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Copper (II) triflate: a versatile catalyst for the one-pot preparation of orthogonally protected glycosides

Smith, Nichola and Galan, M. Carmen and Tran, Anh-Tuan and Jones, Rachel A. and Pastor, Julien and Boisson, Julien (2011) Copper (II) triflate: a versatile catalyst for the one-pot preparation of orthogonally protected glycosides. Advanced Synthesis and catalysis, 353 (14/15). pp. 2593-2598. ISSN 1615-4169

Abstract

The development of general and efficient methodologies for the preparation of orthogonally protected glycoside building blocks is essential for the efficient synthesis of complex oligosaccharides. Herein, we describe the use of copper triflate as a versatile catalyst for the one-pot preparation of orthogonally protected thio- and O-glycosides. The conditions are mild, easy to handle and applicable to two and three one-pot tandem transformations, which include arylide acetalation, esterification, reductive acetal ring opening, glycosylation and silylation processes.

Item Type: Article
Additional Information: author can archive post-print (ie final draft post-refereeing); On personal web site or secure external website at authors institution; Publisher's version/PDF cannot be used
Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4522

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