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Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols

Bello, Claudia and Dal Bello, Giovanna and Grossi, Francesco and Patrone, Franco and Ballestrero, Alberto and Dupuis, Marc and Sordat, Bernard and Nencioni, Alessio and Zimmermann, Kaspar and Loretan, Jacqueline and Wartmann, Markus and Vogel, Pierre and Cea, Michele and Motta, Giulia and Moran, Eva and Aubry, Dominique and Nahimara, Aimable and Duchosal, Michel A. and Fruscione, Floriana and Pronzato, Paolo (2011) Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols. BIOORGANIC & MEDICINAL CHEMISTRY, 19 (24). pp. 7720-7727. ISSN 0968-0896

Abstract

New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. (2R,3R,4S)-(Oleyloxymethyl)pyrroli¬dine-3,4-diol (13, IC50 ~2 uM) and its C18-analogues (IC50 < 10 uM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC50 ~8 uM) growth of JURKAT cells.

Item Type: Article
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Additional Information: DOES NOT CONTAIN ANY NOVARTIS COMPOUNDS.
Keywords: breast cancer iminoalditols Jurkat cells oleyl derivative
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4297

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