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Design and synthesis of a library of chemokine antagonists

Baettig, Urs and Akhlaq, Mohammed and Beer, David and Charlton, Steven and Dunstan, Andrew and Bradley, Michelle and Gedeck, Peter and Owen, Charles and Nicklin, Paul and Rosethorne, Elizabeth and Bhalay, Gurdip (2011) Design and synthesis of a library of chemokine antagonists. Bioorganic & Medicinal Chemistry Letters, 21 (21). pp. 6249-6252. ISSN 0960-894X

Abstract

A library of chemokine antagonists has been synthesized using a combination of solid and solution-phase chemistry. Structures of known chemokine antagonists were used to produce a pharmacophore which served to guide monomer selection. Several combinations of monomers have resulted in providing novel chemokine antagonists which in some cases display dual chemokine receptor antagonism.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Chemokine Library Solid-phase Automation
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/5316

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