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4-Aminothiazolyl Analogs of GE2270 A: Antibacterial Lead Finding

Lamarche, Matthew and Leeds, Jennifer and Gunderson, Karl and Krastel, Philipp and Memmert, Klaus and Patane, Michael and Rann, Elin and Schmitt, Esther and Wang, Bing and Dzink-Fox, Joann and Tiamfook, Stacey (2011) 4-Aminothiazolyl Analogs of GE2270 A: Antibacterial Lead Finding. Journal of medicinal chemistry, 54 (7). pp. 2517-2521. ISSN 0022-2623

Abstract

4-Aminothiazolyl analogs of the antibacterial natural product GE2270 A (1) were designed, synthesized, and evaluated for G+ bacteria growth inhibition. The aminothiazole-based chemical template was evaluated for chemical stability and its decomposition revealed a novel, structurally simplified, des-thiazole analog of GE2270 A. Subsequent stabilization of the 4-aminothiazolyl functional motif was achieved and initial structure activity relationships defined.

Item Type: Article
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Additional Information: archiving not formally supported by this publisher
Keywords: EFT, EF-Tu, elongation factor Tu, GE2270 A, aminothiazole, Curtius
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/3805

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