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4-Aminothiazolyl Analogs of GE2270 A: Antibacterial Lead Finding

Lamarche, Matthew, Leeds, Jennifer, Gunderson, Karl, Krastel, Philipp, Memmert, Klaus, Patane, Michael, Rann, Elin, Schmitt, Esther, Wang, Bing, Dzink-Fox, Joann and Tiamfook, Stacey (2011) 4-Aminothiazolyl Analogs of GE2270 A: Antibacterial Lead Finding. Journal of medicinal chemistry, 54 (7). pp. 2517-2521. ISSN 0022-2623


4-Aminothiazolyl analogs of the antibacterial natural product GE2270 A (1) were designed, synthesized, and evaluated for G+ bacteria growth inhibition. The aminothiazole-based chemical template was evaluated for chemical stability and its decomposition revealed a novel, structurally simplified, des-thiazole analog of GE2270 A. Subsequent stabilization of the 4-aminothiazolyl functional motif was achieved and initial structure activity relationships defined.

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Keywords: EFT, EF-Tu, elongation factor Tu, GE2270 A, aminothiazole, Curtius
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15