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An Automation Assisted Generic Approach for Biological Sample Preparation and LC-MS/MS Method Validation

Zhang, Jie and Wei, Shimin and Ayres, David and Smith, Harold and Tse, Francis (2011) An Automation Assisted Generic Approach for Biological Sample Preparation and LC-MS/MS Method Validation. Bioanalysis Journal, 3 (17). pp. 1975-1986. ISSN 1757-6180

Abstract

Background: Although it is well known that automation can provide significant improvement in the efficiency of biological sample preparation in quantitative LC-MS/MS analysis, it has not been widely implemented in bioanalytical laboratories throughout the industry. This can be attributed to the lack of a sound strategy and practical procedures in working with robotic liquid handling systems. Results: Several comprehensive automation assisted procedures for biological sample preparation and method validation were developed and qualified using two types of Hamilton Microlab liquid handling robots. The procedures developed were generic, user-friendly, and covered the majority of steps involved in routine sample preparation and method validation. Conclusions: Generic automation procedures were established as a practical approach to widely implement automation into the routine bioanalysis of samples in support of drug development programs.

Item Type: Article
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Additional Information: author cannot archive publisher's version/PDF
Keywords: Automation, validation, LC-MS/MS
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4804

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