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ER stress: The link between pancreatic beta cell dysfuntion and death

Fonseca, Sonya and Gromada, Jesper and Urano, Fumihiko (2011) ER stress: The link between pancreatic beta cell dysfuntion and death. Trends in Endocrinology and Metabolism.

Abstract

In pancreatic β cells, the endoplasmic reticulum (ER) is an important cellular compartment for insulin biosynthesis, which accounts for half of total protein production in these cells. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR) which functions in influencing both cellular life and death decisions. β cell loss is a pathological component of both type 1 and type 2 diabetes, and recent findings suggest that ER stress is involved. A dysfunctional UPR and uncontrolled ER stress may be the tipping point between β cell dysfunction and the progression to cell death. In this review, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated β cell loss during the progression of diabetes.

Item Type: Article
Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4034

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