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Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors

Morawska, Marta Magdalena and Buchi, Melanie and Fendt, Markus (2011) Narcoleptic episodes in orexin-deficient mice are increased by both attractive and aversive odors. Behavioural Brain Research, 222 (2). pp. 397-400. ISSN 0166-4328

Abstract

Orexin-deficient mice are an established animal model for narcolepsy. In human patients, narcoleptic events are mainly triggered by emotional events. However, the role of emotional stimuli in murine narcolepsy is not well understood. The present study investigated the effects of attractive and aversive odor stimuli, i.e. urine samples of coyote and female mice, on narcoleptic episodes (cataplexy, sleep attacks) in orexin-deficient mice. Here, we first demonstrate that exposure to both attractive and aversive odors significantly increase the number of narcoleptic episodes in orexin-deficient mice. This behavioral paradigm may be of high interest for studies focused on the question how emotions can trigger narcoleptic episodes.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Cataplexy, emotion, narcolepsy, odors, orexin.
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4378

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