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Impact of high-throughput screening in biomedical research

Macarron, Ricardo, Banks, Martyn, Bojanic, Dejan, Burns, David, Garyantes, Tina, Green, Darren, Hertzberg, Robert, Janzen, William, Paslay, Jeff, Schopfer, Ulrich and Sittampalam, Sitta (2011) Impact of high-throughput screening in biomedical research. Nature Reviews Drug Discovery, 10 (3). pp. 188-195. ISSN 1474-1776


High Throughput Screening (HTS) has been postulated in several quarters to be a contributory factor to the widespread decline in Pharma industry productivity. Moreover, it has been promoted as anti-scientific and labeled as responsible for stifling the creativity that has long been the lifeblood of drug discovery. In this article we aim to dispel some of these myths and present the case for the use of HTS as part of a proven scientific toolkit, the wider use of which is essential for the discovery of new chemotypes. As we gain an even deeper understanding of the underlying mechanistic causes of disease, HTS has been further embraced in academic quarters for the discovery of tool compounds. Its wide adoption in industry and academia is a clear indicator that this technique is a valuable asset for the discovery of novel bioactive substances that can be used as molecular probes or optimized to pharmaceutical products.

Item Type: Article
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Keywords: High-Throughput Screening, Compound Libraries, Lead Discovery, molecular properties
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Date Deposited: 13 Oct 2015 13:16
Last Modified: 13 Oct 2015 13:16