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Design and Synthesis of 5,6-fused Heterocyclic Amides as Raf Kinase Inhibitors

Ramurthy, Savithri and Costales, Abran and Aikawa, Mina and Amiri, Payman and Jansen, Johanna and Lin, Song and Ma, Sylvia and Renhowe, Paul and Shafer, Cynthia and Subramanian, Sharadha and Sung, L and Verhagen, J (2011) Design and Synthesis of 5,6-fused Heterocyclic Amides as Raf Kinase Inhibitors. Bioorganic Medicinal Chemistry Letters, 21 (11). pp. 3286-3289. ISSN 0960-894X

Abstract

Two novel scaffolds based on 5,6-fused heterocyclic backbones were designed and synthesized as Raf kinase inhibitors. The scaffolds were assessed for in vitro pan-Raf inhibition, activity in cell proliferation and target modulation assays, and pharmacokinetic parameters.

Item Type: Article
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Additional Information: author can archive post-print (ie final draft post-refereeing); Publisher's version/PDF cannot be used
Keywords: Benzoxazoles, benzothiazoles, raf inhibitors
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Date Deposited: 13 Oct 2015 13:15
Last Modified: 13 Oct 2015 13:15
URI: https://oak.novartis.com/id/eprint/4316

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