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Lung deposition of inhaled tobramycin with eFlow rapid/LC Plus jet nebuliser in healthy and cystic fibrosis subjects

Kovarik, John M. and Lenney, Warren and Kho, Pearl and Edenborough, Frank (2011) Lung deposition of inhaled tobramycin with eFlow rapid/LC Plus jet nebuliser in healthy and cystic fibrosis subjects. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 10 (1). pp. 9-14. ISSN 1569-1993

Abstract

Background: Reducing nebulisation times for tobramycin solution for inhalation in cystic fibrosis (CF) may improve compliance.
Methods: In this single-dose, open-label, two-way crossover study, 13 subjects (7 CF, 6 healthy) were randomised to receive tobramycin via
eFlow rapid or LC Plus jet nebuliser. Drug deposition in the lung using gamma scintigraphic imaging, nebulisation times, pharmacokinetics, and
safety were evaluated.
Results: In CF patients, whole-lung deposition was 40% less with the eFlow rapid compared with LC Plus nebulisers was (8.9±0.8%, and 15.1±6.0%, pN0.05). Nebulisation time was shorter with eFlow rapid compared to LC Plus (7.0 min versus 20.0 min, pb0.05). Lung deposition in healthy subjects was comparable between both devices.
Conclusions: eFlow rapid reduces the nebulisation time of tobramycin and can potentially improved compliance in patients with CF.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4735

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