharmaceutical Review, 16 (4). pp. 49-52.

Glick, Meir and Jacoby, Edgar (2011) The Role of Computational Methods in the Identification of Bioactive Compounds. Current Opinion in Chemical Biology. ISSN 1367-5931

Glowienke, Susanne (2011) Practical experience of in silico assessment for genotoxic impurities. Regul Pharm Tox.

Gomez-Mancilla, Baltazar (2011) Challenges and opportunities of criteria alignment regarding Neurodegenerative Diseases. World Health Summit.

Gossert, Alvar and Hinniger, Alexandra and Gutmann, Sascha and Jahnke, Wolfgang and Strauss, Andre and Fernandez, Cesar (2011) A simple protocol for amino acid type selective isotope labeling in insect cells with improved yields and high reproducibility. Journal of Biomolecular NMR.

Gottar-Guillier, Marie and Dodeller, Francis and Huesken, Dieter and Iourgenko, Vadim and Mickanin, Craig and Labow, Mark and Kinzel, Bernd and Mueller, Matthias and Gaveriaux, Samuel and Alitalo, Kari and Littlewood-Evans, Amanda and Cenni, Bruno (2011) The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner. Journal of Immunology, 186 (10). pp. 6014-6023. ISSN 0022-1767

Grewe, Anja and Huesken, Dieter and Nitsche, Eric and Hildebrand, Kirsten (2011) Customization of the lysis and reaction setup steps of FastLane Cell kits for an automated workflow. QIAGEN News, 2011.

Grob, Jonathan and Nunez, Jill and Dechantsreiter, Michael and Hamann, Lawrence (2011) One-Pot Reductive Amination and Suzuki-Miyaura Cross-Coupling of Formyl Aryl and Heteroaryl MIDA Boronates in Array Format. The Journal of organic chemistry, 76 (12). pp. 4930-4940. ISSN 0022-3263

Grob, Jonathan and Nunez, Jill and Dechantsreiter, Michael and Hamann, Lawrence (2011) Regioselective Synthesis and Slow-Release Suzuki-Miyaura Cross-Coupling of MIDA Boronate-Functionalized Isoxazoles and Triazoles. Journal of Organic Chemistry, 76 (24). pp. 10241-10248. ISSN 0022-3263

Growcott, Ellie and Coulthard, Alex and Amison, Richard and Hardaker, Liz and Saxena, Vishal and Malt, Layla and Jones, Peter and Grevot, Armelle and Poll, Christopher and Osborne, Colin and Banner, Kathy (2011) Characterisation of a Refined Rat Model of Respiratory Infection with Pseudomonas aeruginosa and the Effect of Ciprofloxacin. Journal of Cystic Fibrosis, 10 (3). pp. 166-174. ISSN 1569-1993

Guagnano, Vito and Furet, Pascal and Spanka, Carsten and Bordas, Vincent and Le Douget, Mickael and Stamm, Christelle and Molle, Sandra and Brueggen, Josef and Schmid, Herbert and Jensen, Michael Rugaard and Schnell, Christian and Wartmann, Markus and Berghausen, Joerg and Drueckes, Peter and Zimmerlin, Alfred Gilbert and Bussiere, Dirksen and Murray, Jeremy and Graus Porta, Diana (2011) Discovery of BGJ398 (3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase. Journal of Medicinal Chemistry, 54 (20). pp. 7066-7083. ISSN 0022-2623

Guenther, Claudia and Carballido-Perrig, Nicole and Kaesler, Susanne and Carballido, Jose and Biedermann, Tilo (2011) CXCR6 and its ligand CXCL16 preferentially mediate CD8+ T cell recruitment into psoriatic skin. Journal Investigative Dermatology. ISSN 0022-202X


Haan, Claude and Rolvering, Catherine and Raulf, Friedrich and Kapp, Manuela and Drueckes, Peter and Thoma, Gebhard and Behrmann, Iris and Zerwes, Hans-Guenter (2011) Jak1 has a dominant role over Jak3 in signal transduction through gammaC containing cytokine receptors. Chemistry and Biology, 18 (3). pp. 214-223. ISSN 1074-5521

Hadziselimovic, Faruk and Hadziselimovic, Nils O. and Demogin, Philippe and Oakeley, Edward James (2011) Testicular gene expression in cryptorchid boys at risk of azoospermia. Journal of Sexual Development, 5 (2). pp. 49-59. ISSN 1661-5425

Hahne, Florian and Durinck, Steffen (2011) GenomeGraphs Biconductor Package. Bioconductor.

Hannedouche, Sébastien and Zhang, Juan and Yi, Tangsheng and Shen, Weijun and Nguyen, Deborah and Pereira, Joao P. and Guerini, Danilo and Baumgarten, Birgit and Roggo, Silvio and Wen, Ben and Knochenmuss, Richard and Noel, Sophie and Gessier, Francois and Kelly, Lisa M. and Vanek, Miroslava and Laurent, Stephane and Preuss, Inga and Miault, Charlotte and Christen, Isabelle and Karuna, Ratnaningrum and Li, Wei and Koo, Dong-In and Suply, Thomas and Schmedt, Christian and Peters, Eric and Falchetto, Rocco Angelo and Katopodis, Andreas and Spanka, Carsten and Roy, Marie-Odile and Detheux, Michel and Chen, Yu and Schultz, Peter and Cho, Charles and Seuwen, Klaus and Cyster, Jason G. and Sailer, Andreas (2011) Oxysterols direct immune cell migration through EBI2. Nature, 475 (7357). pp. 524-527. ISSN 0028-0836

Hartenfeller, Markus and Eberle, Martin and Meier, Peter and Nieto-Oberhuber, Cristina and Altmann, Karl-Heinz and Schneider, Gisbert and Jacoby, Edgar and Renner, Steffen (2011) A collection of robust organic synthesis reactions for in silico molecule design. Journal of Chemical Information and Modeling, 15 (1). ISSN 1549-9596

Hau, Jean-Christophe and Fontana, Patrizia and Zimmermann, Catherine and De Pover, Alain and Erdmann, Dirk and Chene, Patrick (2011) Leveraging the contribution of thermodynamics in drug discovery with the help of fluorescence-based thermal shift assays. Journal of Biomolecular Screening, 16 (5). pp. 552-556. ISSN 1087-0571

Herzig, Martin and Kolly, Carine and Schweizer, Tatjana and Hafner, Thomas and Stemmelen, Christine and Troxler, Thomas J. and Kaupmann, Klemens and Schmid, Peter and Schnell, Christian and Mueller, Matthias and Kinzel, Bernd and Persohn, Elke and Grevot, Armelle and Bolognani, Federico and Stirn, Martina and Theil, Diethilde and Kuhn, Rainer R and Van Der Putten, P. Herman and Rovelli, Giorgio and Shimshek, Derya (2011) LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Human Molecular Genetics. ISSN 0964-6906

Heudi, Olivier and Barteau, Samuel and Kretz, Olivier and Picard, Franck and Tremblay, Patrice and Picard, Pierre (2011) Laser Diode Thermal Desorption-positive mode Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry for the ultra-fast quantification of a pharmaceutical compound in human plasma. Journal of pharmaceutical and Biomedical analysis, 54 (5). pp. 1088-1095. ISSN 0731-7085

Hondeghem, Luc and Dujardin, Karl and Hoffmann, Peter and Dumotier, Berengere and Stockbridge, N and De Clerck, Frederic (2011) DISTURBANCES OF λ-TRIAD ARE MORE PREDICTIVE FOR PROARRHTHMIA THAN QT PROLONGATION: A CASE STUDY OF TERFENADINE. Journal of Cardiovascular Pharmacology 2011, 57 (5). pp. 589-597. ISSN 0160-2446

Huang, YA and Pereira, E and Roper, S (2011) Acid stimulation (sour taste) elicits GABA and serotonin release from mouse taste cells. PLoS one, 6 (10). e25471. ISSN 1932-6203

Hunt, Thomas and Howsham, Catherine and Danahay, Henry and Atherton, Hazel and Axford, Jake and Coote, Kevin and Czarnecki, Sarah and Devereux, Nicholas and Hunt, Peter and Paddock, Victoria and Paisley, Derek and Young, Alice and Collingwood, Stephen (2011) Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 1: Quaternary amines. Bioorganic and Medicinal Chemistry Letters. ISSN 0960-894X


Isebaert, Sofie / F and Swinnen, Johan / V and McBride, William / H and Haustermans, Karin / M (2011) Insulin-like growth factor – type 1 receptor inhibitor NVP-AEW541 enhances radiosensitivity of PTEN wild-type but not PTEN-deficient human prostate cancer cells. Int. J. Radiation Oncology Biol. Phys., 81 (1). pp. 239-247. ISSN 0360-3016

Ito, Moriko and Barys, Louise and O'Reilly, Terence and Young, Sophie and Gorbatcheva, Bella and Monahan, John and Zumstein-Mecker, Sabine and Choong, Peter F.M. and Dickinson, Ian and Crowe, Philip J and Hemmings, Chris and Desai, Jayesh and Thomas, David M and Hergovich Lisztwan, Joanna (2011) Comprehensive mapping of p53 pathway alterations in sarcomas reveals an apparent role for MDM2 SNP309 in sarcomagenesis. Clinical Cancer Research, 17 (3). pp. 416-426. ISSN 1078-0432


Jacoby, Edgar (2011) Computational Chemogenomics. Wiley Interdisciplinary Reviews - Computational Molecular Science, 1 (1). pp. 57-67. ISSN 1759-0884

Jacquemont, Sebastian and Curie, Aurore and Des Portes, Vincent and Torrioli, Maria and Berry-Kravis, Elizabeth and Hageman, Randi and Ramos, Feliciano and Cornish, Kim and He, Yunsheng and neri, Gionanni (2011) Epigenetic modification of the FMR1 gene in fragile X patients leads to a differential response to the mGluR5 antagonist AFQ056. Science Translational Sciences, 3 (64). pp. 64-71. ISSN 1946-6234

Jenkins, Jeremy and Simms, Benjamin and Bender, Andreas (2011) HTS Fingerprints in target prediction. Journal of Proteomics.

Jiang, Zhengjin and Reilly, John and Everatt, Brian and Briard, Emmanuelle (2011) A rapid vesicle electrokinetic chromatography method for the in vitro prediction of non-specific binding for potential PET ligands. Journal of pharmaceutical and biomedical analysis, 54 (4). pp. 722-729. ISSN 1873-264X

Jiang, Zhengjin and Reilly, John and Everatt, Brian and Briard, Emmanuelle (2011) A rapid vesicle electrokinetic chromatography method for the in vitro prediction of non-specific binding for potential PET ligands. Journal of Pharmaceutical and Biomedical Analysis, 54 (4). pp. 722-729. ISSN 1873-264X

Jiao, Shuang and Dai, Wei and Lu, Ling and Liu, Yunzhang and Zhou, Jianfeng and Li, Yun and Korzh, Vladimir and Duan, Cunming (2011) The conserved clusterin gene is expressed in the developing choroid plexus under the regulation of notch but not IGF signaling in zebrafish. Endocrinology, 152 (5). pp. 1860-1871. ISSN 1945-7170

Jin, Yi and Zollinger, Markus and Borell, Hubert and Zimmerlin, Alfred Gilbert and Patten, Christopher (2011) CYP4F Enzymes are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis. Drug Metabolism and Disposition, 39 (2). pp. 191-198. ISSN 1521-009X

John, Markus and Widler, Leo and Gamse, Rainer and Buhl, Thomas and Seuwen, Klaus and Breitenstein, Werner and Bruin, Gerardus and Belleli, Rossella and Klickstein, Lloyd and Kneissel, Michaela (2011) ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans. Bone, 49 (2). pp. 233-241. ISSN 1873-2763


Kalkman, Hans O. (2011) Alterations in the expression of neuronal chloride transporters may contribute to schizophrenia. Progress in Neuro-Psychopharmacology & Biological Psychiatry. ISSN 0278-5846

Kalkman, Hans O. (2011) Circumstantial evidence for a role of glutamine-synthetase in suicide. Medical Hypotheses, 76 (6). pp. 905-907. ISSN 0306-9877

Kalliokoski, Tuomo and Vulpetti, Anna (2011) Large-scale evaluation of CavBase for analyzing the polypharmacology of kinase inhibitors. Molecular Informatics, 30 (11/12). pp. 923-925. ISSN 1868-1751

Kappe, C. Oliver and Lehmann, Hansjoerg (2011) From Lab Scale to Kilolab Scale using a Multimode Batch Microwave Reactor. Organic Process Research and Development.

Khindri, Sanjeev and Woessner, Ralph and Sabo, Ronald and Drollmann, Anton Franz and Harris, Stuart and Jennings, Simon (2011) Cardiac safety of indacaterol in healthy subjects: a randomized, multidose, placebo- and positive-controlled, parallel-group thorough QT study. BMC Pulmonary Medicine, 11. p. 31. ISSN 1471-2466

Kleinberg, David L and Ameri, Pietro and Singh, Baljit (2011) Pasireotide, an IGF-1 action inhibitor, prevents growth hormone and estradiol-induced mammary hyperplasia. Pituary, 14 (1). pp. 44-52. ISSN 1386-341X

Klink, Tony A and Staeben, Matt and Twesten, Kim and Josvai, Rebecca and Kleman-Leyer, Karen and Klumpp, Martin and Lowery, Robert G (2011) Development and validation of a generic fluorescent methyltransferase activity assay based on the Transcreener® AMP/GMP Assay. Journal of Biomolecular Screening, 17 (1). pp. 59-70. ISSN 1087-0571

Konieczka, Katarzyna and Meyer, Peter and Schoetzau, Andreas and Neutzner, Albert and Mozaffarieh, Maneli and Flammer, Josef (2011) Effect of Avosentan (SSP-301) in Porcine Ciliary Arteries. Current Eye Research, 36 (2). pp. 118-124. ISSN 0271-3683

Kovarik, John M and Neuhaus, Peter and Cillo, Umberto and Weber, Markus and Stitah, Sylvie and Gatlik, Ewa and Meiser, Karin and Slade, Alan (2011) Sotrastaurin single-dose pharmacokinetics in de novo liver transplant recipients. Transplant international : official journal of the European Society for Organ Transplantation, 24 (3). pp. 276-283. ISSN 1432-2277

Kovarik, John M. (2011) Pharmacokinetics of Sotrastaurin Combined With Tacrolimus or Mycophenolic Acid in De Novo Kidney Transplant Recipients. Transplantation, 91 (3). pp. 317-322. ISSN 0041-1337

Kovarik, John M. and Lenney, Warren and Kho, Pearl and Edenborough, Frank (2011) Lung deposition of inhaled tobramycin with eFlow rapid/LC Plus jet nebuliser in healthy and cystic fibrosis subjects. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 10 (1). pp. 9-14. ISSN 1569-1993

Kramer, Christian and Gedeck, Peter (2011) Global Free Energy Scoring Functions based on distance-dependent Atom-type Pair Descriptors. Journal of Chemical Information and Modeling, 51 (3). pp. 707-720. ISSN 1549-9596

Kramer, Christian and Gedeck, Peter (2011) Three descriptor model can predict 55% of the CSAR-NRC HiQ benchmark dataset. Journal of Chemical Information and Modeling, 51 (9). pp. 2139-2145. ISSN 1549-9596

Kramer, Christian and Muehlbacher, Markus and El Kerdawy, Ahmed and Hudson, Brian and Clark, Timothy (2011) Conformation-Dependent QSPR-Models: logPOW. Journal of Chemical Information and Modeling, 51 (9). pp. 2408-2416. ISSN 1549-9596

Kramer, Ina and Baertschi, Stefan and Halleux, Christine and Keller, Hansjoerg and Kneissel, Michaela (2011) Mef2c deletion in osteocytes results in increased bone mass. Journal of Bone and Mineral Research (JBMR). ISSN 0884-0431

Krucker, Thomas and Selvaraj, Sandanaraj (2011) Optical imaging for the new grammar of drug discovery. Philosophical Transactions of the Royal Society, 369 (1955). pp. 4651-4665. ISSN 1364-503X

Kuemmel, Anne and Selzer, Paul and Beibel, Martin and Gubler, Hanspeter and Parker, Christian and Gabriel, Daniela (2011) Comparison of multivariate data analysis strategies for high-content screening. Journal of Biomolecular Screening, 16 (3). pp. 338-347. ISSN 1087-0571

Kuemmel, Anne and Selzer, Paul and Siebert, Daniela and Schmidt, Isabel and Reinhardt, Juergen and Goette, Marjo and Ibig-Rehm, Yvonne and Parker, Christian and Gabriel, Daniela (2011) Differentiation and visualization of diverse cellular phenotypic responses in primary high-content screening. Journal of Biomolecular Screening. ISSN 1087-0571

Kurio, Naito and Fukazawa, Takuya and Takaoka, Munenori and Okui, Tatsuo and Hassan, Nur Mohammad Monsur and Honami, Tatsuki and Hatakeyama, Shinji and Ikeda, Masahiko and Naomoto, Yoshio and Sasaki, Akira and Shimo, Tsuyoshi (2011) Anti-tumor effect in human breast cancer by TAE226, a dual inhibitor for FAK and IGF-IR in vitro and in vivo. Experimental Cell Research. ISSN 0014-4827


Lamarche, Matthew and Leeds, Jennifer and Brewer, Jason and Bushell, Simon and Dewhurst, Janetta and Jain, Akash and Mullin, Steve and Neckermann, Georg and Palestrant, Deborah and Patane, Michael and Rann, Elin and Sachdeva, Meena and Shao, Jian and Whitehead, Lewis and Tiamfook, Stacey and Yu, Donghui (2011) ANTIBACTERIAL LEAD OPTIMIZATION OF 4-AMINOTHIAZOLYL ANALOGUES OF GE2270 A: THE CYCLOALKYLCARBOXYLIC ACIDS. Journal of Medicinal Chemistry, 54 (7). pp. 2517-2521. ISSN 0022-2623

Lamarche, Matthew and Leeds, Jennifer and Gunderson, Karl and Krastel, Philipp and Memmert, Klaus and Patane, Michael and Rann, Elin and Schmitt, Esther and Wang, Bing and Dzink-Fox, Joann and Tiamfook, Stacey (2011) 4-Aminothiazolyl Analogs of GE2270 A: Antibacterial Lead Finding. Journal of medicinal chemistry, 54 (7). pp. 2517-2521. ISSN 0022-2623

Lamarche, Matthew and Leeds, Jennifer and Mullin, Steve and Patane, Michael and Rann, Elin and Dzink-Fox, Joann and Tiamfook, Stacey (2011) 4-AMINOTHIAZOLYL ANALOGS OF GE2270 A: DESIGN, SYNTHESIS AND EVALUATION OF IMIDAZOLE ANALOGS. Bioorganic Medicinal Chemistry Letters, 21 (11). pp. 3210-3215. ISSN 0960-894X

Lamarche, Matthew and Leeds, Jennifer and Neckermann, Georg and Osborne, Colin and Palestrant, Deborah and Patane, Michael and Raimondi, Alejandra and Rann, Elin and Sachdeva, Meena and Shao, Jian and Tiamfook, Stacey and Whitehead, Lewis and Brewer, Jason and Yu, Donghui and Amaral, Kerri and Goldovitz, Julie and Bushell, Simon and Deng, Gejing and Dewhurst, Janetta and Dzink-Fox, Joann and Gangl, Eric and Jain, Akash and Mullin, Steve (2011) Antibacterial Optimization of 4-Aminothiazolyl Analogues of the Natural Product GE2270 A: Identification of the Cycloalkylcarboxylic Acids. Journal of Medicinal Chemistry, 54 (23). pp. 8099-8109. ISSN 0022-2623

Landrum, Gregory (2011) RDKit Q42010 Open source submission. RDKit: open source cheminformatics.

Landrum, Gregory and Castaldi, Alfred and Bouton, Christopher and Bakke, Erik and hardwick, James (2011) RDKit Java Wrappers. RDKit: open source cheminformatics.

Langsdorf, Markus and Röhring, Cornelia and Christen, Isabelle and Zhang, Juan and Baur, Manuela and Gössl, Richard (2011) Metabolomic Analysis using the AbsoluteIDQ™ p150 Kit in combination with the AB Sciex 5500 QTrap® Mass Spectrometer. Biocrates Application Note (Biocra). pp. 1-3.

Laurent, Didier and Rooks, Daniel and Roubenoff, Ronenn (2011) Novel Imaging Methods for Early Drug Development. Journal of Nutrition, Health and Aging, 15 (10). pp. 834-846.

Lee, David and Leung, Lawrence (2011) CHEMERIN 158K IS THE DOMINANT CHEMERIN ISOFORM IN SYNOVIAL AND CEREBROSPINAL FLUIDS BUT NOT IN PLASMA. The Journal of biological chemistry, 286 (45). pp. 39520-39527. ISSN 0021-9258

Lee, David and Robinson, William (2011) Identification of a central role for complement in osteoarthritis. Nature Medicine, 17 (12). pp. 1674-1680. ISSN 1078-8956

Leeds, Jennifer and Lamarche, Matthew and Brewer, Jason and Bushell, Simon and Deng, Gejing and Dewhurst, Janetta and Dzink-Fox, Joann and Gangl, Eric and Jain, Akash and Lee, Lac and Lilly, Maria-Dawn and Manni, Kari and Mullin, Steve and Neckermann, Georg and Osborne, Colin and Palestrant, Deborah and Patane, Michael and Raimondi, Alejandra and Ranjitkar, Srijan and Rann, Elin and Sachdeva, Meena and Shao, Jian and Tiamfook, Stacey and Whitehead, Lewis and Yu, Donghui (2011) In vitro and in vivo activities of novel, semi-synthetic thiopeptide inhibitors of bacterial Elongation Factor Tu. Antimicrobial Agents and Chemotherapy, 55 (11). pp. 5277-5283. ISSN 0066-4804

Lefevre, Gilbert and Marrast, Anne Claire and Grueninger, Heiner (2011) Novartis Malaria Initiative: best practice example of pharmaceutical industry's engagement in the fight against malaria. Annals of the New York Academy of Sciences, 1222. pp. 19-29. ISSN 1749-6632

Leupin, Olivier and Piters, Elke and Halleux, Christine and Hu, Shouih and Kramer, Ina and Morvan, Frederic and Bouwmeester, Tewis and Schirle, Markus and Bueno-Lozano, Manuel and Ramos Fuentes, Feliciano J and Itin, Peter H and Boudin, Eveline and De Freitas, Fenna and Jennes, Karen and Brannetti, Barbara and Charara, Nadine and Ebersbach, Hilmar and Geisse, Sabine and Lu, Chris X and Bauer, Andreas and Van Hul, Wim and Kneissel, Michaela (2011) Bone overgrowth-associated mutations in LRP4 impair sclerostin-facilitator function. The Journal of biological chemistry. ISSN 1083-351X

Levenga, Josien and de Vrij, Femke M.S. and van der Linde, Herma C. and Buijsen, Ronald A.M. and Nelson, David L. and Oostra, Ben A. and Koekkoek, Sebastiaan K. and Hayashi, Shigemi and Song, Cheng and Gomez-Mancilla, Baltazar and Gasparini, Fabrizio and Willemsen, Rob and Pop, Andreea S. and Nieuwenhuizen, Ingeborg (2011) AFQ056, a new mGluR5 antagonist for treatment of fragile X syndrome. Neurobiology of Disease. ISSN 0969-9961

Lewis, Richard and Martin, Eric and Ertl, Peter and Hunt, Peter and Duca, Jose (2011) Gazing into the Crystal Ball. Journal of Computer-Aided Molecular Design. ISSN 0920-654X

Li, Wenkui and Lin, Hui and Smith, Harold and Tse, Francis (2011) Developing a robust ultrafiltration-LC-MS/MS method for quantitative analysis of unbound ASA404 in human plasma. Journal of Chromatography B, 879 (1). pp. 1927-1933. ISSN 1570-0232

Li, Wenkui and Smith, Harold and Tse, Francis and Williams, S.M. (2011) Quantitative analysis of NIM811, an antiviral agent, in human dried blood spots using liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 879 (24). pp. 2376-2382. ISSN 1570-0232

Li, Wenkui and Zhang, Jie and Tse, Francis (2011) Strategies in quantitative LC-MS/MS analysis of unstable small molecules in biological matrices. Biomedical Chromatography, 25 (1-2). pp. 258-277. ISSN 0269-3879

Li, Yun and Liang, Fang and Li, Qian and Xu, Yao-Chang and Wang, Quan-Rui and Jiang, Lei (2011) Room Temperature Asymmetric Allylic Trifluoromethylation of Morita Baylis-Hillman Carbonates. Organic Letters, 13 (22). pp. 6082-6085. ISSN 1523-7060

Lin, Zhongping and Li, Wenkui and Weng, Naidong (2011) A Capsule Review on Bioanalytical Method Transfer - Opportunities and Challenges for chromatographic methods. Bioanalysis, 3 (1). pp. 57-66. ISSN 1757-6180

Lindvall, Mika and McBride, Christopher and Mckenna, Maureen and Gesner, Thomas and Yabannavar, Asha and Wong, Kent and Lin, Song and Walter, Annette and Shafer, Cynthia (2011) 3D Pharmacophore Model-Assisted Discovery of Novel CDC7 Inhibitors. Medicinal Chemistry Letters, 2 (11). pp. 720-723. ISSN 1948-5875

Loots, Gabrieal G. and Keller, Hansjoerg and Leupin, Olivier and Murugesh, Deepa and Collette, Nicole M. and Genetos, Damian C. (2011) TGFb Regulates Sclerostin Expression via the ECR5 enhancer. Bone, 50 (3). pp. 663-669. ISSN 8756-3282

Louie, Arnold and Stein, Daniel and Zack, Julia and Liu, Weiguo and Conde, Haley and Fregeau, Christine and VanScoy, Brian and Drusano, George (2011) Dose Range Evaluation of Mycograb C28Y Variant (MYC123 C28Y), a Human Recombinant Antibody Fragment to Heat Shock Protein 90, In Combination with Amphotericin B-Desoxycholate for the Treatment of Murine Systemic Candidiasis. Antimicrobial Agents and Chemotherapy, 55 (7). pp. 3295-3304. ISSN 0066-4804

Lounkine, Eugen and Nigsch, Florian and Jenkins, Jeremy and Glick, Meir (2011) Activity–aware clustering of high throughput screening data and elucidation of orthogonal structure–activity relationships. Journal of Chemical Information and Modelling, 51 (12). pp. 3158-3168. ISSN 1549-9596



MacLennan, Calman A and Huissoon, Aarnoud P and Kumararatne, Dinakantha S (2011) Vaccine-derived poliomyelitis 12 years after infection. The New England Journal of Medicine, 365 (14). 1355; author reply 1355. ISSN 1533-4406

Macarron, Ricardo and Banks, Martyn and Bojanic, Dejan and Burns, David and Garyantes, Tina and Green, Darren and Hertzberg, Robert and Janzen, William and Paslay, Jeff and Schopfer, Ulrich and Sittampalam, Sitta (2011) Impact of high-throughput screening in biomedical research. Nature Reviews Drug Discovery, 10 (3). pp. 188-195. ISSN 1474-1776

Maira, Sauveur-Michel and Pecchi, Sabina and Huang, Alan and Burger, Matthew and Knapp, Mark and Sterker, Dario and Huh, Kay and Schnell, Christian and Guthy, Daniel Alexander and Nagel, Tobi and Wiesmann, Marion and Brachmann, Saskia and Fritsch, Christine and Dorsch, Marion and Chene, Patrick and Shoemaker, Kevin and De Pover, Alain and Menezes, Daniel and Fabbro, Doriano and Wilson, Christopher and garcia-echeverria, carlos and Schlegel, Robert and Sellers, William and Hofmann, Francesco and Voliva, Charles (2011) Identification and characterization of NVP-BKM120, an orally available pan class I PI3-Kinase inhibitor. Molecular Cancer Therapeutics, 11 (2). pp. 317-328. ISSN 1535-7163

Marotta, Lauren L.C and Almendro, Vanessa and Shipitsin, Michail and Marusyk, Andriy and Schemme, Janina and Walker, Sarah R and Bloushtain-Qimron, Noga and Kim, Jessica J and Choudhury, Sibgat A and Maruyama, Reo and Wu, Zhenhua and Gönen, Mithat and Mulvey, Laura A and Bessarabova, Marina O and Huh, Sung Jin and Silver, Serena J and Kim, So Young and Park, So Yeon and Lee, Hee Eun and Anderson, Karen S and Richardson, Andrea L and Nikolskaya, Tatiana and Nikolsky, Yuri and Liu, X Shirley and Root, David E and Hahn, William C and Frank, David A and Polyak, Kornelia and Ritson, Margaret (2011) The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. Journal of Clinical Investigation, 121 (7). pp. 2723-2735. ISSN 0021-9738

Martin, Eric and Mukherjee, Prasenjit and Sullivan, David and Jansen, Johanna (2011) Profile-QSAR: A Novel Meta-QSAR Method that Combines Activities Across the Kinase Family to Accurately Predict Affinity, Selectivity and Cellular Activity. Journal of Chemical Information and Modeling, 51 (8). pp. 1942-1956. ISSN 1549-9596

Matheis, Katja /A and Com, Emmanuelle and Gautier, Jean-Charles and Guerreiro, Nelson and Brandenburg, Arnd and Gmuender, Hans and Sposny, Alexandra and Hewitt, Philip and Amberg, Alexander and Boernsen, K. Olaf and Riefke, Bjoern and Hoffmann, Dana and Mally, Angela and Kalkuhl, Arno and Suter, Laura and Dieterle, Frank and Staedtler, Frank (2011) Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers. Toxicology and Applied Pharmacology, 252 (2). pp. 112-122. ISSN 0041-008X

Matter, Yves and Enea, Ramona and Casse, Olivier and Lee, Cameron and Baryza, Jeremy and Meier, Wolfgang (2011) Amphiphilic PEG-b-PMCL-b-PDMAEMA Triblock Copolymers: From Synthesis to Physico-Chemistry of Self-Assembled Structures. Macromolecular Chemistry and Physics, 212 (9). pp. 937-949.

Mccarren, Patrick and Bebernitz, Gregory and Gedeck, Peter and Glowienke, Susanne and Grondine, Melissa and Kirman, Louise and Klickstein, Jacob and Schuster, Herbert and Whitehead, Lewis (2011) Avoidance of the Ames test liability for Aryl-amines via computation. Bioorganic and Medicinal Chemistry, 19 (10). pp. 3173-3182. ISSN 0968-0896

Mccarren, Patrick and Springer, Clayton and Whitehead, Lewis (2011) An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential. Journal of Cheminformatics, 3 (1). p. 51. ISSN 1758-2946

Mendelson, Seth and Miller, Barbara and Poolman, Robert (2011) Blurring the Line Between Bioinformatics and Patent Analysis. WORLD PATENT INFORMATION, 33 (3). pp. 257-259. ISSN 0172-2190

Meringer, Markus and Reinker, Stefan and Zhang, Juan and Muller, Alban (2011) MS/MS Data Improves Automated Determination Molecular Formulas by Mass Spectrometry. MATCH Communications in Mathematical and Computer Chemistry, 65 (2). pp. 259-290. ISSN 0340-6253

Minetti, Giulia and Rosenstiel, Antonia and Werner, Annick and Meier, Viktor and Kahle, Peter and Glass, David and Feige, Jerome and Fornaro, Mara and Bombard, Florian and Sailer, Andreas and Bassilana, Frederic and Lambert, Christian (2011) Gai2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration. Science Signaling, 4 (201). ra8. ISSN 1945-0877

Morawska, Marta Magdalena and Buchi, Melanie and Fendt, Markus (2011) Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors. Behavioural Brain Research, 222 (2). pp. 397-400. ISSN 0166-4328

Moussaoui, Saliha (2011) Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease. The Journal of Clinical Investigation, 121 (8). pp. 3306-3319. ISSN 0021-9738

Moussaoui, Saliha (2011) Butyrylcholinesterase inhibition (MoA of Exelon) ameliorates cognitive dysfunction induced by amyloid-ß peptide in mice. Behavioural Brain Research, 225 (1). pp. 222-229. ISSN 0166-4328


Nigsch, Florian and Lounkine, Eugen and Mccarren, Patrick and Cornett, Allen and Glick, Meir and Azzaoui, Kamal and Urban, Laszlo and Marc, Philippe and Mueller, Arne and Hahne, Florian and Heard, David and Jenkins, Jeremy (2011) Computational methods for early predictive safety assessment from biological and chemical data. Expert Opinion on Drug Metabolism and Toxicology, 7 (12). pp. 1497-1511. ISSN 1742-5255

Nishiguchi, Gisele and Atallah, Gordana and Bellamacina, Cornelia and Burger, Matthew and Feucht, Paul and Garcia, Pablo and Han, Wooseok and Klivansky, Liana and Ding, Yu and Lindvall, Mika (2011) Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2 and Pim-3 protein kinases. Bioorganic and Medicinal Chemistry Letters, 21 (21). pp. 6366-6369.

Nyfeler, Beat and Bergman, Phillip and Triantafellow, Ellen and Wilson, Christopher and Zhu, Yanyi and Radetich, Branko and Finan, Peter and Klionsky, Daniel and Murphy, Leon (2011) Relieving autophagy and 4EBP1 from rapamycin resistance. Molecular and Cellular Biology, 31 (14). pp. 2867-2876. ISSN 0270-7306


O'Reilly, Terence and Mcsheehy, Paul M.J. and Wartmann, Markus and Lassota, Peter and Brandt, Ralf and Lane, Heidi (2011) Evaluation of the mTOR inhibitor, everolimus, in combination with cytotoxic anti-tumor agents using human tumor models in vitro and in vivo. Anticancer Drugs, 22 (1). pp. 58-78. ISSN 0959-4973

Orain, David and Beerli, Christian and Billich, Andreas and Streiff, Markus and Bigaud, Marc and Auberson, Yves and Briard, Emmanuelle (2011) BZM055, a SPECT tracer candidate for studying FTY720 brain distribution and myelin imaging. ChemMedChem, 6 (4). pp. 667-677.


Pascoe, S and Reynolds, Christine and Pleskow, W and Perry, Sheryl and Hmissi, Abdel and Kaiser, Guenther and Brookman, Laurence (2011) Safety, tolerability and pharmacokinetics of single escalating doses of indacaterol, a once-daily beta2-agonist bronchodilator, in subjects with COPD. International Journal of Clinical Pharmacology and Therapeutics, 49 (2). pp. 153-161. ISSN 0946-1965

Pecchi, Sabina and Renhowe, Paul and Taylor, Clarke and Kaufman, Susan and Merritt, Hanne and Wiesmann, Marion and Shoemaker, Kevin and Knapp, Mark and Hendrickson, Thomas and Fantl, Wendy and Voliva, Charles (2011) Identification and Structure-Activity Relationship of 2-Morpholino 6-(3-Hydroxyphenyl) Pyrimidines, a Class of Potent and Selective PI3-Kinase Inhibitors. Bioorganic and Medicinal Chemistry Letters, 20 (23). pp. 6895-6898. ISSN 0960-894X

Petrone, Paula and Whitehead, Lewis and Dewhurst, Janetta and Tommasi, Ruben and Pomerantz, Andrea (2011) Atomic-Scale Characterization of Conformational Changes in the PreQ1 Riboswitch Aptamer upon Ligand Binding. Journal of Molecular Graphics and Modeling. ISSN 1093-3296

Peukert, Stefan and Nunez, Jill and He, Feng and Dai, Miao and Yusuff, Naeem and Dipesa, Alan and Miller-Moslin, Karen and Karki, Rajesh and Lagu, Bharat and Harwell, Chris and Zhang, Yalin and Bauer, Daniel and Kelleher Iii, Joseph and Egan, William (2011) A method for estimating the risk of drug-induced phototoxicity and its application to Smoothened inhibitors. MedChemComm, 2. pp. 973-976. ISSN 2040-2511

Pilote, Natalie and Endacott, John and Miller, Kimberly and Peterson, Gretchen and Poolman, Robert (2011) Creation and implementation of a customized patent information training program for chemists in a global company. World Patent Information, 33 (4). pp. 340-344. ISSN 01722190

Pirard, Bernard (2011) The quest for novel chemical matter. Expert Opinion in Drug Discovery, 6 (3). pp. 226-231. ISSN 1746-0441

Poellinger, Bernadette (2011) IL-17 producing T cells in mouse models of Multiple Sclerosis and Rheumatoid Arthritis. IL-17 producing T cells in mouse models of Multiple Sclerosis and Rheumatoid Arthritis.

Poellinger, Bernadette and Junt, Tobias and Metzler, Barbara and Ulrich, Walker and Alan, Tyndall and Allard, Cyril and Bay, Serkan and Keller, Roland and Raulf, Friedrich and Patel, Dhavalkumar and Littlewood-Evans, Amanda (2011) Th17 cells, not IL-17+ γδ T cells, drive arthritic bone destruction in mice and humans. Journal of Immunology, 186 (4). pp. 2602-2612. ISSN 0022-1767

Pritz, Stephan and Doering, Klaus and Woelcke, Julian and Hassiepen, Ulrich (2011) Fluorescence Lifetime Assays – Current Advances and Applications in Drug Discovery. Expert Opinion on Drug Discovery, 6 (6). pp. 663-670. ISSN 1746-045X

Pritz, Stephan and Meder, Gabriele and Doering, Klaus and Drueckes, Peter and Woelcke, Julian and Mayr, Lorenz and Hassiepen, Ulrich (2011) A Fluorescence Lifetime-Based Assay for Abelson Kinase. JOURNAL OF BIOMOLECULAR SCREENING, 16 (1). pp. 65-72. ISSN 1087-0571


Raghunathan, Dhaarini and Wells, Timothy J and Morris, Faye C and Shaw, Robert K and Bobat, Saeeda and Peters, Sarah E and Paterson, Gavin K and Jensen, Karina Tveen and Leyton, Denisse L and Blair, Jessica M A and Browning, Douglas F and Pravin, John and Flores-Langarica, Adriana and Hitchcock, Jessica R and Moraes, Claudia T P and Piazza, Roxane M F and Maskell, Duncan J and Webber, Mark A and May, Robin C and Maclennan, Calman A and Piddock, Laura J and Cunningham, Adam F and Henderson, Ian R (2011) SadA, a Trimeric Autotransporter from Salmonella enterica Serovar Typhimurium, Can Promote Biofilm Formation and Provides Limited Protection against Infection. Infection and immunity, 79 (11). pp. 4342-4352. ISSN 0019-9567

Rakhilin, Sergey and Turner, Gordon and Katz, Mark and Warden, Robert and Irelan, Jeffrey and Abassi, Yama and Glass, David (2011) Electrical Impedance as a Novel Biomarker of Myotube Atrophy and Hypertrophy. Journal of Biomolecular Screening. ISSN 1087-0571

Ramurthy, Savithri and Costales, Abran and Aikawa, Mina and Amiri, Payman and Jansen, Johanna and Lin, Song and Ma, Sylvia and Renhowe, Paul and Shafer, Cynthia and Subramanian, Sharadha and Sung, L and Verhagen, J (2011) Design and Synthesis of 5,6-fused Heterocyclic Amides as Raf Kinase Inhibitors. Bioorganic Medicinal Chemistry Letters, 21 (11). pp. 3286-3289. ISSN 0960-894X

Rebello, Sam and Zhao, Sally and Hariry, Sam and Dahlke, Marion and Alexander, Natalya and Vapurcuyan, Arpine and Hanna, Imad and Jarugula, Venkateswar (2011) Intestinal OATP1A2 inhibition as a potential mechanism for the effect of grapefruit juice on aliskiren pharmacokinetics in healthy subjects. European journal of clinical pharmacology. ISSN 0031-6970

Reiss, Simon and Rebhan, Ilka and Backes, Perdita and Romero-Brey, Ines and Erfle, Holger and Matula, Petr and Kaderali, Lars and Poenisch, Marion and Blankenburg, Hagen and Hiet, Marie-Sophie and Longerich, Thomas and Diehl, Sarah and Ramirez, Fidel and Rohr, Karl and Kaul, Artur and Buehler, Sandra and Pepperkok, Rainer and Lengauer, Thomas and Albrecht, Mario and Eils, Roland and Schirmacher, Peter and Lohmann, Volker and Bartenschlager, Ralf (2011) Recruitment and activation of a lipid kinase by NS5A of the hepatitis C virus is essential for integrity of the membranous replication compartment. Cell Host & Microbe, 9 (1). pp. 32-45. ISSN 19313128

Renner, Steffen and Bajorath, Jürgen and Barreca, Maria and Bender, Andreas and Bryce, Richard and Hutter, Michael and Laggner, Christian and Laughton, Charles and Martin, Yvonne and Mitchell, John and Padova, Alessandro and Selzer, Paul and Sherman, Woody and Sippl, Wolfgang and Taft, C and Tuccinardi, Tiziano (2011) Ask the experts: focus on computational chemistry. Future Medicinal Chemistry, 3 (8). pp. 909-921. ISSN 1756-8919

Renner, Steffen and Popov, Maxim and Schuffenhauer, Ansgar and Roth, Hans-Joerg and Breitenstein, Werner and Marzinzik, Andreas and Lewis, Ian and Krastel, Philipp and Nigsch, Florian and Jenkins, Jeremy and Jacoby, Edgar (2011) Recent Trends and Observations in the Design of High Quality Screening Collections. Future Medicinal Chemistry, 3 (6). pp. 751-766.

Ritchie, Timothy J. and Ertl, Peter and Lewis, Richard (2011) The graphical representation of ADME-related molecular properties for medicinal chemists - an overview. Drug Discovery Today, 16 (1-2). pp. 65-72. ISSN 1359-6446

Riviere, Gilles-Jacques and Yeh, Ching-Ming and Reynolds, Christine and Brookman, Laurence and Kaiser, Guenther (2011) Bioequivalence of a novel omalizumab solution for injection compared with the standard lyophilized powder formulation. Journal of Bioequivalence & Bioavailability, 3 (6). pp. 144-150. ISSN 0975-0851

Rolan, Paul and MacLeod, Catherine and Bracken, Kathryn and Sun, Haiying and Evans, Thomas George (2011) Pharmacokinetics and unexpected safety issues of LBM415, a novel oral peptide deformylase inhibitor. Clinical Pharmacology and Therapeutics, 90 (2). pp. 256-262. ISSN 0009-9236

Rondini, Simona and Micoli, Francesca and Lanzilao, Luisa and Hale, Christine and Saul, Allan and Martin, Laura (2011) Evaluation of the Immunogenicity and Biological Activity of the Citrobacter freundii Vi-CRM197 Conjugate as a Vaccine for Salmonella enterica Serovar Typhi. CLINICAL AND VACCINE IMMUNOLOGY, 18 (3). pp. 460-468. ISSN 1556-6811

Rondini, Simona and Micoli, Francesca and Lanzilao, Luisa and Hale, Christine and Saul, Allan and Martin, Laura (2011) Evaluation of the Immunogenicity and Biological Activity of the Citrobacter freundii Vi-CRM197 Conjugate as a Vaccine for Salmonella enterica Serovar Typhi. Clinical and Vaccine Immunology, 18 (3). pp. 460-468. ISSN 1556-6811

Roscic, Ana and Baldo, Barbara and Crochemore, Christophe and Marcellin, David and Paganetti, Paolo (2011) Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model. Journal Neurochemistry, 119 (2). pp. 398-407. ISSN 0022-3042

Rosethorne, Liz and Charlton, Steven (2011) Agonist-biased signalling at the histamine H4 receptor: JNJ7777120 recruits beta-arrestin without activating G proteins. Molecular Pharmacology, 79 (4). pp. 749-757. ISSN 0026-895X

Rubert, Joelle and Qian, Zhiyan and Andraos, Rita and Guthy, Daniel Alexander and Radimerski, Thomas (2011) Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. BMC Cancer, 11. p. 24. ISSN 1471-2407

Rueeger, Heinrich and Rondeau, Jean-Michel and Mccarthy, Clive and Moebitz, Henrik and Tintelnot-Blomley, Marina and Neumann, Ulf and Desrayaud, Sandrine (2011) Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 21 (7). pp. 1942-1947. ISSN 0960-894X

Rueeger, Heinrich and Rondeau, Jean-Michel and Mccarthy, Clive and Moebitz, Henrik and Tintelnot-Blomley, Marina and Neumann, Ulf and Desrayaud, Sandrine (2011) Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters, 21 (7). pp. 1942-1947. ISSN 0960-894X

Russo, Carla and Cornella-Taracido, Ivan and Galli-Stampino, Luisa and Jain, Rishi and Harrington, Edmund and Isome, Yuko and Tavarini, Simona and Sammicheli, Chiara and Nuti, Sandra and Mbow, Lamine and Valiante, Nicholas M. and Tallarico, John and De Gregorio, Ennio and Soldaini, Elisabetta (2011) Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells. Blood Journal, 117 (21). pp. 5683-5691. ISSN 0006-4971


Sampath, Shruthi and Mc Lean, Leeanne and Buono-Dalton, Chiara and Richards, Virgile and Moulin, Pierre and Wolf, Armin and Chibout, Salah-Dine and Pognan, Francois and Shangari, Nandita (2011) The Use of Rat Lens Explant Cultures to Study the Mechanism of Drug-induced Cataractogenesis. Toxicological Sciences. ISSN 1096-6080

Saul, Allan (2011) Vaccines for Neglected Diseases. In: Vaccine Design: Innovative Approaches and Novel Strategies. Caister Academic Press, pp. 243-252. ISBN 978-1-904455-74-5

Schaefer, Michael and Koppole, Sampath (2011) A Discriminative Ramachandran Potential of Mean Force Aimed at Minimizing Secondary Structure Bias. Journal of Computational Chemistry. ISSN 0192-8651

Schiering, Nikolaus and D'Arcy, Allan and Villard, Frederic and Simic, Oliver and Kamke, Marion and Monnet, Gabriela and Hassiepen, Ulrich and Svergun, Dmitri and Pulfer, Ruth and Eder, Joerg and Raman, Prakash and Bodendorf, Ursula (2011) A macrocyclic HCV NS3/4A protease inhibitor interacts with protease and helicase residues in the complex with its full-length target. Proceedings of the National Academy of Sciences, USA. ISSN 0027-8424

Schmid, Herbert and Lambertini, Chiara and Van Vugt, Harmke and Barzaghi-Rinaudo, Patrizia and Schaefer, Judith and Stumm, Michael and Sailer, Andreas and Kaufmann, Martina and Nuciforo, Paolo (2011) Monoclonal antibodies against the human somatostatin receptor subtypes 1–5: Development and immunohistochemical application in neuroendocrine tumors. Neuroendocrinology. ISSN 0028-3835

Schmitt, Esther and Moore, Charles and Krastel, Philipp and Petersen, Frank (2011) Natural products as catalysts for innovation: a pharmaceutical industry perspective. Current Opinion in Chemical Biology.

Schmitt, Esther and Roggo, Silvio and Miault, Charlotte and Krastel, Philipp and Noble, Christian and Beer, David and Rao, Srinivasa and Au, Melvin and Niyomrattanakit, Pornwaratt and Zheng, Jun and Jeffery, Douglas and Pethe, Kevin and Camacho, Luis (2011) The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease. Angewandte.

Schmouder, Robert and Hariry, Sam and David, Olivier J (2011) Placebo-controlled study of the effects of fingolimod on cardiac rate and rhythm and pulmonary function in healthy volunteers. European journal of clinical pharmacology. ISSN 0031-6970

Schuffenhauer, Ansgar and Varin, Thibault (2011) Rule-Based Classification of chemical structures by scaffold. Molecular informatics, 30 (8). ISSN 1868-1751

Sheng, Qing and liu, joyce (2011) The therapeutic potential of targeting the EGFR family in epithelial ovarian cancer. British Journal of Cancer, 104 (8). pp. 1241-1245. ISSN 0007-0920

Shi, Jun and Glass, David (2011) The E3 ubiquitin ligase Fbxo40 targets IRS1 for degradation upon IGF1 treatment in skeletal myotubes, controlling muscle cell size. Developemental Cell, 21 (5). pp. 835-847. ISSN 1534-5807

Shultz, Michael and Cao, Xueying and Chen, Christine and Cho, Young and Davis, Nicole and Eckman Iii, Joseph and Growney, Joseph and Holmqvist, Mats and Hsu, Meier and Jansson, Daniel and Jiang, Lei and Kwon, Paul and Liu, Gang and Lombardo, Franco and Lu, Qiang and Majumdar, Dyuti and Meta, Christopher and Pu, Minying and Ramsey, Timothy and Remiszewski, Stacy and Traebert, Martin and Urban, Laszlo and Uttamsingh, Vinita and Wang, Ping and Whitebread, Steven and Whitehead, Lewis and Yan-Neale, Yan and Yao, Megan and Zhou, Liping and Atadja, Peter (2011) Optimization of the in vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors. Journal of Medicinal Chemistry, 54 (13). pp. 4752-4772. ISSN 0022-2623

Shultz, Michael and Fan, Jianmei and Chen, Christine and Cho, Young and Davis, Nicole and Bickford, Shari and Buteau, Kristen and Cao, Xueying and Holmqvist, Mats and Hsu, Meier and Jiang, Lei and Liu, Gang and Lu, Qiang and Patel, Chetan and Suresh, Joghee and Selvaraj, Mannangatti and Urban, Laszlo and Wang, Ping and Yan-Neale, Yan and Whitehead, Lewis and Zhang, Haiyan and Zhou, Liping and Atadja, Peter (2011) The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters, 21 (16). pp. 4909-4912. ISSN 0960-894X

Siehler Wagner, Sandra and Jacob, Sandra (2011) Lead Discovery for Targeting G Protein-coupled Receptors. European Pharmaceutical Review, 16 (5). pp. 45-51. ISSN 1360-8606

Siggins, Matthew K and Cunningham, Adam F and Marshall, Jennifer L and Chamberlain, Jayne L and Henderson, Ian R and MacLennan, Calman A (2011) Absent bactericidal activity of mouse serum against invasive African nontyphoidal Salmonella results from impaired complement function but not a lack of antibody. Journal of immunology, 186 (4). pp. 2365-2371. ISSN 1550-6606

Sivak, Jeremy and Cherry, Allison and Demirs, John and Cepeda, Rosemarie and Long, Debby and Anderson, Karen and Jaffee, Bruce (2011) PATHOLOGICAL ANGIOGENESIS IS COORDINATED BY REPAIR EPITHELIAL CELLS IN THE CORNEA DISTINCTLY FROM INTERACTIONS WITH INFLAMMATORY INFILTRATES. Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization.

Skvara, Hans and Kalthoff, Frank and Meingassner, Josef G and Wolff-Winiski, Barbara and Aschauer, Heinrich and Kelleher, Joseph F and Wu, Xu and Pan, Shifeng and Mickel, Lesanka and Schuster, Christopher and Stary, Georg and Jalili, Ahmad and David, Olivier J and Emotte, Corinne and Antunes, Ana Monica Costa and Rose, Kristine and Decker, Jeremy and Carlson, Ilene and Gardner, Humphrey and Stuetz, Anton and Bertolino, Arthur P and Stingl, Georg and De Rie, Menno A (2011) Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor. The Journal of investigative dermatology, 131 (8). pp. 1735-1744. ISSN 1523-1747

Smith, Nichola and Galan, M. Carmen and Tran, Anh-Tuan and Jones, Rachel A. and Pastor, Julien and Boisson, Julien (2011) Copper (II) triflate: a versatile catalyst for the one-pot preparation of orthogonally protected glycosides. Advanced Synthesis and catalysis, 353 (14/15). pp. 2593-2598. ISSN 1615-4169

Souza, Sandra/C and Chau, Mary/DL and Yang, Qing and Gauthier, Marie-Soleil and Clairmont, Kevin and Wu, Zhidan and Gromada, Jesper and Dole, William (2011) Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in isolated human adipocytes by activating AMPK. Biochemical and Biophysical Research Communications, 410 (3). pp. 398-403. ISSN 0006-291X

Stadler, Michael and Murr, Rabih and Wirbelauer, Christiane and Burger, Lukas and Ivanek, Robert and Lienert, Florian and Schoeler, Anne and Oakeley, Edward James and Gaidatzis, Dimosthenis and Tiwari, Vijay and Schuebeler, Dirk (2011) DNA-binding factors shape the mouse methylome at distal regulatory regions. Nature, 480 (7378). pp. 490-495. ISSN 0028-0836

Stamp, Craig and Riddy, Darren (2011) Characterisation of hS1P3 Receptor Expression Levels: Their Impact on Recruitment of β-arrestin within the DiscoveRx Assay. Univeristy of York Placement Report.

Stoop, Chatanika and Daniels, Anne (2011) Job Disovery Initiative at NIBR. Novartis Live Magazine, August (4/2011). pp. 28-29.

Stöcklin, Reto and Vorherr, Thomas (2011) Future perspectives of venoms for drug discovery. PharManufacturing.

Stühmer, Thorsten and Iskandarov, Karmol and Gao, Zhenhai and Bumm, Thomas and Grella, Evelyn and Jensen, Michael Rugaard and Einsele, Hermann and Chatterjee, Manik and Bargou, Ralf C. (2011) Preclinical Activity of the Novel Orally Bioavailable HSP90 Inhibitor NVP-HSP990 against Multiple Myeloma Cells. Anticancer Res, 32 (2). pp. 453-462. ISSN 0250-7005

Sutton, J and Clark, D and Dunsdon, J and Fenton, G and Fillmore, A and Harris, N and Higgs, C and Hurley, C and Krintel, S and MacKenzie, R and Duttaroy, Alokesh and Gangl, Eric and Maniara, Wieslawa and Sedrani, Richard and Namoto, Kenji and Ostermann, Nils and Sirockin, Finton and Trappe, Joerg and Hassiepen, Ulrich and Baeschlin, Daniel (2011) Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes II: Optimisation of the PK profile. Bioorganic and medicinal chemistry letters, 22 (3). pp. 1464-1468. ISSN 0960-894X


Tanii, Hiromi and Shitara, Yoshihisa and Horie, Toshiharu (2011) Population pharmacokinetic analysis of letrozole in Japanese postmenopausal women. European Journal of Clinical Pharmacology, 67 (10). pp. 1017-1025. ISSN 0031-6970

Terranova, Remi (2011) Novartis: Genedata Expressionist® for Genomic Profiling used to predict effects of non-genotoxic carcinogens. Case study document from genedata company.

Terranova, Remi (2011) Phenobarbital Mediates an Epigenetic Switch at the Constitutive Androstane Receptor (CAR) Target Gene Cyp2b10 in the Liver of B6C3F1 Mice. PLoS ONE, 6 (3). e118216-e18216. ISSN 1932-6203

Testa, Lisa and Rosser, Paula and Novo, Alfredo (2011) Rodent Duplex. Rodent Duplex.

Testa, Lisa and Rosser, Paula and Novo, Alfredo (2011) Rodent Duplex. Rodent Duplex.

Tetko, Igor V and Sushko, Iurii and Gasteiger, Johann and Todeschini, Roberto and Ertl, Peter (2011) Online Chemical Modeling Environment (OCHEM): Web Platform for Data Storage, Model Development and Publishing of Chemical Information. Journal of Computer Aided Molecular Design, 25 (6). pp. 533-554. ISSN 0920-654X

Thoma, Gebhard and Baenteli, Rolf and Lewis, Ian and Jones, Darryl and Kovarik, Jiri and Streiff, Markus and Zerwes, Hans-Guenter (2011) Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood. Bioorganic & Medicinal Chemistry Letters.

Thoma, Gebhard and Nuninger, Francois and Falchetto, Rocco Angelo and Hermes, Erwin and Tavares, Gisele and Vangrevelinghe, Eric and Zerwes, Hans-Guenter (2011) Identification of a potent Jak3 inhibitor with high selectivity within the Jak kinase family. The Journal of Medicinal Chemistry, 54 (1). pp. 284-288. ISSN 0022-2623

Thomson, Christopher and Reilly, John and Sandham, David (2011) Synthesis of useful fragments in drug discovery: 2-amino-5-tert-butylpyridine and its oxidised analogues. Bioorganic and Medicinal Chemistry Letters, 21 (14). pp. 4281-4283. ISSN 0960-894X

Thrum, Stephan and Lorenz, Jana and Mössner, Joachim and Wiedmann, Marcus (2011) Polo-like Kinase 1 Inhibition as a New Therapeutic Modality in Therapy of Cholangiocarcinoma. Anticancer Research, 31 (10). pp. 3289-3300. ISSN 0250-7005

Tiedt, Ralph and Degenkolbe, Elisa and Furet, Pascal and Appleton, Brent and Schoepfer, Joseph and Ruddy, David and Monahan, John and Blank, Jutta and Haasen, Dorothea and Drueckes, Peter and Wartmann, Markus and Mccarthy, Clive and Hofmann, Francesco (2011) A Drug Resistance Screen Using a Selective MET Inhibitor Reveals a Spectrum of Mutations That Partially Overlap with Activating Mutations Found in Cancer Patients. Cancer Research, 71 (15). pp. 5255-5264. ISSN 0008-5472

Tommasi, Ruben and Weiler, Sven and Mc Quire, Leslie and Rogel, Olivier and Chambers, Mark and Clark, Kirk and Doughty, John and Fang James, - and Ganu, Vishwas and Goldberg, Ronald and Goldstein, Robert and Lavoie, Stacey and Grob, Jonathan and Kulathila, Raviraj and Macchia, William and Melton, Richard and Springer, Clayton and Walker, Marc and Zhang, Jing and Zhu, Lijuan and Shultz, Michael (2011) Potent and Selective 2-Naphthylsulfonamide Substituted Hydroxamic Acid Inhibitors of Matrix Metalloproteinase-13. Bioorganic and Medicinal Chemistry Letters, 21 (21). pp. 6440-6445. ISSN 0960-894X

Trowitzsch, Simon and Klumpp, Martin and Thoma, Ralf and Carralot, Jean-Philippe and Berger, Imre (2011) Light it up: Highly Efficient Multigene Delivery in Mammalian Cells. Bioessays, 33 (12). pp. 946-955. ISSN 0265-9247

Tsukamoto, Naoko and Otsuka, Fumio and Miyoshi, Tomoko and Inagaki, Kenichi and Nakamura, Eri and Suzuki, Jiro and Ogura, Toshio and Makino, Hiofumi and Ritson, Margaret (2011) Activities of bone morphogenetic proteins in prolactin regulation by somatostatin analogs in rat pituitary GH3 cells. Molecular and cellular endocrinology, 332 (1-2). pp. 163-169. ISSN 0303-7207

Turner, Jonathan and Roger, Jan and Fitau, Juliette and Combe, Delphine and Giddings, June and Van Heeke, Gino and Jones, Carol (2011) Goblet Cells are Derived from a FOXJ1-Expressing Progenitor in a Human Airway Epithelium. American Journal of Respiratory Cell and Molecular Biology, 44 (3). pp. 276-284. ISSN 1535-4989

Turner, Oliver and Colman, Karyn and Potenta, Daniel and Sistare, F.D. and Morton, D. and Alden, C. and Christensen, J. and Keller, D. and Jonghe, S.D. and Storer, R.D. and Reddy, M.V. and Kraynak, A. and Trela, B. and Bienvenu, J.G. and Bjurström, S. and Bosmans, v. and Dominick, M. and Evans, J. and Hailey, J.R. and Kinter, L. and Liu, M. and Mahrt, C. and Marien, D and Myer, J. and Perry, R. and Roth, A. and Sherratt, P. and Singer, T. and Slim, r. and Soper, K. and Fransson-Stehn, R. and Stoltz, J. and Turnquist, S. and vanHeerden, M. and Woicke, J. and Degeorge, J.J. (2011) An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing: Support for a Proposal to Modify Current Regulatory Guidelines. Toxicologic Pathology, 39 (4). pp. 716-744. ISSN 0192-6233


Umehara, Ken-Ichi and Camenisch, Gian P. (2011) Novel in vitro-in vivo Extrapolation (IVIVE) Method to Predict Hepatic Organ Clearance in Rat. Pharmaceutical Research. ISSN 0724-8741


Valentin, Marie-Anne and Ma, Shenglin and Zhao, An and Legay, Francois and Avrameas, Alexandre (2011) VALIDATION OF IMMUNOASSAY FOR PROTEIN BIOMARKERS: BIOANALYTICAL STUDY PLAN IMPLEMENTATION TO SUPPORT PRE-CLINICAL AND CLINICAL STUDIES. Journal of Pharmaceutical and Biomedical Analysis, 55 (5). pp. 869-877. ISSN 0731-7085

Van Eis, Maurice and Evenou, Jean-Pierre and Floersheim, Philipp and Gaul, Christoph and Jacob, Sandra and Monovich, Lauren and Rummel, Gabriele and Schuler, Walter and Stark, Wilhelm and Strauss, Andre and Von Matt, Anette and Vangrevelinghe, Eric and Wagner, Juergen and Soldermann, Nicolas (2011) 2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes. Bioorganic & Medicinal Chemistry Letters, 21 (24). pp. 7367-7372. ISSN 0960-894X

Varin, Thibault and Schuffenhauer, Ansgar and Ertl, Peter and Renner, Steffen (2011) Mining for bioactive scaffolds with scaffold networks – improved compound set enrichment from primary screening data. Journal of Chemical Information and Modeling. ISSN 1549-9596

Velcicky, Juraj and Soicke, Arne and Steiner, Roland and Schmalz, Hans-Günther (2011) Palladium-Catalyzed Cyanomethylation of Aryl Halides through Domino Suzuki Coupling-Isoxazole Fragmentation. Journal of the American Chemical Society, 133 (18). pp. 6948-6951. ISSN 1520-5126

Voedisch, Bernd and Patoux, Agnes and Sterkenburgh, Jildou and Buchs, Mirjam and Barry, Emily and Allard, Cyril and Geisse, Sabine (2011) About making a CHO production cell line “research-friendly” by genetic engineering - Extended abstract. BMC Proceedings, 5 (Suppl.). P132. ISSN 0002-9440

Vulpetti, Anna and Dalvit, Claudio (2011) Fluorine Local Environment: From Screening to Drug Design. Drug Discovery Today, 17 (15-16). pp. 890-897. ISSN 1359-6446

Vulpetti, Anna and Dalvit, Claudio (2011) Intermolecular and intramolecular hydrogen bonds involving shielded fluorine atoms: implications for recognition, selectivity and chemical properties. ChemMedChem, 7 (2). pp. 262-272. ISSN 1860-7179

van Damme, Pierre and Kafeja, Froukje and Anemona, Alessandra and Basile, Venere and Hilbert, Anne Katrin and De Coster, Ilse and Rondini, Simona and Micoli, Francesca and Qasim Khan, Rana M and Marchetti, Elisa and Di Cioccio, Vito and Saul, Allan and Martin, Laura B and Podda, Audino (2011) Safety, immunogenicity and dose ranging of a new Vi-CRM₁₉₇ conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults. PloS one, 6 (9). e25398. ISSN 1932-6203


Wagner, Juergen and Von Matt, Peter and Faller, Bernard and Cooke, Nigel Graham and Albert, Rainer and Sedrani, Richard and Beerli, Christian and Weckbecker, Gisbert and Evenou, Jean-Pierre and Zenke, Gerhard and Cottens, Sylvain (2011) SAR and Pharmacokinetic Studies of Sotrastaurin (AEB071), a Promising Novel Medicine to Prevent Graft Rejection and Treat Psoriasis. Journal of Medicinal Chemistry, 54 (17). pp. 6028-6039. ISSN 0022-2623

Wang, Jianling and Collis, Alan (2011) Maximizing the Outcome of Early ADMET Models: Strategies to Win the Drug Hunting Battles? Expert Opinion in Drug Metabolism and Toxicity, 7 (4). pp. 381-386. ISSN 1742-5255

Wang, Tao and Papoutsi, Maria and Decristofaro, Marc and Keselica, Michael and Skuba, Elizabeth and Spaet, Robert and Markovits, Judit and Wolf, Armin and Moulin, Pierre and Pognan, Francois and Vancutsem, Paul and Petryk, Lew and Kluwe, William (2011) Investigation of Correlation between safety biomarkers in serum, histopathological examination and toxicogenomics. International Journal of Toxicology. ISSN 1091-5818

Weber, Christian and Meiler, Svenja and Doering, Yvonne and Koch, Miriam and Drechsler, Maik and Megens, Remco T.A. and Rowinska, Zuzanna and Bidzhekov, Kiril and Ribechini, Eliana and van Zandvoort, Marc A.M.J. and Binder, Christoph J. and Jelinek, Ivett and Hristov, Mihail and Boon, Louis and Jung, Steffen and Korn, Thomas and Lutz, Manfred and Foerster, Irmgard and Zenke, Martin and Hieronymus, Thomas and Junt, Tobias and Zernecke, Alma (2011) CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T-cell homeostasis in mice. Journal of Clinical Investigation, 121 (7). pp. 2898-2910. ISSN 0021-9738

Wedehase, Thomas (2011) Lab logistics for Novartis. Internet.

Weiss, Tilla and Bürge, Thomas (2011) Handling and Restraint. In: The Laboratory Mouse. ELSEVIER Academic Press.

White, John/P/M and Urban, Laszlo and Nagy, Istvan (2011) Molecular structure of the Trnasient Receptor Potential Vanilloid Type 1 (TRPV1). Current Pharmaceutical Biotechnology.

Whitehead, Lewis and Deng, Gejing and Lee, Lac and Chenail, Gregg and Leeds, Jennifer and Luu, Catherine and Palestrant, Deborah and Sachdeva, Meena and Yu, Robert and Lamarche, Matthew (2011) In vitro and in vivo activities of novel, semisynthetic thiopeptide inhibitors of bacterial elongation factor Tu. Antimicrobial Agents and Chemotherapy, 55 (11). pp. 5277-5283. ISSN 0066-4804

Whitehead, Lewis and Vash, Brian and Dobler, Markus and Radetich, Branko and Grob, Jonathan and Mcriner, Andrew and Pancost, Margaret and Patnaik, Anup and Shao, Wenlin and Shultz, Michael and Tichkule, Ritesh and Tommasi, Ruben and Zhu, Yanyi and Wang, Ping and Atadja, Peter and Stams, Travis and Claiborne, Tavina (2011) Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorganic and Medicinal Chemistry.

Widler, Leo (2011) Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis. Future Medicinal Chemistry, 3 (5). pp. 535-547. ISSN 1756-8919

Wiessner, Christoph and Wiederhold, Karl-Heinz and Tissot, Alain C and Frey, Peter and Danner, Simone and Jacobson, Laura and Jennings, Gary T and Lueoend, Rainer Martin and Ortmann, Rainer and Reichwald, Julia and Zurini, Mauro and Mir, Anis Khusro and Bachmann, Martin F and Staufenbiel, Matthias (2011) The second generation active Aβ immunotherapy CAD106 reduces amyloid accumulation in APP transgenic mice while minimizing potential side effects. The Journal of Neuroscience, 31 (25). pp. 9323-9331. ISSN 0270-6474

Wirth, Urs and Bouwmeester, Antonius and Bauer, Andreas and Thoma, Nicolas and Schmidges, Frank W. and Prusty, Archana B. and Faty, Mahamadou and Stützer, Alexandra and Lingaraju, Gondihcathhanlli M. and Aiwazian, Jonathan and Sack, Ragna and Hess, Daniel and Li, ling and Zhou, Shalolian and Bunker, Richard D. and Wirth, Urs and Ly-Hartig, Nga and Zhao, Kehao and Chan, Homan and Gu, Justin and Gut, Heinz and Fischle, Wolfgang and Müller, Jürg and Thomä, Nicolas H. (2011) Histone methylation by PRC2 is inhibited by active chromatin marks. Molecular Cell, 42 (3). pp. 330-341. ISSN 1097-2765

Woehrle, Simon and Bonny, Olivier and Beluch, Noemie and Gaulis, Swann and Stamm, Christelle and Scheibler, Marcel and Mueller, Matthias and Kinzel, Bernd and Thuery, Anne and Brueggen, Josef and Hynes, Nancy and Sellers, William and Hofmann, Francesco and Graus Porta, Diana (2011) FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF23 signaling and regulating FGF23 expression in bone. Journal of Bone and Mineral Research. ISSN 0884-0431

Wolf, Romain (2011) AMBER "Lite": Some AMBER-Tools-Based Utilities. Amber Home Page.

Wu, Kai and Mercier, Francois and David, Olivier J and Schmouder, Robert L and Looby, Michael (2011) Population Pharmacokinetics of Fingolimod Phosphate in Healthy Participants. Journal of clinical pharmacology. ISSN 0091-2700


Zhang, Jie and Wei, Shimin and Ayres, David and Smith, Harold and Tse, Francis (2011) An Automation Assisted Generic Approach for Biological Sample Preparation and LC-MS/MS Method Validation. Bioanalysis Journal, 3 (17). pp. 1975-1986. ISSN 1757-6180

Zhang, Jie and Wei, Shimin and Ayres, David W and Smith, Harold T and Tse, Francis L S (2011) An automation-assisted generic approach for biological sample preparation and LC-MS/MS method validation. Bioanalysis, 3 (17). pp. 1975-1986. ISSN 1757-6199

Zhang, Yun and Mainolfi, Nello and Patel, Sejal and Timothy, Jamison/F (2011) Continuous Flow Coupling and Decarboxylation Reactions Promoted by Copper Tubing. Journal of Organic Letters, 13 (2). pp. 280-283. ISSN 1523-7060

Zhou, Hui and Rao, Jing and Lin, Jian and Yin, Bo and Sheng, Hansong and Lin, Fengchun and Zhang, Nu and Yang, Lin (2011) The Insulin-Like Growth Factor-I Receptor Kinase Inhibitor, NVP-ADW742, Sensitizes medulloblastoma to the Effects of Chemotherapy. Oncology Reports, 25 (6). pp. 1565-1571. ISSN 1021-335X

Zimmerlin, Alfred Gilbert and Trunzer, Markus and Faller, Bernard (2011) CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs. Drug Metabolism and Disposition, 39 (6). pp. 1039-1046. ISSN 0090-9556

Zwilling, Daniel and Huang, Shao-Yi and Guidetti, Paolo and Lee, Jason and Truong, Jennifer and Andrews-Zwilling, Yaisa and Hsieh, Eric and Louie, Jamie and Wu, Tiffany and Scearce-Levie, Kimberly and Wu, Hui-Qiu and Patrick, Christina and Adame, Anthony and Giorgini, Flaviano and Moussaoui, Saliha and Laue, Grit and Rassoulpour, Arash and Huang, Yadong and Muchowski, Joseph M and Masliah, Eliezer and Schwarcz, Robert and Muchowski, Paul J (2011) Kynurenine 3-monoxygenase in blood ameloriates neurodegeneration. Cell, 145 (6). pp. 863-874. ISSN 0092-8674

This list was generated on Thu Jun 30 06:19:19 2022 UTC.


Email Alerts

Register with OAK to receive email alerts for saved searches.